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30821“…It has been validated that some combination therapies, including α-PD-1/PD-L1 plus chemotherapy, radiotherapy, angiogenesis inhibitors, targeted therapy, other immune checkpoint inhibitors, agonists of the co-stimulatory molecule, stimulator of interferon genes agonists, fecal microbiota transplantation, epigenetic modulators, or metabolic modulators, have superior antitumor efficacies and higher response rates. …”
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30822por Lambe, Gaurav, Mansukhani, Dia, Khodaiji, Shanaz, Shetty, Anjali, Rodrigues, Camilla, Kapadia, Farhad“…Lymphocyte subset analysis (CD3+, CD4+, CD8+, CD19+, CD16+/CD56+, and CD25+CD127− regulatory T cells), human leukocyte antigen-DR isotype (HLA-DR) expression on monocytes, programmed death-1 (PD-1) expression on T lymphocytes, and proinflammatory (interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ)), anti-inflammatory cytokines levels (IL-2, IL-4, and IL-10) were analyzed by flow cytometry as markers for immunosuppression. …”
Publicado 2022
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30823por Chen, Xingwang, Shen, Xueyuan, Lai, Jianbo, Yao, Zhijun, Peng, Xian, Wu, Long, Ou, Yuantong, Wu, Huachu, Zhu, Haofeng, Deng, Yiyu“…Levels of oxidative stress-related indexes, inflammatory factor-related indexes, nuclear factor-κB p65 (NF-κB p65), and interferon-γ (IFN-γ) in the rat brain were measured by ELISA. …”
Publicado 2022
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30824por Cheng, Chun-Han, Chu, Chia-Ying, Chen, Huan-Lin, Lin, I-Tsung, Wu, Chia-Hsien, Lee, Yuan-Kai, Bair, Ming-Jong“…METHODS: We screened 704 patients with chronic HCV infection who underwent treatment with interferon-free DAAs. Patients’ baseline characteristics, biochemical and virological data were collected. …”
Publicado 2022
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30825por Wang, Ruikun, Chen, Jingru, Wang, Wei, Zhao, Zhuoqian, Wang, Haoran, Liu, Shiyu, Li, Fan, Wan, Yajuan, Yin, Jie, Wang, Rui, Li, Yuanke, Zhang, Cuizhu, Zhang, Hongkai, Cao, Youjia“…In TME, oHSV-CD40L-treated tumor accommodated more maturated dendritic cells (DCs), which in turn activated T helper 1 and cytotoxic CD8(+) T cells in an interferon-γ-dependent and interleukin-12-dependent manner. …”
Publicado 2022
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30826por Mena, Jorge, Alloza, Iraide, Tulloch Navarro, Raquel, Aldekoa, Ane, Díez García, Javier, Villanueva Etxebarria, Ane, Lindskog, Cecilia, Antigüedad, Alfredo, Boyero, Sabas, Mendibe-Bilbao, María del Mar, Álvarez de Arcaya, Amaya, Sánchez Menoyo, José Luis, Midaglia, Luciana, Villarrubia, Noelia, Malhotra, Sunny, Montalban, Xavier, Villar, Luisa María, Comabella, Manuel, Vandenbroeck, Koen“…ANKRD55 expression levels are further enhanced by retinoic acid agonist AM580 but downregulated following maturation with interferon (IFN)-γ and lipopolysaccharide (LPS). ANKRD55 was detected in the nucleus of moDC in nuclear speckles. …”
Publicado 2022
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30827por Bräuninger, Hanna, Stoffers, Bastian, Fitzek, Antonia D E, Meißner, Kira, Aleshcheva, Ganna, Schweizer, Michaela, Weimann, Jessica, Rotter, Björn, Warnke, Svenja, Edler, Carolin, Braun, Fabian, Roedl, Kevin, Scherschel, Katharina, Escher, Felicitas, Kluge, Stefan, Huber, Tobias B, Ondruschka, Benjamin, Schultheiss, Heinz-Peter, Kirchhof, Paulus, Blankenberg, Stefan, Püschel, Klaus, Westermann, Dirk, Lindner, Diana“…The upregulated DEGs were linked to interferon pathways and originate predominantly from endothelial cells. …”
Publicado 2021
