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31881“…C3 and C4 levels were normal as well. Interferon-gamma release assay was negative. Imaging showed a normal chest X-ray. …”
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31882“…The intracellular cytokine staining assay revealed that 18 out of 54 peptides were active as CTL epitopes because of the induction of gamma interferon (IFN-γ)-producing CD8(+) T cells. Of the 18 peptides, 10 peptides were chosen for the following analyses because of their high responses. …”
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31883por Sobol, Robert E., Menander, Kerstin B., Chada, Sunil, Wiederhold, Dora, Sellman, Beatha, Talbott, Max, Nemunaitis, John J.“…Preliminary gene expression profiling results revealed that Ad-p53 treatment increased interferon signaling, decreased TGF-beta and beta-catenin signaling resulting in an increased CD8(+) T cell signature which are associated with increased responses to immune checkpoint blockade. …”
Publicado 2021
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31884por Alshamrani, Foziah, Alnajashi, Hind, AlJumah, Mohammed, Almuaigel, Mohammad, Almalik, Yaser, Makkawi, Seraj, Alsalman, Sadiq, Almejally, Mousa, Qureshi, Shireen, Aljarallah, Salman, AlKhawajah, Nuha, Kedah, Hanaa, Alotaibi, Hessa, Saeedi, Jameelah, Alamri, Abdulla“…Of the 53 (75.7%) patients receiving a DMT at the time of COVID-19 infection, the most frequently used DMTs were fingolimod (25%) and interferon-beta (25%). Nine (13%) patients had MS relapse and were treated with intravenous methylprednisolone in the four weeks before COVID-19 infection. …”
Publicado 2021
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31885por Werner, Lauryn R, Gibson, Katelin A, Goodman, Merit L, Helm, Dominika E, Walter, Katherine R, Holloran, Sean M, Trinca, Gloria M, Hastings, Richard C, Yang, Howard H, Hu, Ying, Wei, Junping, Lei, Gangjun, Yang, Xiao-Yi, Madan, Rashna, Molinolo, Alfredo A, Markiewicz, Mary A, Chalise, Prabhakar, Axelrod, Margaret L, Balko, Justin M, Hunter, Kent W, Hartman, Zachary C, Lange, Carol A, Hagan, Christy R“…Recently, we reported a link between PR and immune signaling pathways, showing that P4/PR can repress type I interferon signaling pathways. Given these findings, we sought to investigate whether P4/PR drive immunomodulation in the mammary gland and promote tumor formation. …”
Publicado 2021
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31886por Ligon, John A, Choi, Woonyoung, Cojocaru, Gady, Fu, Wei, Hsiue, Emily Han-Chung, Oke, Teniola F, Siegel, Nicholas, Fong, Megan H, Ladle, Brian, Pratilas, Christine A, Morris, Carol D, Levin, Adam, Rhee, Daniel S, Meyer, Christian F, Tam, Ada J, Blosser, Richard, Thompson, Elizabeth D, Suru, Aditya, McConkey, David, Housseau, Franck, Anders, Robert, Pardoll, Drew M, Llosa, Nicolas“…TILs from PMs exhibited significantly higher amounts of PD-1 and LAG-3 and functional cytokines including interferon-γ (IFNγ) by flow cytometry. Gene expression profiling further confirmed the presence of CD8 and CD4 lymphocytes concentrated at the PM interface, along with upregulation of immunoregulatory molecules and IFNγ-driven genes in the same region. …”
Publicado 2021
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31887por Dhindsa, Sandeep, Zhang, Nan, McPhaul, Michael J., Wu, Zengru, Ghoshal, Amit K., Erlich, Emma C., Mani, Kartik, Randolph, Gwendalyn J., Edwards, John R., Mudd, Philip A., Diwan, Abhinav“…Testosterone concentrations were inversely associated with concentrations of interleukin 6 (β = −0.43; 95% CI, −0.52 to −0.17; P < .001), C-reactive protein (β = −0.38; 95% CI, −0.78 to −0.16; P = .004), interleukin 1 receptor antagonist (β = −0.29; 95% CI, −0.64 to −0.06; P = .02), hepatocyte growth factor (β = −0.46; 95% CI, −0.69 to −0.25; P < .001), and interferon γ–inducible protein 10 (β = −0.32; 95% CI, −0.62 to −0.10; P = .007). …”
