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31461por Lum, Lawrence G., Al-Kadhimi, Zaid, Deol, Abhinav, Kondadasula, Vidya, Schalk, Dana, Tomashewski, Elyse, Steele, Patricia, Fields, Kristie, Giroux, Melissa, Liu, Qin, Flaherty, Lawrence, Simon, Michael, Thakur, Archana“…There were statistically significant increases in interferon-γ immunospots, Th(1) cytokines, Th(2) cytokines, and chemokines after HER2 BATs infusions. …”
Publicado 2021
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31462por Sun, Mayu, Gu, Pengfei, Yang, Yang, Yu, Luodan, Jiang, Zheshun, Li, Jingquan, Le, Yingying, Chen, Yu, Ba, Qian, Wang, Hui“…MSNs per se boosted infiltration of CTLs as the early event (days 2–3); and synergistically with anti-PD-1 therapy, MSNs rapidly established a T cell-inflamed microenvironment with abundant high-activated (interferon-γ/tumor necrosis factor-α/Perforin/GranzymeB) and low-exhausted (PD-1/lymphocyte-activation gene 3 (LAG-3)/T-cell immunoglobulin and mucin-domain containing-3 (TIM-3)) CTLs. …”
Publicado 2021
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31463por Karbeyaz, Fatih, Kissling, Seraphina, Jaklin, Paul Julius, Bachofner, Jaqueline, Brunner, Barbara, Müllhaupt, Beat, Winder, Thomas, Mertens, Joachim C, Misselwitz, Benjamin, von Felten, Stefanie, Siebenhüner, Alexander R“…BACKGROUND: Direct-acting antivirals (DAA) have revolutionized the therapy of chronic hepatitis C (CHC) and have replaced previous PEG-interferon/ribavirin (PEG-IFN/RBV) treatment. Patients with CHC and advanced liver disease are at increased risk for hepatocellular carcinoma (HCC). …”
Publicado 2021
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31464por Li, Jin, Wei, Jinli, Xu, Zhixiang, Jiang, Chunmei, Li, Mianhuan, Chen, Jie, Li, Yanjie, Yang, Minghui, Gu, Yuchen, Wang, Fuxiang, Shu, Yuelong, Yang, Yang, Sun, Litao, Liu, Yingxia“…Expression levels of 33 cytokines/chemokines were increased significantly in HAdV-infected patients with ARDS compared with that in healthy controls, and many of them were also significantly higher than those in SARS-CoV-2-infected and panH1N1-infected patients. Expression of interferon (IFN)-γ, interleukin (IL)-1β, hepatocyte growth factor (HGF), monokine induced by IFN-γ (MIG), IL-6, macrophage-colony stimulating factor (M-CSF), IL-10, IL-1α and IL-2Ra was significantly higher in HAdV-infected patients with ARDS than that in those without ARDS, and negatively associated with the ratio of the partial pressure of oxygen in arterial blood/fraction of inspired oxygen (PaO(2)/FiO(2)). …”
Publicado 2021
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31465“…Bone marrow monocytes were isolated and induced by macrophage colony-stimulating factor (M-CSF), lipopolysaccharide (LPS) and interferon (IFN)-γ for M1 polarization and interleukin (IL)-4/IL-13 for M2 polarization. …”
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31466por Wang, Feng, Hu, Mingyuan, Zhu, Hangju, Yang, Chao, Xia, Hui, Yang, Xian, Yang, Ligang, Sun, Guiju“…FO and PO had no impacts on mRNA and protein expression of receptor-interacting protein-1, interferon regulate factor 3, and nuclear factor-kappa B p65. …”
Publicado 2021
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31467por Puro, Vincenzo, Castilletti, Concetta, Agrati, Chiara, Goletti, Delia, Leone, Sara, Agresta, Alessandro, Cimini, Eleonora, Tartaglia, Eleonora, Casetti, Rita, Colavita, Francesca, Meschi, Silvia, Matusali, Giulia, Lapa, Daniele, Najafi Fard, Saeid, Aiello, Alessandra, Farrone, Chiara, Gallì, Paola, Capobianchi, Maria Rosaria, Ippolito, Giuseppe“…Overall, 100% of workers were tested for anti-Spike receptor-binding domain (anti-S/RBD) antibodies, 224 workers for neutralization titer (Micro-neutralization assay, MNA), and 155 workers for a spike-specific T cell interferon-γ response (IFN-γ). The levels of anti-S/RBD, MNA and IFN-γ were evaluated and compared according to sex, age, involvement in direct care of COVID-19 patients, and previous influenza/pneumococcal vaccination. …”
