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30961por Gálvez, Nicolás MS, Pacheco, Gaspar A, Schultz, Bárbara M, Melo-González, Felipe, Soto, Jorge A, Duarte, Luisa F, González, Liliana A, Rivera-Pérez, Daniela, Ríos, Mariana, Berrios, Roslye V, Vázquez, Yaneisi, Moreno-Tapia, Daniela, Vallejos, Omar P, Andrade, Catalina A, Hoppe-Elsholz, Guillermo, Iturriaga, Carolina, Urzua, Marcela, Navarrete, María S, Rojas, Álvaro, Fasce, Rodrigo, Fernández, Jorge, Mora, Judith, Ramírez, Eugenio, Gaete-Argel, Aracelly, Acevedo, Mónica L, Valiente-Echeverría, Fernando, Soto-Rifo, Ricardo, Weiskopf, Daniela, Grifoni, Alba, Sette, Alessandro, Zeng, Gang, Meng, Weining, González-Aramundiz, José V, Johnson, Marina, Goldblatt, David, González, Pablo A, Abarca, Katia, Bueno, Susan M, Kalergis, Alexis M“…Stimulation of peripheral blood mononuclear cells (PBMCs) with Mega pools of Peptides (MPs) induced the secretion of interferon (IFN)-γ and the expression of activation induced markers in CD4(+) T cells for both schedules. …”
Publicado 2022
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30962“…The mechanisms underlying the various manifestations of viral infection are incompletely understood but most data suggest that severe COVID-19 results from virus-driven perturbations in the immune system and resultant tissue injury. Aberrant interferon-related responses lead to alterations in cytokine elaboration that deplete resident immune cells while simultaneously recruiting hyperactive macrophages and functionally altered neutrophils, thereby tipping the balance from adaptive immunity to innate immunity. …”
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30963por Wang, Hong-Jiang, Guo, Yan, He, Meng-Jiao, Liu, Zhong-Yu, Ye, Qing, Huang, Xing-Yao, Deng, Yong-Qiang, Li, Xiao-Feng, Qin, Cheng-Feng“…More importantly, in comparison with the parental 17D, 17D-IRES displayed significantly decreased mouse neurovirulence and viscerotropism in type I interferon (IFN)-signaling-deficient and immunocompetent mouse models. …”
Publicado 2022
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30964por Wang, Kaicen, Wu, Wenrui, Jiang, Xianwan, Xia, Jiafeng, Lv, Longxian, Li, Shengjie, Zhuge, Aoxiang, Wu, Zhengjie, Wang, Qiangqiang, Wang, Shuting, Li, Lanjuan“…Furthermore, the Gsdmd(−/−) mice exhibited higher hepatic expression and serum levels of inflammatory cytokines (gamma interferon [IFN-γ], tumor necrosis factor alpha [TNF-α], and interleukin-17A [IL-17A]) and more infiltration of macrophages and neutrophils after ConA treatment than did wild-type (WT) mice. …”
Publicado 2022
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30965por Liu, Yang, Wang, Qinjin, Liu, Hua, Niu, Jiax‑ing, Jiao, Ning, Huang, Libo, Jiang, Shuzhen, Guan, Qinglin, Yang, Weiren, Li, Yang“…Meanwhile, BP group had significantly higher ZO-1, secretory immunoglobulin A, interferon-γ concentrations, and mRNA expressions of glucose transporter type-2 and sirtuin-1, and significantly lower IL-1β concentration than groups CON and AB in intestinal mucosa (p < 0.05). …”
Publicado 2022
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30966“…ANRIL silencing increased the body weight, recovered renal function [decreased blood urea nitrogen (BUN) and serum creatinine (Scr)] and cardiac function [decreased left ventricular end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), LV systolic anterior wall thickness (LVAWS), LV end-diastolic anterior wall thickness (LVAWD), myocardial performance index (MPI), and isovolumic relaxation time (IVRT); increased LV ejection fraction (LVEF), LVEF/MPI, fractional shortening (FS), and E- and A-waves (E/A)], inhibited the inflammation [decreased interferon (IFN)-γ, interleukin (IL)-2, IL-10, and tumor necrosis factor (TNF)-α], and relieved pathological injuries and fibrosis. …”