Publicado 2021
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31888por Park, Mira, Kim, Jae Yeon, Kang, Jun Mo, Lee, Hey Jin, Banga, Jasvinder Paul, Kim, Gi Jin, Lew, Helen“…Stimulants such as thyroid-stimulating hormone (TSH), insulin-like growth factor 1(IGF-1), IL-1, interferon γ, and platelet-derived growth factor cause differentiation into adipocytes of orbital fibroblasts (OFs) in the orbital fat and extraocular muscles. …”
Publicado 2021
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31889por Wang, Shuxia, Xu, Shuhang, Zhou, Jing, Zhang, Li, Mao, Xiaodong, Yao, Xiaoming, Liu, Chao“…METHODS: M1-polarised BMDMs were induced by lipopolysaccharide (LPS) + interferon (IFN)-γ and M2-polarisation were stimulated with interleukin (IL)-4. …”
Publicado 2021
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31890por Makola, Raymond Tshepiso, Kgaladi, Joe, More, Garland Kgosi, Jansen van Vuren, Petrus, Paweska, Janusz Tadeusz, Matsebatlela, Thabe Moses“…RESULTS: Lithium was shown to stimulate interferon-gamma (IFN-γ) production as early as 3 h pi. …”
Publicado 2021
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31891por Moraru, Manuela, Perez-Portilla, Adriana, Al-Akioui Sanz, Karima, Blazquez-Moreno, Alfonso, Arnaiz-Villena, Antonio, Reyburn, Hugh T., Vilches, Carlos“…Although the FCGR3B/A-encoded hybrid protein CD16B/A reaches the plasma membrane in transfected cells, its possible natural expression, predictably restricted to neutrophils, could not be demonstrated in resting or interferon γ-stimulated cells. As the CNR5-deletion was originally described in an Ecuadorian family from Llano Grande (an indigenous community in North-Eastern Quito), we characterized the FCGR genetic variation in two populations from the highlands of Ecuador. …”
Publicado 2021
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31892“…In addition, the activation of the LINE1 family of elements in IPF is associated with the increased expression of TE cellular regulators (MOV10, IFI16, SAMHD1, and APOBECG3), interferon-stimulating genes (ISG15, IFI6, IFI27, IFI44, and OAS1), chemokines (CX3CL1 and CXCL9), and interleukins (IL15RA). …”
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31893por Shin, Kyong-Oh, Crumrine, Debra A., Kim, Sungeun, Lee, Yerin, Kim, Bogyeong, Abuabara, Katrina, Park, Chaehyeong, Uchida, Yoshikazu, Wakefield, Joan S., Meyer, Jason M., Jeong, Sekyoo, Park, Byeong Deog, Park, Kyungho, Elias, Peter M.“…The high levels of interferon (IFN)γ not only in skin, but also in brain likely account for a significant decline in esterified very-long-chain N-acyl fatty acids in brain ceramides, again mimicking known IFNγ-induced changes in AD. …”
Publicado 2021
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31894por Brauneck, F., Haag, F, Woost, R., Wildner, N., Tolosa, E., Rissiek, A., Vohwinkel, G., Wellbrock, J., Bokemeyer, C., Schulze zur Wiesch, J., Ackermann, C., Fiedler, W.“…Abbreviations: AML: Acute myeloid leukemia; pAML: newly diagnosed AML; rAML: relapse AML; lrAML: AML in remission; HD: healthy donor; PB: peripheral blood; BM: bone marrow; TIGIT: T-cell immunoreceptor with Ig and ITIM domains; PD-1: Programmed cell death protein 1; CD73: ecto-5′-nucleotidase; CD39: ectonucleoside triphosphate diphosphohydrolase 1; ATP: adenosine triphosphate; ADO: adenosine; CD127: interleukin-7 receptor; CAR-T cell: chimeric antigen receptor T cell; TCF-1: transcription factor T-cell factor 1; TOX: Thymocyte selection-associated high mobility group box protein; NFAT: nuclear factor of activated T cells; NA: Naïve; CM: Central Memory; EM Effector Memory; EMRA: Terminal Effector Memory cells; FMO: Fluorescence minus one; PVR: poliovirus receptor; PVRL2: poliovirus receptor-related 2; IFN-γ: Interferon-γ; IL-2: interleukin-2; MCF: multiparametric flow cytometry; TNFα: Tumornekrosefaktor α; RT: room temperature.…”
