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30901por Trujillo-Rodriguez, María, Muñoz-Muela, Esperanza, Serna-Gallego, Ana, Praena-Fernández, Juan Manuel, Pérez-Gómez, Alberto, Gasca-Capote, Carmen, Vitallé, Joana, Peraire, Joaquim, Palacios-Baena, Zaira R., Cabrera, Jorge Julio, Ruiz-Mateos, Ezequiel, Poveda, Eva, López-Cortés, Luis Eduardo, Rull, Anna, Gutierrez-Valencia, Alicia, López-Cortés, Luis Fernando“…When cytokines were included, lower interferon-γ-inducible protein 10 and higher Interleukin 1 beta levels were associated with early discharge (AUC, 0.819; SE, 91.7%; S, 56.6%; PPV, 69.3%; and NPV, 86.5%). …”
Publicado 2022
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30902por Yonemitsu, Kimihiro, Pan, Cheng, Fujiwara, Yukio, Miyasato, Yuko, Shiota, Takuya, Yano, Hiromu, Hosaka, Seiji, Tamada, Koji, Yamamoto, Yutaka, Komohara, Yoshihiro“…Granulocyte–macrophage colony-stimulating factor (GM-CSF) derived from activated lymphocytes was found to be involved in PD-L1 overexpression, in addition to interferon (IFN)-γ, via STAT3 pathway activation. Macrophages suppressed lymphocyte activation, and this inhibition was impaired by PD-1 blocking. …”
Publicado 2022
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30903por Moreno‐Torres, Victor, Castejón, Raquel, Martínez‐Urbistondo, María, Gutiérrez‐Rojas, Ángela, Vázquez‐Comendador, Jose, Tutor, Pablo, Durán‐del Campo, Pedro, Mellor‐Pita, Susana, Rosado, Silvia, Vargas‐Núñez, Juan‐Antonio“…We aimed to explore the role of interleukin (IL)‐6, interferon‐gamma (IFNγ), IL‐10, and tumor necrosis factor (TNF) as predictors of systemic lupus erythematosus (SLE) clinical and serological activity, and their correlation with the treatment received. …”
Publicado 2022
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30904por Lang, Wanying, Yang, Feng, Cai, Fanfan, Shi, Wengui, Dong, Min, An, Qi, Li, Yanping“…RESULTS: The outcomes show that YFJPT might has 33 therapeutic targets on Covid-19, namely, interleukin 2 (IL2), heme oxygenase 1 (HMOX1), interleukin 4 (IL4), interferon gamma (FNG), α nuclear factor of kappa light polypeptide gene enhancer in Bcells inhibitor, alpha (NFKBIA), nuclear factor-k-gene binding (NFKB), nitric oxide synthase 3 (NOS3), intercellular adhesion molecule 1 (ICAM1), hypoxia inducible factor 1 subunit alpha (HIF1A), mitogen-activated protein kinase 3 (MAPK3), epidermal growth factor receptor (EGFR), interleukin 10 (IL10), jun proto-oncogene (JUN), C-C motif chemokine ligand 2 (CCL2), C-X-C motif chemokine ligand 8 (CXCL8), tumor protein p53 (TP53), interleukin 1 beta (IL1B), AKT serine/threonine kinase 1 (AKT1), tumor necrosis factor (TNF), interleukin 6 (IL6), erb-b2 receptor tyrosine kinase 2 (ERBB2), RELA proto-oncogene (RELA), NF-κB subunit, caspase 8 (CASP8), peroxisome proliferator activated receptor alpha (PPARA), TIMP metallopeptidase inhibitor 1 (TIMP1), transforming growth factor beta 1 (TGFB1), interleukin 1 alpha (IL1A), signal transducer and activator of transcription 1 (STAT1), mitogen-activated protein kinase 8 (MAPK8), myeloperoxidase (MPO), matrix metallopeptidase 3 (MMP3), matrix metallopeptidase 1 (MMP1), and NFE2 like bZIP transcription factor 2 (NFE2L2). …”
Publicado 2022
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30905por Lin, Xiao, Song, Aixin, Lu, Junfeng, Zheng, Sujun, Hu, Zhongjie, Ma, Lina, Cao, Zhenhuan, Li, Hong, Zheng, Yanhong, Ren, Shan, Chen, Xinyue“…METHODS: A long-term follow-up was conducted with 32 cumulatively obtained patients who relapsed after cessation of pegylated interferon (Peg-IFN)-based antiviral treatment. The decision of whether to treatment or which therapeutic method to use [Peg-IFN or nucleos(t)ide analogs (NAs)] was based on the patient’s preferences and wishes. …”
