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31901por Pan, Pan, Ma, Zhinan, Zhang, Zhen, Ling, Zhenzhen, Wang, Yao, Liu, Qiuping, Lin, Xiaolin, Xu, Pan, Yang, Dan, Zhi, Hui, Wang, Runmin, Zhang, Xuezhu“…The levels of cytokines [i.e., interleukin (IL)-1β, IL-2, IL-4, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (INF-γ)], chemokines (i.e., macrophage inflammatory protein-2 (MIP-2)), and other inflammatory mediators (i.e., cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS)) in peripheral blood and hippocampus were measured by enzyme linked immunosorbent assay (ELISA). …”
Publicado 2021
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31902por Venhoff, Nils, Schmidt, Wolfgang A., Lamprecht, Peter, Tony, Hans-Peter, App, Christine, Sieder, Christian, Legeler, Carolin, Jentzsch, Claudia, Thiel, Jens“…BACKGROUND: One key pathological finding in giant cell arteritis (GCA) is the presence of interferon-gamma and interleukin (IL)-17 producing T helper (Th) 1 and Th17 cells in affected arteries. …”
Publicado 2021
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31903por Enlow, William, Bordeleau, Maude, Piret, Jocelyne, Ibáñez, Fernando González, Uyar, Olus, Venable, Marie-Christine, Goyette, Nathalie, Carbonneau, Julie, Tremblay, Marie-Eve, Boivin, Guy“…METHODS: We used a mouse model deficient in TRIF and IPS-1 adaptor proteins, which are involved in type I interferon production, to study the role of microglia during brain infection by ZIKV. …”
Publicado 2021
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31904por Song, Wencong, Qiu, Jie, Yin, Lianghong, Hong, Xiaoping, Dai, Weier, Tang, Donge, Liu, Dongzhou, Dai, Yong“…These hub genes were involved in ceRNA signalling pathways, such as the IL-17 signalling pathway and type I interferon signalling pathway. CONCLUSIONS: We explored the differential expression profiles of various kinds of ceRNAs and integrated signalling networks constructed by ceRNAs. …”
Publicado 2021
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31905por Pachynski, Russell K, Morishima, Chihiro, Szmulewitz, Russell, Harshman, Lauren, Appleman, Leonard, Monk, Paul, Bitting, Rhonda L, Kucuk, Omer, Millard, Frederick, Seigne, John D, Fling, Steven P, Maecker, Holden T, Duault, Caroline, Ramchurren, Nirasha, Hess, Bruce, D’Amico, Leonard, Lacroix, Andreanne, Kaiser, Judith C, Morre, Michel, Grégoire, Anne, Cheever, Martin, Yu, Evan Y, Fong, Lawrence“…Immune responses were evaluated using flow cytometry, mass cytometry (CyTOF), interferon (IFN)-γ ELISpot, (3)H-thymidine incorporation, and ELISA. …”
Publicado 2021
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31906por Natarajan, S., Anbarasi, C., Sathiyarajeswaran, P., Manickam, P., Geetha, S., Kathiravan, R., Prathiba, P., Pitchiahkumar, M., Parthiban, P., Kanakavalli, K., Balaji, P.“…The primary outcomes were reduction in the SARS-CoV-2 load [as measured by cyclic threshold (CT) value of RT-PCR], prevention of progression of asymptomatic to symptomatic state, and changes in the immunity markers including interleukins (IL-6, IL-10, IL-2), interferon gamma (IFNγ), and tumor necrosis factor (TNF α). …”
Publicado 2021
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31907por Narayanan, Manojkumar, Kulkarni, Rutuja, Jiang, Shuxian, Kashanchi, Fatah, Prasad, Anil“…Characterizing further the molecular mechanisms involved in how cocaine increased EV release, we found that cocaine decreased the expression of the interferon-inducible protein BST-2; this resulted in altered trafficking of intracellular virus containing vesicles and EV biogenesis and release. …”
