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31281por Wang, Tiehui, Hu, Yehfang, Wangkahart, Eakapol, Liu, Fuguo, Wang, Alex, Zahran, Eman, Maisey, Kevin R., Liu, Min, Xu, Qiaoqing, Imarai, Mónica, Secombes, Christopher J.“…IL-2B had a stronger effect on upregulation of the T helper 1 (Th1) cytokine interferon-γ (IFNγ) and could sustain CD8α and CD8β expression levels. …”
Publicado 2018
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31282por Gaeta, Giovanni Battista, Aghemo, Alessio, Menzaghi, Barbara, D’Offizi, Gianpiero, Giorgini, Alessia, Hasson, Hamid, Brancaccio, Giuseppina, Palma, Maria, Termini, Roberta“…The combination of the direct-acting antivirals, simeprevir (SMV) and sofosbuvir (SOF), was the first highly efficacious interferon-free combination for treating patients with hepatitis C virus (HCV), and was widely used in Italy as a result. …”
Publicado 2018
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31283“…Our results showed that compared with BALB/c mice, C57BL/6 mice infected with T. gondii Pru strain had more severe brain histopathological damage, and higher mRNA expression levels of tachyzoite-specific surface antigen 1, bradyzoite-specific antigen 1, interferon gamma (IFNγ), interleukin (IL)-10, arginase1 (Arg1) (M2 marker), galectin (Gal)-3, Gal-9, T. gondii microneme protein 1 (TgMIC1), TgMIC4, and TgMIC6 during the course of infection by using quantitative real-time reverse transcription-polymerase chain reaction. …”
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31284por Ibrahim, Doaa, El-Sayed, Rania, Khater, Safaa I., Said, Enas N., El-Mandrawy, Shefaa A.M.“…Animal oil source addition, compared to plant oil, to broiler diets enhanced the relative mRNA expression of interferon gamma, interleukin-1 beta, interleukin-2 and interleukin-6 genes, especially at low n-6:n-3 ratios. …”
Publicado 2018
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31285por Romanelli, Luiz C. F., Miranda, Débora M., Carneiro-Proietti, Anna B. F., Mamede, Marcelo, Vasconcelos, Herika M. M., Martins, Marina L, Ferreira, Anísia S. D., Rosa, Daniela V. F., Paula, Jonas J., Romano-Silva, Marco A., Nicolato, Rodrigo“…Individuals with HAM/TSP showed a pro-inflammatory profile in comparison to asymptomatic and symptomatic groups, with a higher level of Interferon-inducible T-cell alpha chemoattractant (ITAC/CXCL(11)), IL-6, IL-12p70 in the plasma; and ITAC, IL-4, IL-5, IL-8 (CXCL(8)) and TNF-alpha in the CSF. …”
Publicado 2018
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31286por Wood, C. David, Carvell, Thomas, Gunnell, Andrea, Ojeniyi, Opeoluwa O., Osborne, Cameron, West, Michelle J.“…Both EBV nuclear antigen 2 (EBNA2) and the B cell transcription factor interferon regulatory factor 4 (IRF4) are known to activate transcription of the host cell gene from which miR-155 is processed (miR-155HG; BIC). …”
Publicado 2018
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31287por Wang, Qiong, Zhou, Xin, Zhao, Yongjian, Xiao, Jun, Lu, Yao, Shi, Qi, Wang, Yongjun, Wang, Hongyan, Liang, Qianqian“…Materials and Methods: In vitro, primary bone marrow-derived macrophages (BMMs) and peritoneal elucidated macrophages (PEMs) were stimulated by lipopolysaccharide (LPS) and Interferon (IFN)-γ and then treated with PPI. We determined the degree of activation of IKKα/β and p65, two key mediators of the NF-κB-mediated inflammatory pathway, by measuring their phosphorylated forms by Western blot. …”
Publicado 2018
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31288por Meurer, Thuja, Arrieta-Bolaños, Esteban, Metzing, Maximilian, Langer, Mona-May, van Balen, Peter, Falkenburg, J. H. Frederik, Beelen, Dietrich W., Horn, Peter A., Fleischhauer, Katharina, Crivello, Pietro“…However, these differences were abrogated by interferon-γ stimulation or differentiation into dendritic cells. …”
Publicado 2018
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31289por Guan, Xiudong, Luo, Lanxin, Begum, Gulnaz, Kohanbash, Gary, Song, Qingkun, Rao, Aparna, Amankulor, Nduka, Sun, Baoshan, Sun, Dandan, Jia, Wang“…Blockade of NHE1 protein also stimulated immunogenic tumor microenvironment via activating CD8 T-cell accumulation, increasing expression of interferon-gamma (Ifng), and sensitized animals to anti-PD-1 therapy. …”
Publicado 2018
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31290por Tian, Ai-Ling, Lu, MingMin, Zhang, Fu-Kai, Calderón-Mantilla, Guillermo, Petsalaki, Evangelia, Tian, XiaoWei, Wang, WenJuan, Huang, Si-Yang, Li, XiangRui, Elsheikha, Hany M., Zhu, Xing-Quan“…This protein exhibited multiple effects on goat PBMCs, including increased production of cytokines [interleukin-2 (IL-2), IL-4, IL-10, transforming growth factor beta (TGF-β) and interferon gamma (IFN-γ)] and total nitric oxide (NO), enhancing apoptosis and migration of PBMCs, and promoting the phagocytic ability of monocytes. …”