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30967por Farroni, Chiara, Aiello, Alessandra, Picchianti-Diamanti, Andrea, Laganà, Bruno, Petruccioli, Elisa, Agrati, Chiara, Garbuglia, Anna Rosa, Meschi, Silvia, Lapa, Daniele, Cuzzi, Gilda, Petrone, Linda, Vanini, Valentina, Salmi, Andrea, Altera, Anna Maria Gerarda, Repele, Federica, Grassi, Germana, Bettini, Aurora, Vita, Serena, Mariano, Andrea, Damiani, Arianna, Infantino, Maria, Grossi, Valentina, Manfredi, Mariangela, Niccoli, Laura, Puro, Vincenzo, Rosa, Roberta Di, Salemi, Simonetta, Sesti, Giorgio, Scolieri, Palma, Bruzzese, Vincenzo, Benucci, Maurizio, Cantini, Fabrizio, Nicastri, Emanuele, Goletti, Delia“…The humoral response was assessed by measuring anti-receptor-binding domain (RBD) and neutralizing antibodies, the T-cell response by interferon-γ-release assay (IGRA), T cell cytokine production, and B cell phenotype at T3 by flow cytometry. …”
Publicado 2022
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30968por Pantzaris, Marios C, Bakirtzis, Christos, Grigoriadis, Nikolaos, Hadjigeorgiou, Georgios, Dardiotis, Efthimos, Loucaides, George, Ntzani, Evangelia, Markozannes, Georgios, Omorfos, Savvas, Valsasina, Paola, Messina, Roberta, Preziosa, Paolo, Rocca, Maria A, Patrikios, Ioannis“…OBJECTIVES: To assess the effectiveness of Neuroaspis plp10 nutritional supplement when added to interferon (IFN)-β treatment in patients with relapsing-remitting multiple sclerosis (RRMS). …”
Publicado 2022
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30969“…Further, a survival analysis of 20 genes with combined scores >0.94 revealed that the low expression of ANXA1 (annexin A1) and TPM1 (tropomyosin 1) was associated with the shorter overall survival of OS patients, while the high expression of FDPS (farnesyl pyrophosphate synthase), IFITM5 (interferon-induced transmembrane protein 5), FKBP11 (FKBP prolyl isomerase 11), SP7, and SQLE (squalene epoxidase) was associated with the shorter overall survival of OS patients. …”
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30970por Zhang, Ziyuan, Liu, Juan, Xiao, Min, Zhang, Quanfeng, Liu, Zhonghua, Liu, Meiyan, Zhang, Peng, Zeng, Youlin“…The activation of the stimulating factor of the interferon gene (STING) pathway can enhance the immune response within the tumor. …”
Publicado 2022
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30971“…Compared to the MOG-IgG-negative group, MOG-IgG-positive ADEM patients had a longer disease duration (median: 10 vs. 6 days), more meningeal involvement (31.4% vs. 8%) and frontal lobe involvement (82.8% vs. 68%), higher relapse rates (14.3% vs. 2%), lower serum tumor necrosis factor (1–12.4 pg/ml, median 1.7 vs. 1–34 pg/ml, median 2.2) and interferon-gamma (1–9.4 pg/ml, median 1.3 vs. 1–64 pg/ml, median 3) (P < 0.05, respectively). …”
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30972por Yao, Huihui, Wang, Suo, Zhou, Xin, Sun, Jinbing, Zhou, Guoqiang, Zhou, Diyuan, Chen, Guoliang, Shi, Xinyu, Chen, Junjie, Shi, Bo, Tai, Qingliang, Mi, Xiuwei, Sun, Liang, Yao, Yizhou, He, Songbing“…BACKGROUND: In recent years, reports regarding stimulator of interferon genes (STING) and the progression of colorectal cancer (CRC) have emerged rapidly, yet their association remains controversial. …”
Publicado 2022
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30973por Angria, Nirmawati, Massi, Muhammad Nasrum, Bukhari, Agussalim, Djaharuddin, Irawaty, Jumadi, Oslan, Ahmad, Ahyar, Miskad, Upik Andriani, Ladju, Rusdina Bte, Santoso, Arif, Halik, Handayani“…The upregulation of miRNA-29a-3p suppresses the immune response by post-transcriptionally inhibiting interferon (INF)-γ expression in T cells, increasing susceptibility to pulmonary TB. …”
