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30681por Prajsnar, Tomasz K., Serba, Justyna J., Dekker, Bernice M., Gibson, Josie F., Masud, Samrah, Fleming, Angeleen, Johnston, Simon A., Renshaw, Stephen A., Meijer, Annemarie H.“…Abbreviations: ATG: autophagy related; CFU: colony-forming units; CMV: cytomegalovirus; Cyba/P22phox: cytochrome b-245, alpha polypeptide; DMSO: dimethyl sulfoxide; DPI: diphenyleneiodonium; EGFP: enhanced green fluorescent protein; GFP: green fluorescent protein; hpf: hours post-fertilization; hpi: hours post-infection; Irf8: interferon regulatory factor 8; LAP: LC3-associated phagocytosis; lyz: lysozyme; LWT: london wild type; Map1lc3/Lc3: microtubule-associated protein 1 light chain 3; NADPH oxidase: nicotinamide adenine dinucleotide phosphate oxidase; RFP: red fluorescent protein; ROS: reactive oxygen species; RT-PCR: reverse transcriptase polymerase chain reaction; Sqstm1/p62: sequestosome 1; Tg: transgenic; TSA: tyramide signal amplification.…”
Publicado 2020
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30682por Sauce, Delphine, Pourcher, Valérie, Ferry, Tristan, Boddaert, Jacques, Slama, Laurence, Allavena, Clotilde“…Six biomarkers (interleukin [IL]-1B, IL-7, IL-18, neopterin, sCD14, and fatty acid-binding protein) were significantly higher in the HIV-infected group compared to the control group, 11 biomarkers (myeloperoxydase, interleukin-1 receptor antagonist, tumor necrosis factor receptor 1, interferon-gamma, MCP-1, tumor necrosis factor receptor 2, IL-22, ultra sensitivity C-reactive protein, fibrinogen, IL-6, and NF-L) were lower. …”
Publicado 2021
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30683por Zhang, Shiqiang, Zheng, Wenzhong, Jiang, Donggen, Xiong, Haiyun, Liao, Guolong, Yang, Xiangwei, Ma, He, Li, Jun, Qiu, Miaojuan, Li, Binbin, Sun, Chunhui, Zhao, Jing, Wang, Liling, Pang, Jun“…High KLF12 expression negatively correlates with interferon gamma response, IL2-STAT5 signaling, TNF-alpha signaling via NFKB, IL6-JAK-STAT3 signaling. …”
Publicado 2021
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30684por Niewold, Timothy B., Meves, Alexander, Lehman, Julia S., Popovic-Silwerfeldt, Karin, Häyry, Aliisa, Söderlund-Matell, Therese, Charlesworth, Cristine M., Madden, Benjamin, Lundberg, Ingrid E., Wahren-Herlenius, Marie, Svenungsson, Elisabet, Oke, Vilija“…RESULTS: Proteome investigation identified abundant expression of interferon-regulated proteins (IRP) as a common feature of CLE and DM. …”
Publicado 2021
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30685por Antonaros, Francesca, Zenatelli, Rossella, Guerri, Giulia, Bertelli, Matteo, Locatelli, Chiara, Vione, Beatrice, Catapano, Francesca, Gori, Alice, Vitale, Lorenza, Pelleri, Maria Chiara, Ramacieri, Giuseppe, Cocchi, Guido, Strippoli, Pierluigi, Caracausi, Maria, Piovesan, Allison“…Interestingly, the most over-expressed genes encode for interferon-induced proteins, two of them (MX1 and MX2 genes) mapping on Hsa21 (21q22.3). …”
Publicado 2021
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30686por Ryan, Feargal J., Carr, Jillian M., Furtado, João M., Ma, Yuefang, Ashander, Liam M., Simões, Milena, Oliver, Genevieve F., Granado, G. Bracho, Dawson, Abby C., Michael, Michael Z., Appukuttan, Binoy, Lynn, David J., Smith, Justine R.“…Correlation of gene expression with read counts assigned to the ZIKV genome identified a negative correlation between interferon signaling and viral load across isolates. …”
Publicado 2021
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30687por Johnston, Dayle, Earley, Bernadette, McCabe, Matthew S., Kim, Jaewoo, Taylor, Jeremy F., Lemon, Ken, McMenamy, Michael, Duffy, Catherine, Cosby, S. Louise, Waters, Sinéad M.“…There were eight enriched pathways among the DE predicted target genes with inverse fold changes to their corresponding DE miRNA including: granulocyte and agranulocyte adhesion and diapedesis, interferon signalling and role of pathogen recognition receptors in recognition of bacteria and viruses. …”