Publicado 2022
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30906por Dijmărescu, Anda Lorena, Boldeanu, Lidia, Radu, Mirela, Rotaru, Ionela, Siminel, Mirela Anişoara, Manolea, Maria Magdalena, Vrabie, Sidonia Cătălina, Novac, Marius Bogdan, Boldeanu, Mihail Virgil, Tănase, Florentina“…Aim: This study aims to detect and measure the serum level of some biomarkers [hypoxia-inducible factor-1 subunit alpha (HIF-1A), vascular endothelial growth factor (VEGF), interferon-gamma-inducible protein of 10 kDa (IP-10), matrix metalloproteinase-13 (MMP-13)] in patients with PE and their correlation with the severity of the disease, to find a good predictor for PE. …”
Publicado 2021
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30907por Russo, Cinzia Valeria, Saccà, Francesco, Frau, Jessica, Annovazzi, Pietro, Signoriello, Elisabetta, Bonavita, Simona, Grasso, Roberta, Clerico, Marinella, Cordioli, Cinzia, Laroni, Alice, Capobianco, Marco, Torri Clerici, Valentina, Sartori, Arianna, Cavalla, Paola, Maniscalco, Giorgia Teresa, La Gioia, Sara, Caleri, Francesca, Giugno, Alessia, Iodice, Rosa, Carotenuto, Antonio, Cocco, Eleonora, Fenu, Giuseppe, Zaffaroni, Mauro, Baroncini, Damiano, Lus, Giacomo, Gallo, Antonio, De Mercanti, Stefania Federica, Lapucci, Caterina, Di Francescantonio, Valeria, Brambilla, Laura, Sormani, Maria Pia, Signori, Alessio“…Previous treatments were: fingolimod (106), natalizumab (80), first‐line oral agents (56), first‐line injectables (interferon/glatiramer acetate; 30), and other drugs (15). …”
Publicado 2021
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30908por Qu, Ying, Sun, Zhengxu, Yuan, Yan, Li, Zifeng, Wang, Fen, Wu, Kunpeng, Yu, Huihui, Lin, Qiwang, Fei, He, Chen, Jian, Qian, Maoxiang, Cheng, Yunfeng, Jiang, Hua, Chen, Tong“…Activated CD8(+) T cells and interferon-γ (IFN-γ) were found to stimulate adipogenesis of BM-MSCs either in vitro or in vivo of AA mouse model. …”
Publicado 2022
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30909por Bah, Thierno M., Allen, Elyse M., Garcia-Jaramillo, Manuel, Perez, Ruby, Zarnegarnia, Yalda, Davis, Catherine M., Bloom, Madeline B., Magana, Armando A., Choi, Jaewoo, Bobe, Gerd, Pike, Martin M., Raber, Jacob, Maier, Claudia S., Alkayed, Nabil J.“…Interleukin-10 (IL-10) was lower in KO mice on HFD than standard diet (STD), whereas IL-4, interferon γ-induced protein-10 (IP-10) and monocyte chemotactic protein-3 (MCP-3) were altered by diet in both WT and KO, but were not affected by genotype. …”
Publicado 2022
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30910por Elhusseiny, Shaza M., El-Mahdy, Taghrid S., Elleboudy, Nooran S., Farag, Mohamed M. S., Aboshanab, Khaled M., Yassien, Mahmoud A.“…From each animal, in each group, blood samples were collected after 15 days for complete blood counts and for measurement of immunologic parameters, including lysozyme activity, nitric oxide (NO) production and serum cytokines including tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and interleukin 1 beta (IL-1β) levels. …”
Publicado 2022
