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31641“…Furthermore, CCH induced differentiation of pathogenic Th17 cells, promoted the formation of complexes of interferon regulatory factor 4 and signal transducer and activator of transcription 3 (STAT3), and increased the phosphorylation of STAT3. …”
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31642por Bellan, Mattia, Apostolo, Daria, Albè, Alice, Crevola, Martina, Errica, Nicolò, Ratano, Giacomo, Tonello, Stelvio, Minisini, Rosalba, D’Onghia, Davide, Baricich, Alessio, Patrucco, Filippo, Zeppegno, Patrizia, Gramaglia, Carla, Balbo, Piero Emilio, Cappellano, Giuseppe, Casella, Sara, Chiocchetti, Annalisa, Clivati, Elisa, Giordano, Mara, Manfredi, Marcello, Patti, Giuseppe, Pinato, David James, Puricelli, Chiara, Raineri, Davide, Rolla, Roberta, Sainaghi, Pier Paolo, Pirisi, Mario“…In the subgroup of subjects with normal DLCO (> 80%), for whom residual lung damage was an unlikely explanation for long COVID, the presence of anxiety and depressive symptoms was significantly associated to persistent symptoms, together with increased levels of a set of pro-inflammatory cytokines: interferon-gamma, tumor necrosis factor-alpha, interleukin (IL)-2, IL-12, IL-1β, IL-17. …”
Publicado 2022
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31643por Zhang, Lei, Yang, Jiaqing, Lai, Changchun, Wan, Li, Xiong, Shilong, Kong, Weiya, Liu, Zijian, Yu, Pei, Chen, Mingxiao, Mai, Weikang, Khan, Shahzad Akbar, Deng, Min, Chen, Lu, Lei, Yu, Zhou, Qiang, Yu, Nan, Li, Pingchao, Chen, Zheng, Ji, Tianxing“…Cellular immunity was analyzed using interferon-γ enzyme-linked immunospot assay. RESULTS: The results showed that there were no severe adverse effects and apparent changes of clinical laboratory biomarkers in KTRs and healthy volunteers (HVs) after homologous inactivated vaccine booster. …”
Publicado 2023
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31644por Hong, David S., Van Tine, Brian A., Biswas, Swethajit, McAlpine, Cheryl, Johnson, Melissa L., Olszanski, Anthony J., Clarke, Jeffrey M., Araujo, Dejka, Blumenschein, George R., Kebriaei, Partow, Lin, Quan, Tipping, Alex J., Sanderson, Joseph P., Wang, Ruoxi, Trivedi, Trupti, Annareddy, Thejo, Bai, Jane, Rafail, Stavros, Sun, Amy, Fernandes, Lilliam, Navenot, Jean-Marc, Bushman, Frederic D., Everett, John K., Karadeniz, Derin, Broad, Robyn, Isabelle, Martin, Naidoo, Revashnee, Bath, Natalie, Betts, Gareth, Wolchinsky, Zohar, Batrakou, Dzmitry G., Van Winkle, Erin, Elefant, Erica, Ghobadi, Armin, Cashen, Amanda, Grand’Maison, Anne, McCarthy, Philip, Fracasso, Paula M., Norry, Elliot, Williams, Dennis, Druta, Mihaela, Liebner, David A., Odunsi, Kunle, Butler, Marcus O.“…Exploratory analyses showed that afami-cel infiltrates tumors, has an interferon-γ-driven mechanism of action and triggers adaptive immune responses. …”
Publicado 2023
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31645por Chen, Deng, Zhang, Cong, Luo, Jialiu, Deng, Hai, Yang, Jingzhi, Chen, Shunyao, Zhang, Peidong, Dong, Liming, Chang, Teding, Tang, Zhao-hui“…Biological process analysis shows that antigen uptake, processing presentation, and major histocompatibility complex (MHC) class II protein complex assembly pathways were up-regulated in autophagy-positive monocytes, whereas antigen processing and presentation of endogenous antigen and type I interferon signaling pathways were up-regulated in autophagy-positive neutrophils during the early stages of major trauma. …”
Publicado 2023
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31646por Xiao, Jie, Chen, Hao, Zheng, Ruoyu, Pu, Jiayan, Gu, Xiaobin, Xie, Yue, He, Ran, Xu, Jing, Jing, Bo, Peng, Xuerong, Yang, Guangyou“…Significantly increased interleukin (IL)-2, interferon (IFN)-γ, and IL-17 levels were evident in the rGC and rRC groups (p < 0.05). …”
Publicado 2023