Publicado 2021
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30688por Matsui, Hiroyuki, Shirakawa, Kotaro, Konishi, Yoshinobu, Hirabayashi, Shigeki, Sarca, Anamaria Daniela, Fukuda, Hirofumi, Nomura, Ryosuke, Stanford, Emani, Horisawa, Yoshihito, Kazuma, Yasuhiro, Matsumoto, Tadahiko, Yamazaki, Hiroyuki, Murakawa, Yasuhiro, Battivelli, Emilie, Verdin, Eric, Koyanagi, Yoshio, Takaori-Kondo, Akifumi“…HIV-1 viral RNA/DNA or viral proteins are recognized by cellular mechanisms and induce interferon responses in virus-producing cells, but changes in latently infected cells remain unknown. …”
Publicado 2021
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30689por Guo, Hai-Yan, Zhong, Qian-Hong, Zhou, Jie, Zhao, Zhi-Meng, Zhang, Xi-Lin, Chen, Zhen-Huang, Qiu, Xin-Cai, Wu, Zhi-Long“…Furthermore, the pooled OR for LTBI was 1.90 and 1.65 separately from the results of the tuberculin skin test (TST) and the interferon-gamma release assay. Lastly, upon comparing the HCWs with the control groups from the community and the nosocomial source, it was observed that the pooled OR favored for the prevalence of LTBI, which was primarily community-sourced (3.12 and 1.54). …”
Publicado 2021
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30690por Gharib-Naseri, Kosar, de Las Heras-Saldana, Sara, Kheravii, Sarbast, Qin, Lihong, Wang, Jingxue, Wu, Shu-Biao“…The DEG were mostly related to fatty acid metabolism and degradation (cluster of differentiation 36 [CD36], acyl-CoA synthetase bubblegum family member-1 [ACSBG1], fatty acid-binding protein-1 and -2 [FABP1] and [FABP2]; and acyl-coenzyme A synthetase-1 [ACSL1]), bile acid production and transportation (acyl-CoA oxidase-2 [ACOX2], apical sodium–bile acid transporter [ASBT]) and essential genes in the immune system (interferon-, [IFN-γ], LCK proto-oncogene, Src family tyrosine kinase [LCK], zeta chain of T cell receptor associated protein kinase 70 kDa [ZAP70], and aconitate decarboxylase 1 [ACOD1]). …”
Publicado 2021
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30691por Chen, Cai-Tao, Shan, Chun-Xiao, Ran, Jun, Yin, Lei-Miao, Li, Hai-Yan, Wang, Yu, Xu, Yu-Dong, Guo, Jing-Lei, Shi, Yang-Lin, Chen, Yan-Jiao, Yang, Yong-Qing“…CD4(+) T cells were separated by MicroBeads, and the levels of interleukin (IL)-4 and interferon-γ (IFN-γ) were detected by ELISA. RESULTS: rCypA (10 ng/kg) significantly reduced RL within 2–7 min in OVA-challenged asthmatic rats in vivo, and there were no significant differences compared with terbutaline (TB) and hydrocortisone (HC). …”
Publicado 2021
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30692por Yuan, Wenli, Deng, Deyao, Li, Hanyu, Hu, Xinghui, Shang, Xueqin, Hou, Xia, Jiang, Hongchao, He, Hongchun“…INTRODUCTION: Programmed cell death 1 ligand 1 (PD-L1) can be upregulated in cancer cells via interferon gamma (IFNγ) in the tumor microenvironment. …”
Publicado 2021
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30693por Tani, Joji, Senoh, Tomonori, Moriya, Akio, Ogawa, Chikara, Deguchi, Akihiro, Sakamoto, Teppei, Takuma, Kei, Nakahara, Mai, Oura, Kyoko, Tadokoro, Tomoko, Mimura, Shima, Fujita, Koji, Yoneyama, Hirohito, Kobara, Hideki, Morishita, Asahiro, Himoto, Takashi, Tsutsui, Akemi, Nagano, Takuya, Takaguchi, Koichi, Masaki, Tsutomu“…The results of this study indicate that interferon (IFN)-free DAA treatment after treatment for HCC could be recommended to improve prognosis in this subset of cases. …”
Publicado 2021
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30694por Hervier, Baptiste, Ribon, Matthieu, Tarantino, Nadine, Mussard, Julie, Breckler, Magali, Vieillard, Vincent, Amoura, Zahir, Steinle, Alexander, Klein, Reinhild, Kötter, Ina, Decker, Patrice“…In order to study the mechanism and the potential source of sMICA, we analyzed circulating sMICA concentration in Behcet patients before and after interferon (IFN)-α therapy: no modulation was observed, suggesting that IFN-α is not intrinsically crucial for sMICA release in vivo. …”