Publicado 2022
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30974por Zhang, Fan, Liang, Jiayu, Lu, You, Tang, Yongquan, Liu, Shengzhuo, Wu, Kan, Zhang, Fuxun, Lu, Yiping, Liu, Zhihong, Wang, Xianding“…High CTSZ expression was significantly correlated with the enrichment of interferon-γ, epithelial‐to‐mesenchymal transition, cell cycle, apoptosis pathways, and B cell, macrophage, neutrophil, and dendritic cell infiltrations, as well as the expression of immune checkpoints CTLA4, LAG3, HAVCR2, PDCD1LG2, PDCD1, TIGIT, and SIGLEC15. …”
Publicado 2022
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30975por Salem, Gamal A., Mohamed, Amany Abdel-Rahman, Ghonimi, Wael A. M., Abdallah, H. M., Rhouma, Nasreddin R., Ali, Reem I.“…It also induced a significant (p < 0.05) amplification of WBCs, myeloperoxidase (MPO), malondialdehyde (MDA), nuclear factor kappa B (NF-kB) expression and proinflammatory cytokines tumor necrosis factor alpha (TNFα), interferon gamma (INFγ), and interleukin-1 beta (IL-1β) while depressed the antioxidant enzymes glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) when compared with the DSS and control groups. …”
Publicado 2022
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30976por Gholami, Melika, Sakhaee, Fatemeh, Sotoodehnejadnematalahi, Fattah, Zamani, Mohammad Saber, Ahmadi, Iraj, Anvari, Enayat, Fateh, Abolfazl“…BACKGROUND: The interferon-induced transmembrane-protein 3 (IFITM3) is a vital component of the immune system's defense against viral infection. …”
Publicado 2022
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30977por Westfall, Jesse J., Schwind, Wesley N., Sran, Sahibjot, Navarro, Jason B., Leonard, Jeffrey, Pindrik, Jonathan A., Pierson, Christopher R., Boué, Daniel R., Koboldt, Daniel C., Ostendorf, Adam P., Wilson, Richard K., Mardis, Elaine R., Miller, Katherine E., Bedrosian, Tracy A.“…Specifically, microglia in RE tissues demonstrated increased expression of genes associated with cytokine signaling, interferon-mediated pathways, and T-cell activation. …”
Publicado 2022
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30978por Lin, Yuning, Zhang, Zhongying, Li, Ying, Chen, Yongquan, Su, Meiying, Zhao, Wenzhen“…GSEA demonstrated that E2F target, G2M checkpoint, Myc target, interferon γ reaction were differentially enriched in the high DIRC1 expression phenotype. …”
Publicado 2022
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30979por Mohnke, Jonas, Stark, Irmgard, Fischer, Mara, Fischer, Patrick M., Schlosser, Andreas, Grothey, Arnhild, O’Hare, Peter, Sodeik, Beate, Erhard, Florian, Dölken, Lars, Hennig, Thomas“…While its N-terminal deubiquitinase (DUB) activity is dispensable for infection in cell culture, it is required for efficient virus spread in vivo, as it acts as a potent viral immune evasin. Interferon (IFN) induces the expression of hundreds of antiviral factors, including many ubiquitin modulators, which HSV-1 needs to neutralize to efficiently initiate a productive infection. …”
Publicado 2022
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30980por Maniscalco, Giorgia Teresa, Scavone, Cristina, Mascolo, Annamaria, Manzo, Valentino, Prestipino, Elio, Guglielmi, Gaspare, Aiezza, Maria Luisa, Cozzolino, Santolo, Bracco, Adele, Moreggia, Ornella, Di Giulio Cesare, Daniele, Ziello, Antonio Rosario, Falco, Angela, Massa, Marida, Majolo, Massimo, Raiola, Eliana, Soprano, Roberto, Russo, Giuseppe, Longo, Giuseppe, Andreone, Vincenzo, Capuano, Annalisa“…The majority of patients received a Disease Modifying Therapy (DMT) during the study period, mainly interferon beta 1-a, dimethyl fumarate, and natalizumab and fingolimod. …”
Publicado 2022
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