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31261por Li, Ming-Hui, Zhang, Lu, Zhang, Dan, Cao, Wei-Hua, Qi, Tian-Lin, Hao, Hong-Xiao, Wang, Xing-Yue, Ran, Chong-Ping, Qu, Xiao-Jing, Liu, Shun-Ai, Lu, Yao, Shen, Ge, Wu, Shu-Ling, Chang, Min, Liu, Ru-Yu, Hu, Lei-Ping, Hua, Wen-Hao, Wan, Gang, Cheng, Jun, Xie, Yao“…The quantitative determinations of cytokines, including Fms-like tyrosine kinase 3 ligand (Flt-3L), interferon (IFN)-α2, IFN-γ, interleukin (IL)-17A, IL-6, IL-10, transforming growth factor (TGF)-β1 and TGF-β2, were performed using Luminex multiplex technology. …”
Publicado 2018
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31262por Otiti-Sengeri, Juliet, Colebunders, Robert, Reynolds, Steven J., Muwonge, Musa, Nakigozi, Getrude, Kiggundu, Valerian, Nalugoda, Fred, Nakanjako, Damalie“…We determined levels of Granulocyte macrophage stimulating factor (GM-CSF), interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrotic factor alpha (TNF-a), interferon gamma (IFN-g), interleukin 4 (IL-4), interleukin 2 (IL-2), and interleukin (IL-10) in the aqueous fluid using a multiplexed cytokine analysis. …”
Publicado 2018
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31263por Sohrabi, Yahya, Volkova, Valeryia, Kobets, Tatyana, Havelková, Helena, Krayem, Imtissal, Slapničková, Martina, Demant, Peter, Lipoldová, Marie“…Interferon-induced GTPases [guanylate-binding proteins (GBPs)] play an important role in inflammasome activation and mediate innate resistance to many intracellular pathogens, but little is known about their role in leishmaniasis. …”
Publicado 2018
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31264por Turkington, Hannah L., Juozapaitis, Mindaugas, Tsolakos, Nikos, Corrales-Aguilar, Eugenia, Schwemmle, Martin, Hale, Benjamin G.“…Like all FLUAV NS1 proteins, bat FLUAV NS1s bind double-stranded RNA and act as interferon antagonists. Unexpectedly, we found that bat FLUAV NS1s are unique in being unable to bind host p85β, a regulatory subunit of the cellular metabolism-regulating enzyme, phosphoinositide 3-kinase (PI3K). …”
Publicado 2018
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31265por Saeed, Sahar, Strumpf, Erin C, Moodie, Erica EM, Young, Jim, Nitulescu, Roy, Cox, Joseph, Wong, Alexander, Walmsely, Sharon, Cooper, Curtis, Vachon, Marie‐Lousie, Martel‐Laferriere, Valerie, Hull, Mark, Conway, Brian, Klein, Marina B“…Among 911 HCV RNA + participants, there were 202 second‐generation DAA initiations (93% with interferon‐free regimens). After adjustment (aHR, 95% CI), active PWID (0.60, 0.38–0.94 compared to people not injecting drugs) and more generally, people with lower income (<$18 000 CAD/year) (0.50, 0.35, 0.71) were less likely to initiate treatment. …”
Publicado 2017
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31266por Balsitis, Scott, Gali, Volodymyr, Mason, Pamela J., Chaniewski, Susan, Levine, Steven M., Wichroski, Michael J., Feulner, Michael, Song, Yunling, Granaldi, Karen, Loy, James K., Thompson, Chris M., Lesniak, Jacob A., Brockus, Catherine, Kishnani, Narendra, Menne, Stephan, Cockett, Mark I., Iyer, Renuka, Mason, Stephen W., Tenney, Daniel J.“…Pre-treatment WHV surface antigen (sAg) level was identified as a statistically significant predictor of treatment response, while PD-1 expression on peripheral CD8+ T cells, T cell production of interferon gamma (IFN-γ) upon in vitro antigen stimulation (WHV ELISPOT), and circulating levels of liver enzymes were not. …”
Publicado 2018