Publicado 2021
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31468por Bai, Miaomiao, Liu, Hongnan, Wang, Shanshan, Shu, Qingyan, Xu, Kang, Zhou, Jian, Xiong, Xia, Huang, Ruilin, Deng, Jinping, Yin, Yulong, Liu, Zheng'an“…Results: Supplemental 4,000 mg/kg MCR significantly increased (P < 0.05) the average daily weight gain (ADG), average daily feed intake (ADFI), total antioxidative capability, colonic short-chain fatty acids (SCFA) concentrations, and the crypt depth in the jejunum but decreased (P < 0.05) the mRNA expression levels of interferon γ, tumor necrosis factor-α, interleukin-1β, inhibiting kappa-B kinase β (IKKβ), inhibiting nuclear factor kappa-B (IκBα), and NF-κB in the jejunum and ileum. …”
Publicado 2021
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31469por Ouarhache, Maryem, Marquet, Sandrine, Frade, Amanda Farage, Ferreira, Ariela Mota, Ianni, Barbara, Almeida, Rafael Ribeiro, Nunes, Joao Paulo Silva, Ferreira, Ludmila Rodrigues Pinto, Rigaud, Vagner Oliveira-Carvalho, Cândido, Darlan, Mady, Charles, Zaniratto, Ricardo Costa Fernandes, Buck, Paula, Torres, Magali, Gallardo, Frederic, Andrieux, Pauline, Bydlowsky, Sergio, Levy, Debora, Abel, Laurent, Cardoso, Clareci Silva, Santos-Junior, Omar Ribeiro, Oliveira, Lea Campos, Oliveira, Claudia Di Lorenzo, Nunes, Maria Do Carmo, Cobat, Aurelie, Kalil, Jorge, Ribeiro, Antonio Luiz, Sabino, Ester Cerdeira, Cunha-Neto, Edecio, Chevillard, Christophe“…Chronic Chagas disease cardiomyopathy (CCC) is an inflammatory cardiomyopathy prevalent in Latin America, developing in 30% of the 6 million patients chronically infected by the protozoan Trypanosoma cruzi, while 60% remain free of heart disease (asymptomatic (ASY)). The cytokine interferon-γ and mitochondrial dysfunction are known to play a major pathogenetic role. …”
Publicado 2021
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31470por Semmler, Georg, Binter, Teresa, Kozbial, Karin, Schwabl, Philipp, Hametner‐Schreil, Stefanie, Zanetto, Alberto, Gavasso, Sabrina, Chromy, David, Bauer, David J.M., Simbrunner, Benedikt, Scheiner, Bernhard, Bucsics, Theresa, Stättermayer, Albert F., Pinter, Matthias, Steindl‐Munda, Petra, Schöfl, Rainer, Russo, Francesco Paolo, Simioni, Paolo, Trauner, Michael, Ferenci, Peter, Reiberger, Thomas, Mandorfer, Mattias“…APPROACH AND RESULTS: A total of 276 patients with pretreatment ACLD and information on pretreatment and posttreatment follow‐up (FU)‐LSM and FU‐VITRO were followed for a median of 36.6 months after the end of interferon‐free therapy. FU‐LSM (area under the receiver operating characteristic curve [AUROC]: 0.875 [95% confidence interval [CI]: 0.796‐0.954]) and FU‐VITRO (AUROC: 0.925 [95% CI: 0.874‐0.977]) showed an excellent predictive performance for hepatic decompensation. …”
Publicado 2021
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31471por He, Shuo, Chen, Xi-Xi, Ge, Wei, Yang, Shuai, Chen, Jun-Tao, Niu, Jing-Wen, Xia, Lan, Chen, Gui-Hai“…Serum levels of anti-inflammatory interleukins (IL-1RA, IL-4, IL-5, IL-10, IL-13, and IL-28A), transforming growth factor (TGF)-β1, granulocyte-macrophage colony-stimulating factor, interferon-γ, and the chemokine regulated upon activation, normal T cell expressed and secreted (RANTES) were measured by enzyme-linked immunosorbent assay. …”
Publicado 2021
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31472por Tan, Yaoju, Tan, Yunhong, Li, Junlian, Hu, Pengnan, Guan, Ping, Kuang, Haobin, Liang, Qide, Yu, Yanyan, Chen, Zhongnan, Wang, Quan, Yang, Zhenping, AiKeReMu, DiLiNaZi, Pang, Yu, Liu, Jianxiong“…BACKGROUND: We performed a prospective multicentre diagnostic study to evaluate the combined interferon-γ (IFN-γ) and interleukin-2 (IL-2) release assay for detect active pulmonary tuberculosis (TB) in China. …”
Publicado 2021
