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31241“…METHODS: Primary microglia from Sprague-Dawley rats and C57BL/6 mice were cultured, then stimulated with interferon-γ + tumor necrosis factor-α (I + T; M1 activation), interleukin (IL)-4 (M2a, alternative activation), or IL-10 (M2c, acquired deactivation). …”
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31242por Silva, Andrea Alice, Silva, Rafael Rodrigues, Gibaldi, Daniel, Mariante, Rafael Meyer, dos Santos, Jessica Brandão, Pereira, Isabela Resende, Moreira, Otacílio Cruz, Lannes-Vieira, Joseli“…In experimental T. cruzi infection, interferon gamma (IFNγ)(+) microglial cells surround astrocytes harboring amastigote parasites. …”
Publicado 2017
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31243por Kleiter, Ingo, Lang, Michael, Jeske, Judith, Norenberg, Christiane, Stollfuß, Barbara, Schürks, Markus“…The BETACONNECT® is a fully electronic autoinjector for the injection of interferon beta-1b (IFN beta-1b) automatically recording injections. …”
Publicado 2017
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31244por Wang, Jun, Heng, Yujing J., Eliassen, A. Heather, Tamimi, Rulla M., Hazra, Aditi, Carey, Vincent J., Ambrosone, Christine B., de Andrade, Victor P., Brufsky, Adam, Couch, Fergus J., King, Tari A., Modugno, Francesmary, Vachon, Celine M., Hunter, David J., Beck, Andrew H., Hankinson, Susan E.“…Among ER- tumors, in addition to upregulation in RNA processing and cell cycle, alcohol intake was linked to overexpression of genes involved in cytokine signaling, including interferon and transforming growth factor (TGF)-β signaling pathways, and translation and post-translational modifications. …”
Publicado 2017
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31245por Ellison, Michael A., Gearheart, Christy M., Porter, Christopher C., Ambruso, Daniel R.“…The cytokine interferon-γ (IFN-γ) is approved as a drug to treat chronic granulomatous disease (CGD) and osteopetrosis and is also used in hyperimmunoglobulin E syndromes. …”
Publicado 2017
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31246por Schlaudecker, Elizabeth P, Goll, Johannes, Jensen, Travis, Petrie, Carey, Gelber, Casey, Dexheimer, Phillip, Steinhoff, Mark, Bernstein, David I“…Response time trends for co-expressed gene clusters by vaccine group showed that LAIV generally induced an early (day 2) up-regulation of innate immune signaling pathway genes, while TIV induced peak innate immune signaling gene responses ahead of LAIV (day 8 vs. day 28). A group of known interferon-alpha/β-inducible genes (IFIT3, OAS3, IFI44L, MX1, OAS2, IFIT1, IFI6) showed higher responses at day 2 for TIV but stronger peak levels by day 28 for the LAIV group (Fig 1). …”
Publicado 2017
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31247por Boeckh, Michael, Arvin, Ann, Mullane, Kathleen, Winston, Drew J, Brown, Janice (Wes), Pergam, Steven, Hurtado, Kimberly, Pang, Lei, Lee, Ingi, Popmihajlov, Zoran“…VZV-specific antibody responses were measured by glycoprotein enzyme-linked immunosorbent assay (gpELISA) in all patients; cell-mediated immune responses were measured by VZV interferon-gamma enzyme-linked immunospot (IFN-γ ELISPOT) assay in a randomized subset of patients (n = 403). …”
Publicado 2017
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31248por Valanparambil, Rajesh M., Tam, Mifong, Gros, Pierre-Paul, Auger, Jean-Philippe, Segura, Mariela, Gros, Philippe, Jardim, Armando, Geary, Timothy G., Ozato, Keiko, Stevenson, Mary M.“…Interferon regulatory factor-8 (IRF-8) is critical for Th1 cell differentiation and negatively regulates myeloid cell development including myeloid-derived suppressor cells (MDSC). …”
