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31661“…On day 35, IL 8 and IL 12 increased and then decreased (quadratic, P < 0.05) and interferon-gamma decreased and then increased (quadratic, P < 0.01) as hybrid rye inclusion increased. …”
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31662por Mohamed, Sara, Lucchini, Elisa, Sirianni, Francesca, Porrazzo, Marika, Ballotta, Laura, Ballerini, Mario, De Sabbata, Giovanni Maria, De Bellis, Eleonora, Cappuccio, Ilaria, Granzotto, Marilena, Toffoletto, Barbara, Fortunati, Ilaria, Russignan, Anna, Florea, Emilia Elzbieta, Torelli, Lucio, Zaja, Francesco“…SARS-CoV2-reactive T-cell analysis (interferon gamma release assays) was available since June 2022 and was evaluated at 12 months (T4) from the first dose of vaccine in 31/39 pts (79%). …”
Publicado 2023
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31663por Hyun, Hakjun, Jang, A-Yeung, Park, Heedo, Heo, Jung Yeon, Seo, Yu Bin, Nham, Eliel, Yoon, Jin Gu, Seong, Hye, Noh, Ji Yun, Cheong, Hee Jin, Kim, Woo Joo, Yoon, Soo-Young, Seok, Jong Hyeon, Kim, Jineui, Park, Man-Seong, Song, Joon Young“…The IgG anti-receptor binding domain (RBD) antibody titers, neutralizing antibody (NAb) titers (against wild type [WT] and Omicron [BA.1 and BA.5]), and Spike-specific interferon-γ responses of the participants were estimated at baseline, 3–4 weeks, 3 months, and 6 months after booster vaccination. …”
Publicado 2023
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31664por Mortensen, Rasmus Erik Johansson, Holmström, Morten Orebo, Lisle, Thomas Landkildehus, Hasselby, Jane P, Willemoe, Gro L, Met, Özcan, Marie Svane, Inge, Johansen, Julia, Nielsen, Dorte L, Chen, Inna M, Andersen, Mads Hald“…METHODS: Immune responses to a TGF-β-derived epitope entitled TGF-β-15 as well as epitopes from Clostridium tetani (tetanus) and influenza were measured in peripheral blood mononuclear cells (PBMCs) with interferon-ɣ enzyme-linked immunospot assays. PBMCs were isolated before and after treatment. …”
Publicado 2023
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31665por Gatti, Arianna, Fassini, Paola, Mazzone, Antonino, Rusconi, Stefano, Brando, Bruno, Mistraletti, Giovanni“…Monocyte CD169 is a type I interferon-inducible receptor that is up-regulated during viral infections, including COVID-19. …”
Publicado 2023
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31666por Larsen, Trine V., Dybdal, Nina, Daugaard, Tina F., Lade-Keller, Johanne, Lin, Lin, Sorensen, Boe S., Nielsen, Anders L.“…However, inducing PD-L1 mRNA expression with interferon-γ did not decrease the methylation level for these CpG sites, and using CRISPR-Cas9, we found that the CpG sites did not directly confer a negative regulation. dCas9-TET1 and dCas9-DNMT3A could induce PD-L1 hypo- and hyper-methylation, respectively, with the latter conferring a decrease in expression showing the functional impact of methylation. …”
Publicado 2023
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31667por Zhong, Fang-Min, Yao, Fang-Yi, Yang, Yu-Lin, Liu, Jing, Li, Mei-Yong, Jiang, Jun-Yao, Zhang, Nan, Xu, Yan-Mei, Li, Shu-Qi, Cheng, Ying, Xu, Shuai, Huang, Bo, Wang, Xiao-Zhong“…Cluster A was an immunosuppressive phenotype with reduced immune cell infiltration and significant activation of metabolism-related pathways such as reactive oxygen species, glycolysis and mTORC1; Cluster B was an immune activating phenotype with increased infiltration of CD4 + and CD8 + T cells and NK cells, and increased activation of signaling pathways such as interferon gamma (IFN-γ) response, IL6-JAK-STAT3 and inflammatory response. …”