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31473por Beeson, Rachel, Coe, Antoinette B, Reyes-Gastelum, David, Haymart, Megan R, Papaleontiou, Maria“…First, we described the prevalence of concurrent use of thyroid hormone and medications that commonly interfere with thyroid function tests (i.e., prednisone, prednisolone, carbamazepine, phenytoin, phenobarbital, amiodarone, lithium, interferon-alpha, tamoxifen). Then, we performed a multivariable logistic regression analysis to determine patient characteristics associated with concurrent use of thyroid hormone and at least one interfering medication during the study period. …”
Publicado 2021
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31474por Ao, Zhujun, Wang, Lijun, Azizi, Hiva, Olukitibi, Titus Abiola, Kobinger, Gary, Yao, Xiaojian“…Moreover, the splenocytes isolated from mice immunized with VLPs containing EbGPΔM-V3 produced significantly higher levels of gamma interferon (IFN-γ), interleukin 2 (IL-2), IL-4, IL-5, and macrophage inflammatory protein 1α (MIP-1α). …”
Publicado 2021
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31475por Magro, Cynthia, Nuovo, Gerard, Mulvey, J. Justin, Laurence, Jeffrey, Harp, Joanna, Crowson, A. Neil“…In this regard we propose three main pathways: (1) complement mediated thrombotic vascular injury syndromes deploying the alternative and mannan binding lectin pathways and resulting in the elaboration of cytokines like interleukin 6 from endothelium in the setting of severe and critical COVID-19 and (2) the robust T cell and type I interferon-driven inflammatory and (3) humoral-driven immune complex mediated vasculitic cutaneous reactions observed with mild and moderate COVID-19. …”
Publicado 2021
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31476por Cook, Katherine W, Xue, Wei, Symonds, Peter, Daniels, Ian, Gijon, Mohamed, Boocock, David, Coveney, Clare, Miles, Amanda K, Shah, Sabaria, Atabani, Suha, Choudhury, Ruhul H, Vaghela, Poonam, Weston, Daisy, Metheringham, Rachael L, Brentville, Victoria A, Durrant, Lindy G“…Vaccine efficacy was assessed in tumor therapy studies using HLA-matched B16 melanoma expressing constitutive or interferon γ (IFNγ)-inducible major histocompatibility complex class II (MHC-II) as represented by most human tumors. …”
Publicado 2021
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31477“…Functional enrichment analysis revealed these DEGs were enriched for functional terms of type I interferon signaling pathway, innate immune response, inflammatory response, and infectious diseases. …”
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31478por Lin, Hsien‐Hong, Hsu, Shih‐Jer, Lu, Sheng‐Nan, Chuang, Wan‐Long, Hsu, Chao‐Wei, Chien, Rong‐Nan, Yang, Sien‐Sing, Su, Wei‐Wen, Wu, Jaw‐Ching, Lee, Tzong‐Hsi, Peng, Cheng‐Yuan, Tseng, Kuan‐Chiao, Qin, Albert, Huang, Yi‐Wen, Chen, Pei‐Jer“…BACKGROUND AND AIM: Ropeginterferon alfa‐2b (P1101) is a novel long‐acting mono‐PEGylated recombinant proline interferon (IFN) conjugated to a 40 kDa branched polyethylene glycol (PEG) chain at its N‐terminus, allowing every‐two‐week injection. …”
Publicado 2021
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31479por Mysore, Vijayashree, Cullere, Xavier, Settles, Matthew L., Ji, Xinge, Kattan, Michael W., Desjardins, Michaël, Durbin-Johnson, Blythe, Gilboa, Tal, Baden, Lindsey R., Walt, David R., Lichtman, Andrew H., Jehi, Lara, Mayadas, Tanya N.“…T cell activation and phenotype were detected by interferon-γ (IFN-γ) enzyme-linked immunospot (ELISpot) assays and flow cytometry. …”
Publicado 2021
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31480por Ding, Mei, Malhotra, Rajneesh, Ottosson, Tomas, Lundqvist, Magnus, Mebrahtu, Aman, Brengdahl, Johan, Gehrmann, Ulf, Bäck, Elisabeth, Ross-Thriepland, Douglas, Isaksson, Ida, Magnusson, Björn, Sachsenmeier, Kris F., Tegel, Hanna, Hober, Sophia, Uhlén, Mathias, Mayr, Lorenz M., Davies, Rick, Rockberg, Johan, Schiavone, Lovisa Holmberg“…A catalytic-dead version of the protein did not induce an increase in FOXP3 expression. Ten interferon proteins were identified as negative regulators that reduced the expression of both CTLA4 and FOXP3, without affecting cell viability. …”
Publicado 2021
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