-
31701A new NRF2 activator for the treatment of human metabolic dysfunction-associated fatty liver diseasepor Hammoutene, Adel, Laouirem, Samira, Albuquerque, Miguel, Colnot, Nathalie, Brzustowski, Angélique, Valla, Dominique, Provost, Nicolas, Delerive, Philippe, Paradis, Valérie“…Additional inflammatory markers (chemokine (C–C motif) ligand 5 [CCL5], stimulator of interferon genes [STING], intercellular adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1]) were downregulated by S217879. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31702por Shisha, Tamas, Posch, Maximilian G., Lehmann, Jeanette, Feifel, Roland, Junt, Tobias, Hawtin, Stuart, Schuemann, Jens, Avrameas, Alexandre, Danekula, Rambabu, Misiolek, Patrycja, Siegel, Richard, Gergely, Peter“…BACKGROUND AND OBJECTIVE: MHV370, a dual antagonist of human Toll-like receptors (TLR) 7 and 8, suppresses cytokines and interferon-stimulated genes in vitro and in vivo, and has demonstrated efficacy in murine models of lupus. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31703por Zhang, Yandong, Ma, Shu, Li, Tie, Tian, Yu, Zhou, Huangao, Wang, Hongsheng, Huang, Lan“…Type 1 innate lymphocytes (ILC1s) are present in high numbers in intestinal tissues and are characterized by the expression of the transcription factor T-bet and the secretion of interferon (IFN)-γ, which can promote macrophages to polarize toward the classically activated antitumor M1 phenotype. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31704por Schäfer, Helene, Subbarayan, Karthikeyan, Massa, Chiara, Vaxevanis, Christoforos, Mueller, Anja, Seliger, Barbara“…RESULTS: Bioinformatics analysis revealed a heterogeneous, but statistically significant reduced PRELP expression in available datasets of skin cutaneous melanoma when compared to adjacent normal tissues, which was associated with reduced patients’ survival, low expression levels of components of the MHC class I antigen processing machinery (APM) and interferon (IFN)-γ signal transduction pathway, but increased expression of the transforming growth factor (TGF)-β isoform 1 (TFGB1) and TGF-β receptor 1 (TGFBR1). …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31705por Selich, Anton, Fleischauer, Jenni, Roepke, Tina, Weisskoeppel, Luisa, Galla, Melanie, von Kaisenberg, Constantin, Maus, Ulrich A., Schambach, Axel, Rothe, Michael“…The best candidates were combined with interferon-induced GAS or ISRE DNA motifs. The constructs with the highest transgene expression upon addition of pro-inflammatory cytokines were compared to vectorized promoters from inflammation-induced genes (CD317, CXCL9, CXCL10, CXCL11 and IDO1). …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31706por Wang, Shichong, Huo, Jiali, Liu, Yilin, Chen, Lingyun, Ren, Xiang, Li, Xingxin, Wang, Min, Jin, Peng, Huang, Jinbo, Nie, Neng, Zhang, Jing, Shao, Yingqi, Ge, Meili, Zheng, Yizhou“…The Gene Ontology analysis of differentially expressed genes (DEGs) revealed involvement of various cellular processes, such as lymphocyte chemotaxis, lymphocyte migration and response to interferon-gamma. The Kyoto Encyclopedia of Genes and Genomes analysis illustrated upregulation of critical pathways associated with T cell function after coculturing with AA-Exos compared with HD-Exos, such as graft-versus-host disease, Th17 cell differentiation and JAK-STAT signaling pathway. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31707“…To assess how GPR31 might impact macrophage function, we induced proinflammatory M1 polarization by lipopolysaccharide and interferon gamma in bone marrow-derived macrophages. …”
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31708por Lin, Ching-Hung, Chen, BoJia, Chao, Day-Yu, Hsieh, Feng-Cheng, Yang, Chun-Chun, Hsu, Hsuan-Wei, Tam, Hon-Man-Herman, Wu, Hung-Yi“…In addition, the alterations of DVGs in amounts and species under different infection environments and selection pressures including the treatment of antiviral remdesivir and interferon were evaluated based on the banding patterns by RT-PCR. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31709por Langer-Gould, Annette M., Smith, Jessica B., Gonzales, Edlin G., Piehl, Fredrik, Li, Bonnie H.“…RESULTS: Six thousand, six hundred and twenty-six patients with MS with 11,929 treatment episodes (2,487 rituximab, 546 natalizumab, 298 fingolimod, 4,629 interferon-beta/glatiramer acetate, IFN/GLAT, and 3,969 untreated) and 33,550 population controls were included in the analyses. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31710“…Oral administration of QL-1200186 dose-dependently inhibited interferon-γ (IFNγ) production after interleukin-12 (IL-12) challenge and significantly ameliorated skin lesions in psoriatic mice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31711por O’Brien, Eleanor, Tse, Carmen, Tracy, Ian, Reddin, Ian, Selfe, Joanna, Gibson, Jane, Tapper, William, Pengelly, Reuben J., Gao, Jinhui, Aladowicz, Ewa, Petts, Gemma, Thway, Khin, Popov, Sergey, Kelsey, Anna, Underwood, Timothy J., Shipley, Janet, Walters, Zoë S.