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30721por Bullenkamp, Jessica, Mengoni, Veronica, Kaur, Satdip, Chhetri, Ismita, Dimou, Paraskevi, Astroulakis, Zoë M J, Kaski, Juan Carlos, Dumitriu, Ingrid E“…Additionally, IL-7/IL-15 markedly augmented CD28(null) T-cell cytotoxic function and interferon-γ production. Further mechanistic analyses revealed differences in baseline expression of component chains of IL-7/IL-15 receptors (CD127 and CD122) and increased baseline STAT5 phosphorylation in CD28(null) T cells from ACS patients compared to the control CD28(+) T-cell subset. …”
Publicado 2020
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30722por Wittwer, Jennifer Ann“…Early identification is essential to organize a multidisciplinary team to ensure accurate diagnosis and to initiate appropriate therapy. Presently interferon-alpha is the first line treatment, but other biologics are often used and provide promising outcomes. …”
Publicado 2021
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30723por Adam, Khalid Mohamed“…Several immunoinformatics tools were used to assess the antigenicity (VaxiJen server), immunogenicity (IEDB immunogenicity tool), allergenicity (AlgPred), toxigenicity (ToxinPred server), interferon-gamma inducing capacity (IFNepitope server), and the physicochemical properties of the construct (ProtParam tool). …”
Publicado 2021
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30724por Schramm, René, Costard-Jäckle, Angelika, Rivinius, Rasmus, Fischer, Bastian, Müller, Benjamin, Boeken, Udo, Haneya, Assad, Provaznik, Zdenek, Knabbe, Cornelius, Gummert, Jan“…To test for a specific T-cell response, heparinized whole blood was stimulated with SARS-CoV-2 specific peptides, covering domains of the viral spike, nucleocapsid and membrane protein, and the interferon-γ release was measured (QuantiFERON Monitor ELISA, Qiagen). …”
Publicado 2021
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30725por Lu, Yi, Chen, Yonghe, Peng, Xiang, Yao, Jiayin, Zhong, Weijie, Li, Chujun, Zhi, Min“…Multivariate analysis showed that, positive interferon-gamma release assays (IGRAs), ≥ 4 segments involved, longitudinal ulcer, circular ulcer, and aphthous ulcer were confirmed as independent discriminating factors. …”
Publicado 2021
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30726por Tang, Zan, Gao, Junxiao, Wu, Jie, Zeng, Guifang, Liao, Yan, Song, Zhenkun, Liang, Xiao, Hu, Junyuan, Hu, Yong, Liu, Muyun, Li, Nan“…By using single cell RNA sequencing, a subcluster of interferon-sensitive macrophages (IFNSMs) were identified after hucMSC infusion. …”
Publicado 2021
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30727por Jan, Michael, Cueto, Ramon, Jiang, Xiaohua, Lu, Liu, Sardy, Jason, Xiong, Xinyu, Yu, Justine E., Pham, Hung, Khan, Mohsin, Qin, Xuebing, Ji, Yong, Yang, Xiao-Feng, Wang, Hong“…We established a hypothetical model to describe the biochemical and molecular network with these specified miRNA/mRNA axes, finding: 1) HHcy causes metabolic reprogramming by increasing glucose uptake and oxidation, by glycogen debranching and NAD(+)/CoA synthesis, and by stimulating mitochondrial reactive oxygen species production via NNT/IDH2 suppression-induced NAD(+)/NADP-NADPH/NADP(+) metabolism disruption; 2) HHcy activates inflammatory responses by activating inflammasome-pyroptosis mainly through ↓miR193b→↑CASP-9 signaling and by inducing IL-1β and adhesion molecules through the ↓miR29c→↑NEDD9 and the ↓miR1256→↑ICAM-1 axes, as well as GPCR and interferon α/β signaling; 3) HHcy promotes cell degradation by the activation of lysosome autophagy and ubiquitin proteasome systems; 4) HHcy causes cell cycle arrest at G1/S and S/G2 transitions, suppresses spindle checkpoint complex and cytokinetic abscission, and suppresses proliferation through ↓miRNA335/↑VASH1 and other axes. …”
Publicado 2021
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30728“…Interestingly, TMPRSS2 expression levels were positively correlated with the enrichment levels of four immune signatures (B cells, CD8(+) T cells, NK cells, and interferon response) in SARS-CoV-2-infected patients but likely to be negatively correlated with them in the normal lung tissue. …”
