-
31141por Qureshi, Asaf A, Guan, Xiu Qin, Reis, Julia C, Papasian, Christopher J, Jabre, Sandra, Morrison, David C, Qureshi, Nilofer“…These compounds also inhibited the production of NO by RAW-264.7 cells stimulated with LPS alone (>40%; P < 0.05), or LPS + interferon-γ (IFN-γ; >60%; P < 0.02). Furthermore, resveratrol, pterostilbene, morin hydrate, and quercetin suppressed secretion of TNF-α (>40%; P < 0.05) in LPS-stimulated RAW 264.7 cells, and suppressed NF-κB activation (22% to 45%; P < 0.05) in LPS-stimulated HEK293T cells. …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31142por Sugita, Sunao, Kawazoe, Yuko, Imai, Ayano, Yamada, Yukiko, Horie, Shintaro, Mochizuki, Manabu“…For the induction of Th17 cells, CD4(+ )T cells from BD patients were co-cultured with anti-CD3/CD28, anti-interferon-gamma (anti-IFN-γ), anti-interleukin-4 (anti-IL-4), and recombinant proteins such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-23 (IL-23), and TNF-α. …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31143por Zhao, Hongwei, Zhang, Hong, Wu, Hui, Li, Hui, Liu, Lei, Guo, Jian, Li, Chenyang, Shih, David Q, Zhang, Xiaolan“…Severity of colitis was evaluated by disease activity index (DAI), body weight (BW) change, colon length, histology, myeloperoxidase (MPO) activity, and proinflammatory cytokine production including tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). In vitro the protective role of 1,25(OH)(2)D(3) was assessed by incubating Caco-2 cells with or without DSS and measuring transepithelial electrical resistance (TEER) and fluorescein isothiocyanate dextran (FITC-D). …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31144por Kohli, Arunima, Garcia, Marco A, Miller, Rachel L, Maher, Christina, Humblet, Olivier, Hammond, S Katharine, Nadeau, Kari“…In the current study, we examined the association between SHS and AAP with DNA methylation and expression of interferon-gamma (IFN-γ) and forkhead box protein 3 (Foxp3) in T cell populations. …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31145por Jaspe, Rossana C, Sulbarán, Yoneira F, Sulbarán, Maria Z, Loureiro, Carmen L, Rangel, Hector R, Pujol, Flor H“…BACKGROUND: Recent reports show that R70Q and L/C91M amino acid substitutions in the core from different hepatitis C virus (HCV) genotypes have been associated with variable responses to interferon (IFN) and ribavirin (RBV) therapy, as well to an increase of hepatocellular carcinoma (HCC) risk, liver steatosis and insulin resistance (IR). …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31146por Badaoui, Bouabid, Tuggle, Christopher K, Hu, Zhiliang, Reecy, James M, Ait-Ali, Tahar, Anselmo, Anna, Botti, Sara“…Other transcription factors like interferon regulatory factors IRF1, IRF3, IRF5 and IRF8 were also involved in the pig specific response to PRRSV infection. …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31147por Gardiner, David, Lalezari, Jay, Lawitz, Eric, DiMicco, Michael, Ghalib, Rheem, Reddy, K. Rajender, Chang, Kyong-Mi, Sulkowski, Mark, Marro, Steven O’, Anderson, Jeffrey, He, Bing, Kansra, Vikram, McPhee, Fiona, Wind-Rotolo, Megan, Grasela, Dennis, Selby, Mark, Korman, Alan J., Lowy, Israel“…The antiviral potential of BMS-936558 (MDX-1106) – a fully human anti-PD-1 monoclonal immunoglobulin-G4 that blocks ligand binding – was explored in a proof-of-concept, placebo-controlled single-ascending-dose study in patients (N = 54) with chronic HCV infection. Interferon-alfa treatment-experienced patients (n = 42) were randomized 5∶1 to receive a single infusion of BMS-936558 (0.03, 0.1, 0.3, 1.0, 3.0 mg/kg [n = 5 each] or 10 mg/kg [n = 10]) or of placebo (n = 7). …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31148por