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31561“…Two key sex-specific pathways (Ras-MAPK signaling pathway and type I interferon response) play an important role in the SATs of males and females, respectively. …”
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31562por Antolí, Arnau, Rocamora-Blanch, Gemma, Framil, Mario, Mas-Bosch, Virgínia, Navarro, Sergio, Bermudez, Carla, Martinez-Yelamos, Sergio, Dopico, Eva, Calatayud, Laura, Garcia-Muñoz, Nadia, Hernández-Benítez, Luis Humberto, Riera-Mestre, Antoni, Bas, Jordi, Masuet-Aumatell, Cristina, Rigo-Bonnin, Raúl, Morandeira, Francisco, Solanich, Xavier“…T-cell specific response was assessed by analysis of pre- and post-SARS-CoV-2 vaccination blood samples with an interferon-gamma release assay. The baseline blood sample also included several biochemical, haematological and immunological analyses. …”
Publicado 2022
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31563“…Inflammatory markers [tumor necrosis factor (TNF-α), interleukin (IL)-6, IL-10 and interferon (IFN)-γ] in serum were evaluated using ELISA-based kits. …”
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31564por Sasamoto, Naoko, Stewart, Paul A., Wang, Tianyi, Yoder, Sean J., Chellappan, Srikumar, Hecht, Jonathan L., Fridley, Brooke L., Terry, Kathryn L., Tworoger, Shelley S.“…The association of greater ovulatory years with downregulation of genes involved in inflammatory response such as interferon gamma response pathways (FDR = 7.81 × 10(–17)) was stronger in postmenopausal women. …”
Publicado 2022
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31565por Kaushik, Dharam, Shah, Pankil K., Mukherjee, Neelam, Ji, Niannian, Dursun, Furkan, Kumar, Addanki P., Thompson, Ian M., Mansour, Ahmed M., Jha, Richapriya, Yang, Xiaoyu, Wang, Hanzhang, Darby, Nydia, Ricardo Rivero, J., Svatek, Robert S., Liss, Michael A.“…The yoga group showed increased numbers of circulating CD4+ and CD8+ T-cells, more production of interferon-gamma by natural killer cells, and increased Fc receptor III expression in natural killer cells. …”
Publicado 2021
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31566“…We used a coculture system without cell-to-cell contact formed by miR-124 modulated SWE cells and human CHME3 microglia stimulated with interferon-gamma (IFNγ-MG), in which we assessed their adopted gene/miRNA profile and proteomic signature. …”
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31567por Sheng, Dandan, Ma, Wei, Zhang, Rui, Zhou, Lei, Deng, Qiaodan, Tu, Juchuanli, Chen, Weilong, Zhang, Fuchuang, Gao, Nailong, Dong, Mengxue, Wang, Dong, Li, Fengkai, Liu, Yin, He, Xueyan, Duan, Shengzhong, Zhang, Lixing, Liu, Tong, Liu, Suling“…Mechanistically, DTX induced Ccl3 by relieving the inhibition of cAMP-response element binding protein on Ccl3 via reactive oxygen species accumulation, and Ccl3 then promoted proinflammatory macrophage polarization via activation of the Ccl3–C-C motif chemokine receptor 5–p38/interferon regulatory factor 5 pathway. High CCL3 expression predicted better prognosis, and high CCL3 induction revealed better DTX chemosensitivity in patients with breast cancer. …”
Publicado 2022
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31568por De Marchi, Elena, Pegoraro, Anna, Turiello, Roberta, Di Virgilio, Francesco, Morello, Silvana, Adinolfi, Elena“…Here, we show that, in C57/bl6 P2X7 null mice inoculated with B16-F10 melanoma cells, several pro-inflammatory cytokines, including interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 12 (IL-12), interleukin 17 (IL-17), interferon gamma (IFN-γ) were significantly decreased, while the immune suppressant transforming growth factor beta (TGF-β) was almost three-fold increased. …”
Publicado 2022
