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31581por Yu, Chuanqi, Wang, Lu, Cai, Wanghe, Zhang, Wenping, Hu, Zhonghua, Wang, Zirui, Yang, Zhuqing, Peng, Mo, Huo, Huanhuan, Zhang, Yazhou, Zhou, Qiubai“…The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the differentially expressed genes (DEGs), such as the acetyl-coenzyme A synthetase (acss1), alcohol dehydrogenase (adh), interferon-induced protein with tetratricopeptide repeats 1 (ifit1), aldo-keto reductase family 1 member D1 (akr1d1), cholesterol 7-alpha-monooxygenase (cyp7a1), and UDP-glucuronosyltransferase (ugt), indicated that the pathway of glycolysis/gluconeogenesis was the main metabolic pathway altered in the HC group compared with the NC group. …”
Publicado 2022
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31582por Lee, Won Suk, Kim, Dong Sung, Kim, Jeong Hun, Heo, Yoonki, Yang, Hannah, Go, Eun-Jin, Kim, Jin Hyoung, Lee, Seung Joon, Ahn, Byung Cheol, Yum, Jung Sun, Chon, Hong Jae, Kim, Chan“…LP-induced immune responses were mediated by CD8(+) T cells and interferon-γ, but not by CD4(+) T cells and CD25(+) T cells. …”
Publicado 2022
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31583por Hyun, Hakjun, Choi, Min Joo, Heo, Jung Yeon, Seo, Yu Bin, Nham, Eliel, Yoon, Jin Gu, Seong, Hye, Noh, Ji Yun, Cheong, Hee Jin, Kim, Woo Joo, Choi, Ju-Yeon, Lee, Young Jae, Lee, Hye Won, Kim, Sung Soon, Kim, Byoungguk, Song, Joon Young“…The main outcomes included anti-spike (S) IgG antibody and neutralizing antibody responses, S-specific T-cell responses (interferon-γ enzyme-linked immunospot assay), solicited adverse events (AEs), and serious AEs. …”
Publicado 2022
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31584por Lin, Jonah, Law, Ryan, Korosec, Chapin S., Zhou, Christine, Koh, Wan Hon, Ghaemi, Mohammad Sajjad, Samaan, Philip, Ooi, Hsu Kiang, Matveev, Vitaliy, Yue, FengYun, Gingras, Anne-Claude, Estacio, Antonio, Buchholz, Megan, Cheatley, Patti Lou, Mohammadi, Avid, Kaul, Rupert, Pavinski, Katerina, Mubareka, Samira, McGeer, Allison J., Leis, Jerome A., Heffernan, Jane M., Ostrowski, Mario“…All subjects demonstrated SARS-CoV-2-specific gamma interferon (IFN-γ), interleukin 2 (IL-2), and granzyme B (GzmB) T cell responses at presentation, with greater frequencies in severe disease. …”
Publicado 2022
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31585por Harberts, Aenne, Schaub, Golda M., Ruether, Darius F., Duengelhoef, Paul M., Brehm, Thomas T., Karsten, Hendrik, Fathi, Anahita, Jahnke-Triankowski, Jacqueline, Fischer, Lutz, Addo, Marylyn M., Haag, Friedrich, Luetgehetmann, Marc, Lohse, Ansgar W., Schulze zur Wiesch, Julian, Sterneck, Martina“…METHODS: In this prospective study, humoral (anti-SARS-CoV-2 receptor-binding domain [anti-S RBD]) and cellular (interferon-gamma release assay) immune responses were determined after mRNA-based SARS-CoV-2 vaccination in 106 LTRs after a third vaccination and in 36 LTRs after a fourth vaccination. …”
Publicado 2022
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31586por Barhoum, Petra, Pineton de Chambrun, Marc, Dorgham, Karim, Kerneis, Mathieu, Burrel, Sonia, Quentric, Paul, Parizot, Christophe, Chommeloux, Juliette, Bréchot, Nicolas, Moyon, Quentin, Lebreton, Guillaume, Boussouar, Samia, Schmidt, Matthieu, Yssel, Hans, Lefevre, Lucie, Miyara, Makoto, Charuel, Jean-Luc, Marot, Stéphane, Marcelin, Anne-Geneviève, Luyt, Charles-Edouard, Leprince, Pascal, Amoura, Zahir, Montalescot, Gilles, Redheuil, Alban, Combes, Alain, Gorochov, Guy, Hékimian, Guillaume“…MIS-A(+) had higher circulating levels of interleukin (IL)-22, IL-17, and tumor necrosis factor-α (TNF-α), whereas MIS-A(−) had higher interferon-α2 (IFN-α2) and IL-8 levels. RNA polymerase III autoantibodies were present in 7 of 13 MIS-A(−) patients (54%) but in none of the MIS-A(+) patients. …”
Publicado 2022