Sedegah, Martha, Kim, Yohan, Ganeshan, Harini, Huang, Jun, Belmonte, Maria, Abot, Esteban, Banania, Jo Glenna, Farooq, Fouzia, McGrath, Shannon, Peters, Bjoern, Sette, Alessandro, Soisson, Lorraine, Diggs, Carter, Doolan, Denise L, Tamminga, Cindy, Villasante, Eileen, Hollingdale, Michael R, Richie, Thomas L“…Recently, a DNA prime / adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1, also elicited sterile protection, but in this case associated with interferon gamma ELISpot and CD8+ T cell but not antibody responses. …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31149Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosispor Alhamad, Esam H, Cal, Joseph G, Shakoor, Zahid, Almogren, Adel, AlBoukai, Ahmad A“…We therefore examined polymorphisms in the genes encoding interleukin (IL)-6, IL-10, interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and transforming growth factor-beta 1 (TGF-β(1)), and compared the serum levels of these cytokines in IPF patients and healthy controls. …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31150por Kouakou, Koffi, Schepetkin, Igor A, Jun, SangMu, Kirpotina, Liliya N, Yapi, Ahoua, Khramova, Daria S, Pascual, David W, Ovodov, Yury S, Jutila, Mark A, Quinn, Mark T“…Levels of IL-13, TNF, interferon (IFN)-γ, IL-17, and GM-CSF were also significantly decreased, whereas transforming growth factor (TGF)-β was increased in LN cells from CSP-AU1-treated EAE mice. …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31151por OH, JI-EUN, KIM, JEONG-OH, SHIN, JUNG-YOUNG, ZHANG, XIANG-HUA, WON, HYE-SUNG, CHUN, SANG-HOON, JUNG, CHAN-KWON, PARK, WON-SANG, NAM, SUK-WOO, EUN, JUNG-WOO, KANG, JIN-HYOUNG“…Our data suggest that upregulated STAT1 and interferon signals by HPV16 E6 and E7 genes may play a major role in the relatively favorable prognosis for HPV-positive oropharyngeal squamous cell carcinoma cases with non-disruptive p53 mutations.…”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31152por Prando, Carolina, Samarina, Arina, Bustamante, Jacinta, Boisson-Dupuis, Stéphanie, Cobat, Aurelie, Picard, Capucine, AlSum, Zobaida, Al-Jumaah, Suliman, Al-Hajjar, Sami, Frayha, Husn, Al-Mousa, Hamoud, Ben-Mustapha, Imen, Adimi, Parisa, Feinberg, Jacqueline, de Suremain, Maylis, Jannière, Lucile, Filipe-Santos, Orchidée, Mansouri, Nahal, Stephan, Jean-Louis, Nallusamy, Revathy, Kumararatne, Dinakantha S., Bloorsaz, Mohamad Reza, Ben-Ali, Meriem, Elloumi-Zghal, Houda, Chemli, Jalel, Bouguila, Jihene, Bejaoui, Mohamed, Alaki, Emadia, AlFawaz, Tariq S., Al Idrissi, Eman, ElGhazali, Gehad, Pollard, Andrew J., Murugasu, Belinda, Wah Lee, Bee, Halwani, Rabih, Al-Zahrani, Mohammed, Al Shehri, Mohammed A., Al-Zahrani, Mofareh, Bin-Hussain, Ibrahim, Mahdaviani, Seyed Alireza, Parvaneh, Nima, Abel, Laurent, Mansouri, Davood, Barbouche, Ridha, Al-Muhsen, Saleh, Casanova, Jean-Laurent“…As a result, the patients lack detectable IL-12p70 and IL-12p40 and have low levels of interferon gamma (IFN-γ). The clinical features are characterized by childhood onset of bacille Calmette-Guérin (attenuated Mycobacterium bovis strain) (BCG) and Salmonella infections, with recurrences of salmonellosis (36.4%) more common than recurrences of mycobacterial disease (25%). …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31153por Bernier, Annie, Cleret-Buhot, Aurélie, Zhang, Yuwei, Goulet, Jean-Philippe, Monteiro, Patricia, Gosselin, Annie, DaFonseca, Sandrina, Wacleche, Vanessa Sue, Jenabian, Mohammad-Ali, Routy, Jean-Pierre, Tremblay, Cécile, Ancuta, Petronela“…Th1 cells (proteasome, interferon α/β). Differentially expressed genes were classified into biological categories using Gene Ontology. …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31154por Lazarenko, Liudmyla M, Nikitina, Olena E, Nikitin, Evgen V, Demchenko, Olga M, Kovtonyuk, Galyna V, Ganova, Larysa O, Bubnov, Rostyslav V, Shevchuk, Veronika O, Nastradina, Natalia M, Bila, Viktoria V, Spivak, Mykola Ya“…The production of pro-inflammatory cytokines, interferon-γ (IFN-γ), IFN-α, TNF-α, and interleukin-1β (IL-1β), and anti-inflammatory cytokines, IL-4, IL-10, and transforming growth factor-β1 (TGF-β1), were studied by ELISA. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31155por Menezes, Soraya Maria, Decanine, Daniele, Brassat, David, Khouri, Ricardo, Schnitman, Saul V, Kruschewsky, Ramon, López, Giovanni, Alvarez, Carolina, Talledo, Michael, Gotuzzo, Eduardo, Vandamme, Anne-Mieke, Galvão-Castro, Bernardo, Liblau, Roland, Weyenbergh, Johan Van“…We hypothesized ex vivo CD80 and CD86 expressions and their in vitro regulation by interferon (IFN)-α/β mirror similarities between HAM/TSP and MS and hence might reveal clinically useful biomarkers in HAM/TSP. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31156por Robinson, Scott M., Tsueng, Ginger, Sin, Jon, Mangale, Vrushali, Rahawi, Shahad, McIntyre, Laura L., Williams, Wesley, Kha, Nelson, Cruz, Casey, Hancock, Bryan M., Nguyen, David P., Sayen, M. Richard, Hilton, Brett J., Doran, Kelly S., Segall, Anca M., Wolkowicz, Roland, Cornell, Christopher T., Whitton, J. Lindsay, Gottlieb, Roberta A., Feuer, Ralph“…Induction of a type I interferon response or ribavirin treatment reduced the progression of cell-to-cell virus spread in HeLa cells or NPSCs infected with Timer-CVB3. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31157por Gokhale, Mamata S, Vainstein, Vladimir, Tom, Jamie, Thomas, Simmy, Lawrence, Chris E, Gluzman-Poltorak, Zoya, Siebers, Nicholas, Basile, Lena A“…Elimination of rHuIL-12 was biphasic, suggesting significant distribution into extravascular spaces. rHuIL-12 triggered transient changes in neutrophils, platelets, reticulocytes, lymphocytes, natural killer cells, and CD34(+) hematopoietic progenitor cells, and induced increases in interferon-γ and C-X-C motif chemokine 10. CONCLUSION: A single low dose of rHuIl-12 administered subcutaneously can elicit hematological and immune-mediated effects without undue toxicity. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31158por Tymoszuk, Piotr, Charoentong, Pornpimol, Hackl, Hubert, Spilka, Rita, Müller-Holzner, Elisabeth, Trajanoski, Zlatko, Obrist, Peter, Revillion, Françoise, Peyrat, Jean-Philippe, Fiegl, Heidi, Doppler, Wolfgang“…However, in breast cancer data from microarray analysis indicated a predictive value of high mRNA expression levels of STAT1 and STAT1 target genes belonging to the interferon-related signature for a poor response to therapy. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31159por Chang, Katherine, Svabek, Catherine, Vazquez-Guillamet, Cristina, Sato, Bryan, Rasche, David, Wilson, Strother, Robbins, Paul, Ulbrandt, Nancy, Suzich, JoAnn, Green, Jonathan, Patera, Andriani C, Blair, Wade, Krishnan, Subramaniam, Hotchkiss, Richard“…Effects of anti-PD-1, anti-PD-L1, or isotype-control antibody on lymphocyte apoptosis and interferon gamma (IFN-γ) and interleukin-2 (IL-2) production were quantitated by flow cytometry. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31160“…The treatment of anti-PD-1/GITR mAb increased the frequencies of interferon-γ-producing effector T cells and decreased immunosuppressive regulatory T cells and myeloid-derived suppressor cells, shifting an immunosuppressive tumor milieu to an immunostimulatory state in peritoneal cavity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto