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31421por Chun, June Young, Kim, Kichun, Lee, Min Kyeong, Kang, Chang Kyung, Koh, Youngil, Shin, Dong-Yeop, Hong, Junshik, Choe, Pyoeng Gyun, Kim, Nam Joong, Yoon, Sung-Soo, Park, Wan Beom, Kim, Inho, Oh, Myoung-don“…Humoral and cellular immunogenicity were measured using a glycoprotein enzyme-linked immunosorbent assay (gpELISA) and an interferon-γ (IFN-γ) enzyme-linked immunospot (ELISPOT) assay. …”
Publicado 2021
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31422por Huang, Mao, Yang, Yi, Shang, Futai, Zheng, Yishan, Zhao, Wenjing, Luo, Liang, Han, Xudong, Lin, Aihua, Zhao, Hongsheng, Gu, Qing, Shi, Yi, Li, Jun, Xu, Xingxiang, Liu, Kexi, Deng, YiJun, Cao, Quan, Wang, Weiwei“…Logistic regression analysis identified higher levels of troponin T (odds ratio [OR]: 1.04; 95% confidence interval [CI]: 1.00-1.08; P = 0.04), antiviral therapy with aerosol inhalation of interferon (OR: 6.33; 95% CI: 1.18-33.98; P = 0.03), and the application of non-invasive mechanical ventilation (OR: 1.99; 95%CI: 1.17-3.41; P = 0.01) as predictors of disease progression, whereas higher lymphocyte count (OR: 0.11; 95% CI: 0.02-0.57; P = 0.01) and early prone ventilation were associated with improvement (OR: 0.11; 95% CI: 0.01-0.98; P = 0.04). …”
Publicado 2020
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31423por Yamashita, Nami, Long, Mark, Fushimi, Atsushi, Yamamoto, Masaaki, Hata, Tsuyoshi, Hagiwara, Masayuki, Bhattacharya, Atrayee, Hu, Qiang, Wong, Kwok-Kin, Liu, Song, Kufe, Donald“…We found that MUC1-C activates the inflammatory interferon (IFN)-γ-driven JAK1→STAT1→IRF1 pathway and induces the IDO1 and COX2/PTGS2 effectors, which play key roles in immunosuppression. …”
Publicado 2021
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31424por Horspool, Alexander M., Kieffer, Theodore, Russ, Brynnan P., DeJong, Megan A., Wolf, M. Allison, Karakiozis, Jacqueline M., Hickey, Brice J., Fagone, Paolo, Tacker, Danyel H., Bevere, Justin R., Martinez, Ivan, Barbier, Mariette, Perrotta, Peter L., Damron, F. Heath“…Cytokine analysis of SARS-CoV-2(+) patients exhibited increases in proinflammatory markers (interleukin 6 [IL-6], IL-8, IL-18, and gamma interferon [IFN-γ]) and chemotactic markers (IP-10 and eotaxin) relative to healthy individuals. …”
Publicado 2021
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31425por Xu, Wei-Li, Shi, Bao-Jun, Li, Suo-Lin, Yu, Feng-Xue, Guo, Li-Na, Li, Meng, Hu, Zhi-Gang, Li, Gui-Xin, Zhou, Hui“…The levels of human leukocyte antigen (HLA)-I, CD8, interleukin (IL)-2 and interferon (IFN)-γ in peripheral blood, CTLs, T-helper 1 (Thl)/Th2 cytokines, perforin, granzyme and tumor growth were compared among the groups. …”
Publicado 2021
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31426“…Additionally, LF-CQPC07 caused the decrease in the amounts of inflammatory cytokines interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), IL-6, and interferon-γ (IFN-γ), and the increase in the amounts of the anti-inflammatory cytokines IL-10 and IL-4. …”
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31427“…METHODS: Low-dose stimulator of interferon genes (STING) agonist ADU S-100 (5 µg/mouse) was delivered intratumorally to established subcutaneous B16.F10 melanomas on days 10, 14 and 17 post-tumor inoculation. …”
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31428por Dong, Qian, Lunney, Joan K., Lim, Kyu-Sang, Nguyen, Yet, Hess, Andrew S., Beiki, Hamid, Rowland, Raymond R. R., Walker, Kristen, Reecy, James M., Tuggle, Christopher K., Dekkers, Jack C. M.“…Presence of high tonsil virus was associated with a stronger immune response, especially innate immune response through interferon signaling, but these differences were not significant when accounting for CE. …”
