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31001por Shi, Fangfang, Xue, Rui, Xu, Hui, Mei, Feng, Bao, Xueyang, Dou, Jun, Zhao, Fengshu“…As compared with B16F10-vaccinated mice, B16F10-vaccinated mice in which MUC1 was silenced had reduced natural killer (NK) cytotoxicity, lower production of interferon-γ (IFN-γ), anti-MUC1 antibodies, perforin, granzyme B, and elevated tumor growth factor-β (TGF-β) level. …”
Publicado 2022
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31002por Midttun, Øivind, Ulvik, Arve, Meyer, Klaus, Zahed, Hana, Giles, Graham G., Manjer, Jonas, Sandsveden, Malte, Langhammer, Arnulf, Sørgjerd, Elin Pettersen, Behndig, Annelie F., Johansson, Mikael, Freedman, Neal D., Huang, Wen-Yi, Chen, Chu, Prentice, Ross, Stevens, Victoria L., Wang, Ying, Le Marchand, Loïc, Weinstein, Stephanie J., Cai, Qiuyin, Arslan, Alan A., Chen, Yu, Shu, Xiao-Ou, Zheng, Wei, Yuan, Jian-Min, Koh, Woon-Puay, Visvanathan, Kala, Sesso, Howard D., Zhang, Xuehong, Gaziano, J. Michael, Fanidi, Anouar, Robbins, Hilary A., Brennan, Paul, Johansson, Mattias, Ueland, Per M.“…Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine pathway of tryptophan metabolism increase during inflammation, particularly in response to interferon-gamma (IFN-γ). Neopterin and the kynurenine/tryptophan ratio (KTR) are IFN-γ induced inflammatory markers, and together with C-reactive protein (CRP) and kynurenines they are associated with various diseases, but comprehensive data on the strength of associations of inflammatory markers with circulating concentrations of kynurenines are lacking. …”
Publicado 2023
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31003por Victorio, Carla Bianca Luena, Msallam, Rasha, Novera, Wisna, Ong, Joanne, Yang, Tham Jing, Ganasarajah, Arun, Low, Jenny, Watanabe, Satoru, Chacko, Ann-Marie“…This study investigates ZIKV-associated changes in adult brain TSPO expression, evaluates the effectiveness of TSPO radioligands in detecting TSPO expression, and identifies cells that drive brain TSPO expression in a mouse infection model. METHODS: The interferon-deficient AG129 mouse infected with ZIKV was used as neuroinflammation model. …”
Publicado 2022
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31004por Aboelsoued, Dina, Abdullah, Hend H. A. M., Megeed, Kadria N. Abdel, Hassan, Soad E., Toaleb, Nagwa I.“…In addition, the production of cytokines interferon-gamma, interleukin (IL)-10, IL-12, and IL-15 was activated post-vaccination. …”
Publicado 2022
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31005por Mathias, Amandine, Pantazou, Vasiliki, Perriot, Sylvain, Canales, Mathieu, Jones, Samuel, Oberholster, Larise, Moulin, Michaël, Fenwick, Craig, Bernard-Valnet, Raphaël, Théaudin, Marie, Pot, Caroline, Du Pasquier, Renaud A.“…In parallel, viral-specific CD8(+) T-cell responses were assessed by the quantification of interferon-γ secretion using the enzyme-linked immunospot assay on cytomegalovirus, Epstein-Barr virus, and influenza stimulations. …”
Publicado 2023
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31006por Goto, Ryo, Shiota, Seiji, Kaimori, Ryo, Horinouchi, Noboru, Utsunomiya Nishimizu, Rie, Yamamoto, Kyoko, Miyazaki, Eishi“…However, disseminated NTM diseases have also been reported in immunocompetent patients. Autoantibodies to interferon-gamma (IFN-γ) are known to be involved in disseminated NTM disease, although anti-IFN-γ antibodies are mainly seen in immunocompetent patients rather than those with immunodeficiency. …”
Publicado 2023
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31007por Baek, Yae Jee, Kim, Woo-Joong, Ko, Jae-Hoon, Lee, Youn-Jung, Ahn, Jin Young, Kim, Jung Ho, Jang, Ho Cheol, Jeong, Hye Won, Kim, Yong Chan, Park, Yoon Soo, Kim, Sung-Han, Peck, Kyong Ran, Shin, Eui-Cheol, Choi, Jun Yong“…However, the frequency of interferon-γ-producing CD4(+) T cells was highest in the BNT162b2/BNT162b2 vaccination group. …”
Publicado 2023
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31008por Coll, Elisabeth, Fernández-Ruiz, Mario, Sánchez-Álvarez, J. Emilio, Martínez-Fernández, José R., Crespo, Marta, Gayoso, Jorge, Bada-Bosch, Teresa, Oppenheimer, Federico, Moreso, Francesc, López-Oliva, María O., Melilli, Edoardo, Rodríguez-Ferrero, Marisa L., Bravo, Carlos, Burgos, Elena, Facundo, Carme, Lorenzo, Inmaculada, Yañez, Íñigo, Galeano, Cristina, Roca, Ana, Cabello, Mercedes, Gómez-Bueno, Manuel, García-Cosío, MaDolores, Graus, Javier, Lladó, Laura, de Pablo, Alicia, Loinaz, Carmelo, Aguado, Beatriz, Hernández, Domingo, Domínguez-Gil, Beatriz“…Therapies included hydroxychloroquine (84%), azithromycin (53%), protease inhibitors (37%), and interferon-β (5%), whereas immunomodulation was based on corticosteroids (41%) and tocilizumab (21%). …”
Publicado 2021