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30911por Yuan, Yuncong, Wang, Xingran, Li, Jiadai, Han, Lingling, Du, Hang, Sun, Yidan, Yang, Pu, Zhou, Zhou, Gu, Meijia, Lu, Yang, Shen, Chao“…By further comparing the transcripts in cell clusters, we found that these genes were involved in changes in ribosome biogenesis, cell cycle, and intracellular signaling including the interferon signaling pathway and mitogen-activated protein kinase (MAPK) signaling pathway. …”
Publicado 2022
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30912por Chaudhary, Jitendra Kumar, Saini, Deepika, Chaudhary, Pankaj Kumar, Maurya, Anurag, Verma, Ganesh Kumar, Gupta, Akhilesh Kumar, Roshan, Rakesh, Vats, Tarun Kumar, Garg, Nidhi, Yadav, Deepika, Kant, Nimita, Meena, Anil Kumar, Mirza-Shariff, Anissa Atif“…Thereupon, immune responses are elicited, which may devolve into a cytokine storm characterized by enhanced secretion of multitude of inflammatory cytokines/chemokines and growth factors, such as interleukin (IL)-2, IL-6, IL-7, IL-8, IL-9, tumor necrosis factor alpha (TNF-α), granulocyte colony-stimulating factor (GCSF), basic fibroblast growth factor 2 (bFGF2), monocyte chemotactic protein-1 (MCP1), interferon-inducible protein 10 (IP10), macrophage inflammatory protein 1A (MIP1A), platelet-derived growth factor subunit B (PDGFB), and vascular endothelial factor (VEGF)-A. …”
Publicado 2022
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30913por Aicher, Sophie-Marie, Streicher, Felix, Chazal, Maxime, Planas, Delphine, Luo, Dongsheng, Buchrieser, Julian, Nemcova, Monika, Seidlova, Veronika, Zukal, Jan, Serra-Cobo, Jordi, Pontier, Dominique, Pain, Bertrand, Zimmer, Gert, Schwartz, Olivier, Roingeard, Philippe, Pikula, Jiri, Dacheux, Laurent, Jouvenet, Nolwenn“…E. serotinus brain cells and M. myotis nasal epithelial cells expressing hACE2 efficiently controlled viral replication, which correlated with a potent interferon response. Our data highlight the existence of species-specific and cell-specific molecular barriers to viral replication in bat cells. …”
Publicado 2022
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30914por Wang, Miaomiao, Bohórquez, José Alejandro, Muñoz-González, Sara, Gerber, Markus, Alberch, Mònica, Pérez-Simó, Marta, Abad, Xavier, Liniger, Matthias, Ruggli, Nicolas, Ganges, Llilianne“…However, the viremia and viral excretion were surprisingly low, while the virus load was high in the tonsils. Only alpha interferon (IFN-α) and interleukin 12 (IL-12) were highly and consistently elevated in the two groups. …”
Publicado 2022
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30915por Wai, Cho Mar Myint, Chen, Shangying, Phyu, The, Fan, Shuangyi, Leong, Sai Mun, Zheng, Wenning, Low, Louis Ching Yi, Choo, Shoa-Nian, Lee, Chi-Kuen, Chung, Tae-Hoon, Ban, Kenneth Hon Kim, Ghosh, Soumita, Lie, Stefanus, Kato, Seiichi, Nakamura, Shigeo, Takahashi, Emiko, Ko, Young-Hyeh, Khoury, Joseph D., Chuang, Shih-Sung, Au-Yeung, Rex K.H., Tan, Soo-Yong, Lim, Soon-Thye, Ong, Choon-Kiat, Ho, Yong-Howe, Poon, Li Mei, de Mel, Sanjay, Jeyasekharan, Anand D., Chng, Wee-Joo, Otto, Franziska, Quintanilla-Martinez, Leticia, Zanardi, Federica, Iannelli, Fabio, Tripodo, Claudio, Pitt, Jason J., Ng, Siok-Bian“…Gene set enrichment analysis revealed that many immune-related pathways, interferon α/γ response, and IL6_JAK_STAT3 signaling were significantly upregulated in PTCLEBV and correlated with lower genomic instability scores. …”
Publicado 2022