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30828por Carter, Jodi M., Polley, Mei-Yin C., Leon-Ferre, Roberto A., Sinnwell, Jason, Thompson, Kevin J., Wang, Xue, Ma, Yaohua, Zahrieh, David, Kachergus, Jennifer M., Solanki, Malvika, Boughey, Judy C., Liu, Minetta C., Ingle, James N., Kalari, Krishna R., Couch, Fergus J., Thompson, E. Aubrey, Goetz, Matthew P.“…PD-L1+ stromal and intraepithelial TIMEs were highly enriched in IDO-1, HLA-DR, CD40, and CD163 compared with PD-L1-TIME, with spatially specific alterations in CTLA-4, Stimulator of Interferon Genes (STING), and fibronectin. Macrophage- and antigen presentation–related proteins correlated most strongly with PD-L1 protein. …”
Publicado 2021
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30829por Ferreira, Maria de Fátima Carvalho, Pavon, Janeth Aracely Ramirez, Napoleão, Amanda Colichio Bini, Figueiredo, Gláucia Maria Duarte Preza, Florêncio, Patricia Cristina Borges, Arantes, Rayssa Basílio dos Santos, Rizzo, Paula Sossai, Carmo, Maria Aparecida Mazzutti Verlangieri, Nakazato, Luciano, Dutra, Valéria, Hahn, Rosane Christine, Slhessarenko, Renata Dezengrini“…Genomes recovered from two placentas belong to the B.1.1.28 and B.1.1.33 lineages and present nonsynonymous mutations associated with virus fitness and infectivity; other not frequently reported mutations (B.1.1.33: NSP3 V2090G, M A2S and ORF3ab S253P and Y264N; B.1.1.28: NSP3 E995D, NSP12 R240K, NSP14H1897Y and in ORF7b V21F) were found in proteins involved in viral replication, viral induction of apoptosis, viral interference on interferon and on NF-Κβ pathways. Phylogeny indicates the south of Brazil as the possible origin of these lineages circulating in Mato Grosso State. …”
Publicado 2022
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30830por Lui, David Tak Wai, Li, Yan Kiu, Lee, Chi Ho, Chow, Wing Sun, Lee, Alan Chun Hong, Tam, Anthony Raymond, Pang, Polly, Ho, Tip Yin, Cheung, Chloe Yu Yan, Fong, Carol Ho Yi, To, Kelvin Kai Wang, Tan, Kathryn Choon Beng, Woo, Yu Cho, Hung, Ivan Fan Ngai, Lam, Karen Siu Ling“…Older age (p = 0.001), higher CRP (p = 0.038), elevated lactate dehydrogenase (p = 0.046) and interferon treatment (p = 0.001), but not glycaemic status/HbA1c, independently predicted Nab titres. …”
Publicado 2022
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30831por Rosani, Umberto, del Vecchio, Claudia, Franchin, Elisa, Brun, Paola, Ferrari, Stefano, Ponzin, Diego, Leonardi, Andrea“…The DEGs in common with the 2 PD clusters included several genes associable to the interferon pathway, such as ADAMTS4, RSAD2, MMP1, IL6, ISG15 and proinflammatory cytokines. …”
Publicado 2022
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30832por Gandhi, Shipra, Khoury, Thaer, Attwood, Kristopher, Yao, Song, Ambrosone, Christine, Takabe, Kazuaki, Kalinski, Pawel“…Tumor explants will be prepared & cultured in the absence and presence of CKM (Interferon-ð 〉1/4, TLR3 agonist rintatolimod and COX-2 inhibitor celecoxib). …”
Publicado 2021
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30833por Harris, Macallister, Dilisio, James, Gary, Hadley, Chan, Edward, Moody, D. Branch, Podell, Brendan“…Assays to detect lipid-specific CD1 T cell activation include cellular proliferation, cytotoxicity assays, and interferon-gamma (IFNγ) release assay (Elispot) using both synthetic and Mtb-derived lipids. …”
Publicado 2021
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30834por Augustin, Ryan C., Leone, Robert D., Naing, Aung, Fong, Lawrence, Bao, Riyue, Luke, Jason J.“…In the context of known immuno-oncology biomarkers such as tumor mutational burden and interferon-associated gene expression, a comparison of adenosine-related gene signatures associated with clinical response indicates an underlying biology related to immunosuppression, angiogenesis, and T cell inflammation. …”
Publicado 2022