Publicado 2023
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31668por Hwang, Mark, Assassi, Shervin, Zheng, Jim, Castillo, Jessica, Chavez, Reyna, Vanarsa, Kamala, Mohan, Chandra, Reveille, John“…IPA showed interleukin 23/17 (interleukin 22, interleukin 23A), TNF (TNF receptor-associated factor 3), cGAS-STING (cyclic GMP-AMP synthase, Stimulator of Interferon Gene 1), and Jak/Stat (Signal transducer and activator of transcription 1), signaling in predicted upstream regulators. …”
Publicado 2023
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31669por Tembo, Dumizulu, Harawa, Visopo, Tran, Tam C., Afran, Louise, Molyneux, Malcolm E., Taylor, Terrie E., Seydel, Karl B., Nyirenda, Tonney, Russell, David G., Mandala, Wilson“…RESULTS: Hz contributed towards an increase in the production of inflammatory cytokines, such as Interferon Gamma (IFN-γ), Tumor Necrosis Factor (TNF) and Interleukin 2 (IL-2) by various cells. …”
Publicado 2023
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31670por Harazim, Markéta, Perrot, Juliette, Varet, Hugo, Bourhy, Hervé, Lannoy, Julien, Pikula, Jiri, Seidlová, Veronika, Dacheux, Laurent, Martínková, Natália“…Bat adaptations to infection include localized immune response, early pathogen sensing, high interferon expression without pathogen stimulation, and regulated inflammatory response. …”
Publicado 2023
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31671por Ahmad, Syed Mudasir, Bhat, Sahar Saleem, Shafi, Shaista, Dar, Mashooq Ahmad, Saleem, Afnan, Haq, Zulfqarul, Farooq, Nida, Nazir, Junaid, Bhat, Basharat“…All the three differentially expressed genes (NF-κB1, FOXO3 and PaX5) showed their influence on 12 interacting proteins and 16 TFs, where cyclic adenosine monophosphate Response Element Binding protein (CREBBP), erythroblast transformation-specific (ETSI), Tumour-protein 53(TP53I), IKKBK, lymphoid enhancer-binding factor-1 (LEF1), and interferon regulatory factor-4 (IRF4) play role in immune responses. …”
Publicado 2023
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31672por Hernandez, Grethel N, Seffah, Kofi, Zaman, Mustafa Abrar, Awais, Nimra, Satnarine, Travis, Haq, Ayesha, Patel, Deepkumar, Gutlapalli, Sai Dheeraj, Ahmed, Areeg, Khan, Safeera“…All new dialysis patients should undergo interferon-gamma release assay testing. TB-infected patients with severe renal disease (eGFR 30 ml/min) had increased morbidity and mortality; however, the use of directly observed treatment, short-course (DOTS), and renal-dose adjustment of anti-TB medications significantly reduced these risks. …”
Publicado 2023
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31673por Yang, Li, Chen, Xiaomin, Lee, Christy, Shi, Jiejun, Lawrence, Emily B., Zhang, Lanjing, Li, Yumei, Gao, Nan, Jung, Sung Yun, Creighton, Chad J., Li, Jingyi Jessica, Cui, Ya, Arimura, Sumimasa, Lei, Yunping, Li, Wei, Shen, Lanlan“…Intriguingly, colon tumors with p16 epimutation exhibited an activated interferon pathway, increased expression of programmed death-ligand 1 (Pdl1), and enhanced infiltration of immune cells. scRNA-seq further revealed the presence of Foxp3(+) Tregs and γδT17 cells, which contribute to an immunosuppressive tumor microenvironment (TME). …”
Publicado 2023
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31674por Martini, Stefano, Marino, Franca, Magistrelli, Luca, Contaldi, Elena, Cosentino, Marco, Comi, Cristoforo“…Our primary endpoint is the assessment of changes in extracellular cytokine levels (Interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-4, and IL-10) and ROS production. …”