Publicado 2021
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31908por Guo, Peng-Wei, Huang, Hai-Ting, Ma, Jing, Zuo, Yao, Huang, Dan, He, Lin-Lin, Wan, Zi-Ming, Chen, Cheng, Yang, Fa-Fen, You, Yan-Wu“…RESULTS: In the present study, the expression of circ_0007059 in type I interferon (IFN)-treated renal mesangial cells (RMCs), lupus nephritis (LN) specimens, and HEK293 cells was downregulated compared with that in normal healthy samples and untreated cells. …”
Publicado 2021
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31909por Markewitz, Robert, Pauli, Daniela, Dargvainiene, Justina, Steinhagen, Katja, Engel, Sarah, Herbst, Victor, Zapf, Dorinja, Krüger, Christina, Sharifzadeh, Shahpour, Schomburg, Benjamin, Leypoldt, Frank, Rupp, Jan, Görg, Siegfried, Junker, Ralf, Wandinger, Klaus-Peter“…T- and B-cell responses were examined via interferon-γ (IFN-γ) release assay, and antibodies against different epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (S1 and NCP) were detected via ELISA and surrogate neutralization assay. …”
Publicado 2022
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31910“…GSEA and over-representation analyses revealed gene sets related to immune processes including neutrophil degranulation, interleukin 10 signaling, and interferon gamma signaling, complement and coagulation cascades, phosphatidylinositol signaling system, phagosome and neurotransmitter receptors and postsynaptic signal transmission were enriched from this study and replicated in an independent study. …”
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31911por Jain, Puneet, Finger, Paul T, Fili, Maria, Damato, Bertil, Coupland, Sarah E, Heimann, Heinrich, Kenawy, Nihal, J Brouwer, Niels, Marinkovic, Marina, Van Duinen, Sjoerd G, Caujolle, Jean Pierre, Maschi, Celia, Seregard, Stefan, Pelayes, David, Folgar, Martin, Yousef, Yacoub A, Krema, Hatem, Gallie, Brenda, Calle-Vasquez, Alberto“…Adjuvant therapies included topical mitomycin (n=107/288, 37.1%), plaque-brachytherapy (n=55/288, 19.1%), proton-beam (n=36/288, 13.5%), topical interferon (n=20/288, 6.9%) and EBRT (n=15/288, 5.2%). …”
Publicado 2021
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31912por Wang, Weiyi, Liu, Shuaitong, Dai, Peihong, Yang, Ning, Wang, Yi, Giese, Rachel A, Merghoub, Taha, Wolchok, Jedd, Deng, Liang“…RESULTS: Heat-iOV-GM infection of dendritic cells (DCs) and tumor cells in vitro induced type I interferon and proinflammatory cytokines and chemokines, whereas live OV-GM did not. …”
Publicado 2021
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31913por Lejeune, Pascale, Cruciani, Véronique, Berg-Larsen, Axel, Schlicker, Andreas, Mobergslien, Anne, Bartnitzky, Lisa, Berndt, Sandra, Zitzmann-Kolbe, Sabine, Kamfenkel, Claudia, Stargard, Stefan, Hammer, Stefanie, Jørgensen, Jennifer S, Jackerott, Malene, Nielsen, Carsten H, Schatz, Christoph A, Hennekes, Hartwig, Karlsson, Jenny, Cuthbertson, Alan S, Mumberg, Dominik, Hagemann, Urs B“…RESULTS: MSLN-TTC treatment induced upregulation of DNA sensing pathway transcripts (IL-6, CCL20, CXCL10, and stimulator of interferon genes (STING)-related genes) in vitro as determined by RNASeq analysis. …”
Publicado 2021
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31914“…The results of ssGSEA suggested that the immune cells with different infiltration degrees between the high-risk and low-risk groups were T cells including follicular helper T cells, Th1_cells, Th2_cells, and CD8+_T_cells, and the main differences in immune-related functions between the two groups were the interferon response and T cell costimulation. In addition, qRT-PCR experiments confirmed our results in renal cell lines and tissue samples. …”