“…In PAX3-FOXO1 positive RMS cells this is due to an RA-driven induction of the interferon pathway resulting in apoptosis. In fusion negative RMS, combination therapy led to an EZH2i-driven upregulation of myogenic signalling resulting in differentiation. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31712por Mizera, Dorota, Dziedzic, Radosław, Drynda, Anna, Gradzikiewicz, Ada, Jakieła, Bogdan, Celińska-Löwenhoff, Magdalena, Padjas, Agnieszka, Matyja-Bednarczyk, Aleksandra, Zaręba, Lech, Bazan-Socha, Stanisława“…T-cell responses were assessed at a median of 21 (13 – 30) weeks after the booster dose (mainly the third dose) using commercially available interferon-gamma release assay (IGRA) with recombinant SARS-CoV-2 spike S1 protein. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31713“…Results: AS-IV exhibited a dose-dependent inhibition of proliferation in Huh-7 and SMMC-7721 while inhibiting PD-L1 expression induced by interferon-γ (IFN-γ), thus attenuating PD-L1-mediated immune suppression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31714por Elgendy, Salwa A., Soliman, Mohamed Mohamed, Ghamry, Heba I., Shukry, Mustafa, Mohammed, Lina Abdelhady, Nasr, Hend Elsayed, Alotaibi, Badriyah S., Jafri, Ibrahim, Sayed, Samy, Osman, Amira, Elnoury, Heba A.“…Quantitative RT-PCR was used to express interferon-gamma (INF-γ), cyclooxygenase-2 (COX-2), OGG1, BAX, caspase-3, B-cell lymphoma-2 (Bcl-2), and superoxide dismutase (SOD) genes in cardiac tissues, which are correlated with inflammation, antioxidants, and apoptosis. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31715A comprehensive prognostic score for head and neck squamous cancer driver genes and phenotype traitspor Zeng, Wen, Xie, Fangfang, Pan, Yiyun, Chen, Zhengcong, Chen, Hailong, Liu, Xiaomei, Tian, Keqiang, Xu, Dechang“…High APMHO samples showed significantly higher mutation rate, enriched tumor-related pathways including Hypoxia, unfold_protein_response, Glycolysis, and mTORC1 signaling, along with differences in immune cell infiltration and immune checkpoint, interferon-γ pathway and m6A regulator expression patterns. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31716por Dragon, Anna Christina, Beermann, Luca Marie, Umland, Melina, Bonifacius, Agnes, Malinconico, Chiara, Ruhl, Louisa, Kehler, Patrik, Gellert, Johanna, Weiß, Lisa, Mayer-Hain, Sarah, Zimmermann, Katharina, Riese, Sebastian, Thol, Felicitas, Beutel, Gernot, Maecker-Kolhoff, Britta, Yamamoto, Fumiichiro, Blasczyk, Rainer, Schambach, Axel, Hust, Michael, Hudecek, Michael, Eiz-Vesper, Britta“…Importantly, they also released effector molecules (e.g. interferon-γ, granzyme B and perforin), mediated cytotoxicity against CD176(+) cancer cells, and maintained functionality upon repetitive antigen stimulation. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31717por Song, Guangjun, Yang, Ruifeng, Jin, Qian, Liu, Juan, Rao, Huiying, Feng, Bo, Xie, Yandi“…BACKGROUND: Previous studies have indicated that HBV pregenome RNA (HBV pgRNA) could predict HBeAg seroconversion among the chronic hapatitis B (CHB) patients treated with pegylated interferon (Peg-IFN) or nucleos(t)ide analogues (NAs). …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31718por Liu, Senrui, Cheng, Shengwen, Chen, Bowen, Xiao, Pengcheng, Zhan, Jingdi, Liu, Jiacheng, Chen, Zhuolin, Liu, Junyan, Zhang, Tao, Lei, Yiting, Huang, Wei“…RESULT: We employed Interferon-gamma (IFN-γ) as a stem cell-specific stimulus to generate IFN-γ-microvesicles (iMVs) with enhanced anti-ageing effects. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31719por Neale, Isabel, Ali, Mohammad, Kronsteiner, Barbara, Longet, Stephanie, Abraham, Priyanka, Deeks, Alexandra S., Brown, Anthony, Moore, Shona C., Stafford, Lizzie, Dobson, Susan L., Plowright, Megan, Newman, Thomas A. H., Wu, Mary Y., Carr, Edward J., Beale, Rupert, Otter, Ashley D., Hopkins, Susan, Hall, Victoria, Tomic, Adriana, Payne, Rebecca P., Barnes, Eleanor, Richter, Alex, Duncan, Christopher J. A., Turtle, Lance, de Silva, Thushan I., Carroll, Miles, Lambe, Teresa, Klenerman, Paul, Dunachie, Susanna“…Using samples from 28 d after the second vaccine dose, before all breakthroughs occurred, we observed future cases had lower ancestral spike (S)- and receptor binding domain-specific IgG titers and S1- and S2-specific T cell interferon gamma (IFNγ) responses compared with controls, although these differences did not persist when individuals were stratified according to previous infection status before vaccination. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
31720por Mithal, Leena B, Lorenzo-Redondo, Ramon, Sunderraj, Ashwin, Shanes, Elisheva D, Goldstein, Jeffrey A“…We found significantly upregulated genes in villous areas of placentitis (neutrophil degranulation and interferon signaling; Fig 3) compared to normal SARS-CoV-2 cases. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Online Artículo Texto