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31321“…Gene ontology and Kyoto Encyclopedia of Genes and Genomes analysis was performed on the 32 characteristic genes, and it was demonstrated that these genes were primarily associated with the type I interferon (IFN) pathway. In the established model of THP-1-derived macrophages infected by M. tb, the actual differential expression levels of IFN-stimulated gene 15 (ISG15), 2′-5-oligoadenylate synthetase like (OASL), IFN regulatory factor 7 (IRF7) and DExD/H-box helicase 58 (DDX58), the first 4 genes of the 32 characteristic genes, were verified by reverse transcription quantitative polymerase chain reaction. …”
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31322por Hillen, Maarten R., Pandit, Aridaman, Blokland, Sofie L. M., Hartgring, Sarita A. Y., Bekker, Cornelis P. J., van der Heijden, Eefje H. M., Servaas, Nila H., Rossato, Marzia, Kruize, Aike A., van Roon, Joel A. G., Radstake, Timothy R. D. J.“…A majority of patients with pSS have a type-I interferon (IFN)-signature, which is defined as the increased expression of IFN-induced genes in circulating immune cells and is associated with increased disease activity. …”
Publicado 2019
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31323“…The serum levels of macrophage inflammatory protein 1β (MIP-1β), tumor necrosis factor α (TNF-α), interleukin (IL)-3, interferon (IFN)-γ, IL-17A, IL-4, IL-12p70, and P-selectin were detected and the NLR was calculated from routine blood test. …”
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31324por Sharma, Hema, Turner, Claire E., Siggins, Matthew K., El-Bahrawy, Mona, Pichon, Bruno, Kearns, Angela, Sriskandan, Shiranee“…Interleukin 6 (IL-6), gamma interferon (IFN-γ), KC (CXCL1), and MCP-1 were consistent markers of inflammation during infection. …”
Publicado 2019
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31325por Zewude, Aboma, Mohammed, Temesgen, Terfassa, Lemma, Hunt, W. Garrett, Pan, Xueliang, Balada-Llasat, Joan Miquel, Gebreyes, Wondwossen, Torrelles, Jordi B., Wang, Shu-Hua, Ameni, Gobena“…A combination of the SICTT and gamma interferon (IFN-γ) test was used as the gold standard for the validation of these point-of-care tests, as it was not feasible to slaughter the study animals to carry out the historical gold standard of mycobacterial culture. …”
Publicado 2019
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31326“…BACKGROUND: Direct-acting antivirals (DAAs) have substantially increased the rate of sustained virologic response in patients with hepatitis C compared with interferon therapy (IFN), while causing fewer adverse events. …”
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31327por Nsubuga, Julius, Kato, Charles Drago, Nanteza, Ann, Matovu, Enock, Alibu, Vincent Pius“…Plasma cytokine levels of Interferon-gamma (IFN-γ), Tumour Necrosis Factor-alpha (TNF-α), Interleukin (IL)-6, IL-10 and Transforming Growth Factor-beta (TGF-β) were measured by sandwich Enzyme-Linked Immuno Sorbent Assay and data statistically analysed using Graphpad Prism 6.0. …”
Publicado 2019
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31328por Wu, Die, Liu, Ying, Pang, Nannan, Sun, Mingling, Wang, Xiujuan, Haridia, Yasen, Zhao, Fang, Qin, Yuting, Fan, Wenxia, Guo, Xinhong, Ding, Jianbing“…Compared with the healthy control group, the percentages of PD-1+CD3+CD4+ T cells and PD-L1+HLA-DR+CD11c+ DC cells were increased in ITP patients. The levels of interferon-gamma (IFN-γ), interleukin-17 (IL-17), and sPD-1 in the serum of ITP patients were increased, while IL-4 and transforming growth factor-β (TGF-β) were decreased. …”