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30729por Latour, Ewa, Arlet, Jaroslaw, Latour, Emilia E., Juszkiewicz, Artur, Łuczkowska, Karolina, Marcinkiewicz, Anita, Basta, Piotr, Trzeciak, Jerzy, Machaliński, Bogusław, Skarpańska-Stejnborn, Anna“…The levels of interleukin 2 (IL2), interleukin 4 (IL4), interleukin 10 (IL10), interferon ɤ (IFN-ɣ), and lactic acid were determined. …”
Publicado 2021
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30730por Stumpf, Julian, Siepmann, Torsten, Lindner, Tom, Karger, Claudia, Schwöbel, Jörg, Anders, Leona, Faulhaber-Walter, Robert, Schewe, Jens, Martin, Heike, Schirutschke, Holger, Barnett, Kerstin, Hüther, Jan, Müller, Petra, Langer, Torsten, Pluntke, Thilo, Anding-Rost, Kirsten, Meistring, Frank, Stehr, Thomas, Pietzonka, Annegret, Escher, Katja, Cerny, Simon, Rothe, Hansjörg, Pistrosch, Frank, Seidel, Harald, Paliege, Alexander, Beige, Joachim, Bast, Ingolf, Steglich, Anne, Gembardt, Florian, Kessel, Friederike, Kröger, Hannah, Arndt, Patrick, Sradnick, Jan, Frank, Kerstin, Klimova, Anna, Mauer, René, Grählert, Xina, Anft, Moritz, Blazquez-Navarro, Arturo, Westhoff, Timm H, Stervbo, Ulrik, Tonn, Torsten, Babel, Nina, Hugo, Christian“…METHODS: We conducted a prospective study exploring the eight week time course of specific cellular (interferon-γ release assay and flow cytometry) or/and humoral immune responses (ELISA) to SARS-CoV-2 boost vaccination in more than 3100 participants including medical personnel, dialysis patients and kidney transplant recipients using mRNA vaccines BNT162b2 or mRNA-1273. …”
Publicado 2021
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30731por Zheng, Yan, Hua, Lingling, Zhao, Qiannan, Li, Mengyao, Huang, Meixia, Zhou, Yunlian, Wang, Yingshuo, Chen, Zhimin, Zhang, Yuanyuan“…Meanwhile, we found that the percentage of neutrophil (N%) and CD(8) (+) lymphocyte (CD(8) (+)%), C-reactive protein (CRP), lactate dehydrogenase (LDH), interleukin (IL)-6, IL-10, and interferon-gamma (IFN-γ) trended higher with increasing D-dimer, whereas the percentage of lymphocyte (L%) and prealbumin (PAB) trended lower (P<0.01). …”
Publicado 2021
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30732por So, Jisun, Tai, Albert K., Lichtenstein, Alice H., Wu, Dayong, Lamon-Fava, Stefania“…Moreover, signaling pathways of immune or inflammatory responses, including interferon (IFN) signaling [z-score = 2.45, -log(p) = 3.88], were found to be more upregulated in female versus male monocytes, based on a set of genes exhibiting sex-biased expression (p < 0.03). …”
Publicado 2021
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30733por Prokop, Jeremy W., Hartog, Nicholas L., Chesla, Dave, Faber, William, Love, Chanise P., Karam, Rachid, Abualkheir, Nelly, Feldmann, Benjamin, Teng, Li, McBride, Tamara, Leimanis, Mara L., English, B. Keith, Holsworth, Amanda, Frisch, Austin, Bauss, Jacob, Kalpage, Nathisha, Derbedrossian, Aram, Pinti, Ryan M., Hale, Nicole, Mills, Joshua, Eby, Alexandra, VanSickle, Elizabeth A., Pageau, Spencer C., Shankar, Rama, Chen, Bin, Carcillo, Joseph A., Sanfilippo, Dominic, Olivero, Rosemary, Bupp, Caleb P., Rajasekaran, Surender“…There are 770 genes significantly altered in the blood of COVID-19 patients associated with antiviral defense, mitotic cell cycle, type I interferon signaling, and severe viral infections. Immune genes activated include those associated with neutrophil mechanisms, secretory granules, and neutrophil extracellular traps (NETs), along with decreased gene expression in lymphocytes and clonal expansion of the acquired immune response. …”
Publicado 2021
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30734por Arai, Toru, Matsuoka, Hiroto, Hirose, Masaki, Kida, Hiroshi, Yamamoto, Suguru, Ogata, Yoshitaka, Mori, Masahide, Hatsuda, Kazuyoshi, Sugimoto, Chikatoshi, Tachibana, Kazunobu, Akira, Masanori, Inoue, Yoshikazu“…RESULTS: Univariate analysis revealed that higher serum levels of interleukin (IL)-2, IL-7, IL-9, IL-12, IL13, basic fibroblast growth factor, granulocyte-macrophage colony-stimulating factor, interferon-γ inducible protein-10, platelet-derived growth factor and regulated on activation, normal T cell expressed and secreted (RANTES) at AE were significant predictors of 90-day survival. …”