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31569por Liu, Qiuliang, Pian, Kai, Tian, Zhen, Duan, Haitao, Wang, Qi, Zhang, Hui, Shi, Longyan, Song, Dongjian“…Collectively, overexpressing CAB39 heightened macrophages’ M2 polarization and declined chondrocyte injury in OA by activating the AMPK/Sirt-1 pathway.Abbreviations AMPK: AMP-activated protein kinaseArg1: arginase 1Bax: Bcl-2-associated X proteinBcl-2: B-cell lymphoma-2CAB39: Calcium-binding protein 39CM: Conditioned mediumDMM: destabilization of the medial meniscusECM: extracellular matrixELISA: enzyme-linked immunosorbent assayFCM: Flow cytometryIL-1β: interleukin-1βIL-4: interleukin-4IL-6: interleukin-6IL-10: interleukin-10IFN – γ: Interferon-gammaIHC: ImmunohistochemistryiNOS: Inducible nitric oxide synthaseLKB1: liver kinase B1MMP3: Matrix metalloproteinase3MMP13:Matrix metalloproteinase13NF-κB: NF-kappaBOA: OsteoarthritisqRT-PCR: Quantitative reverse transcription-polymerase chain reactionRT: room temperatureSirt-1: sirtuin 1STRAD: STE20-related adaptor alphaWB: Western blot…”
Publicado 2022
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31570Gpr174 Knockout Alleviates DSS-Induced Colitis via Regulating the Immune Function of Dendritic Cellspor Wei, Wei, Mu, Sucheng, Han, Yi, Chen, Yao, Kuang, Zhongshu, Wu, Xingyue, Luo, Yue, Tong, Chaoyang, Zhang, Yiqun, Yang, Yilin, Song, Zhenju“…The expression of cytokines (tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), interferon-γ (IFN-γ), interleukin -4 (IL-4)) and GPR174 mRNA were measured by Elisa, quantitative polymerase chain reaction (qPCR), and immunofluorescence. …”
Publicado 2022
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31571por Vandoorn, Elien, Stadejek, Wojciech, Parys, Anna, Chepkwony, Sharon, Chiers, Koen, Van Reeth, Kristien“…Their attenuation is believed to be due to an impaired ability to counteract the type I interferon (IFN)-mediated antiviral host response. However, this mechanism has been documented only in vitro for H3N2 strain A/swine/Texas/4199-2/98 NS1del126 (lvTX98), and several cases of clinical respiratory disease in the field were associated with the LAIV strains. …”
Publicado 2022
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31572por Drake, Charles G., Pachynski, Russell K., Subudhi, Sumit K., McNeel, Douglas G., Antonarakis, Emmanuel S., Bauer, Todd M., Lauer, Peter, Brockstedt, Dirk, Patricia, Daniel, Wade, Mark, Zudaire, Enrique, Bandyopadhyay, Nibedita, Parasrampuria, Dolly A., Girgis, Suzette, Mason, Gary E., Knoblauch, Roland E., Stone, Nicole, Infante, Jeffrey R., Gottardis, Marco M., Fong, Lawrence“…JNJ-809 transiently induced peripheral cytokines, including interferon-γ, interleukin-10, and tumor necrosis factor-α. …”
Publicado 2021
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31573por Leng, Qingyang, Zhou, Jianhua, Li, Chang, Xu, Yanhong, Liu, Lu, Zhu, Yi, Yang, Ying, Zhang, Hongli, Li, Xiaohua“…In addition, we also find that DHM enhances interferon regulatory factor 4 (IRF4) expression, which is a key transcriptional regulator of PGC-1α. …”
Publicado 2022
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31574por Yang, Lu M., Costales, Cristina, Ramanathan, Muthukumar, Bulterys, Philip L., Murugesan, Kanagavel, Schroers-Martin, Joseph, Alizadeh, Ash A., Boyd, Scott D., Brown, Janice M., Nadeau, Kari C., Nadimpalli, Sruti S., Wang, Aileen X., Busque, Stephan, Pinsky, Benjamin A., Banaei, Niaz“…METHODS: : We performed a retrospective observational cohort study at a large Northern California healthcare system of infection-naïve individuals fully vaccinated against SARS-CoV-2 (mRNA-1273, BNT162b2, or Ad26.COV2.S) with clinical SARS-CoV-2 interferon gamma release assay (IGRA) ordered between January through November 2021. …”
Publicado 2022
