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31441por Slingluff, Craig L., Zarour, Hassane M., Tawbi, Hussein Abdul-Hassan, Kirkwood, John M., Postow, Michael A., Friedlander, Philip, Devoe, Craig E., Gaughan, Elizabeth M., Mauldin, Ileana S., Olson, Walter C., Smith, Kelly T., Macri, Mary J., Ricciardi, Toni, Ryan, Aileen, Venhaus, Ralph, Wolchok, Jedd D.“…List of Abbreviations: Ab = antibody; CTCAE = NCI Common Terminology Criteria for Adverse Events; DHFR/DHRP = dihydrofolate reductase; DLT = Dose-limiting toxicity; ELISA = enzyme-linked immunosorbent assay; IFA = incomplete Freund’s adjuvant (Montanide ISA-51); IFNγ = Interferon gamma; IPI = Ipilimumab; irRC = immune-related response criteria; mIFH = multispectral immunofluorescence histology; OLP = NY-ESO-1 overlapping long peptides; PBMC = peripheral blood mononuclear cells; PD = Progressive disease; pICLC = poly-ICLC (Hiltonol), a TLR3/MDA-5 agonist; RLT = Regimen-limiting Toxicity; ROI = regions of interest; RT = room temperature; SAE = serious adverse event; SD = stable disease; TEAE = treatment-emergent adverse events; TLR = toll-like receptor; TME = tumor microenvironment; TRAE = treatment-related adverse events.…”
Publicado 2021
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31442por Secolin, Rodrigo, de Araujo, Tânia K., Gonsales, Marina C., Rocha, Cristiane S., Naslavsky, Michel, Marco, Luiz De, Bicalho, Maria A. C., Vazquez, Vinicius L., Zatz, Mayana, Silva, Wilson A., Lopes-Cendes, Iscia“…Recent studies have also shown that variants in 15 genes related to type I interferon immunity to influenza virus might predispose patients toward life-threatening COVID-19 pneumonia. …”
Publicado 2021
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31443por Tan, Karen, Minejima, Emi, Lou, Mimi, Mack, Wendy J., Nieberg, Paul, Wong-Beringer, Annie“…Blood samples were obtained for cytokine measurements by ELISA: interferon-gamma (IFNγ), interleukin (IL-1β, IL-6, IL-8, IL-10, IL-17) and tissue necrosis factor (TNF). …”
Publicado 2021
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31444por Kim, Yoo Jung, Schiopu, Elena, Dankó, Katalin, Mozaffar, Tahseen, Chunduru, Srinivas, Lees, Kirstin, Goyal, Namita, Sarazin, Jeffrey, Fiorentino, David F., Sarin, Kavita Y.“…BACKGROUND: Dermatomyositis (DM) is an inflammatory disease of skin and muscle. Increased interferon (IFN) signaling is a prominent feature of DM, but the mechanisms leading to IFN production in DM are not understood. …”
Publicado 2021
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31445“…Patient n(o) 3 (7 ans de SEP; EDSS 1; utilisation antérieure d’interféron) COVID-19 bénigne; rétabli. DISCUSSION: Aucun des trois cas d’infection suspectée par la COVID-19 identifiés (CLARIFY-MS, n = 2; MAGNIFY-MS, n = 1) n’a nécessité une ventilation mécanique ou n’a eu d’issue fatale. …”
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31446por Yin, Fan, Xi, Yue-Ling, Wang, Ying, Li, Bi-Ru, Qian, Juan, Ren, Hong, Zhang, Jian, Tang, Hong-Zhi, Ning, Bo-Tao“…Severe sepsis/septic patients with severe neutropenia had a higher plasma level of the following biomarkers: c-reaction protein (CRP) (180.5 vs. 121 mg/mL, P<0.001), procalcitonin (PCT) (12.15 vs. 2.7 ng/mL; P=0.005), interleukin (IL)-6 (316.83 vs. 55.77 pg/mL, P<0.001), IL-10 (39.165 vs. 10.09 pg/mL, P<0.001), interferon (IFN)-γ (6.155 vs. 3.71 pg/mL, P=0.016), and the percentage of regulatory T cells (Tregs) (2.7% vs. 2.09%, P=0.003). …”
Publicado 2021
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31447por Vlasova-St Louis, Irina, Musubire, Abdu K., Meya, David B., Nabeta, Henry W., Mohei, Hesham, Boulware, David R., Bohjanen, Paul R.“…RESULTS: We identified 12 inflammatory and stress response pathways, including interferon type 1 signaling, that were upregulated at the time of ART initiation in patients with future fatal C-IRIS, as compared with survivors. …”
Publicado 2021
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31448por Sen, S., Karabudak, R., Schiavetti, I., Demir, S., Ozakbas, S., Tutuncu, M., Petek Balci, B., Turan, O.F., Uzunkopru, C., Koseoglu, M., Yetkin, M.F., Gunduz, T., Gumus, H., Kale Icen, N., Carmisciano, L., Terzi, M., Acar, P., Gungor Dogan, I., Baba, C., Tuncer, A., Uygunoglu, U., Sormani, M.P., Efendi, H., Siva, A.“…The EDSS score was<= 1 in 134 (43%) of the patients. 91.6% of the patients were on a DMT, Fingolimod was the most frequently used drug (22.0%), followed by Interferon (20.1%). The comorbidity rate is 11.7%. We were not able to detect any significant association of DMTs with Covid-19 severity. …”
