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31401por Wang, Yibing, Li, Long, Gou, Zhongyong, Chen, Fang, Fan, Qiuli, Lin, Xiajing, Ye, Jinling, Zhang, Chang, Jiang, Shouqun“…Maternal feeding with 5,400 and 21,600 IU/kg VA decreased (P < 0.05) splenic interferon-γ (IFN-γ) transcripts and increased (P < 0.05) those of interleukin-2 (IL-2) in the progeny. …”
Publicado 2020
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31402por Jenkin, Daniel, Wright, Daniel, Folegatti, Pedro M., Platt, Abigail, Poulton, Ian, Lawrie, Alison, Tran, Nguyen, Boyd, Amy, Turner, Cheryl, Gitonga, John N., Karanja, Henry K., Mugo, Daisy, Ewer, Katie J., Bowden, Thomas A., Gilbert, Sarah C., Charleston, Bryan, Kaleebu, Pontiano, Hill, Adrian V. S., Warimwe, George M.“…High titres of binding IgG targeting Gc glycoprotein were detected while those targeting Gn were comparatively low. Interferon gamma (IFNγ) cellular responses against RVF Gn and Gc glycoproteins were observed in all but one vaccinee in the 5×10(9) vp dose group. …”
Publicado 2023
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31403por Vacher, Sophie, Suybeng, Voreak, Girard, Elodie, Masliah Planchon, Julien, Thomson, Grégory, Le Goux, Constance, Garinet, Simon, Schnitzler, Anne, Chemlali, Walid, Firlej, Virginie, Damotte, Diane, Allory, Yves, Kamal, Maud, Pignot, Géraldine, Bieche, Ivan“…Interestingly, this signature was associated with high tumor mutational burden (TMB) and high expression levels of APOBEC3B and interferon inducible genes. We identified a new type of somatic genomic instability targeting the TGAACA core motif loci flanked by palindromic sequences in bladder cancer. …”
Publicado 2020
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31404por Shigesaka, Minoru, Ito, Tomoki, Inaba, Muneo, Imai, Kai, Yamanaka, Hideki, Azuma, Yoshiko, Tanaka, Akihiro, Amuro, Hideki, Nishizawa, Tohru, Son, Yonsu, Satake, Atsushi, Ozaki, Yoshio, Nomura, Shosaku“…Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of SLE via the dysregulation of type I interferon (IFN) production; these cells act together with activated myeloid DCs (mDCs) to amplify the vicious pathogenic spiral of autoimmune disorders. …”
Publicado 2020
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31405por Wasiak, Sylwia, Dzobo, Kim E., Rakai, Brooke D., Kaiser, Yannick, Versloot, Miranda, Bahjat, Mahnoush, Stotz, Stephanie C., Fu, Li, Sweeney, Michael, Johansson, Jan O., Wong, Norman C. W., Stroes, Erik S. G., Kroon, Jeffrey, Kulikowski, Ewelina“…RESULTS: Monocytes isolated from DM2 + CVD patients and matched controls were treated ex vivo with apabetalone, interferon γ (IFNγ), IFNγ + apabetalone or vehicle and phenotyped for gene expression and protein secretion. …”
Publicado 2020
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31406por Peters, Eva M. J., Neusetzer, Melanie, Akinci, Secil, Murat, Aysenur, Treuherz, Sabine, Rose, Matthias, Leweke, Frank, Leichsenring, Falk, Conrad, Melanie L., Kruse, Johannes“…Second, patients with high TNFα (hTNF) at baseline produced significantly more acute inflammatory cytokines [interleukin (IL)1β, IL6), TH1/TH2 cytokines [interferon gamma (IFNγ), IL4] as well as eotaxin and IL2 compared to low TNFα producers (lTNF) (Cohen's ds between −0.532 and −1.013). …”
Publicado 2020
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31407por Pontarini, Elena, Murray-Brown, William James, Croia, Cristina, Lucchesi, Davide, Conway, James, Rivellese, Felice, Fossati-Jimack, Liliane, Astorri, Elisa, Prediletto, Edoardo, Corsiero, Elisa, Romana Delvecchio, Francesca, Coleby, Rachel, Gelbhardt, Eva, Bono, Aurora, Baldini, Chiara, Puxeddu, Ilaria, Ruscitti, Piero, Giacomelli, Roberto, Barone, Francesca, Fisher, Benjamin, Bowman, Simon J, Colafrancesco, Serena, Priori, Roberta, Sutcliffe, Nurhan, Challacombe, Stephen, Carlesso, Gianluca, Tappuni, Anwar, Pitzalis, Costantino, Bombardieri, Michele“…In ELS+SG and MALT-L parotids, conventional CXCR5(+)CD4(+)PD1(+)ICOS(+)Foxp3(-) Tfh-cells and a uniquely expanded population of CXCR5(-)CD4(+)PD1(hi)ICOS(+)Foxp3(-) Tph-cells displayed frequent IL-21/interferon-γ double-production but poor IL-17 expression. …”