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31267por Liu, Lulu, Wan, Xiaoling, Zhou, Peipei, Zhou, Xiaoyuan, Zhang, Wei, Hui, Xinhui, Yuan, Xiujie, Ding, Xiaodan, Zhu, Ruihong, Meng, Guangxun, Xiao, Hui, Ma, Feng, Huang, He, Song, Xianmin, Zhou, Bin, Xiong, Sidong, Zhang, Yan“…A cell-autonomous requirement of Baf200 for hematopoietic stem cell function was confirmed utilizing the interferon-inducible Mx1-Cre mouse strain. Transcriptomes analysis revealed that expression of several erythropoiesis- and hematopoiesis-associated genes were regulated by Baf200. …”
Publicado 2018
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31268“…Our study shows that: (1) ectopic expression of NOP53 greatly increases the intracellular and extracellular viral yields of HSV-1 (wild strain F) in type I interferon-deficient Vero cells, and more subtly promotes viral replication of γ34.5 deletion mutant virus HSV-1/Δγ34.5. (2) NOP53 is migrated from nuclei in HSV-1/F infected cells, but is redistributed incompletely after infection by either HSV-1/Δγ34.5 or ICP4 deletion mutant virus HSV-1/d120 (replication inadequate). …”
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31269por Xin, Ting, Gao, Xintao, Yang, Hongjun, Li, Pingjun, Liang, Qianqian, Hou, Shaohua, Sui, Xiukun, Guo, Xiaoyu, Yuan, Weifeng, Zhu, Hongfei, Ding, Jiabo, Jia, Hong“…To screen for cytokines fostering early and accurate detection of bTB, peripheral blood mononuclear cells were isolated from naturally M. bovis-infected, experimentally M. bovis 68002-infected, and uninfected cattle, then these cells were stimulated by PPD-B, CFP-10-ESAT-6 (CE), or phosphate-buffered saline (PBS) for 6 h. The levels of interferon gamma (IFN-γ), IFN-γ-induced protein 10 (IP-10), IL-6, IL-12, IL-17A, and tumor necrosis factor alpha mRNA were measured using real-time PCR. …”
Publicado 2018
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31270por Ahmed-Hassan, Hanaa, Abdul-Cader, Mohamed Sarjoon, De Silva Senapathi, Upasama, Sabry, Maha Ahmed, Hamza, Eman, Nagy, Eva, Sharif, Shayan, Abdul-Careem, Mohamed Faizal“…A subset of in ovo dsRNA treated and control groups were observed for the expressions of TLR3 and type I interferon (IFN)s, mRNA expression of interleukin (IL)-1β and macrophage recruitment coinciding with the time of H4N6 LPAIV infection (24 h post-treatment). …”
Publicado 2018
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31271por Maunoury, Franck, Clément, Aurore, Nwankwo, Chizoba, Levy-Bachelot, Laurie, Abergel, Armand, Di Martino, Vincent, Thervet, Eric, Durand-Zaleski, Isabelle“…CONCLUSIONS: This cost-utility model is an innovative approach that simultaneously looks at the disease evolution of chronic hepatitis C and chronic kidney disease. EBR/GZR without interferon and ribavirin, produced the greatest benefit in terms of life expectancy and quality-adjusted life years (QALY) in treatment-naïve or experienced patients with chronic hepatitis C genotype 1 and stage 4–5 chronic kidney disease including dialysis patients. …”
Publicado 2018
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31272por Giannelou, Angeliki, Wang, Hongying, Zhou, Qing, Park, Yong Hwan, Abu-Asab, Mones S, Ylaya, Kris, Stone, Deborah L, Sediva, Anna, Sleiman, Rola, Sramkova, Lucie, Bhatla, Deepika, Serti, Elisavet, Tsai, Wanxia Li, Yang, Dan, Bishop, Kevin, Carrington, Blake, Pei, Wuhong, Deuitch, Natalie, Brooks, Stephen, Edwan, Jehad H, Joshi, Sarita, Prader, Seraina, Kaiser, Daniela, Owen, William C, Sonbul, Abdullah Al, Zhang, Yu, Niemela, Julie E, Burgess, Shawn M, Boehm, Manfred, Rehermann, Barbara, Chae, JaeJin, Quezado, Martha M, Ombrello, Amanda K, Buckley, Rebecca H, Grom, Alexi A, Remmers, Elaine F, Pachlopnik, Jana M, Su, Helen C, Gutierrez-Cruz, Gustavo, Hewitt, Stephen M, Sood, Raman, Risma, Kimberly, Calvo, Katherine R, Rosenzweig, Sergio D, Gadina, Massimo, Hafner, Markus, Sun, Hong-Wei, Kastner, Daniel L, Aksentijevich, Ivona“…Inflammatory cytokines, mainly interleukin (IL)-6, interferon gamma (IFN-γ) and IFN-induced cytokines were elevated in the serum, whereas tumour necrosis factor (TNF) and IL-1β were present in tissue biopsies of patients with active inflammatory disease. …”