Publicado 2019
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31329por Merlini, Esther, Cazzaniga, Federico A., Casabianca, Anna, Orlandi, Chiara, Magnani, Mauro, Ancona, Giuseppe, Tincati, Camilla, d’Arminio Monforte, Antonella, Marchetti, Giulia“…At baseline (week 0 [W0]) and after 12 (W12) and 24 (W24) weeks we analyzed HLA-DR (human leukocyte antigen–DR isotype)/CD38/Ki67/CCR7 (C-C chemokine receptor type 7)/CD45RA/CD127/PD-1 (programmed cell death-1) on CD4/CD8, interferon (IFN)-γ/interleukin (IL)-2 after HIV/Staphylococcal enterotoxin B (SEB) exposure (flow cytometry); total, integrated, and unintegrated HIV-DNA; and residual low-level HIV viremia (quantitative polymerase chain reaction [qPCR]). …”
Publicado 2019
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31330“…To assess the inflammatory cytokines tumour necrosis factor α (TNF-α), interferon-γ (IFN-γ), and interleukin-10 (IL-10), blood samples were analysed by flow cytometry. …”
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31331por Manuel Sousa, José, Vergara, Mercedes, Pulido, Federico, Sánchez Antolín, Gloria, Hijona, Lander, Carnicer, Fernando, Rincón, Diego, Salmerón, Javier, Mateos-Muñoz, Beatriz, Jou, Antoni, Polo-Lorduy, Benjamín, Rubín, Ángel, Escarda, Ana, Aguilar, Patricia, Aldámiz-Echevarría, Teresa, García-Buey, Luisa, Carrión, José A., Hernández-Guerra, Manuel, Chimeno-Hernández, Sonia, Espinosa, Nuria, Morillas, Rosa Mª, Andrade, Raúl J., Delgado, Manuel, Gallego, Adolfo, Magaz, Marta, Moreno-Planas, José María, Estébanez, Ángel, Rico, Mikel, Menéndez, Fernando, Sampedro, Blanca, Morano, Luís, Izquierdo, Sonia, Zozaya, José Manuel, Rodríguez, Manuel, Morán-Sánchez, Senador, Lorente, Sara, Martín-Granizo, Ignacio, Von-Wichmann, Miguel Ángel, Delgado, Marcial, Manzanares, Amanda“…AIM: We describe the effectiveness and safety of the interferon-free regimen ombitasvir/paritaprevir/ritonavir plus dasabuvir with or without ribavirin (OBV/PTV/r ± DSV ± RBV) in a nationwide representative sample of the hepatitis C virus (HCV) monoinfected and human immunodeficiency virus-1/hepatitis C virus (HIV/HCV) coinfected population in Spain. …”
Publicado 2019
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31332por Ghezzi, Angelo, Chitnis, Tanuja, K-Laflamme, Annik, Meinert, Rolf, Häring, Dieter A., Pohl, Daniela“…INTRODUCTION: Fingolimod has demonstrated clinical and MRI benefits versus placebo/interferon β-1a in young adults with multiple sclerosis (MS). …”
Publicado 2019
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31333por Okai, Annette F., Amezcua, Lilyana, Berkovich, Regina R., Chinea, Angel R., Edwards, Keith R., Steingo, Brian, Walker, Aljoeson, Jacobs, Alan K., Daizadeh, Nadia, Williams, Mitzi J.“…METHODS: Patients in the CARE-MS studies received alemtuzumab 12 mg/day [initial alemtuzumab treatment (IAT); baseline: 5 days; 12 months later: 3 days] or subcutaneous interferon beta-1a (SC IFNB-1a) 3 ×/week. Core study outcomes were compared between treatment groups. …”
Publicado 2019
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31334por Kim, Dong-Kyu, Kim, Jin Youp, Han, Young Eun, Kim, Joon Kon, Lim, Hee-Suk, Eun, Kyoung Mi, Yang, Seung Koo, Kim, Dae Woo“…Additionally, exploratory factor analysis revealed that interleukin (IL)-18, interferon-γ, IL-1Ra, tumor necrosis factor-α, oncostatin M, and MPO were associated with good disease control status, whereas IL-36α and IL-1α were associated with refractory disease control status. …”
