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31681por Ilori, Titilayo O., Brooks, Marquita S., Desai, Parin N., Cheung, Katharine L., Judd, Suzanne E., Crews, Deidra C., Cushman, Mary, Winkler, Cheryl A., Shlipak, Michael G., Kopp, Jeffrey B., Naik, Rakhi P., Estrella, Michelle M., Gutiérrez, Orlando M., Kramer, Holly“…RATIONALE & OBJECTIVE: Dietary factors may impact inflammation and interferon production, which could influence phenotypic expression of Apolipoprotein1 (APOL1) genotypes. …”
Publicado 2023
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31682por Arana Echarri, Ainhoa, Struszczak, Lauren, Beresford, Mark, Campbell, John P., Thompson, Dylan, Turner, James E.“…T cell function was assessed by unstimulated HLA-DR expression or interferon gamma (IFN-γ) production with Enzyme-linked ImmunoSpot assays following stimulation with virus or tumour-associated antigens. …”
Publicado 2023
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31683“…LPS lipopolysaccharide, TNF-α tumor necrosis factor-α, INF-γ Interferon gamma, ATP adenosine triphosphate, 49 P2Y12/13R purinergic P2Y 12/13 receptor, P2X4/7R purinergic P2X 4/7 receptor, SP Substance P, NK-1R Neurokinin 1 receptor, CCL2 CC motif ligand 2, CCR2 CC motif ligand 2 receptor, CSF-1 colony-stimulating factor 1, CSF-1R colony-stimulating factor 1 receptor, CX3CL1 CX3C motif ligand 1, CX3XR1 CX3C motif ligand 1 receptor, TLR toll-like receptor, MAPK mitogen-activated protein kinases, JNK jun N-terminal kinase, ERK extracellular signal-regulated kinase, iNOS Inducible nitric oxide synthase, IL-1β interleukin-1β, IL-6 interleukin-6, BDNF brain-derived neurotrophic factor, GABA γ-Aminobutyric acid, GABAR γ-Aminobutyric acid receptor, NMDAR N-methyl-D-aspartate receptor, AMPAR α-amino-3-hydroxy-5-methyl-4-isoxazolepropi-onic acid receptor, IL-4 interleukin-4, IL-13 interleukin-13, IL-10 interleukin-10, Arg-1 Arginase 1, FGF fibroblast growth factor, GDNF glial cell-derived neurotrophic factor, IGF-1 insulin-like growth factor-1, NGF nerve growth factor, CD Cluster of differentiation. …”
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31684por Cao, Wei, Liu, Xiaosheng, Han, Yang, Song, Xiaojing, Lu, Lianfeng, Li, Xiaodi, Lin, Ling, Sun, Lijun, Liu, An, Zhao, Hongxin, Han, Ning, Wei, Hongxia, Cheng, Jian, Zhu, Biao, Wang, Min, Li, Ying, Ma, Ping, Gao, Liying, Wang, Xicheng, Yu, Jianhua, Zhu, Ting, Routy, Jean-Pierre, Zuo, Min, Li, Taisheng“…The mean change of serum interferon-γ-induced protein 10 was −72.1 mg/L (95% CI −97.7, −46.5) in HT8 group at 48 weeks, markedly decreased compared to −22.8 mg/L (95% CI −47.1, 1.5, p = 0.007) in placebo group. …”
Publicado 2023
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31685por El-Raghi, Ali Ali, Hassan, Mahmoud A. E., Hashem, Nesrein M., Abdelnour, Sameh A.“…The addition of MEONE (400 or 800 mg/kg) decreased the concentrations of serum interleukin-4 (p = 0.0003), interferon gamma (p = 0.0004), and tumor necrosis factor-α (p < 0.0001) but significantly elevated (p < 0.001) the activity of nitric oxide, amyloid A and lysozyme. …”
Publicado 2023
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31686por Liao, Tsai-Ling, Chen, Yi-Ming, Tang, Kuo-Tung, Yang, Ying-Ying, Chen, Der-Yuan, Chan, Tsung-Hsien, Tsai, Hui-Ju, Hsieh, Shie-Liang“…Upregulated CLEC18A interacts with Rab5 and Rab7 and enhances type I/III interferon production to inhibit HCV replication in hepatocytes. …”
Publicado 2023
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31687por Raupov, Rinat, Suspitsin, Evgeny, Belozerov, Konstantin, Gabrusskaya, Tatiana, Kostik, Mikhail“…Both proteins are parts of the interferon (IFN) I signaling pathway and are responsible for antiviral defense and innate immune response. …”