Publicado 2021
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31449por Lai, Jenn-Haung, Hung, Li-Feng, Huang, Chuan-Yueh, Wu, De-Wei, Wu, Chien-Hsiang, Ho, Ling-Jun“…Both mitochondrial machinery and proinflammatory cytokine interferon alpha (IFN-α) potentially contribute to atherogenic processes in SLE. …”
Publicado 2021
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31450por Samayoa-Reyes, Gabriela, Jackson, Conner, Ogolla, Sidney, Sabourin, Katherine, Obajemu, Adeola, Dent, Arlene E., Prokunina-Olsson, Ludmilla, Rochford, Rosemary“…BACKGROUND: Interferon (IFN)- λ4, a type III IFN, production is controlled by a dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of the IFNL4 gene. …”
Publicado 2021
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31451por Knitz, Michael W, Bickett, Thomas E, Darragh, Laurel B, Oweida, Ayman J, Bhatia, Shilpa, Van Court, Benjamin, Bhuvane, Shiv, Piper, Miles, Gadwa, Jacob, Mueller, Adam C, Nguyen, Diemmy, Nangia, Varuna, Osborne, Douglas G, Bai, Xiyuan, Ferrara, Sarah E, Boss, Mary-Keara, Goodspeed, Andrew, Burchill, Matthew A, Tamburini, Beth A Jirón, Chan, Edward D, Pickering, Curtis R, Clambey, Eric T, Karam, Sana D“…Simultaneously, Tregs are reprogrammed to an effector phenotype demonstrated by increases in interferonγ(+), tumor necrosis factorα(+), PI3K(+), pAKT(+) and Eomes(+) populations as well as decreases in CTLA4(+) and NRP-1(+) populations. …”
Publicado 2021
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31452por Marstein, Henriette Schermacher, Godang, Kristin, Flatø, Berit, Sjaastad, Ivar, Bollerslev, Jens, Sanner, Helga“…In patients, BMD Z-scores for whole body and/or spine were found to correlate negatively with prednisolone use at follow-up (yes/no) (age < 20y), inflammatory markers (age ≥ 20y) and levels of interferon gamma-induced protein 10 (IP-10) (both age groups). …”
Publicado 2021
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31453por Lu-Culligan, Alice, Chavan, Arun R., Vijayakumar, Pavithra, Irshaid, Lina, Courchaine, Edward M., Milano, Kristin M., Tang, Zhonghua, Pope, Scott D., Song, Eric, Vogels, Chantal B.F., Lu-Culligan, William J., Campbell, Katherine H., Casanovas-Massana, Arnau, Bermejo, Santos, Toothaker, Jessica M., Lee, Hannah J., Liu, Feimei, Schulz, Wade, Fournier, John, Muenker, M. Catherine, Moore, Adam J., Konnikova, Liza, Neugebauer, Karla M., Ring, Aaron, Grubaugh, Nathan D., Ko, Albert I., Morotti, Raffaella, Guller, Seth, Kliman, Harvey J., Iwasaki, Akiko, Farhadian, Shelli F.“…To better understand potential immune mechanisms shielding placental cells from infection in vivo, we performed bulk and single-cell transcriptomics analyses and found that the maternal-fetal interface of SARS-CoV-2-infected women exhibited robust immune responses, including increased activation of natural killer (NK) and T cells, increased expression of interferon-related genes, as well as markers associated with pregnancy complications such as preeclampsia. …”
Publicado 2021
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31454por Sinha, Meenal, Zhang, Li, Subudhi, Sumit, Chen, Brandon, Marquez, Jaqueline, Liu, Eric V, Allaire, Kate, Cheung, Alexander, Ng, Sharon, Nguyen, Christopher, Friedlander, Terence W, Aggarwal, Rahul, Spitzer, Matthew, Allison, James P, Small, Eric J, Sharma, Padmanee, Fong, Lawrence“…Luminex assay for anti-prostatic acid phosphatase (PAP) and anti-PA2024-specific serum immunoglobulin G (IgG) and ELISpot for interferon-γ (IFN-γ) production against PAP and PA2024 were used to assess antigen-specific B and T cell responses, respectively. …”
Publicado 2021
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31455“…ELISA measured the concentrations of interleukin (IL)-1β, IL-8, IL-4, and IL-10. qRT-PCR was performed to detect molecular expressions of ATCC 4356, oxidative stress-related factors [nuclear factor-related factor 2 (Nrf2), heme oxygenase 1 (HO-1)], inflammatory factors [tumor necrosis factor (TNF)-α, IL-1β, IL-8, interferon (IFN)-γ, IL-4, IL-10], and apoptosis-related factors [caspase 3, Bax, Bcl2, high-mobility group box protein 1 (HMGB1)]. …”