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31009“…More importantly, aged DUSP22 knockout mice spontaneously developed syndesmophyte formation, which was accompanied by an increase of TNF-α(+), interleukin-17A(+), and interferon-γ(+) CD3(+) T cells. CONCLUSIONS: DUSP22 may play a crucial role in the pathogenesis and regulation of disease activity of AS. …”
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31010“…Siponimod relieved the symptom severity and decreased the expression of interferon-gamma and IL-10 mRNAs in lymph nodes and CE compared with that in the EAN group. …”
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31011por Xu, Jing-xiao, Zhang, Rong, Huang, Dai-jia, Tang, Ying, Ping, Li-qin, Huang, Bi-jun, Huang, Hui-qiang, Busson, Pierre, Li, Jiang“…Mechanically, stimulator of interferon gene (STING) activation or signal transducer and activator of transcription 3 (STAT3) inhibition impeded the outgrowth of EBV-infected B cells and promotion of Gal-9-induced lymphoblastoid cell line (LCL) transformation. …”
Publicado 2023
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31012por Lopes, Ana P, Hillen, Maarten R, Hinrichs, Anneline C, Blokland, Sofie LM, Bekker, Cornelis PJ, Pandit, Aridaman, Kruize, Aike A, Radstake, Timothy RDJ, van Roon, Joel A“…RESULTS: Transcriptome of cDC2s from patients with pSS revealed alterations in type I interferon (IFN), toll-like receptor (TLR), antigen processing and presentation pathways. …”
Publicado 2023
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31013por Chamboux, Morgane, Simon, Corinne, Beau-Salinas, Frédérique, Maurier, Anaïs, Agier, Marie Sara, Thillard, Eve Marie, Largeau, Bérenger, Jonville-Bera, Annie Pierre“…The potential mechanism of PFP after COVID-19 vaccine, which don’t have a specific profile, is probably the interferon-γ. Moreover, the risk of recurrence after a new injection appears to be very low, which makes it possible to continue the vaccination.…”
Publicado 2023
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31014por Schmitt Junior, Antonio Augusto, Primo de Carvalho Alves, Lucas, Padilha, Barbara Larissa, da Rocha, Neusa Sica“…Generalized estimating equations were used to analyze variations in SCL [interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin (IL)-2, IL-4, IL-6, IL-10, and IL-17] at hospital admission and discharge. …”
Publicado 2023
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31015por Jin, Qianmei, Liu, Yaoyang, Zhang, Zhiguo, Wen, Xingzhu, Chen, Ziqiang, Tian, Haijun, Kang, Zijian, Wu, Xin, Xu, Huji“…In addition, the ALP and BMP2 were confirmed to be the direct target genes of MYC. Furthermore, interferon-γ (IFN-γ), which showed high expression in AS ligaments, was found to promote the expression of MYC in fibroblasts in the process of ossification in vitro. …”
Publicado 2023
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31016por Liu, Yingru, Hammer, Laura A., Daamen, Jikke, Stork, Michiel, Egilmez, Nejat K., Russell, Michael W.“…Male mice responded with serum IgG and salivary IgA antibodies similarly to female mice. Gamma interferon (IFN-γ) production by CD4(+) T cells from iliac lymph nodes was elevated after i.n. or i.vag. immunization with OMVs plus IL-12 ms. …”
Publicado 2022
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31017por Wu, Linfang, Gao, Yibo, Wang, Daquan, Chen, Yanhua, Qian, Mingmin, Xu, Xin, Zhang, Tao, Bi, Nan, Wang, Luhua“…Its activity was primarily induced by interferon-γ (IFN-γ), which was reported to play a role in the development of acute radiation-induced pneumonitis. …”
Publicado 2023
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31018por Albright, Jack, Mick, Eran, Sanchez-Guerrero, Estella, Kamm, Jack, Mitchell, Anthea, Detweiler, Angela M., Neff, Norma, Tsitsiklis, Alexandra, Hayakawa Serpa, Paula, Ratnasiri, Kalani, Havlir, Diane, Kistler, Amy, DeRisi, Joseph L., Pisco, Angela Oliveira, Langelier, Charles R.“…We find that optimal classifiers include an interferon-stimulated gene that is strongly induced in COVID-19 compared with nonviral conditions, such as IFI6, and a second immune-response gene that is more strongly induced in other viral infections, such as GBP5. …”
Publicado 2022
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31019“…Unfortunately, treatment with recombinant human interferon gel was not effective. To achieve a correct diagnosis, dermoscopy and RCM were performed. …”
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31020“…Finally, enzyme-linked immunosorbent assay (ELISA) revealed that the expressions of tumor necrosis factor-α (TNF-α), interleukin 8 (IL-8), IL-6, and interferon-γ (IFN-γ) in tumor tissues were remarkably higher compared with those in adjacent tissues. …”
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