Publicado 2023
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31688por Jin, Jie, Zhang, Lei, Qin, Albert, Wu, Daoxiang, Shao, Zonghong, Bai, Jie, Chen, Suning, Duan, Minghui, Zhou, Hu, Xu, Na, Zhang, Sujiang, Zuo, Xuelan, Du, Xin, Wang, Li, Li, Pei, Zhang, Xuhan, Li, Yaning, Zhang, Jingjing, Wang, Wei, Shen, Weihong, Zagrijtschuk, Oleh, Urbanski, Raymond, Sato, Toshiaki, Xiao, Zhijian“…Ropeginterferon alfa-2b represents a new-generation pegylated interferon-based therapy and is administered every 2–4 weeks. …”
Publicado 2023
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31689por Yang, Tao, Qu, Xiaoye, Zhao, Jiaying, Wang, Xiao, Wang, Qian, Dai, Jingjing, Zhu, Chuanlong, Li, Jun, Jiang, Longfeng“…However, it remains unidentified whether and how the macrophage PTEN may govern the innate immune signaling stimulator of interferon genes (STING) mediated inflammation and hepatocyte necroptosis in APAP-induced liver injury (AILI). …”
Publicado 2023
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31690por Gentile, Giordano, Mattiesing, Rozemarijn M., Brouwer, Iman, van Schijndel, Ronald A., Uitdehaag, Bernard M.J., Twisk, Jos W.R., Kappos, Ludwig, Freedman, Mark S., Comi, Giancarlo, Jack, Dominic, Barkhof, Frederik, De Stefano, Nicola, Vrenken, Hugo, Battaglini, Marco“…Patients received early (from baseline; N = 258; ET) or delayed treatment (from month-24; N = 129; DT) with subcutaneous interferon beta-1a. FSL-SIENA/VIENA were used to provide yearly percentage volume change of brain (PBVC) and ventricles (PVVC). …”
Publicado 2023
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31691por Wang, Xin-Yuan, Zhou, Yu-Jie, Chen, Hai-Ying, Chen, Jin-Nan, Chen, Shan-Shan, Chen, Hui-Min, Li, Xiao-Bo“…Bioinformatics analyses revealed that its low expression was associated with a low interferon γ response and also with many metabolic pathways such as riboflavin, retinol, and cytochrome p450 drug metabolism pathways. …”
Publicado 2023
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31692por Dybowska, Dorota, Zarębska-Michaluk, Dorota, Rzymski, Piotr, Berak, Hanna, Lorenc, Beata, Sitko, Marek, Dybowski, Michał, Mazur, Włodzimierz, Tudrujek-Zdunek, Magdalena, Janocha-Litwin, Justyna, Janczewska, Ewa, Klapaczyński, Jakub, Parfieniuk-Kowerda, Anna, Piekarska, Anna, Sobala-Szczygieł, Barbara, Dobrowolska, Krystyna, Pawłowska, Malgorzata, Flisiak, Robert“…Patients with severe psychiatric disorders could not be treated with previously available interferon-based therapies due to their unfavorable side effect profile. …”
Publicado 2023
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31693por São José, Celina, Garcia-Pelaez, José, Ferreira, Marta, Arrieta, Oscar, André, Ana, Martins, Nelson, Solís, Samantha, Martínez-Benítez, Braulio, Ordóñez-Sánchez, María Luisa, Rodríguez-Torres, Maribel, Sommer, Anna K., te Paske, Iris B. A. W., Caldas, Carlos, Tischkowitz, Marc, Tusié, Maria Teresa, Hoogerbrugge, Nicoline, Demidov, German, de Voer, Richarda M., Laurie, Steve, Oliveira, Carla“…CRISPR-Cas9 edited cells mimicking the CDH1-TANGO6 deletion display the strongest CDH1 mRNA downregulation, more impacted adhesion-associated, type-I interferon immune-associated and oncogenic signalling pathways, compared to wild-type or CDH1-deleted cells. …”
Publicado 2023
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31694por Gao, Jing, Wang, Zhengyi, Jiang, Wenqing, Zhang, Yanni, Meng, Zhen, Niu, Yanling, Sheng, Zhen, Chen, Chan, Liu, Xuejun, Chen, Xi, Liu, Chanjuan, Jia, Keren, Zhang, Cheng, Liao, Haiyan, Jung, Jaeho, Sung, Eunsil, Chung, Hyejin, Zhang, Jingwu Z., Zhu, Andrew X., Shen, Lin“…Mechanistically, givastomig/ABL111 treatment could upregulate the expression of a panel of pro-inflammatory and interferon-γ-responsive genes in human peripheral blood mononuclear cells when co-cultured with CLDN18.2(+) tumor cells. …”
Publicado 2023
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31695por Fan, Yu-Ching, Fong, Yu-Cin, Kuo, Chun-Tse, Li, Chia-Wei, Chen, Wei-Yu, Lin, Jian-Da, Bürtin, Florian, Linnebacher, Michael, Bui, Quoc Thang, Lee, Kuan-Der, Tsai, Yuan-Chin“…We showed that IL-1Ra suppressed T cell receptor signaling and inhibited antigen-specific interferon-γ (IFN-γ) secretion and cytolytic activity in splenocytes. …”
Publicado 2023
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31696por Al-Zghoul, Mohammad Borhan, Jaradat, Ziad Waheed, Ababneh, Mustafa M., Okour, Mohammad Ziad, Saleh, Khaled Musa Mohammad, Alkofahi, Ayesha, Alboom, Mohammad Hussien“…This study aimed to evaluate the impact of TM during embryogenesis, concomitant with an Escherichia coli challenge, on body weight (BW), body temperature (T(b)), and splenic mRNA expression of cytokines (Interleukin [IL]-1β, IL-2, IL-6, IL-8, IL-12, IL-15, IL-16, IL-18, and interferon [IFN]-γ) in poultry. MATERIALS AND METHODS: A total of 740 fertile eggs were procured from a certified Ross broiler breeder. …”
Publicado 2023
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31697por Bell, Christopher, Graham, Jonathan, Earnshaw, Stephanie, Oleen-Burkey, MerriKay, Castelli-Haley, Jane, Johnson, Kenneth“…Symptomatic management for MS has been supplemented in the past decade by 2 new classes of immunomodulatory therapies that have been approved as first-line treatments for relapsing-remitting multiple sclerosis (RRMS): subcutaneous glatiramer acetate (SC GA) and 3 b-interferons: intramuscular interferon b-1a (IM IFNb-1a), SC IFNb-1a, and SC IFNb-1b. …”
Publicado 2007
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31698por Manos, M. Michele, Darbinian, Jeanne, Rubin, Jaime, Ray, G. Thomas, Shvachko, Valentina, Deniz, Baris, Velez, Fulton, Quesenberry, Charles“…METHODS: Kaiser Permanente Medical Care Program patients receiving HCV treatment with pegylated interferon and ribavirin (Peg-IFN/RBV) from 2002 to 2007 were retrospectively analyzed, excluding those with human immunodeficiency virus (HIV) or chronic hepatitis B. …”
Publicado 2013
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31699por Trono, Paola, Tocci, Annalisa, Palermo, Belinda, Di Carlo, Anna, D'Ambrosio, Lorenzo, D'Andrea, Daniel, Di Modugno, Francesca, De Nicola, Francesca, Goeman, Frauke, Corleone, Giacomo, Warren, Sarah, Paolini, Francesca, Panetta, Mariangela, Sperduti, Isabella, Baldari, Silvia, Visca, Paolo, Carpano, Silvia, Cappuzzo, Federico, Russo, Vincenzo, Tripodo, Claudio, Zucali, Paolo, Gregorc, Vanesa, Marchesi, Federica, Nistico, Paola“…Among the pathways that can affect ICB response is the interferon (IFN) pathway that may be both detrimental and beneficial. …”
Publicado 2023
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31700“…Meanwhile, ATG5 was inversely associated with T helper (Th) 1 cells (P = 0.008), while it was positively linked with Th2 cells (P < 0.001), Th2/Th1 ratio (P < 0.001), interleukin (IL)-4 (P = 0.002), and IL-4/interferon-γ ratio (P = 0.015). Additionally, ATG5 was positively correlated with tumor necrosis factor-α (P < 0.001), IL-1β (P = 0.001), IL-6 (P = 0.003), and IL-17 (P = 0.029). …”
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