Publicado 2017
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31249por Li, Wenting, Shen, Xiaokun, Fu, Binqing, Guo, Chuang, Liu, Yanyan, Ye, Ying, Sun, Rui, Li, Jiabin, Tian, Zhigang, Wei, Haiming“…To date, several on-treatment-level virological and serological indices that may predict the response to interferon alpha (IFN-α) have been reported. However, no effective predictors, such as drug–response genes, that can be detected before administration of anti-hepatitis B virus (HBV) therapy with IFN-α, have been found. …”
Publicado 2017
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31250por Chen Yi Mei, Swee Lin G., Thompson, Alexander J., Christensen, Britt, Cunningham, Georgina, McDonald, Lucy, Bell, Sally, Iser, David, Nguyen, Tin, Desmond, Paul V.“…The median period between fibrosis assessments was 14-years (IQR 12–17). 109 (83%) participants had received interferon-based antiviral therapy. 40% attained SVR. …”
Publicado 2017
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31251por Hehlmann, R, Lauseker, M, Saußele, S, Pfirrmann, M, Krause, S, Kolb, H J, Neubauer, A, Hossfeld, D K, Nerl, C, Gratwohl, A, Baerlocher, G M, Heim, D, Brümmendorf, T H, Fabarius, A, Haferlach, C, Schlegelberger, B, Müller, M C, Jeromin, S, Proetel, U, Kohlbrenner, K, Voskanyan, A, Rinaldetti, S, Seifarth, W, Spieß, B, Balleisen, L, Goebeler, M C, Hänel, M, Ho, A, Dengler, J, Falge, C, Kanz, L, Kremers, S, Burchert, A, Kneba, M, Stegelmann, F, Köhne, C A, Lindemann, H W, Waller, C F, Pfreundschuh, M, Spiekermann, K, Berdel, W E, Müller, L, Edinger, M, Mayer, J, Beelen, D W, Bentz, M, Link, H, Hertenstein, B, Fuchs, R, Wernli, M, Schlegel, F, Schlag, R, de Wit, M, Trümper, L, Hebart, H, Hahn, M, Thomalla, J, Scheid, C, Schafhausen, P, Verbeek, W, Eckart, M J, Gassmann, W, Pezzutto, A, Schenk, M, Brossart, P, Geer, T, Bildat, S, Schäfer, E, Hochhaus, A, Hasford, J“…Chronic myeloid leukemia (CML)-study IV was designed to explore whether treatment with imatinib (IM) at 400 mg/day (n=400) could be optimized by doubling the dose (n=420), adding interferon (IFN) (n=430) or cytarabine (n=158) or using IM after IFN-failure (n=128). …”
Publicado 2017
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31252por Bichoupan, Kian, Tandon, Neeta, Crismale, James F, Hartman, Joshua, Del Bello, David, Patel, Neal, Chekuri, Sweta, Harty, Alyson, Ng, Michel, Sigel, Keith M, Bansal, Meena B, Grewal, Priya, Chang, Charissa Y, Leong, Jennifer, Im, Gene Y, Liu, Lawrence U, Odin, Joseph A, Bach, Nancy, Friedman, Scott L, Schiano, Thomas D, Perumalswami, Ponni V, Dieterich, Douglas T, Branch, Andrea D“…METHODS: The real-world performance of patients treated with SMV/SOF ± ribavirin (RBV), SOF/RBV, and SOF/RBV with pegylated-interferon (PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. …”
Publicado 2017
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31253por Hegazy, Ahmed N., West, Nathaniel R., Stubbington, Michael J.T., Wendt, Emily, Suijker, Kim I.M., Datsi, Angeliki, This, Sebastien, Danne, Camille, Campion, Suzanne, Duncan, Sylvia H., Owens, Benjamin M.J., Uhlig, Holm H., McMichael, Andrew, Bergthaler, Andreas, Teichmann, Sarah A., Keshav, Satish, Powrie, Fiona“…These cells were functionally heterogeneous, produced barrier-protective cytokines, and stimulated intestinal stromal and epithelial cells via interleukin 17A, interferon gamma, and tumor necrosis factor. In patients with inflammatory bowel diseases, microbiota-reactive CD4(+) T cells were reduced in the blood compared with intestine; T-cell responses that we detected had an increased frequency of interleukin 17A production compared with responses of T cells from blood or intestinal tissues of controls. …”