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31575por Hwang, Michael, Canzoniero, Jenna Vanliere, Rosner, Samuel, Zhang, Guangfan, White, James R, Belcaid, Zineb, Cherry, Christopher, Balan, Archana, Pereira, Gavin, Curry, Alexandria, Niknafs, Noushin, Zhang, Jiajia, Smith, Kellie N, Sivapalan, Lavanya, Chaft, Jamie E, Reuss, Joshua E, Marrone, Kristen, Murray, Joseph C, Li, Qing Kay, Lam, Vincent, Levy, Benjamin P, Hann, Christine, Velculescu, Victor E, Brahmer, Julie R, Forde, Patrick M, Seiwert, Tanguy, Anagnostou, Valsamo“…Reductions in NLR were associated with induction of interferon-γ responses driving the expression of antigen presentation and proinflammatory gene sets coupled with reshaping of the intratumoral T cell repertoire. …”
Publicado 2022
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31576por Yu, Xiaoli, Wang, Li, Yang, Xinru, Zhang, Songsong, Li, Guiwei, Zhang, Lanlan, Li, Jiaxuan, Wang, Xiaona, Zhou, Han, Jiang, Yanping, Cui, Wen, Li, Yijing, Tang, Lijie, Qiao, Xinyuan“…Following incubation with pCI-PoRV-VP6-loaded BGs, the mRNA expression levels of IL-1β, IL-6 and interferon (IFN)-γ in DCs were significantly increased. …”
Publicado 2022
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31577por Huang, Peng, Tang, Li, Zhang, Lu, Ren, Yi, Peng, Hong, Xiao, Yangyang, Xu, Jie, Mao, Dingan, Liu, Lingjuan, Liu, Liqun“…RESULTS: In the brown module, 5 key genes (chromosome 1 open reading frame 106 (C1orf106), component of oligomeric Golgi complex 8 (COG8), envoplakin (EVPL), GTPases of immunity-associated protein family member 6 (GIMAP6), and interferon-alpha inducible protein 6 (IFI6)) highly associated with CD4(+) T-cell infiltration were identified. …”
Publicado 2022
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31578por Huang, Jing, Wang, Xiaobo, Li, Bing, Shen, Shiyu, Wang, Ruina, Tao, Hongru, Hu, Junchi, Yu, Jin, Jiang, Hualiang, Chen, Kaixian, Luo, Cheng, Dang, Yongjun, Zhang, Yuanyuan“…METHODS: Cell-based screen of 200 metabolic molecules using a high-throughput flow cytometry assay of PD-L1 surface expression was conducted, and L-5-hydroxytryptophan (L-5-HTP) was found to suppress PD-L1 expression induced by interferon gamma (IFN-γ). Inhibition of PD-L1 induction and antitumor effect of L-5-HTP were evaluated in two syngeneic mouse tumor models. …”
Publicado 2022
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31579por Marastoni, Damiano, Pisani, Anna I., Schiavi, Gianmarco, Mazziotti, Valentina, Castellaro, Marco, Tamanti, Agnese, Bosello, Francesca, Crescenzo, Francesco, Ricciardi, Giuseppe K., Montemezzi, Stefania, Pizzini, Francesca B., Calabrese, Massimiliano“…CSF levels of 10 pro-inflammatory markers – CXCL13 [chemokine (C-X-C motif) ligand 13 or B lymphocyte chemoattractant], CXCL12 (stromal cell-derived factor or C-X-C motif chemokine 12), tumour necrosis factor (TNF), APRIL (a proliferation-inducing ligand, or tumour necrosis factor ligand superfamily member 13), LIGHT (tumour necrosis factor ligand superfamily member 14 or tumour necrosis factor superfamily member 14), interferon (IFN) gamma, interleukin 12 (IL-12), osteopontin, sCD163 [soluble-CD163 (cluster of differentiation 163)] and Chitinase3-like1 – were assessed using immune-assay multiplex techniques. …”
Publicado 2022
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31580por Reyes-Leiva, David, López-Contreras, Joaquín, Moga, Esther, Pla-Juncà, Francesc, Lynton-Pons, Elionor, Rojas-Garcia, Ricardo, Turon-Sans, Janina, Querol, Luis, Olive, Montse, Álvarez-Velasco, Rodrigo, Caballero-Ávila, Marta, Carbayo, Álvaro, Vesperinas-Castro, Ana, Domingo, Pere, Illa, Isabel, Gallardo, Eduard, Cortés-Vicente, Elena“…Humoral and cellular immune responses after vaccination were assessed using a spike-antibody ELISA and interferon gamma release assay in plasma. The primary outcomes were clinically significant changes in MG symptoms after vaccination, adverse events (AEs), and seroconversion and T-cell immune response rates. …”
Publicado 2022
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