Publicado 2023
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31675por Saini, Chhavi, Jiang, Shuhong, Devlin, Julia, Pan, Li, Tang, Yizhen, Tang, Jing, Sun, Jessica A., Lorenzo, Maltish M., Wang, Qingyi, Pasquale, Louis R., Cho, Kin-Sang, Chen, Dong Feng, Shen, Lucy Q.“…METHODS: Peripheral blood monocytes (PBMC) were stimulated in culture with HSP27, α-crystallin, a member of the small HSP family, or HSP60. Both interferon-γ (IFN-γ)+ CD4+ T helper type 1 cells (Th1) and transforming growth factor-β1 (TGF-β1)+ CD4+ regulatory T cells (Treg) were quantified by flow cytometry and presented as a percentage of total PBMC counts. …”
Publicado 2023
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31676“…Serum interleukin-6 (IL-6), interferon -ɣ (IFN-ɣ), and vascular endothelial growth factor-α (VEGF-α) were also measured. …”
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31677por Kelly, Edward, Carney, Bonnie, Ziedins, Eriks, Parajuli, Babita, Burmeister, David, Moffatt, Lauren, Shupp, Jeffrey“…RNA was isolated from normal skin and peri-burn skin biopsies at hour 6 and qRT-PCR was conducted to assess levels of common inflammatory cytokines: interlukein-6 (IL-6), chemokine CXC motif ligand-8 (CXCL8), and interferon-gamma (IFN-y). RESULTS: At hour 2, LDI analysis demonstrated increased perfusion in the peri-burn skin of over-resuscitated animals when compared to adequate and under-resuscitated groups (p=0.002 and p=0.007, respectively). …”
Publicado 2023
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31678por Wang, Chih-Liang, Ho, Ai-Sheng, Chang, Chun-Chao, Sie, Zong-Lin, Peng, Cheng-Liang, Chang, Jungshan, Cheng, Chun-Chia“…Radiotherapy (RT) not only damages tumors but also induces interferon (IFN) expression in tumors. IFNs mediate PD-L1 to exhaust CD8(+) T cells, but which also directly impact tumor cells and potentially activate anti-tumor immune surveillance. …”
Publicado 2023
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31679por Vereertbrugghen, Alexia, Pizzano, Manuela, Sabbione, Florencia, Keitelman, Irene Angelica, Shiromizu, Carolina Maiumi, Aguilar, Douglas Vera, Fuentes, Federico, de Paiva, Cintia S., Giordano, Mirta, Trevani, Analía, Galletti, Jeremías G.“…Both Th1-skewed mice (measured by interferon-γ production) and Th2-skewed (measured by interleukin-4 production) developed comparable ocular surface inflammation and conjunctival CD4+ T cell recruitment but no appreciable corneal epithelial changes upon repeated local antigenic challenge. …”
Publicado 2023
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31680por Yuan, Hao-Xiang, Chen, Ya-Ting, Li, Yu-Quan, Wang, Yan-Sheng, Ou, Zhi-Jun, Li, Yan, Gao, Jian-Jun, Deng, Meng-Jie, Song, Yuan-Kai, Fu, Li, Ci, Hong-Bo, Chang, Feng-Jun, Cao, Yang, Jian, Yu-Peng, Kang, Bi-Ang, Mo, Zhi-Wei, Ning, Da-Sheng, Peng, Yue-Ming, Liu, Ze-Long, Liu, Xiao-Jun, Xu, Ying-Qi, Xu, Jun, Ou, Jing-Song“…The eEVs derived from PAI-1-stimulated endothelial cells could recognize TLR4 to stimulate a downstream signaling cascade identified as the Janus kinase 2/3 (JAK2/3)-signal transducer and activator of transcription 3 (STAT3)-interferon regulatory factor 1 (IRF-1) pathway, along with iNOS induction, and cytokine/chemokine production in vascular endothelial cells and C57BL/6 mice, ultimately contributing to ALI. …”
Publicado 2023
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