Publicado 2021
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31895por Duan, Ruo-Nan, Yang, Chun-Lin, Du, Tong, Liu, Ai, Wang, An-Ran, Sun, Wen-Jie, Li, Xi, Li, Jiang-Xia, Yan, Chuan-Zhu, Liu, Qi-Ji“…Moreover, dysfunction of the IDO1-AhR pathway resulted from the reduction of interferon γ (IFN-γ), enhanced antigen presentation ability, and inhibition of anti-inflammatory processes in Smek1(-/+) EAE mice. …”
Publicado 2021
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31896por Xiong, Shue, Zhu, Dan, Liang, Boyun, Li, Mingyue, Pan, Wen, He, Junyi, Wang, Hua, Sutter, Kathrin, Dittmer, Ulf, Lu, Mengji, Liu, Di, Yang, Dongliang, Liu, Jia, Zheng, Xin“…The changes in the T cell phenotype in cHBV patients were even more profound during rapid HBsAg decrease and was associated with interferon α treatment. The expression of HLA-DR (r = 0·3269, p = 0·0037), CD95 (r = 0·2796, p = 0·0151), CD40L (r = 0·2747, p = 0·0156), CTLA-4 (r = 0·2786, p = 0·0148), TIM-3 (r = 0·3082, p = 0·0068), CD107a (r = 0·3597, p = 0·0013) on CD4(+) T cells, and HLA-DR (r = 0·3542, p = 0·0016), CD69 (r = 0·2507, p = 0·0279), CD107a (r = 0·2875, p = 0·0112) on CD8(+) T cells were positively correlated with the rate of HBsAg decrease. …”
Publicado 2021
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31897“…HS exposure elevated the concentration of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-4, and IL-6, while decreased the concentration of interferon-γ (INF-γ) and IL-2 (P < 0.05), and dietary inclusion of ADP reduced the IL-1β level and increased the IL-2 level of bursa of Fabricius (P < 0.05). …”
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31898por Scherlinger, Marc, Felten, Renaud, Gallais, Floriane, Nazon, Charlotte, Chatelus, Emmanuel, Pijnenburg, Luc, Mengin, Amaury, Gras, Adrien, Vidailhet, Pierre, Arnould-Michel, Rachel, Bibi-Triki, Sabrina, Carapito, Raphaël, Trouillet-Assant, Sophie, Perret, Magali, Belot, Alexandre, Bahram, Seiamak, Arnaud, Laurent, Gottenberg, Jacques-Eric, Fafi-Kremer, Samira, Sibilia, Jean“…Extensive biologic studies were unremarkable, and multiplex cytokines and ultra-sensitive interferon-α2 measurements were similar between long-haulers and convalescent COVID-19 individuals without persistent symptoms. …”
Publicado 2021
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31899por Bernardo-Faura, Marti, Rinas, Melanie, Wirbel, Jakob, Pertsovskaya, Inna, Pliaka, Vicky, Messinis, Dimitris E., Vila, Gemma, Sakellaropoulos, Theodore, Faigle, Wolfgang, Stridh, Pernilla, Behrens, Janina R., Olsson, Tomas, Martin, Roland, Paul, Friedemann, Alexopoulos, Leonidas G., Villoslada, Pablo, Saez-Rodriguez, Julio“…Patients were either untreated or treated with fingolimod, natalizumab, interferon-β, glatiramer acetate, or the experimental therapy epigallocatechin gallate (EGCG). …”
Publicado 2021
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31900por Su, Rui, Wang, Yanyan, Hu, Fangyuan, Li, Baochen, Guo, Qiaoling, Zheng, Xinyu, Liu, Yue, Gao, Chong, Li, Xiaofeng, Wang, Caihong“…Interleukin (IL)-2, IL-4, IL-17, interferon-γ, and tumor necrosis factor-α were positively correlated with Tfr-like and mTfr-like cells. …”
Publicado 2021
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