Publicado 2021
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30695por Chánez-Paredes, Sandra, Montoya-García, Armando, Castro-Ochoa, Karla F., García-Cordero, Julio, Cedillo-Barrón, Leticia, Shibayama, Mineko, Nava, Porfirio, Flemming, Sven, Schlegel, Nicolas, Gautreau, Alexis M., Vargas-Robles, Hilda, Mondragón-Flores, Ricardo, Schnoor, Michael“…Arpin expression decreased in response to tumor necrosis factor (TNF)α and interferon (IFN)γ treatment, whereas the expression of gadkin and protein interacting with protein C-kinase α-subunit 1 (PICK1), other Arp2/3 inhibitors, remained unchanged. …”
Publicado 2021
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30696por Arunachalam, Prabhu S., Scott, Madeleine K. D., Hagan, Thomas, Li, Chunfeng, Feng, Yupeng, Wimmers, Florian, Grigoryan, Lilit, Trisal, Meera, Edara, Venkata Viswanadh, Lai, Lilin, Chang, Sarah Esther, Feng, Allan, Dhingra, Shaurya, Shah, Mihir, Lee, Allie Skye, Chinthrajah, Sharon, Sindher, Tina, Mallajosyula, Vamsee, Gao, Fei, Sigal, Natalia, Kowli, Sangeeta, Gupta, Sheena, Pellegrini, Kathryn, Tharp, Gregory, Maysel-Auslender, Sofia, Bosinger, Steven, Maecker, Holden T., Boyd, Scott D., Davis, Mark M., Utz, Paul J., Suthar, Mehul S., Khatri, Purvesh, Nadeau, Kari C., Pulendran, Bali“…Consistent with these observations, single-cell transcriptomics analysis of 242,479 leukocytes demonstrated a ~100-fold increase in the frequency of a myeloid cell cluster containing monocytes and dendritic cells, enriched in interferon-response transcription factors (TFs) and reduced in AP-1 TFs, only after the second immunization. …”
Publicado 2021
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30697“…Analogous to DNA-histone interactons, positively charged PF4-DNA complexes stimulate strong interferon responses via Toll-Like Receptor (TLR) 9 engagement. …”
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30698por Abdel-mannan, Omar A., Manchoon, Celeste, Rossor, Thomas, Southin, Justine-Clair, Tur, Carmen, Brownlee, Wallace, Byrne, Susan, Chitre, Manali, Coles, Alasdair, Forsyth, Rob, Kneen, Rachel, Mankad, Kshitij, Ram, Dipak, West, Siobhan, Wright, Sukhvir, Wassmer, Evangeline, Lim, Ming, Ciccarelli, Olga, Hemingway, Cheryl, Hacohen, Yael“…CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that newer DMTs (oral or infusions) are superior to injectables (interferon beta/glatiramer acetate) in reducing both clinical relapses and radiologic activity in children with RRMS.…”
Publicado 2021
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30699por Morris, Gerwyn, Bortolasci, Chiara C., Puri, Basant K., Marx, Wolfgang, O'Neil, Adrienne, Athan, Eugene, Walder, Ken, Berk, Michael, Olive, Lisa, Carvalho, Andre F., Maes, Michael“…Elevated levels of IL-18 are detected in patients with COVID-19 and MAS but have not been reported in patients with H1N1 influenza and CRS. Elevated interferon-γ is common to H1N1, MAS, and CRS but levels of this molecule appear to be depressed in patients with COVID-19. …”
Publicado 2021
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30700por Laanesoo, Anet, Urgard, Egon, Periyasamy, Kapilraj, Laan, Martti, Bochkov, Yury A., Aab, Alar, Magilnick, Nathaniel, Pooga, Margus, Gern, James E., Johnston, Sebastian L., Coquet, Jonathan M., Boldin, Mark P., Wengel, Jesper, Altraja, Alan, Bochenek, Grazyna, Jakiela, Bogdan, Rebane, Ana“…However, transfection with cell‐penetrating peptide (CPP)‐miR‐146a nanocomplexes before infection with RV significantly reduced the expression of the pro‐inflammatory chemokines CCL5, IL‐8 and CXCL1, increased interferon‐λ production, and attenuated infection with the green fluorescent protein (GFP)‐expressing RV‐A16 in HBECs. …”
Publicado 2021
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