Publicado 2021
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30735por Hesselstrand, Roger, Distler, Jörg H. W., Riemekasten, Gabriela, Wuttge, Dirk M., Törngren, Marie, Nyhlén, Helén C., Andersson, Fredrik, Eriksson, Helena, Sparre, Birgitta, Tuvesson, Helén, Distler, Oliver“…Blood and skin biopsies were collected at baseline, during treatment, and at follow-up for the analyses of type I interferon (IFN) activity, chemokine (C-C motif) ligand 2 (CCL2), and the number of myofibroblasts. …”
Publicado 2021
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30736por Healy, Katie, Pavesi, Andrea, Parrot, Tiphaine, Sobkowiak, Michał J., Reinsbach, Susanne E., Davanian, Haleh, Tan, Anthony T., Aleman, Soo, Sandberg, Johan K., Bertoletti, Antonio, Sällberg Chen, Margaret“…RESULTS: HBV TCR-MAIT cells demonstrated polyfunctional properties (CD107a, interferon [IFN] γ, tumour necrosis factor [TNF], and IL-17A) with strong HBV target sensitivity and liver-homing chemokine receptor expression when compared with HBV TCR-ConT cells. …”
Publicado 2021
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30737por Goldwater, Deena S., Leng, Mei, Karlamangla, Arun, Seeman, Teresa, Elashoff, David, Wanagat, Jonathan M., Reuben, David B., Lindman, Brian R., Cole, Steve“…METHODS: We performed a retrospective case–control study comparing pre-procedural pro-inflammatory and Type 1 interferon (IFN) gene expression in 48 controls with favorable outcomes (alive 1 year after TAVR with improved quality of life [QoL]) versus 48 individuals with unfavorable outcomes (dead by 1 year or alive at 1 year but with reduced QoL). …”
Publicado 2021
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30738por Bayissa, Berecha, Sirak, Asegedech, Worku, Adane, Zewude, Aboma, Zeleke, Yemisrach, Chanyalew, Mahlet, Gumi, Balako, Berg, Stefan, Conlan, Andrew, Hewinson, R. Glyn, Wood, James L. N., Vordermeier, H. Martin, Ameni, Gobena“…Immune responses were monitored by interferon gamma (IFN-γ) release assay (IGRA), SICCT test, and antibody assay. …”
Publicado 2021
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30739por Ghenea, Alice Elena, Ungureanu, Anca Marilena, Turculeanu, Adriana, Popescu, Mihaela, Carsote, Mara, Ţieranu, Maria Loredana, Ţieranu, Eugen Nicolae, Vasile, Corina Maria, Cioboată, Ramona, Udriştoiu, Anca Loredana, Alexandru, Dragoş Ovidiu, Sălan, Alex Ioan, Drocaş, Andrei Ioan“…Our primary aim for this study was to evaluate biological response rates and sustained virological response (SVR) in patients diagnosed with CHC, treated with Interferon-alpha (IFN-α), Pegylated (PEG)–IFN-α2a or -α2b plus Ribavirin. …”
Publicado 2020
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30740por Tsiakos, Konstantinos, Tsakiris, Antonios, Tsibris, Georgios, Voutsinas, Pantazis-Michael, Panagopoulos, Periklis, Kosmidou, Maria, Petrakis, Vasileios, Gravvani, Areti, Gkavogianni, Theologia, Klouras, Eleftherios, Katrini, Konstantina, Koufargyris, Panagiotis, Rapti, Iro, Karageorgos, Athanassios, Vrentzos, Emmanouil, Damoulari, Christina, Zarkada, Vagia, Sidiropoulou, Chrysanthi, Artemi, Sofia, Ioannidis, Anastasios, Papapostolou, Androniki, Michelakis, Evangelos, Georgiopoulou, Maria, Myrodia, Dimitra-Melia, Tsiamalos, Panteleimon, Syrigos, Konstantinos, Chrysos, George, Nitsotolis, Thomas, Milionis, Haralampos, Poulakou, Garyphallia, Giamarellos-Bourboulis, Evangelos J.“…Clarithromycin use was associated with decreases in circulating C-reactive protein, tumour necrosis factor-alpha and interleukin (IL)-6; by increase of production of interferon-gamma and decrease of production of interleukin-6 by mononuclear cells; and by suppression of SARS-CoV-2 viral load. …”
Publicado 2021
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