Publicado 2020
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31408por Loos, Julia, Schmaul, Samantha, Noll, Theresa Marie, Paterka, Magdalena, Schillner, Miriam, Löffel, Julian T., Zipp, Frauke, Bittner, Stefan“…Moreover, using genetically encoded reporter mice (B6.IL17A-EGFP.acRFP x 2d2/2d2.RFP), we show that the motility of interferon (IFN)γ-producing ex-Th17 cells more closely resembles Th1 cells than Th17 cells in transfer EAE. …”
Publicado 2020
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31409por Rodriguez-Gonzalez, Carmen Guadalupe, Chamorro-de-Vega, Esther, Valerio, Maricela, Amor-Garcia, Miguel Angel, Tejerina, Francisco, Sancho-Gonzalez, Milagros, Narrillos-Moraza, Alvaro, Gimenez-Manzorro, Alvaro, Manrique-Rodriguez, Silvia, Machado, Marina, Olmedo, Maria, Escudero-Vilaplana, Vicente, Villanueva-Bueno, Cristina, Torroba-Sanz, Beatriz, Melgarejo-Ortuño, Alejandra, Vicente-Valor, Juan, Herranz, Ana, Bouza, Emilio, Muñoz, Patricia, Sanjurjo, Maria“…The most frequent antiviral combinations were lopinavir/ritonavir plus hydroxychloroquine (44.2%), followed by triple therapy with interferon beta-1b (32.7%). Corticosteroids and tocilizumab were used in 25.3% and 12.9% of patients, respectively. …”
Publicado 2021
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31410por Lantier, Louis, Poupée-Beaugé, Agathe, di Tommaso, Anne, Ducournau, Céline, Epardaud, Mathieu, Lakhrif, Zineb, Germon, Stéphanie, Debierre-Grockiego, Françoise, Mévélec, Marie-Noëlle, Battistoni, Arthur, Coënon, Loïs, Deluce-Kakwata-Nkor, Nora, Velge-Roussel, Florence, Beauvillain, Céline, Baranek, Thomas, Lee, Gordon Scott, Kervarrec, Thibault, Touzé, Antoine, Moiré, Nathalie, Dimier-Poisson, Isabelle“…Analysis of immune responses showed that N. caninum had the ability to 1) lyze infected cancer cells, 2) reactivate the immunosuppressed immune cells and 3) activate the systemic immune system by generating a protective antitumor response dependent on natural killer cells, CD8-T cells and associated with a strong interferon (IFN)-γ secretion in the tumor microenvironment. …”
Publicado 2020
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31411por Bhattacharyya, Anusuya, Kumar, Subodh, Sarma, Phulen, Kaur, Hardeep, Prajapat, Manisha, Shekhar, Nishant, Bansal, Seema, Avti, Pramod, Hazarika, Mythili, Sharma, Saurabh, Mahendru, Dhruv, Prakash, Ajay, Medhi, Bikash“…Single studies report efficacy of L/R + interferon (IFN, either alpha or 1-beta) combination. …”
Publicado 2020
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31412por Cheng, Anastasia, Choi, Dongsic, Lora, Maximilien, Shum-Tim, Dominique, Rak, Janusz, Colmegna, Inés“…METHODS: We evaluated the effects of interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) on human adipose-derived MSC: (a) vesiculation (custom RT(2) Profiler PCR Array), (b) EV profiles (Nanoparticle Tracking Analysis and Nanoparticle Flow Cytometry), (c) EV cargo (proteomic analysis and Western blot analysis), and (d) immunopotency (standard MSC:CD4 T cell proliferation inhibition assay). …”
Publicado 2020