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30835por Brennan, Christina M, Nadella, Sandeep, Zhao, Xiang, Dima, Richard J, Jordan-Martin, Nicole, Demestichas, Breanna R, Kleeman, Sam O, Ferrer, Miriam, von Gablenz, Eva Carlotta, Mourikis, Nicholas, Rubin, Michael E, Adnani, Harsha, Lee, Hassal, Ha, Taehoon, Prum, Soma, Schleicher, Cheryl B, Fox, Sharon S, Ryan, Michael G, Pili, Christina, Goldberg, Gary, Crawford, James M, Goodwin, Sara, Zhang, Xiaoyue, Preall, Jonathan B, Costa, Ana S H, Conigliaro, Joseph, Masci, Joseph R, Yang, Jie, Tuveson, David A, Tracey, Kevin J, Janowitz, Tobias“…On day 7, fewer patients on famotidine had detectable interferon alpha plasma levels (p=0.04). Plasma immunoglobulin type G levels to SARS-CoV-2 nucleocapsid core protein were similar between both arms. …”
Publicado 2022
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30836por Nebreda-Mayoral, Teresa, Miguel-Gómez, María Antonia, March-Rosselló, Gabriel Alberto, Puente-Fuertes, Lucía, Cantón-Benito, Elena, Martínez-García, Ana María, Muñoz-Martín, Ana Belén, Orduña-Domingo, Antonio“…The profiles of ICU patients (44%) included male, SARS-CoV-2 pneumonia, leukocytosis, elevated inteleukin-6, with interferon β-1b and tocilizumab and superinfection (p < 0.05). …”
Publicado 2022
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30837por Frahm, Niklas, Fneish, Firas, Ellenberger, David, Flachenecker, Peter, Paul, Friedemann, Warnke, Clemens, Kleinschnitz, Christoph, Parciak, Tina, Krefting, Dagmar, Hellwig, Kerstin, Haas, Judith, Rommer, Paulus S., Stahmann, Alexander, Zettl, Uwe K.“…RESULTS: Overall, 28.3% of PwMS were treatment-naïve before fingolimod initiation. Interferon beta (30.7%) was the most common pre-fingolimod treatment. …”
Publicado 2022
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30838por Rahman, S H, Scharr, Y, Jeyaparan, J, Manko, A, Coffin, C S, Congly, S E, Ramji, A, Fung, S, Cooper, C, Ma, M, Bailey, R, Minuk, G, Wong, A, Doucette, K, Elkhashab, M, Wong, P, Brahmania, M“…The median ALT was 40 (IQR: 26–59.5) and the median tumor number was 1(IQR: 1- 2) with a median tumor size of 2.6 cm (IQR: 1.9- 4.5). 98 (74.5%) patients were HBeAg negative with a median viral load of 3.8 logs (IQR 1.9 – 5.8). 58 (43%) patients had cirrhosis at diagnosis. 36% of patients were diagnosed with HCC on their first screening imaging whereas 39% were found to have HCC on repeated surveillance imaging. 116 (87.9%) were on treatment at the time of diagnosis or after (70 (60.3%) NA and 46 (39%) Combination therapy with double NA or NA plus interferon). Out of the 132 patients, BCLC stage 0, A, B, and C represented 30 (23%), 42 (32%), 17 (13%), and 5 (4%) patients, respectively, with 38 (28%) patients with unknown BCLC stage. …”
Publicado 2022
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30839por Gómez-Carballa, Alberto, Rivero-Calle, Irene, Pardo-Seco, Jacobo, Gómez-Rial, José, Rivero-Velasco, Carmen, Rodríguez-Núñez, Nuria, Barbeito-Castiñeiras, Gema, Pérez-Freixo, Hugo, Cebey-López, Miriam, Barral-Arca, Ruth, Rodriguez-Tenreiro, Carmen, Dacosta-Urbieta, Ana, Bello, Xabier, Pischedda, Sara, Currás-Tuala, María José, Viz-Lasheras, Sandra, Martinón-Torres, Federico, Salas, Antonio“…Mild and asymptomatic cases showed a powerful innate antiviral response in nasal epithelium, characterized by activation of interferon (IFN) pathway and downstream cascades, successfully controlling the infection at local level. …”
Publicado 2022
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30840por Zhao, Yaqi, Wu, Jie, Li, Lan, Zhang, Huibo, Zhang, Haohan, Li, Jing, Zhong, Hao, Lei, Tianyu, Jin, Yan, Xu, Bin, Song, Qibin“…Guanylate-binding protein 1 (GBP1) is an interferon (IFN)-inducible guanosine triphosphatases (GTPases) involving inflammation and infection. …”
Publicado 2022
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