Publicado 2021
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31429por Liou, Theodore G., Adler, Frederick R., Cahill, Barbara C., Cox, David R., Cox, James E., Grant, Garett J., Hanson, Kimberly E., Hartsell, Stephen C., Hatton, Nathan D., Helms, My N., Jensen, Judy L., Kartsonaki, Christiana, Li, Yanping, Leung, Daniel T., Marvin, James E., Middleton, Elizabeth A., Osburn‐Staker, Sandra M., Packer, Kristyn A., Shakir, Salika M., Sturrock, Anne B., Tardif, Keith D., Warren, Kristi J., Waddoups, Lindsey J., Weaver, Lisa J., Zimmerman, Elizabeth, Paine, Robert“…Transcripts for two interferons (IFN) were elevated, IFN‐λ1 (OR =71, CI =7.07–713) and IFN‐λ2 (OR =40.2, CI =3.86–419), and closely associated with viral N1 transcripts (OR =1.35, CI =1.23–1.49 and OR =1.33 CI =1.20–1.47, respectively). …”
Publicado 2021
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31430por Choi, Jung-ah, Goo, Junghyun, Yang, Eunji, Jung, Dae-Im, Lee, Sena, Rho, Semi, Jeong, Yuji, Park, Young-Shin, Park, Hayan, Moon, Young-hye, Park, Uni, Seo, Sang-Hwan, Lee, Hyeja, Lee, Jae Myun, Cho, Nam-Hyuk, Song, Manki, Kim, Jae-Ouk“…DNA priming/protein boosting increased gamma interferon production, while protein-alone immunization did not. …”
Publicado 2020
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31431por Wilkins, Anna, Fontana, Elisa, Nyamundanda, Gift, Ragulan, Chanthirika, Patil, Yatish, Mansfield, David, Kingston, Jennifer, Errington-Mais, Fiona, Bottomley, Daniel, von Loga, Katharina, Bye, Hannah, Carter, Paul, Tinkler-Hundal, Emma, Noshirwani, Arish, Downs, Jessica, Dillon, Magnus, Demaria, Sandra, Sebag-Montefiore, David, Harrington, Kevin, West, Nick, Melcher, Alan, Sadanandam, Anguraj“…Unlike poor responders, good responders showed longitudinal (preradiotherapy vs postradiotherapy samples) upregulation of 198 immune genes, reflecting an increased T-cell-inflamed GEP, type-I interferon and macrophage populations. Longitudinal pathway analysis suggested viral-like pathogen responses occurred in post-treatment resected samples compared with pretreatment biopsies in good responders. …”
Publicado 2021
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31432por Handlos Grauslund, Jacob, Holmström, Morten Orebo, Jørgensen, Nicolai Grønne, Klausen, Uffe, Weis-Banke, Stine Emilie, El Fassi, Daniel, Schöllkopf, Claudia, Clausen, Mette Borg, Gjerdrum, Lise Mette Rahbek, Breinholt, Marie Fredslund, Kjeldsen, Julie Westerlin, Hansen, Morten, Koschmieder, Steffen, Chatain, Nicolas, Novotny, Guy Wayne, Petersen, Jesper, Kjær, Lasse, Skov, Vibe, Met, Özcan, Svane, Inge Marie, Hasselbalch, Hans Carl, Andersen, Mads Hald“…Immunomonitoring revealed that four of 10 patients had an in vitro interferon (IFN)-γ ELISPOT response to the CALRLong36 peptide at baseline, and four additional patients displayed a response in ELISPOT upon receiving three or more vaccines. …”
Publicado 2021
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31433por Gao, Junxin, Pan, Yu, Xu, Yunfei, Zhang, Wenli, Zhang, Lin, Li, Xi, Tian, Zhijun, Chen, Hongyan, Wang, Yue“…BACKGROUND: Long noncoding RNA (lncRNA) is highly associated with inflammatory response and virus-induced interferon production. By far the majority of studies have focused on the immune-related lncRNAs of mice and humans, but the function of lncRNAs in porcine immune cells are poorly understood. …”
Publicado 2021
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31434por Lamarca, Angela, Cives, Mauro, de Mestier, Louis, Crona, Joakim, Spada, Francesca, Öberg, Kjell, Pavel, Marianne, Alonso-Gordoa, Teresa“…Generally speaking, 3(rd)-line treatment for Wd-SBNETs was: everolimus (EVE) (66.7%), PRRT (18.5%), liver embolization (LE) (7.4%) and interferon-alpha (IFN) (3.7%); chemotherapy (0%); decision was based on clinical trial data (59.3%), or personal experience (22.2%). …”