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31587por Ye, Jian, Mills, Bradley N, Qin, Shuyang S, Garrett-Larsen, Jesse, Murphy, Joseph D, Uccello, Taylor P, Han, Booyeon J, Vrooman, Tara G, Johnston, Carl J, Lord, Edith M, Belt, Brian A, Linehan, David C, Gerber, Scott A“…The combination of R848 and SBRT results in significant immune activation of the pancreatic TME, including increased tumor antigen-specific CD8(+) T cells, decreased regulatory T cells, and enhanced antigen-presenting cells maturation, as well as increased interferon gamma, granzyme B, and CCL5 along with decreased levels of interleukin 4 (IL-4), IL-6, and IL-10. …”
Publicado 2022
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31588por Kelly, Robert F., Gonzaléz Gordon, Lina, Egbe, Nkongho F., Freeman, Emily J., Mazeri, Stella, Ngwa, Victor N., Tanya, Vincent, Sander, Melissa, Ndip, Lucy, Muwonge, Adrian, Morgan, Kenton L., Handel, Ian G., Bronsvoort, Barend M. de C.“…The interferon-gamma (IFN-γ) assay and single comparative cervical skin test (SCITT) are used to estimate bovine tuberculosis (bTB) prevalence globally. …”
Publicado 2022
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31589por Motamedi Sedeh, Farahnaz, Khalili, Iraj, Wijewardana, Viskam, Unger, Hermann, Shawrang, Parvin, Behgar, Mehdi, Moosavi, Sayed Morteza, Arbabi, Arash, Hosseini, Sayedeh Maede“…The mRNA transcription levels of T-helper type 1 cytokines such as interferon-gamma (IFN-γ) and interleukin 2 (IL-2) were upregulated in all vaccinated groups at the late regime. …”
Publicado 2022
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31590“…We found that co-DEGs were significantly enhanced in the type I interferon and IL-17 signal transduction pathways. Thirteen potential hub genes were identified using Cytoscape. …”
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31591por Ma, Xuan, Hao, Meng, Zhang, Ming Hui, Zeng, Ya, Yang, Qing Qing, Zhao, Lu, Fan, Chen Yang, Ji, Zhi Hong, Li, Ke Ao, Li, Zhi Jian, Maimaiti, Mirzat, Nie, Ji Hong“…Skin tissues were observed by hematoxylin–eosin (HE) staining, and the levels of serum interferon-γ (IFN-γ) and interleukin-4 (IL-4) were determined by enzyme-linked immunosorbent assay (ELISA). …”
Publicado 2022
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31592por Trajman, Anete, Adjobimey, Menonli, Bastos, Mayara Lisboa, Valiquette, Chantal, Oxlade, Olivia, Fregonese, Federica, Affolabi, Dissou, Cordeiro-Santos, Marcelo, Stein, Renato T., Benedetti, Andrea, Menzies, Dick“…METHODS: This superiority cluster-randomized multicenter trial with three arms of equal size compares, in Benin and Brazil, three strategies for HHC investigation aged 0–50: (i) tuberculin skin testing (TST) or interferon gamma release assay (IGRA) for TBI and if positive, chest X-Ray (CXR) to rule out TBD in persons with positive TST or IGRA; (ii) same as (i) but GeneXpert (GX) replaces CXR; and (iii) no TBI testing. …”
Publicado 2022
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31593por Taglieri, Nevio, Bonfiglioli, Rachele, Bon, Isabella, Malosso, Pietro, Corovic, Andrej, Bruno, Matteo, Le, Elizabeth, Granozzi, Bianca, Palmerini, Tullio, Ghetti, Gabriele, Tamburello, Martina, Bruno, Antonio Giulio, Saia, Francesco, Tarkin, Jason M., Rudd, James H. F., Calza, Leonardo, Fanti, Stefano, Re, Maria Carla, Galié, Nazzareno“…HIV infection was independently associated with higher values of interleukin-10 (coef = 0.83; 95%CI 0.34, 1.32; P = .001), interferon-γ (coef. = 0.90; 95%CI 0.32, 1.47; P = .003), and vascular cell adhesion molecule-1 (VCAM-1) (coef. = 0.75; 95%CI: 0.42, 1.08, P < .001). …”
Publicado 2021
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31594por Wen, Zhaohai, Zhang, Zhaoying, Aimulajiang, Kalibixiati, Aleem, Muhammad Tahir, Feng, Jiajun, Liang, Meng, Lu, Mingmin, Xu, Lixin, Song, Xiaokai, Li, Xiangrui, Yan, Ruofeng“…The rHc-HAP also induced the expression of interferon gamma (IFN-γ) and the phosphorylated STAT 1 transcription factor, while inhibiting interleukin-4 expression. …”