Publicado 2019
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31335por Heinze, Annekathrin, Grebe, Beatrice, Bremm, Melanie, Huenecke, Sabine, Munir, Tasleem Ah., Graafen, Lea, Frueh, Jochen T., Merker, Michael, Rettinger, Eva, Soerensen, Jan, Klingebiel, Thomas, Bader, Peter, Ullrich, Evelyn, Cappel, Claudia“…CIK cells were generated from PBMCs by ex vivo stimulation with interferon-γ, IL-2, OKT-3, and IL-15. Comparative analysis of expansion rate, purity, phenotype and cytotoxicity was performed. …”
Publicado 2019
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31336por Momtazi-Borojeni, Amir Abbas, Jaafari, Mahmoud Reza, Badiee, Ali, Banach, Maciej, Sahebkar, Amirhossein“…To evaluate the inflammatory response, interferon-gamma (IFN-γ)- and interleukin (IL)-10-producing splenic cells were assayed using ELISpot analysis. …”
Publicado 2019
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31337por Shin, Samuel D., Shin, Alexandra, Mayagoitia, Karina, Siebold, Lorraine, Rubini, Marsilio, Wilson, Christopher G., Bellinger, Denise L., Soriano, Salvador“…In that regard, neuroinflammation occurs early in the disease and we have recently unveiled an atypical pattern of interferon signaling in pre-symptomatic Npc1(−/−) mice, with microglial activation, anti-viral response, activation of antigen-presenting cells, and activation and chemotaxis of T lymphocytes as the key affected pathologic pathways. …”
Publicado 2019
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31338por Zhu, Bin, Tse, Lap Ah, Wang, Difei, Koka, Hela, Zhang, Tongwu, Abubakar, Mustapha, Lee, Priscilla, Wang, Feng, Wu, Cherry, Tsang, Koon Ho, Chan, Wing-cheong, Law, Sze Hong, Li, Mengjie, Li, Wentao, Wu, Suyang, Liu, Zhiguang, Huang, Bixia, Zhang, Han, Tang, Eric, Kan, Zhengyan, Lee, Soohyeon, Park, Yeon Hee, Nam, Seok Jin, Wang, Mingyi, Sun, Xuezheng, Jones, Kristine, Zhu, Bin, Hutchinson, Amy, Hicks, Belynda, Prokunina-Olsson, Ludmila, Shi, Jianxin, Garcia-Closas, Montserrat, Chanock, Stephen, Yang, Xiaohong R.“…Tumors in a second subtype were characterized by increased expression of interferon-stimulated genes and enrichment for TP53 somatic mutations. …”
Publicado 2019
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31339por Holmes, Laurens, Lim, Andrew, Comeaux, Camillia R., Dabney, Kirk W., Okundaye, Osatohamwen“…We aimed to synthesize epigenomic findings in HTN namely (a) angiotensin-converting enzyme 2 (ACE II) gene, (b) Toll-like receptor 2 (TLR2) gene, (c) interferon γ (IFN-γ) gene, and (d) Capping Actin Protein, Gelosin-Like (CAPG) gene, adducin 1(ADD1) gene, (e) Tissue inhibitor of metalloproteinase 3 (TIMP3), (f) mesoderm specific transcript (MEST) loci, (g) sodium channel epithelial 1 alpha subunit 2 (SCNN1B), (h) glucokinase (CKG) gene (i) angiotensin II receptor, type1 (AGTR1), and DNA methylation (mDNA). …”
Publicado 2019
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31340por Tsai, Wei-Lun, Wang, Chih-Feng, Cheng, Jin-Shiung, Chen, Wen-Chi, Bair, Ming-Jong, Lo, Ching-Chu“…Fifty-five patients (12%) had already experienced interferon-alpha/RBV treatment. Forty-two patients (9%) had a history of hepatocellular carcinoma (HCC) in the baseline. …”
Publicado 2020
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