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30916OnabotulinumtoxinA alters inflammatory gene expression and immune cells in chronic headache patientspor Gfrerer, Lisa, Xu, Wenjie, Austen, William, Ashina, Sait, Melo-Carrillo, Agustin, Longhi, Maria Serena, Adams, Aubrey Manack, Houle, Timothy, Brin, Mitchell F, Burstein, Rami“…We found that (i) onabotulinumtoxinA alters expression of inflammatory genes largely in periosteum, minimally in muscle and not at all in fascia; (ii) expression of inflammatory genes in uninjected periosteum and muscle is significantly higher in historical onabotulinumA responders than historical non-responders; (iii) in historical responders’ periosteum, onabotulinumA decreases expression of nearly all significantly altered genes, gene sets that define well recognized inflammatory pathways (e.g. pathways involved in adaptive/innate immune response, lymphocyte activation, and cytokine, chemokine, NF-kB, TNF and interferon signalling), and abundance of 12 different immune cell classes (e.g. neutrophils, macrophages, cytotoxic T-, NK-, Th1-, B- and dendritic-cells), whereas in historical non-responders it increases gene expression but to a level that is nearly identical to the level observed in the uninjected periosteum and muscle of historical responders; and surprisingly (iv) that the anti-inflammatory effects of onabotulinumA are far less apparent in muscles and absent in fascia. …”
Publicado 2021
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30917por Xie, Min, Li, Cuifang, She, Zhou, Wu, Feifeng, Mao, Jueyi, Hun, Marady, Luo, Senlin, Wan, Wuqing, Tian, Jidong, Wen, Chuan“…Both hUCMSCs and hUCMSC-EVs inhibited CD4(+) T cells, increased the production of T helper (Th)17 cells, promoted the production of interleukin (IL)-17 and transforming growth factor beta1 (TGF-β1) (P < 0.05), although they had no significant effects on Th1, Th2, T follicular helper (Tfh), regulatory T (Treg) cells and IL-10 (P > 0.05); only hUCMSCs inhibited CD19(+) B cells, promoted the production of interferon-gamma (IFN-γ) and IL-4 (P < 0.05). hUCMSCs exert immunoregulatory effects on SLE at least partially through hUCMSC-EVs in vitro, therefore, hUCMSC-EVs play novel and potential regulator roles in SLE.…”
Publicado 2022
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30918por Manurung, Mikhael D., de Jong, Sanne E., Kruize, Yvonne, Mouwenda, Yoanne D., Ongwe, Madeleine Eunice Betouke, Honkpehedji, Yabo Josiane, Zinsou, Jeannot Frézus, Dejon-Agobe, Jean Claude, Hoffman, Stephen L., Kremsner, Peter G., Adegnika, Ayola Akim, Fendel, Rolf, Mordmüller, Benjamin, Roestenberg, Meta, Lell, Bertrand, Yazdanbakhsh, Maria“…In the TBS(−) Africans, we observed higher baseline frequencies of CD4(+) T cells producing interferon-gamma (IFNγ) that significantly decreased 5 days after PfSPZ DVI. …”
Publicado 2022
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30919por Macedo, Amanda B., Levinger, Callie, Nguyen, Bryan N., Richard, Jonathan, Gupta, Mamta, Cruz, Conrad Russell Y., Finzi, Andrés, Chiappinelli, Katherine B., Crandall, Keith A., Bosque, Alberto“…We showed that HODHBt increased IL-15-mediated STAT phosphorylation in NK cells, resulting in increases in the secretion of CXCL-10 and interferon gamma (IFN-γ) and the expression of cytotoxic proteins, including granzyme B, granzyme A, perforin, granulysin, FASL, and TRAIL. …”
Publicado 2022
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30920“…Liver anti-inflammatory ELISA results showed that BCP reduced the levels of interleukin (IL)-6, IL-1β, IL-17, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ, and enhanced the level of anti-inflammatory factor IL-10. …”
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