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  1. 31101
    “…RNA-sequence analysis of the temporal cortex tissue revealed significant enrichment of interferon-gamma and complement pathways and increased expression of antigen presenting molecules (Cd86, Cd74, and H2-Aa) in PS19 mice treated with ASO-Ttbk1, suggesting its potential effect on microglial phenotype although neurotoxic effect was absent. …”
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    Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
  2. 31102
    “…Age emerged as a modulating factor, dampening innate immune reactions, as evidenced by reduced interleukin-2 and interferon-γ concentrations (both adjusted P < 0.05). …”
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    Impact of patient characteristics on innate immune responses and inflammasome activation in ex vivo human lung tissues infected with influenza A virus
  3. 31103
    “…RESULTS: Intraperitoneal or locoregional administration, but not other routes of administration, resulted in a potent immune response characterized by increased levels of tumor-specific CD8(+) T lymphocytes with the ability to produce both interferon-γ and tumor necrosis factor-α. The antitumor immune response was detectable not only in the peritoneal cavity but also systemically. …”
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    Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis
  4. 31104
    “…It was then found that Srg3 can be transcriptionally activated by interferon regulatory factor 7 (Irf7), and specific inhibition of Irf7 significantly improved the symptoms of ALI. …”
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    Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury
  5. 31105
    “…A(2B)-adenosine receptor inhibition alleviated metabolic stress, downregulated expression of adenosine-generating ectonucleotidases, increased expression of adenosine deaminase, decreased tumor growth and metastasis, increased interferon γ production, and enhanced the efficacy of antitumor therapies following combination regimens in animal models (anti–programmed cell death 1 protein vs anti–programmed cell death 1 protein plus PBF-1129 treatment hazard ratio = 11.74 [95% confidence interval = 3.35 to 41.13], n = 10, P < .001, 2-sided F test). …”
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    Improving combination therapies: targeting A(2B)-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression
  6. 31106
    “…Furthermore, Fp-EVs downregulated the expression of the proinflammatory cytokines interleukin-1β (IL-1β), IL-2, IL-6, IL-12a, IL-17a, Interferon-γ (IFN-γ), tumor necrosis factor - α (TNF-α), granulocyte-macrophage colony stimulating factor (GM-CSF) and upregulated the anti-inflammatory cytokines IL-4, IL-10, and transforming growth factor β (TGF-β) in DSS-treated mice. …”
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    F. prausnitzii-derived extracellular vesicles attenuate experimental colitis by regulating intestinal homeostasis in mice
  7. 31107
    “…Patients were treated in two cohorts with or without interferon-α (IFNa), as conditioning and TIL support regimen. …”
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    Timed adoptive T cell transfer during chemotherapy in patients with recurrent platinum-sensitive epithelial ovarian cancer
  8. 31108
    “…He tested negative for ANA, HIV, Hepatitis C, Mycobacterium TB Interferon-Gamma. The patient underwent skin biopsy and excisional lymph node biopsy. …”
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    Hypothalamic involvement of sarcoidosis presenting with behavioral disorder
  9. 31109
    “…The infection pathobiology in SJL/J mice and susceptible mice was similar for the first 7–10 days then markedly diverged toward pathogen clearance. Interferon-gamma (IFN-γ) expression was critical for SJL/J resistance while tumor necrosis factor-alpha was also important. …”
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    Inbred SJL mice recapitulate human resistance to Cryptococcus infection due to differential immune activation
  10. 31110
    “…ZIKV persistence requires inhibiting interferon (IFN) responses that direct viral clearance. …”
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    ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNβ/λ expression and promotes ZIKV persistence
  11. 31111
    “…Using immunohistochemistry, quantitative polymerase chain reaction, and immunofluorescence techniques, we evaluated the therapeutic effect of UC-MSCs pretreated with interferon alpha 2 (IFN-α2) (pre-MSCs) in an animal model of cirrhosis. …”
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    Pretreatment of UC-MSCs with IFN-α2 improves treatment of liver fibrosis by recruiting neutrophils
  12. 31112
    “…More than 50% of evaluable patients showed augmented immune responses to GD2+ targets after GD2BATs as measured by interferon-gamma (IFN-γ) EliSpots, Th1 cytokines, and/or chemokines. …”
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    Targeting GD2-positive Refractory/Resistant Neuroblastoma and Osteosarcoma with Anti- CD3 x Anti-GD2 Bispecific Antibody Armed T cells
  13. 31113
    “…Moreover, we investigated whether activated hAECs stimulated by the proinflammatory cytokines tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) were more effective than native hAECs in repairing ovarian injury induced by chemotherapy. …”
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    TNF-α and IFN-γ prestimulation enhances the therapeutic efficacy of human amniotic epithelial stem cells in chemotherapy-induced ovarian dysfunction
  14. 31114
    “…TB infection screening was defined as testing with interferon gamma release assay or tuberculin skin test. …”
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    2511. Screening for Hepatitis B Virus (HBV) and Tuberculosis (TB) Infection among Non-U.S.-Born Adults from High HBV and TB Burden Countries
  15. 31115
    “…The most significantly regulated gene set of each miRNA related to cell cycle (hsa-miRNA-144-3p and -5p [P(adj) = 4 × 10(−40) and P(adj) = 4 × 10(−6)], -miR-17-5p [P(adj) = 9.5 × 10(−23)], -miR-30e-5p [P(adj) = 8.2 × 10(−18)], -miR-130a-3p [P(adj) = 5 × 10(−15)]), integrin cell surface interaction (-miR-223-3p [P(adj) = 2.4 × 10(−7)]), and interferon signaling (-miR-142-3p [P(adj) = 5 × 10(−11)]). …”
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    miRNAs from Inflamed Gingiva Link Gene Signaling to Increased MET Expression
  16. 31116
    “…Administration of DMX, the activator of stimulator of interferon genes (STING), was performed to investigate the effects of the STING-related pathway on APAP-treated P2rx1(−/−) mice. …”
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    P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway
  17. 31117
    “…These genes were organized into seven co-expression modules associated with relevant pathways, including interferon signaling, T-cell receptor signaling, and specific granule pathways. …”
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    Comprehensive analysis of immune cell landscapes revealed that immune cell ratio eosinophil/B.cell.memory is predictive of survival in sepsis
  18. 31118
    “…A priming and post-chemotherapy schedule of the myeloid cell mobilizing and immune stimulatory growth factor, granulocyte monocyte stimulating factor (GM-CSF, Leukine(®)) and the MO/MA activating cytokine recombinant interferon gamma 1b (rIFN-γ1b, Actimmune(®)) has been developed. …”
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    Cytokines, GM-CSF and IFNγ administered by priming and post-chemotherapy cycling in recurrent ovarian cancer patients receiving carboplatin
  19. 31119
    “…Several cytokines--interleukin 2 (IL-2), tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma)--and prostaglandin E2 (PGE2) known to modulate tumour growth and metastasis were examined to determine whether they regulate nm23 expression in JAR in vitro. …”
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    Differential nm23 gene expression at the fetal-maternal interface.
  20. 31120
    “…Elevated plasma levels of tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) were detected at the MTD. …”
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    Phase I study of intravenously applied bispecific antibody in renal cell cancer patients receiving subcutaneous interleukin 2.
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