Publicado 2021
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31435por Goodyear, Trevor, Brown, Helen, Browne, Annette J., Hoong, Peter, Ti, Lianping, Knight, Rod“…Second, participants described how individual and community-level accounts of evolving HCV treatments, including skepticism following negative experiences with Interferon-based treatment and uncertainty regarding treatment eligibility, negatively influenced willingness and opportunities to access DAAs. …”
Publicado 2021
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31436por Kuipers, Demy J. S., Mandemakers, Wim, Lu, Chin‐Song, Olgiati, Simone, Breedveld, Guido J., Fevga, Christina, Tadic, Vera, Carecchio, Miryam, Osterman, Bradley, Sagi‐Dain, Lena, Wu‐Chou, Yah‐Huei, Chen, Chiung C., Chang, Hsiu‐Chen, Wu, Shey‐Lin, Yeh, Tu‐Hsueh, Weng, Yi‐Hsin, Elia, Antonio E., Panteghini, Celeste, Marotta, Nicolas, Pauly, Martje G., Kühn, Andrea A., Volkmann, Jens, Lace, Baiba, Meijer, Inge A., Kandaswamy, Krishna, Quadri, Marialuisa, Garavaglia, Barbara, Lohmann, Katja, Bauer, Peter, Mencacci, Niccolò E., Lubbe, Steven J., Klein, Christine, Bertoli‐Avella, Aida M., Bonifati, Vincenzo“…Intriguingly, PKR can also be regulated by PRKRA (protein interferon‐inducible double‐stranded RNA‐dependent protein kinase activator A), the product of another gene causing monogenic dystonia. …”
Publicado 2020
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31437por Cecil, Denise, Park, Kyong Hwa, Curtis, Benjamin, Corulli, Lauren, Disis, Mary (Nora)“…The T-cell subtype and cytokine essential for vaccine-induced tumor inhibition was determined by in vivo neutralization studies and immunohistochemistry. The role of interferon gamma (IFN-γ) in receptor tyrosine kinase and downstream signaling was determined by immunoblotting. …”
Publicado 2021
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31438por Kießler, Maximilian, Plesca, Ioana, Sommer, Ulrich, Wehner, Rebekka, Wilczkowski, Friederike, Müller, Luise, Tunger, Antje, Lai, Xixi, Rentsch, Anke, Peuker, Kenneth, Zeissig, Sebastian, Seifert, Adrian M, Seifert, Lena, Weitz, Jürgen, Bachmann, Michael, Bornhäuser, Martin, Aust, Daniela, Baretton, Gustavo, Schmitz, Marc“…In addition, we found that a proportion of pDCs shows a nuclear expression of the transcription factor interferon regulatory factor 7 (IRF7), which is characteristic for an activated phenotype. …”
Publicado 2021
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31439por Jeong, Hyein, Kim, Dong Hyun, Choi, Yu-Min, Choi, HyeLim, Kim, Donghyun, Kim, Bum-Joon“…In conclusion, our data showed that rt269I types versus rt269L types are more prone to overall genome mutations, particularly in the Pol region and in the MHR or “a” determinant in genotype C2 infections and are more prevalent in signature NS mutations related to lowered HBV DNA replication, HBsAg and HBeAg secretion and potential NAr variants and hepatocellular carcinoma (HCC), possibly via type I interferon (IFN-I)-mediated enhanced inflammation. Our data suggest that rt269L types could contribute to liver disease progression via the generation of immune escape or enhanced persistent infection in chronic patients of genotype C2.…”
Publicado 2021
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31440por Abdelrahman, Zeinab, Liu, Qian, Jiang, Shanmei, Li, Mengyuan, Sun, Qingrong, Zhang, Yue, Wang, Xiaosheng“…The combination of lopinavir/ritonavir, ribavirin, and interferon-β (RR = 0.34, 95% CI: [0.22, 0.54]); hydroxychloroquine (RR = 0.58, 95% CI: [0.39, 0.58]); and lopinavir/ritonavir (RR = 0.72, 95% CI: [0.56, 0.91]) was associated with reduced hospitalization length. …”
Publicado 2021
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