Publicado 2022
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31595por Lu, Zhihao, Yang, Silu, Luo, Xuerui, Shi, Yang, Lee, Jong-Seok, Deva, Sanjeev, Liu, Tianshu, Chao, Yee, Zhang, Yun, Huang, Ruiqi, Xu, Yaling, Shen, Zhirong, Shen, Lin“…Programmed death-ligand 1 (PD-L1) expression (Tumor Area Positivity [TAP] ≥ 5%), interferon gamma (IFNγ)-related gene signature, gene expression profile, tumor mutational burden (TMB), and gene hyperamplification (HA) were analyzed for correlation with tislelizumab. …”
Publicado 2022
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31596por Fontvieille, Emma, His, Mathilde, Biessy, Carine, Navionis, Anne-Sophie, Torres-Mejía, Gabriela, Ángeles-Llerenas, Angélica, Alvarado-Cabrero, Isabel, Sánchez, Gloria Inés, Navarro, Edgar, Cortes, Yorlany Rodas, Porras, Carolina, Rodriguez, Ana Cecilia, Garmendia, Maria Luisa, Soto, José Luis, Moyano, Leonor, Porter, Peggy L., Lin, Ming Gang, Guenthoer, Jamie, Romieu, Isabelle, Rinaldi, Sabina“…METHODS: We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. …”
Publicado 2022
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31597por Manangeeswaran, Mohanraj, Ireland, Derek D. C., Thacker, Seth G., Lee, Ha-Na, Kelley-Baker, Logan, Lewkowicz, Aaron P., Rothlauf, Paul W., Cornejo Pontelli, Marjorie, Bloyet, Louis-Marie, Eckhaus, Michael A., Mendoza, Mirian I., Whelan, Sean, Verthelyi, Daniela“…Although disease progression was faster in SARS-CoV-2 infected mice, infection with both viruses resulted in neuronal infection and encephalitis with increased expression of Interferon-stimulated Irf7, Bst2, Ifi294, as well as CxCL10, CCL5, CLC2, and LILRB4, and both models were uniformly lethal. …”
Publicado 2022
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31598por Chen, Jun, Qi, Haihua, Liu, Lijun, Niu, Yandong, Yu, Shuping, Qin, Shucun, He, Lei“…Immunohistochemistry of the epidermis and dermis revealed a high proportion of proliferating cell nuclear antigen (PCNA) positivity within psoriatic skin lesions of CETP-Tg and PLTP-Tg mice compared with WT mice. Interferon-α (IFN-α), interleukin-1β (IL-1β), IL-6, IL-17A, IL-17F, IL-22, and IL-23p19 mRNA levels increased within CETP-Tg and PLTP-Tg mice compared with WT counterparts. …”
Publicado 2022
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31599por Choi, Gwang Hyeon, Jang, Eun Sun, Kim, Young Seok, Lee, Youn Jae, Kim, In Hee, Cho, Sung Bum, Lee, Han Chu, Jang, Jeong Won, Ki, Moran, Choi, Hwa Young, Baik, Dahye, Jeong, Sook-Hyang“…BACKGROUND: Prospective studies of the long-term outcomes of patients with hepatitis C virus (HCV) infection after treatment with interferon-based therapy (IBT) or direct-acting antivirals (DAA) are limited in many Asian countries. …”
Publicado 2022
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31600por Tagoma, Aili, Haller‐Kikkatalo, Kadri, Oras, Astrid, Roos, Kristine, Kirss, Anne, Uibo, Raivo“…MATERIALS AND METHODS: We quantified the levels of adipokines: adiponectin, leptin, plasminogen activator inhibitor‐1 and resistin; chemokines: C‐C motif chemokine ligand 2 (CCL2), CCL4, C‐X‐C motif chemokine ligand 8 (CXCL8) and CXCL10; and cytokines: granulocyte‐macrophage colony‐stimulating factor, interferon‐γ, interleukin (IL)‐1β, soluble (s)IL‐1RI, IL‐2, sIL‐2Ra, IL‐4, IL‐5, IL‐6, IL‐7, IL‐10, IL‐12(p70), IL‐13, IL‐15, IL‐17A, IL‐17F, IL‐21, IL‐22, IL‐23, IL‐27, transforming growth factor (TGF)‐β1, TGF‐β2, TGF‐β3, tumor necrosis factor‐α and soluble tumor necrosis factor receptor 2 using the Milliplex®MAP Magnetic Bead assay on Luminex®200™, and compared the results with clinical data from pregnancy and post‐partum follow up. …”
Publicado 2022
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