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31647por Shi, Huibin, Li, Taotao, Su, Manchun, Wang, Huihui, Li, Qiao, Lang, Xia, Ma, Youji“…Genome-wide scanning using the Fst and π ratio methods revealed a list of potentially selected related genes in Panou sheep compared to Oula sheep, including histone deacetylase 9 (HDAC9), protein tyrosine kinase 2 (PTK2), microphthalmia-related transcription factor (MITF), vesicular amine transporter 1 (VAT1), trichohyalin-like 1 (TCHHL1), amine oxidase, copper containing 3 (AOC3), interferon-inducible protein 35 (IFI35). CONCLUSIONS: The results suggest that traits related to growth and development and plateau adaptation may be selection targets for the domestication and breeding improvement of Tibetan sheep. …”
Publicado 2023
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31648por Guo, Piaoyi, Jin, Liang, Zhou, Huifen, Bao, Yida, Yang, Jiehong, Chen, Jing, He, Yu, Yu, Daojun, Wan, Haitong“…Interestingly, GA inhibited MDR-AB induced myeloiddifferentiationfactor88 expression (MYD88), one downstream con-factors of TLRs, but no affection on Interferon regulatory Factor 3 (IRF3), the other one, indicating GA inhibited MDR-AB induced cell injury by impact TLR/MYD88 pathway to attenuate inflammation. …”
Publicado 2023
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31649por Temerozo, Jairo R., Ferreira, Pedro L. C., Linhares-Lacerda, Leandra, Vieira, Rhaíssa C., Cister-Alves, Bruno, Gobbo, Livia, Ribeiro-Alves, Marcelo, Menna-Barreto, Rubem F. S., Bou-Habib, Dumith Chequer“…We detected that the increase of HIV-1 dissemination is due to enhanced cell-to-cell transmission with the involvement of the interferon-induced HIV-1 restriction factor BST-2/Tetherin and CD11a (LFA-1), an integrin that participates in formation of virological synapse.…”
Publicado 2023
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31650por Gordy, James T., Sandhu, Avinaash K., Fessler, Kaitlyn, Luo, Kun, Kapoor, Aakanksha R., Ayeh, Samuel K., Hui, Yinan, Schill, Courtney, Chen, Fengyixin, Wang, Tianyin, Karanika, Styliani, Sunshine, Joel C., Karakousis, Petros C., Markham, Richard B.“…Previous work has shown that type-I interferon (IFNα or IFN) and 5-Aza-2’-deoxycytidine (5Aza) significantly enhance the therapeutic benefit of DNA vaccines as measured by reduced tumor burden and improved mouse survival. …”
Publicado 2023
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31651por Liu, Bin, Lyu, Linshuoshuo, Zhou, Wenkai, Song, Jie, Ye, Ding, Mao, Yingying, Chen, Guo-Bo, Sun, Xiaohui“…We also observed suggestive evidence that interferon gamma-induced protein 10 (IP-10) was associated with a 10% higher risk of ALS (OR: 1.10, 95% CI: 1.03–1.17, P = 0.005) in the primary study. …”
Publicado 2023
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31652por Kleczko, Emily K., Hinz, Trista K., Nguyen, Teresa T., Gurule, Natalia J., Navarro, Andre, Le, Anh T., Johnson, Amber M., Kwak, Jeff, Polhac, Diana I., Clambey, Eric T., Weiser-Evans, Mary, Merrick, Daniel T., Yang, Michael C., Patil, Tejas, Schenk, Erin L., Heasley, Lynn E., Nemenoff, Raphael A.“…We previously demonstrated a positive association of a TKI-induced interferon gamma (IFNγ) transcriptional response with DOT in EGFR-mutant lung cancers. …”
Publicado 2023
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31653por Wang, Fengqing, Zhang, Qing, Zhang, Fanqing, Zhang, En, Li, Mei, Ma, Shiwei, Guo, Jianming, Yang, Zhibiao, Zhu, Jianguo“…We previously identified four single chain variable fragments (scFvs), ZW1-16, ZW3-21, ZW1-41, and ZW4-16, which specifically targeted the PEDV N protein and significantly inhibited PEDV replication and up-regulated interferon-λ1 (IFN-λ1) expression in host cells. In our current study, the four scFvs were subcloned into replication-defective adenovirus vectors to generate recombinant adenoviruses rAdV-ZW1-16, rAdV-ZW3-21, rAdV-ZW1-41, and rAdV-ZW4-16. …”
Publicado 2023
