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30701por Pradelli, Lorenzo, Pinciroli, Matteo, Houshmand, Hirad, Grassi, Beatrice, Bonelli, Fabrizio, Calleri, Mariella, Ruscio, Maurizio“…PURPOSE: This Lyme disease early detection economic model, for patients with suspected Lyme disease without erythema migrans (EM), compares outcomes of standard two-tier testing (sTTT), modified two-tier testing (mTTT) and the DiaSorin Lyme Detection Algorithm (LDA), a combination of both serology tests and Interferon-ɤ Release Assay. PATIENTS AND METHODS: A patient-level simulation model was built to incorporate effectiveness estimation from a structured focused literature review, and health-care cost inputs for the United States, Germany, and Italy. …”
Publicado 2021
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30702por Chen, Shengbo, Liu, Hongbin, Li, Zhijun, Tang, Jingyi, Huang, Bing, Zhi, Fachao, Zhao, Xinmei“…PBLD overexpression in intestinal epithelial cells (IECs) consistently inhibited TNF-α/interferon-γ-induced intestinal barrier disruption and TNF-α-induced inflammatory responses via the suppression of NF-κB. …”
Publicado 2021
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30703por Mulas, Floriana, Wang, Xu, Song, Shanshan, Nishanth, Gopala, Yi, Wenjing, Brunn, Anna, Larsen, Pia-Katharina, Isermann, Berend, Kalinke, Ulrich, Barragan, Antonio, Naumann, Michael, Deckert, Martina, Schlüter, Dirk“…Consequently, DC-specific deletion of OTUB1 impaired the production of cytokines, in particular IL-12, by DCs over the first 2 days of T. gondii infection, resulting in the diminished production of protective interferon-γ (IFN-γ) by natural killer cells, impaired control of parasite replication, and, finally, death from chronic T. encephalitis, all of which could be prevented by low-dose IL-12 treatment in the first 3 days of infection. …”
Publicado 2020
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30704por Kang, Kyung-Don, Bernstock, Joshua, Mott, Bryan, Nan, Li, Li, Rong, Totsch, Stacie, Gary, Sam, Ghajar-Rahimi, Gelare, Etminan, Tina, Eisemann, Tanja, Wechsler-Reya, Robert, Beierle, Elizabeth, Gillespie, George, Markert, James, Friedman, Gregory“…Utilizing an immunocompetent, HSV-sensitive murine strain, we determined that a standard 1x10(7) plaque-forming units (PFU) dose of G207 resulted in damage to the ependymal lining. However, interferon induction with an intraventricular low-dose (1x10(4) PFU) of G207 or polyinosinic-polycytidylic acid (poly I:C), a toll-like receptor 3 agonist, three days prior to standard treatment dose protected the ependymal lining. …”
Publicado 2021
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30705“…In granulocytes from tolerized mice compared to saline-treated littermate controls, real-time PCR analysis indicated that expression of interferon-induced TNFAIP2 increased more than 2-fold while Ptdss2 and GATA1 mRNA were up-regulated more than 10-fold. …”
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30706“…Levels of intracellular interleukin (IL)-2, IL-4, and interferon (IFN)-gamma were measured (flow microfluorimetry); IFN-gamma was measured in supernatants (ELISA). …”
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30707por Shenderov, Eugene, Kandasamy, Matheswaran, Gileadi, Uzi, Chen, Jili, Shepherd, Dawn, Gibbs, James, Prota, Gennaro, Silk, Jonathan D, Yewdell, Jonathan W, Cerundolo, Vincenzo“…In contrast, their activation by HLA-A2 NY-ESO-1(157-165) complexes was evident by proliferation, CD69 upregulation, interferon-γ production, and interleukin-2 production, and could be tuned using a twofold higher affinity altered peptide ligand, NY-ESO-1(157-165V). …”
Publicado 2021
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30708por Jeremiah, Kidola, Lyimo, Eric, Ritz, Christian, PrayGod, George, Rutkowski, Kathryn Tucker, Korsholm, Karen Smith, Ruhwald, Morten, Tait, Dereck, Grewal, Harleen M. S., Faurholt-Jepsen, Daniel“…Blood was drawn and tested using QuantiFERON-TB Gold In-Tube (QFT-GIT), and Early Secretory Antigenic Target-6–Free Interferon-gamma Release Assay (ESAT-6 free IGRA). Concordance between QFT-GIT and ESAT-6 free IGRA was evaluated using the McNemar’s test. …”
Publicado 2021
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30709por Pellizzari, Giulia, Martinez, Olivier, Crescioli, Silvia, Page, Robert, Di Meo, Ashley, Mele, Silvia, Chiaruttini, Giulia, Hoinka, Jan, Batruch, Ihor, Prassas, Ioannis, Grandits, Melanie, López-Abente, Jacobo, Bugallo-Blanco, Eva, Ward, Malcolm, Bax, Heather J, French, Elise, Cheung, Anthony, Lombardi, Sara, Figini, Mariangela, Lacy, Katie E, Diamandis, Eleftherios P, Josephs, Debra H, Spicer, James, Papa, Sophie, Karagiannis, Sophia N“…SLC3A2-specific CAR T cells demonstrated cytotoxicity against tumor cells, stimulated interferon-γ and interleukin-2 production in vitro. …”
Publicado 2021
