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31861por Bharadwaj, Alamelu G., Dahn, Margaret L., Liu, Rong-Zong, Colp, Patricia, Thomas, Lynn N., Holloway, Ryan W., Marignani, Paola A., Too, Catherine K. L., Barnes, Penelope J., Godbout, Roseline, Marcato, Paola, Waisman, David M.“…The PyMT/p11-KO tumors displayed a remarkable increase in inflammatory cytokines such as interleukin (Il)-6, Il-10, and interferon (Ifn)-γ. Gene expression profiling and IHC of primary breast cancer samples showed that p11 mRNA and protein levels were significantly higher in tumor tissues compared to normal mammary tissue. …”
Publicado 2020
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31862“…Physiological function of TMEFF2 is elusive; however, the protein is reported to be involved in wide-ranging physiological and pathological functions including neuroprotection in Alzheimer’s diseases, interferon induction and one-carbon metabolism. Moreover, the TMEFF2 promoter and 5′-upstream regions harbour a CpG island which is progressively methylated upon progression in a wide variety of cancers. …”
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31863por Prokopi, Anastasia, Tripp, Christoph H, Tummers, Bart, Hornsteiner, Florian, Spoeck, Sarah, Crawford, Jeremy Chase, Clements, Derek R, Efremova, Mirjana, Hutter, Katharina, Bellmann, Lydia, Cappellano, Giuseppe, Cadilha, Bruno L, Kobold, Sebastian, Boon, Louis, Ortner, Daniela, Trajanoski, Zlatko, Chen, Suzie, de Gruijl, Tanja D, Idoyaga, Juliana, Green, Douglas R, Stoitzner, Patrizia“…At the same time, the DC boost approach reinforced migratory dermal DC subsets to prime gp100-specific CD8+ T cells in tumor-draining LNs that expressed PD-1/TIM-3 and produced interferon γ (IFNγ)/tumor necrosis factor α (TNFα). …”
Publicado 2021
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31864por Slingluff, Jr., Craig L, Petroni, Gina R, Chianese-Bullock, Kimberly A, Wages, Nolan A, Olson, Walter C, Smith, Kelly T, Haden, Kathleen, Dengel, Lynn T, Dickinson, Anna, Reed, Caroline, Gaughan, Elizabeth M, Grosh, William W, Kaur, Varinder, Varhegyi, Nikole, Smolkin, Mark, Galeassi, Nadejda V, Deacon, Donna, Hall, Emily H“…T cell responses were measured by interferon γ ELIspot assay ex vivo. Serum Ab responses to 6MHP were measured by ELISA. …”
Publicado 2021
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31865por Schares, Gereon, Globokar Vrhovec, Majda, Tuschy, Mareen, Joeres, Maike, Bärwald, Andrea, Koudela, Bretislav, Dubey, Jitender P., Maksimov, Pavlo, Conraths, Franz J.“…The newly established TaqMan PCR (Hham-qPCR1) was applied to tissues collected from H. hammondi-infected gamma-interferon gene knockout (GKO) mice at varying time points post-infection. …”
Publicado 2021
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31866por Bastard, Paul, Rosen, Lindsey B., Zhang, Qian, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Zhang, Yu, Dorgham, Karim, Philippot, Quentin, Rosain, Jérémie, Béziat, Vivien, Manry, Jérémy, Shaw, Elana, Haljasmägi, Liis, Peterson, Pärt, Lorenzo, Lazaro, Bizien, Lucy, Trouillet-Assant, Sophie, Dobbs, Kerry, de Jesus, Adriana Almeida, Belot, Alexandre, Kallaste, Anne, Catherinot, Emilie, Tandjaoui-Lambiotte, Yacine, Le Pen, Jeremie, Kerner, Gaspard, Bigio, Benedetta, Seeleuthner, Yoann, Yang, Rui, Bolze, Alexandre, Spaan, András N., Delmonte, Ottavia M., Abers, Michael S., Aiuti, Alessandro, Casari, Giorgio, Lampasona, Vito, Piemonti, Lorenzo, Ciceri, Fabio, Bilguvar, Kaya, Lifton, Richard P., Vasse, Marc, Smadja, David M., Migaud, Mélanie, Hadjadj, Jérome, Terrier, Benjamin, Duffy, Darragh, Quintana-Murci, Lluis, van de Beek, Diederik, Roussel, Lucie, Vinh, Donald C., Tangye, Stuart G., Haerynck, Filomeen, Dalmau, David, Martinez-Picado, Javier, Brodin, Petter, Nussenzweig, Michel C., Boisson-Dupuis, Stéphanie, Rodríguez-Gallego, Carlos, Vogt, Guillaume, Mogensen, Trine H., Oler, Andrew J., Gu, Jingwen, Burbelo, Peter