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31456por Mubarak, Ayman, Alrfaei, Bahauddeen, Aljurayyan, Abdullah, Alqafil, Mahfoudh M, Farrag, Mohamed A, Hamed, Maaweya E, Alosaimi, Bandar, Almajhdi, Fahad, Alturaiki, Wael“…RESULTS: Comparative analysis of MERS-CoV-infected patients (4 samples) and noninfected healthy controls (HCs) (5 samples) showed that serum levels of the following cytokines and chemokines were significantly higher in MERS-CoV patients than in the HCs (*p < 0.05): interferon (IFN)-α2 (43.4 vs 5.4), IFN-β (17.7 vs 6.2), IFN-γ (43.4 vs 9.7), interleukin (IL)-8 (13.7 vs 0), IL-2 (11.2 vs 3), IL-27p28 (57.8 vs 13.8), and IL-35 (167.5 vs 87.5). …”
Publicado 2021
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31457por Kosmicki, Jack A., Horowitz, Julie E., Banerjee, Nilanjana, Lanche, Rouel, Marcketta, Anthony, Maxwell, Evan, Bai, Xiaodong, Sun, Dylan, Backman, Joshua D., Sharma, Deepika, Kury, Fabricio S.P., Kang, Hyun M., O’Dushlaine, Colm, Yadav, Ashish, Mansfield, Adam J., Li, Alexander H., Watanabe, Kyoko, Gurski, Lauren, McCarthy, Shane E., Locke, Adam E., Khalid, Shareef, O’Keeffe, Sean, Mbatchou, Joelle, Chazara, Olympe, Huang, Yunfeng, Kvikstad, Erika, O’Neill, Amanda, Nioi, Paul, Parker, Meg M., Petrovski, Slavé, Runz, Heiko, Szustakowski, Joseph D., Wang, Quanli, Wong, Emily, Cordova-Palomera, Aldo, Smith, Erin N., Szalma, Sandor, Zheng, Xiuwen, Esmaeeli, Sahar, Davis, Justin W., Lai, Yi-Pin, Chen, Xing, Justice, Anne E., Leader, Joseph B., Mirshahi, Tooraj, Carey, David J., Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Rader, Daniel J., Povysil, Gundula, Goldstein, David B., Kiryluk, Krzysztof, Pairo-Castineira, Erola, Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Meynert, Alison, Kousathanas, Athanasios, Moutsianas, Loukas, Tenesa, Albert, Caulfield, Mark, Scott, Richard, Wilson, James F., Baillie, J. Kenneth, Butler-Laporte, Guillaume, Nakanishi, Tomoko, Lathrop, Mark, Richards, J. Brent, Jones, Marcus, Balasubramanian, Suganthi, Salerno, William, Shuldiner, Alan R., Marchini, Jonathan, Overton, John D., Habegger, Lukas, Cantor, Michael N., Reid, Jeffrey G., Baras, Aris, Abecasis, Goncalo R., Ferreira, Manuel A.R.“…After accounting for multiple testing, we did not identify any clear associations with rare variants either exome wide or when specifically focusing on (1) 13 interferon pathway genes in which rare deleterious variants have been reported in individuals with severe COVID-19, (2) 281 genes located in susceptibility loci identified by the COVID-19 Host Genetics Initiative, or (3) 32 additional genes of immunologic relevance and/or therapeutic potential. …”
Publicado 2021
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31458por Sabree, Shakoora A, Voigt, Andrew P, Blackwell, Sue E, Vishwakarma, Ajaykumar, Chimenti, Michael S, Salem, Aliasger K, Weiner, George J“…Our group previously demonstrated that the immunostimulatory effects of CMP-001 are dependent on an anti-Qβ antibody response which results in opsonization of CMP-001 and uptake by plasmacytoid dendritic cells (pDCs) that then produce interferon (IFN)-α. IFN-α then leads to an antitumor T-cell response that is responsible for the in vivo efficacy of CMP-001. …”
Publicado 2021
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31459“…Western blot assay was conducted to measure the protein level of interferon‐induced protein with tetratricopeptide repeat 2 (IFIT2). …”
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31460por Hasni, Sarfaraz A., Gupta, Sarthak, Davis, Michael, Poncio, Elaine, Temesgen-Oyelakin, Yenealem, Carlucci, Philip M., Wang, Xinghao, Naqi, Mohammad, Playford, Martin P., Goel, Rishi R., Li, Xiaobai, Biehl, Ann J., Ochoa-Navas, Isabel, Manna, Zerai, Shi, Yinghui, Thomas, Donald, Chen, Jinguo, Biancotto, Angélique, Apps, Richard, Cheung, Foo, Kotliarov, Yuri, Babyak, Ashley L., Zhou, Huizhi, Shi, Rongye, Stagliano, Katie, Tsai, Wanxia Li, Vian, Laura, Gazaniga, Nathalia, Giudice, Valentina, Lu, Shajia, Brooks, Stephen R., MacKay, Meggan, Gregersen, Peter, Mehta, Nehal N., Remaley, Alan T., Diamond, Betty, O’Shea, John J., Gadina, Massimo, Kaplan, Mariana J.“…Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute to this enhanced CVD risk. …”
Publicado 2021
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