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31413por Mantovani, Stefania, Varchetta, Stefania, Mele, Dalila, Donadon, Matteo, Torzilli, Guido, Soldani, Cristiana, Franceschini, Barbara, Porta, Camillo, Chiellino, Silvia, Pedrazzoli, Paolo, Santambrogio, Roberto, Barabino, Matteo, Cigala, Claudia, Piccolo, Gaetano, Opocher, Enrico, Maestri, Marcello, Sangiovanni, Angelo, Bernuzzi, Stefano, Lhospice, Florence, Kraiem, Manel, Mondelli, Mario Umberto, Oliviero, Barbara“…Moreover, in vitro IL-15 stimulation enhanced degranulation and interferon-γ production by PB NK from patients at month one of treatment with sorafenib. …”
Publicado 2020
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31414por He, Ming, Wang, Caiying, Xu, Lin, Zhang, Huimin, Liu, Yuhuan, Zhao, Yang, He, Shuxin, Zhang, Yanlan, Yang, Hongling, Liu, Yang, Miao, Min, Chen, Zhihai, Pang, Lin“…Eleven patients were treated with interferon atomization inhalation. No patients required oxygen therapy. …”
Publicado 2020
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31415por Wang, Ranran, Zhou, Kexiang, Xiong, Rongrong, Yang, Yi, Yi, Ruokun, Hu, Jing, Liao, Wei, Zhao, Xin“…Compared with the gastric injury model group mice, LF-XY18 reduced the serum levels of motilin, substance P, interleukin-6, interleukin-12, tumor necrosis factor-α, and interferon-γ but increased the serum levels of somatostatin and vasoactive intestinal peptide. …”
Publicado 2020
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31416por Islam, Abul Bashar Mir Md. Khademul, Khan, Md. Abdullah-Al-Kamran, Ahmed, Rasel, Hossain, Md. Sabbir, Kabir, Shah Md. Tamim, Islam, Md. Shahidul, Siddiki, A. M. A. M. Zonaed“…Functional enrichment analyses exhibited that the host induced responses are mediated by innate immunity, interferon, and cytokine stimulation. Surprisingly, induction of apoptosis, phagosome, antigen presentation, hypoxia response was lacking within these patients. …”
Publicado 2021
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31417por Zhang, Shengchao, Fang, Jiankai, Liu, Zhanhong, Hou, Pengbo, Cao, Lijuan, Zhang, Yuyan, Liu, Rui, Li, Yanan, Shang, Qianwen, Chen, Yongjing, Feng, Chao, Wang, Guan, Melino, Gerry, Wang, Ying, Shao, Changshun, Shi, Yufang“…Human mesenchymal stem cells (hMSCs) treated with interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) were reported to possess anti-inflammatory functions by producing TNF-stimulated gene 6 (TSG-6). …”
Publicado 2021
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31418“…LP-KSFY06 upregulated the anti-inflammatory factor interleukin (IL)-10 and downregulated the pro-inflammatory factors IL-6, IL-1β, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ). These oxidative and inflammatory indicators were consistent with the results of gene detections. …”
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31419por Kumar, Jitendra, Kumar, Ritesh, Kumar Singh, Amir, Tsakem, Elviche L, Kathania, Mahesh, Riese, Matthew J, Theiss, Arianne L, Davila, Marco L, Venuprasad, K“…Depletion of Cbl-b inhibited CAR T-cell exhaustion, resulting in reduced MC38-CEA tumor growth, reduced PD1(+)Tim3(+) cells and increased expression of interferon gamma, tumor necrosis factor alpha, and increased tumor cell killing. …”
Publicado 2021
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31420por Xue, Xiaomin, Ren, Shuguang, Yang, Xiaohong, Masoudi, Abolfazl, Hu, Yuhong, Wang, Xiaoshuang, Li, Hongxia, Zhang, Xiaojing, Wang, Minjing, Wang, Hui, Liu, Jingze“…Using bioinformatics methods to analyse dynamic changes in a large number of proteins, we found that the spleen still initiated immune responses to combat the infection, with immune-related proteins playing an important role, including cathepsin D (CTSD), interferon-induced protein 44 (IFI44), interleukin-2 enhancer-binding factor 2 (ILF2), interleukin enhancer-binding factor 3 (ILF3) and signal transducer and activator of transcription 5A (STAT5A). …”
Publicado 2021
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