D., Cohen, Jeffrey I., Biondi, Andrea, Bettini, Laura Rachele, D'Angio, Mariella, Bonfanti, Paolo, Rossignol, Patrick, Mayaux, Julien, Rieux-Laucat, Frédéric, Husebye, Eystein S., Fusco, Francesca, Ursini, Matilde Valeria, Imberti, Luisa, Sottini, Alessandra, Paghera, Simone, Quiros-Roldan, Eugenia, Rossi, Camillo, Castagnoli, Riccardo, Montagna, Daniela, Licari, Amelia, Marseglia, Gian Luigi, Duval, Xavier, Ghosn, Jade, Tsang, John S., Goldbach-Mansky, Raphaela, Kisand, Kai, Lionakis, Michail S., Puel, Anne, Zhang, Shen-Ying, Holland, Steven M., Gorochov, Guy, Jouanguy, Emmanuelle, Rice, Charles M., Cobat, Aurélie, Notarangelo, Luigi D., Abel, Laurent, Su, Helen C., Casanova, Jean-Laurent“…We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. …”
Publicado 2020
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31867por Lasseter, Heather C., Provost, Allison C., Chaby, Lauren E., Daskalakis, Nikolaos P., Haas, Magali, Jeromin, Andreas“…This initial assessment focused on four cytokines that have been implicated PTSD – interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ. To assess platform performance and understand likely measurements in individuals with brain disorders, serum and plasma samples were obtained from individuals with PTSD (n = 13) or Parkinson’s Disease (n = 14) as well as healthy controls (n = 5). …”
Publicado 2020
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31868por Chiamulera, Mayara Martina Abatti, Zancan, Caroline Biazzolo, Remor, Aline Pertile, Cordeiro, Marcos Freitas, Gleber-Netto, Frederico Omar, Baptistella, Antuani Rafael“…METHODS: In this systematic review and meta-analysis we identified SC studied as OC biomarkers by systematically reviewing the PubMed and Cochrane Library databases using the terms: “oral cancer”, “cytokine”, and “saliva”, and also combined with “interleukin” or “interferon”. Only case-control studies that measured SC by ELISA from treatment naïve patients were included in the qualitative review. …”
Publicado 2021
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31869“…Second, we used western blotting (WB) and quantitative real-time polymerase chain reaction (qRT-PCR) to detect the expression of interferon stimulated gene 15 (ISG15) and transcription factor EB (TFEB) in mBMSCs. …”
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31870por Florian, Maria, Wang, Jia-Pey, Deng, Yupu, Souza-Moreira, Luciana, Stewart, Duncan J., Mei, Shirley H. J.“…Moreover, compared to pANGPT1, the MC-ANGPT1 transfected MSCs significantly reduced pulmonary inflammation, as observed in decreased levels of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-2 (MIP-2). pANGPT1-transfected MSCs significantly reduced BAL albumin levels by 71%, while MC-ANGPT1-transfected MSCs reduced it by 85%. …”
Publicado 2021
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31871por Spinnen, J., Fröhlich, K., Sinner, N., Stolk, M., Ringe, J., Shopperly, L., Sittinger, M., Dehne, T., Seifert, M.“…Direct stimulation of peripheral blood mononuclear cells (PBMCs) with high dosages of CCL25 resulted in strong increases in the secretion of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), interleukin-1β (IL-1β), tumor-necrosis-factor-α (TNF-α) and interferon-γ (IFN-γ), upregulation of human leukocyte antigen-DR (HLA-DR) on monocytes and CD4(+) T-cells, as well as immune cell migration along a CCL25 gradient. …”
Publicado 2021
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31872por Gatti, Gerardo, Betts, Courtney, Rocha, Darío, Nicola, Maribel, Grupe, Verónica, Ditada, Cecilia, Nuñez, Nicolas G., Roselli, Emiliano, Araya, Paula, Dutto, Jeremías, Boffelli, Lucia, Fernández, Elmer, Coussens, Lisa M., Maccioni, Mariana“…To this end, we focused in the expression of interferon regulatory factor 8 (IRF8) in BC cells. IRF8 is a transcription factor which plays a well-determined role in myeloid cells and that seems to have multiple antitumoral roles: it has tumor suppressor functions; it acts downstream IFN/STAT1, required for the success of some therapeutic regimes, and its expression in neoplastic cells seems to depend on a cross talk between the immune contexture and the tumor cells. …”