Publicado 2018
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31273por Chen, Can, Fan, Wenhui, Li, Jing, Zheng, Weinan, Zhang, Shuang, Yang, Limin, Liu, Di, Liu, Wenjun, Sun, Lei“…Interferon (IFN)-sensitive and replication-incompetent influenza viruses are likely to be the alternatives to inactivated and attenuated virus vaccines. …”
Publicado 2018
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31274por Cooles, Faye A. H., Anderson, Amy E., Skelton, Andrew, Pratt, Arthur G., Kurowska-Stolarska, Mariola S., McInnes, Iain, Hilkens, Catharien M. U., Isaacs, John D.“…There was no association between the whole blood interferon gene signature (IGS) and pDC or CD1c+ DC parameters but an inverse association between CD141+ DC frequency and IGS was noted. …”
Publicado 2018
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31275por Harker, James A., Wong, Kurt A., Dallari, Simone, Bao, Phuc, Dolgoter, Aleksandr, Jo, Yeara, Wehrens, Ellen J., Macal, Monica, Zuniga, Elina I.“…In particular, plasmacytoid DCs (pDCs), the most potent type 1 interferon (IFN-I)-producing cells, significantly increased il27p28 in a Toll-like receptor 7 (TLR7)-dependent fashion. …”
Publicado 2018
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31276por Wang, Cong, Cheng, Weisheng, Yu, Qian, Xing, Tian, Chen, Shoubin, Liu, Lei, Yu, Li, Du, Jian, Luo, Qingli, Shen, Jilong, Xu, Yuanhong“…Toxoplasma gondii infection evokes a strong Th1-type response with interleukin (IL)-12 and interferon (IFN)-γ secretion. Recent studies suggest that the infection of pregnant mice with T. gondii may lead to adverse pregnancy results caused by subversion of physiological immune tolerance at maternofetal interface rather than direct invasion of the parasite. …”
Publicado 2018
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31277por Guo, Qingling, Wu, Ying, Hou, Yuanyuan, Liu, Yongping, Liu, Tingting, Zhang, Hao, Fan, Chenling, Guan, Haixia, Li, Yushu, Shan, Zhongyan, Teng, Weiping“…The Nthy-ori 3-1 thyroid cell line was stimulated with tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-17A, interleukin-6, and poly(dA:dT). …”
Publicado 2018
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31278por Ngo, Dong Tien, Phan, Phuc Huu, Kawachi, Shoji, Nakajima, Noriko, Hirata, Naoyuki, Ainai, Akira, Phung, Thuy Thi Bich, Tran, Dien Minh, Le, Hai Thanh“…In addition, inflammatory biomarkers, including interferon-gamma (IFN-γ) and interleukin-6 (IL-6), decreased after the administration of rTM. …”
Publicado 2018
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31279por Mao, Fang-yuan, Zhao, Yong-liang, Lv, Yi-pin, Teng, Yong-sheng, Kong, Hui, Liu, Yu-gang, Wu, Xiao-long, Hao, Chuan-jie, Chen, Weisan, Duan, Mu-bing, Han, Bin, Ma, Qiang, Wang, Ting-ting, Peng, Liu-sheng, Zhang, Jin-yu, Cheng, Ping, Su, Chong-yu, Fu, Xiao-long, Zou, Quan-ming, Guo, Gang, Guo, Xiao-lan, Zhuang, Yuan“…Circulating CD45(+)CD33(low)CD11b(dim) MDSCs effectively suppressed CD8(+) T cells activity through the inhibition of CD8(+) T cell proliferation and interferon-γ (IFN-γ) and granzyme B (GrB) production. …”
Publicado 2018
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31280“…Blood samples were also taken, and the Luminex(®) platform (Cytokine Human Ultrasensitive Magnetic 10-Plex Panel) was used for quantifying human cytokines’ profile (granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin [IL]-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, and tumor necrosis factor [TNF]-α) in serum. …”
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