Publicado 2018
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31291por Bubak, Andrew N., Como, Christina N., Blackmon, Anna M., Jones, Dallas, Nagel, Maria A.“…Conditioned supernatants were analyzed for proinflammatory cytokines [interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-gamma, and tumor necrosis factor-α] using the Meso Scale Discovery multiplex ELISA platform. …”
Publicado 2018
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31292por Yamanishi, Kyosuke, Maeda, Seishi, Kuwahara-Otani, Sachi, Hashimoto, Takuya, Ikubo, Kaoru, Mukai, Keiichiro, Nakasho, Keiji, Gamachi, Naomi, El-Darawish, Yosif, Li, Wen, Okuzaki, Daisuke, Watanabe, Yuko, Yamanishi, Hiromichi, Okamura, Haruki, Matsunaga, Hisato“…BACKGROUND: The cytokine, interleukin-18 (IL-18), was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence suggesting that it has non-immunological effects on physiological functions. …”
Publicado 2018
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31293por Kusztos, Amanda E, Cheng, Matthew P, Bold, Tyler D, Ho, Vincent T, Glotzbecker, Brett E, Hsieh, Candace, Baker, Meghan A, Hammond, Sarah P, Baden, Lindsey R, Marty, Francisco M“…LTBI diagnostic tests included purified protein derivative (PPD) and interferon-gamma release assays (IGRA). Baseline chest radiography, history of BCG vaccination, and previous LTBI therapy were documented. …”
Publicado 2018
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31294por Deng, Rui, Zhang, Peng, Liu, Weizhen, Zeng, Xiangyu, Ma, Xianxiong, Shi, Liang, Wang, Tao, Yin, Yuping, Chang, Weilong, Zhang, Pei, Wang, Guobin, Tao, Kaixiong“…Elucidation of the regulation of B7-H1 expression is urgently required to guide B7-H1-targeted cancer therapy. Interferon gamma (IFN-γ) is thought to be the main driving force behind B7-H1 expression, and epigenetic factors including histone acetylation are recently linked to the process. …”
Publicado 2018
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31295por Ng, Xinyi, Nwankwo, Chizoba, Arduino, Jean Marie, Corman, Shelby, Lasch, Kathryn Eilene, Lustrino, Jacqueline Mary, Patel, Sushma, Platt, Heather Loryn, Qiu, Jingjun, Sperl, Jan“…This study aimed to compare the impact of elbasvir/grazoprevir (EBR/GZR) treatment versus sofosbuvir with pegylated interferon and ribavirin (SOF/PR) on changes in PROs: 1) during the treatment period and 2) at posttreatment follow-up. …”
Publicado 2018
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31296“…Another component of cachexia is profound systemic inflammation driven by pro-cachectic cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interferon gamma (INF-γ). IL-6 antagonism has been shown to reduce inflammation, reduce skeletal muscle loss, and ameliorate cachexia. …”
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31297por Toka, Felix N., Dunaway, Kiera, Smaltz, Felicia, Szulc-Dąbrowska, Lidia, Drnevich, Jenny, Mielcarska, Matylda Barbara, Bossowska-Nowicka, Magdalena, Schweizer, Matthias“…By contrast, poly(I:C) highly induced exclusively canonical pathways directly related to antiviral immune functions mediated by interferon signalling genes. The transcriptomic profile after poly(I:C)-stimulation was consistent with induction of TLR3 signalling. …”
Publicado 2019
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31298por Helman, Sarah R., Stevanović, Sanja, Campbell, Tracy E., Kwong, Mei Li M., Doran, Stacey L., Faquin, William C., Hinrichs, Christian S.“…Cross-reactivity was assessed by enzyme-linked immunospot assays and interferon-γ production assays. RESULTS: The median (range) age of 65 referred patients was 44 (24-64) years. …”
Publicado 2018
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31299por Chacón, Matías Rodrigo, Enrico, Diego Hernán, Burton, Jeannette, Waisberg, Federico Daniel, Videla, Viviana Marina“…Trials using chemotherapy, interferon, and endocrine therapy were excluded. Two authors (D.H.E. and F.D.W.) independently reviewed the studies for inclusion. …”
Publicado 2018
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31300por Ding, Jiwei, Ma, Ling, Zhao, Jianyuan, Xie, Yongli, Zhou, Jinming, Li, Xiaoyu, Cen, Shan“…RESULTS: 30 up-regulated genes and 83 down-regulated genes were identified in lymphocytes from integrative meta-analysis of expression data. The interferon response and innate immune activation was reduced in both CD4+ and CD8+ T cells from ECs. …”
Publicado 2019
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