Publicado 2021
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31873por Brochado, Óscar, Martínez, Isidoro, Berenguer, Juan, Medrano, Luz, González-García, Juan, Jiménez-Sousa, María Ángeles, Carrero, Ana, Hontañón, Víctor, Navarro, Jordi, Guardiola, Josep M., Fernández-Rodríguez, Amanda, Resino, Salvador“…OBJECTIVE: To evaluate the impact of hepatitis C virus (HCV) elimination via interferon (IFN)-based therapy on gene expression profiles related to the immune system in HIV/HCV-coinfected patients. …”
Publicado 2021
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31874por Chen, Zhilei, Liu, Suying, He, Chengmei, Sun, Jinlei, Wang, Li, Chen, Hua, Zhang, Fengchun“…MAIT cells from PBC produced significantly more interferon-γ (IFN-γ) (88.3 ± 4.2% vs. 64.2 ± 10.1%, p < 0.01), tumor necrosis factor-α (TNF-α) (93.0 ± 1.1% vs. 80.1 ± 5.3%, p < 0.01), Granzyme B (89.3 ± 3.3% vs. 72.1 ± 7.0%, p < 0.01), and perforin (46.8 ± 6.6% vs. 34.8 ± 7.7%, p < 0.05). …”
Publicado 2021
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31875por de Lima, Lorena Leticia Peixoto, de Oliveira, Allysson Quintino Tenório, Moura, Tuane Carolina Ferreira, da Silva Graça Amoras, Ednelza, Lima, Sandra Souza, da Silva, Andrea Nazaré Monteiro Rangel, Queiroz, Maria Alice Freitas, Cayres-Vallinoto, Izaura Maria Vieira, Ishak, Ricardo, Vallinoto, Antonio Carlos Rosário“…The production of type I interferon (IFN) is key to the innate immune response to viral infections. …”
Publicado 2021
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31876por Van der Meer, J. M. R., Maas, R. J. A., Guldevall, K., Klarenaar, K., de Jonge, P. K. J. D., Evert, J. S. Hoogstad-van, van der Waart, A. B., Cany, J., Safrit, J. T., Lee, J. H., Wagena, E., Friedl, P., Önfelt, B., Massuger, L. F., Schaap, N. P. M., Jansen, J. H., Hobo, W., Dolstra, H.“…N-803 increased HPC-NK cell proliferation and interferon (IFN)γ production. On leukemia cells, co-culture with HPC-NK cells and N-803 increased ICAM-1 expression. …”
Publicado 2020
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31877por Schnappauf, Oskar, Heale, Liane, Dissanayake, Dilan, Tsai, Wanxia L., Gadina, Massimo, Leto, Thomas L., Kastner, Daniel L., Malech, Harry L., Kuhns, Douglas B., Aksentijevich, Ivona, Laxer, Ronald M.“…Gene expression analysis in peripheral blood detected an interferon gene expression signature, which was further supported by cytokine analyses of supernatants of cultured patient’s cells. …”
Publicado 2021
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31878por Thudium, Rebekka F., Ringheim, Hedda, Ronit, Andreas, Hoel, Hedda, Benfield, Thomas, Mocroft, Amanda, Gerstoft, Jan, Trøseid, Marius, Borges, Álvaro H., Ostrowski, Sisse R., Vestbo, Jørgen, Nielsen, Susanne D.“…We investigated whether elevated cytokine concentrations (interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-2, IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor-alpha (TNFα), interferon-gamma (IFNγ), soluble CD14 (sCD14) and sCD163 were independently associated with radiographic emphysema in PLWH. …”
Publicado 2021
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31879“…Infectious workup was unremarkable other than a positive interferon-gamma release assay. As for TB risk factors, the patient immigrated to the United States from Albania about 13 years prior. …”
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31880por Wilfinger, William W., Miller, Robert, Eghbalnia, Hamid R., Mackey, Karol, Chomczynski, Piotr“…STRING database analysis of these genes identified interferon-mediated response networks in 11–20% of the individuals sampled at the time of blood collection. …”
Publicado 2021
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