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30710por Guo, Shuangshuang, Xi, Yu, Xia, Yi, Wu, Tao, Zhao, Di, Zhang, Zhengfan, Ding, Binying“…Both probiotic groups upregulated jejunal IL-1β, interferon (IFN)-γ, IL-17, and TGF-β4 on day 28 as well as IFN-γ on day 21 (P < 0.05). …”
Publicado 2021
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30711por Pahlitzsch, Milena, Fritsche-Guenther, Raphaela, Pompös, Inga, Pohlmann, Dominika, Maier, Anna-Karina B, Winterhalter, Sibylle, Erb, Carl, Rübsam, Anne“…Increased concentrations of 11 cytokines (GM-CSF, Interferon-γ, Interleukin-1β, IL-2, 4, 5, 6, 7, 10, 12 and TNF-α) were detected in POAG. …”
Publicado 2021
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30712por Ozawa, Naoya, Yokobori, Takehiko, Osone, Katsuya, Katayama, Chika, Suga, Kunihiko, Komine, Chika, Shibasaki, Yuta, Shiraishi, Takuya, Okada, Takuhisa, Kato, Ryuji, Ogawa, Hiroomi, Sano, Akihiko, Sakai, Makoto, Sohda, Makoto, Ojima, Hitoshi, Miyazaki, Tatsuya, Motegi, Yoko, Ide, Munenori, Yao, Takashi, Kuwano, Hiroyuki, Shirabe, Ken, Saeki, Hiroshi“…Ulcerative colitis (UC) is a DNA damage-associated chronic inflammatory disease; the DNA double-strand break (DSB) repair pathway participates in UC-associated dysplasia/colitic cancer carcinogenesis. The DSB/interferon regulatory factor-1 (IRF-1) pathway can induce PD-L1 expression transcriptionally. …”
Publicado 2021
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30713por Huang, Hsien-Juang, Weng, Bor-Chun, Hsuuw, Yan-Der, Lee, Yueh-Sheng, Chen, Kuo-Lung“…The lipopolysaccharide (LPS) and concanavalin A (ConA) in 5% TSFP group and interferon-γ (IFN-γ) content in 2.5% and 5% TSFP groups are significantly higher than the other groups (p < 0.05). …”
Publicado 2021
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30714por Deng, Haijing, Kan, Anna, Lyu, Ning, He, Meng, Huang, Xin, Qiao, Shuang, Li, Shaolong, Lu, Wenhua, Xie, Qiankun, Chen, Huiming, Lai, Jinfa, Chen, Qifeng, Jiang, Xiongying, Liu, Shousheng, Zhang, Zhenfeng, Zhao, Ming“…Further investigation indicated that JAK/STAT1 pathway activated by immune-cell-derived interferon γ and MCT1/NF-kB/COX-2 pathway activated by high concentrations of tumor-derived lactate could induce PD-L1(+) neutrophils. …”
Publicado 2021
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30715por Traves, Paqui G, Murray, Bernard, Campigotto, Federico, Galien, René, Meng, Amy, Di Paolo, Julie A“…JAK1-dependent pathways (interferon (IFN)α/pSTAT5, interleukin (IL)-6/pSTAT1) were among the most potently inhibited by all JAKinibs in healthy and RA blood, with filgotinib exhibiting the greatest selectivity for JAK1 pathways. …”
Publicado 2021
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30716“…Based on previous observations that interleukin (IL)-17-producing T-cells can traffic to the CNS in autoimmune conditions, we evaluated CD8(+) T-cells that produce IL-17 and interferon-γ (IFN-γ) (Tc17-1) cells in a preclinical GBM model. …”
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30717por Vecellio, Matteo, Chen, Liye, Cohen, Carla J., Cortes, Adrian, Li, Yan, Bonham, Sarah, Selmi, Carlo, Brown, Matthew A., Fischer, Roman, Knight, Julian C., Wordsworth, B. Paul“…Further functional effects were tested by small interfering RNA knockdown of the gene for interferon regulatory factor 5 (IRF5), followed by reverse transcription–qPCR (RT‐qPCR) and enzyme‐linked immunosorbent assay (ELISA) to measure the levels of IFNγ messenger RNA (mRNA) and protein, respectively. …”
Publicado 2021
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30718“…BACKGROUND: The requirement of promyelocytic leukaemia protein (PML) in interferon (IFN)-induced cell apoptosis is well-established. …”
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30719“…However, in LO2 cells, expression of ER stress-related genes (x box-binding protein, binding immunoglobulin protein, and activating transcription factor 6), inflammatory response-related genes (interleukin-6 [IL-6], interleukin-1β [IL-1β], and interferon-γ) and apoptosis-related genes (bcl-2-associated X protein, b-cell lymphoma 2, Caspase-3, and Caspase-9) was significantly enhanced with 0.6 mM PA treatment. …”
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30720por Lauret Marie Joseph, Elodie, Kirilovsky, Amos, Lecoester, Benoît, El Sissy, Carine, Boullerot, Laura, Rangan, Laurie, Marguier, Amélie, Tochet, Florent, Dosset, Magalie, Boustani, Jihane, Ravel, Patrice, Boidot, Romain, Spehner, Laurie, Haicheur-Adjouri, Nacilla, Marliot, Florence, Pallandre, Jean-René, Bonnefoy, Francis, Scripcariu, Viorel, Van den Eynde, Marc, Cornillot, Emmanuel, Mirjolet, Céline, Pages, Franck, Adotevi, Olivier“…The therapy-exposed TME was screened by RNA sequencing and flow cytometry and tumor-infiltrating T lymphocyte functionality was evaluated by interferon (IFN)-γ ELIspot and intracellular cytokine staining. …”
Publicado 2021
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