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31654por Zhu, Yanbin, Sun, Guangming, Dunzhu, Luosang, Li, Xin, Zhaxi, Luosang, Zhaxi, Suolang, Suolang, Ciyang, Yangji, Cidan, Wangdui, Basang, Pan, Feng, Peng, Quanhui“…Plasma aspartate aminotransferase (p = 0.002), alanine aminotransferase (p < 0.001), malondialdehyde (p = 0.001), tumor necrosis factor-α (p = 0.032) and interferon-γ (p = 0.017) of the high-protein group were significantly lesser, whereas superoxide dismutase (p = 0.004) and interleukin-2 (p = 0.007) was significantly greater than that of the low-protein group. …”
Publicado 2023
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31655por Labouret, Mathilde, Costi, Stefania, Bondet, Vincent, Trebossen, Vincent, Le Roux, Enora, Ntorkou, Alexandra, Bartoli, Sophie, Auvin, Stéphane, Bader-Meunier, Brigitte, Baudouin, Véronique, Corseri, Olivier, Dingulu, Glory, Ducrocq, Camille, Dumaine, Cécile, Elmaleh, Monique, Fabien, Nicole, Faye, Albert, Hau, Isabelle, Hentgen, Véronique, Kwon, Théresa, Meinzer, Ulrich, Ouldali, Naim, Parmentier, Cyrielle, Pouletty, Marie, Renaldo, Florence, Savioz, Isabelle, Rozenberg, Flore, Frémond, Marie-Louise, Lepelley, Alice, Rice, Gillian I., Seabra, Luis, Benoist, Jean-François, Duffy, Darragh, Crow, Yanick J., Ellul, Pierre, Melki, Isabelle“…A combination of standardized diagnostic criteria and multidisciplinary pediatric clinical expertise was combined to attribute NP involvement in the context of j-SLE. Neopterin and interferon-alpha (IFN-α) protein levels in cerebrospinal fluid (CSF) were assessed, together with routine biological and radiological investigations. …”
Publicado 2022
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31656por Taus, Ellie, Hofmann, Christian, Ibarrondo, F. Javier, Gong, Laura S., Hausner, Mary Ann, Fulcher, Jennifer A., Krogstad, Paul, Kitchen, Scott G., Ferbas, Kathie G., Tobin, Nicole H., Rimoin, Anne W., Aldrovandi, Grace M., Yang, Otto O.“…Although several studies have documented rapidly waning levels of vaccine-elicited antibodies, the kinetics of T cell responses have not been well defined. METHODS: Interferon (IFN)-γ enzyme-linked immunosorbent spot (ELISpot) assay and intracellular cytokine staining (ICS) were utilized to assess cellular immune responses (in isolated CD8+ T cells or whole peripheral blood mononuclear cells, PBMCs) to pooled peptides spanning spike. …”
Publicado 2023
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31657por Wang, Xiuneng, Wan, Min, Wang, Zhen, Zhang, Haitao, Zhu, Si, Cao, Xiufei, Xu, Ning, Zheng, Jichang, Bu, Xianyong, Xu, Wei, Mai, Kangsen, Ai, Qinghui“…The mRNA expressions of tumor necrosis factor α (tnfα), interleukin-1β (il-1β), interleukin-6 (il-6), and interferon γ (ifnγ) were significantly downregulated in fish fed diets with 0.05%-0.2% tributyrin, and the mRNA expression of il-10 was significantly upregulated in fish fed the 0.2% tributyrin diet (P < 0.05). …”
Publicado 2023
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31658“…He had a complete resolution of symptoms 1 month after a course of pulsed corticosteroid therapy, and was subsequently placed on maintenance therapy with interferon beta-1a. CONCLUSION: This case illustrates eight-and-a-half syndrome as the first presentation of a diffuse central nervous system pathology. …”
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31659“…In another set of experiments, littermate WT and NOD2 KO mice were re-infected with LCMV-C13 30-days following LCMV-Armstrong immunization, and the interferon-response in the small intestine was profiled by quantitative PCR to assess the effect of NOD2-deficiency on antigen recall responses. …”
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31660por Bhat, Sajad Ahmad, Hasan, Syed Kazim, Parray, Zahoor Ahmad, Siddiqui, Zaheenul Islam, Ansari, Shabnam, Anwer, Ayesha, Khan, Saniya, Amir, Fatima, Mehmankhah, Mahboubeh, Islam, Asimul, Minuchehr, Zarrin, Kazim, Syed Naqui“…BACKGROUND: Interferon and nucleos(t)ide analogues are current therapeutic treatments for chronic Hepatitis B virus (HBV) infection with the limitations of a functional cure. …”
Publicado 2023
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