Publicado 2017
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31254por Sun, Hui-Chuan, Xie, Lu, Yang, Xin-Rong, Li, Wei, Yu, Jian, Zhu, Xiao-Dong, Xia, Yong, Zhang, Ti, Xu, Yang, Hu, Bo, Du, Li-Ping, Zeng, Ling-Yao, Ouyang, Jian, Zhang, Wei, Song, Tian-Qiang, Li, Qiang, Shi, Ying-Hong, Zhou, Jian, Qiu, Shuang-Jian, Liu, Qian, Li, Yi-Xue, Tang, Zhao-You, Shyr, Yu, Shen, Feng, Fan, Jia“…Furthermore, Shanghai Score provided evaluation for adjuvant treatment choices (transcatheter arterial chemoembolization or interferon-α). The identified subset of patients at low risk could be ideal candidates for curative surgery, and subsets of patients at moderate or high risk could be recommended with possible adjuvant therapies after surgery. …”
Publicado 2017
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31255por Dillon, Patrick M., Petroni, Gina R., Smolkin, Mark E., Brenin, David R., Chianese-Bullock, Kimberly A., Smith, Kelly T., Olson, Walter C., Fanous, Ibrahim S., Nail, Carmel J., Brenin, Christiana M., Hall, Emily H., Slingluff, Craig L.“…CD8(+) T cell responses to the vaccine were assessed by both direct and stimulated interferon gamma ELIspot assays. RESULTS: Twelve patients with breast cancer were treated: five had estrogen receptor positive disease and five were HER2 amplified. …”
Publicado 2017
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31256por Pérez Brandán, Cecilia, Mesías, Andrea C., Parodi, Cecilia, Cimino, Rubén O., Pérez Brandán, Carolina, Diosque, Patricio, Basombrío, Miguel Ángel“…In T. cruzi infection, early Interferon-gamma (IFN-γ) is critical to lead type 1 responses able to control intracellular parasites. …”
Publicado 2017
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31257por Morioka, Chikako, Komaki, Motohiro, Taki, Atsuko, Honda, Izumi, Yokoyama, Naoki, Iwasaki, Kengo, Iseki, Sachiko, Morio, Tomohiro, Morita, Ikuo“…Four-day-old rats were intraperitoneally injected with LPS (15 mg/kg) to cause the PVL-like brain injury and were treated immediately after the LPS-injection with UCMSCs, conditioned medium prepared from MSCs (UCMSC-CM) or interferon-gamma (IFN-γ)-pretreated MSC (IFN-γ-UCMSC-CM). …”
Publicado 2017
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31258por Yang, Ke-Qin, Liu, Yan, Huang, Qing-Hua, Mo, Ning, Zhang, Qing-Yun, Meng, Qing-Gui, Cheng, Ji-Wen“…The murine prostate cancer cells (RM-1) mixing with MSCs treated with tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) or vehicle were subcutaneously injected into C57 mice. …”
Publicado 2017
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31259por McDonnell, Peter J., Pflugfelder, Stephen C., Stern, Michael E., Hardten, David R., Conway, Taryn, Villanueva, Linda, Hollander, David A.“…Tear cytokines levels were determined and included interferon-γ, interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, tumor necrosis factor-α, epidermal growth factor, IL-13, IL-17, IL-1α, and inducible protein-10. …”
Publicado 2017
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31260“…It was found that the subnetworks formed by CCR5 and IFNAR1 and their neighbors were a fragments of two key pathways functioning during the course of tick-borne encephalitis: (1) the attenuation of interferon-I signaling pathway by the TBEV NS5 protein that targeted peptidase D; (2) proinflammation and tissue damage pathway triggered by chemokine receptor CCR5 interacting with CD4, CCL3, CCL4, CCL2. …”
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