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31915“…The enhanced GC3111 generated similar humoral response compare to the commercial vaccine for filamentous hemagglutinin (FHA). The interferon gamma (IFN-γ) (Th1), interleukin 5 (IL-5) (Th2) and interleukin 17 (IL-17) (Th17) cytokines were assessed 4 weeks after booster vaccination by stimulation with three simulators: heat inactivated Bordetella pertussis (hBp), vaccine antigens, and hBp mixed with antigens (hBp + antigen). …”
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31916por Duarte, Luisa F., Gálvez, Nicolás M. S., Iturriaga, Carolina, Melo-González, Felipe, Soto, Jorge A., Schultz, Bárbara M., Urzúa, Marcela, González, Liliana A., Vázquez, Yaneisi, Ríos, Mariana, Berríos-Rojas, Roslye V., Rivera-Pérez, Daniela, Moreno-Tapia, Daniela, Pacheco, Gaspar A., Vallejos, Omar P., Hoppe-Elsholz, Guillermo, Navarrete, María S., Rojas, Álvaro, Fasce, Rodrigo A., Fernández, Jorge, Mora, Judith, Ramírez, Eugenio, Zeng, Gang, Meng, Weining, González-Aramundiz, José V., González, Pablo A., Abarca, Katia, Bueno, Susan M., Kalergis, Alexis M.“…An increase in the number of interferon-γ-secreting T cells specific for SARS-CoV-2 was detected 2 weeks after the second dose in seven cases and after symptoms onset. …”
Publicado 2021
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31917por Sacconi, Andrea, De Vitis, Claudia, de Latouliere, Luisa, di Martino, Simona, De Nicola, Francesca, Goeman, Frauke, Mottini, Carla, Paolini, Francesca, D’Ascanio, Michela, Ricci, Alberto, Tafuri, Agostino, Marchetti, Paolo, Di Napoli, Arianna, De Biase, Luciano, Negro, Andrea, Napoli, Christian, Anibaldi, Paolo, Salvati, Valentina, Duffy, Darragh, Terrier, Benjamin, Fanciulli, Maurizio, Capalbo, Carlo, Sciacchitano, Salvatore, Blandino, Giovanni, Piaggio, Giulia, Mancini, Rita, Ciliberto, Gennaro“…Gene set enrichment analysis highlights an increased gene expression linked to Interferon α, γ, α/β response and signaling which paired with aberrant cell cycle regulation in cancer patients. …”
Publicado 2021
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31918por Zhu, Shaoming, Ma, A-Hong, Zhu, Zheng, Adib, Elio, Rao, Ting, Li, Na, Ni, Kaiyuan, Chittepu, Veera Chandra Sekhar Reddy, Prabhala, Rao, Garisto Risco, Juan, Kwiatkowski, David, Mouw, Kent, Sonpavde, Guru, Cheng, Fan, Pan, Chong-xian“…Pan-PI3K inhibition significantly upregulated CD80, CD86, MHC-I, and MHC-II in dendritic cells, and downregulated the transforming growth factor beta pathway with a false discovery rate-adjusted q value of 0.001. Interferon alpha response was significantly upregulated with aPD1 therapy (q value: <0.001) and combination (q value: 0.027). …”
Publicado 2021
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31919por Hunter, Samuel F., Aburashed, Rany A., Alroughani, Raed, Chan, Andrew, Dive, Dominique, Eichau, Sara, Kantor, Daniel, Kim, Ho Jin, Lycke, Jan, Macdonell, Richard A. L., Pozzilli, Carlo, Scott, Thomas, Sharrack, Basil, Wiendl, Heinz, Chung, Luke, Daizadeh, Nadia, Baker, Darren P., Vermersch, Patrick“…INTRODUCTION: In the 2-year CARE-MS trials (NCT00530348; NCT00548405) in patients with relapsing–remitting multiple sclerosis, alemtuzumab showed superior efficacy versus subcutaneous interferon beta-1a. Efficacy was maintained in two consecutive extensions (NCT00930553; NCT02255656). …”
Publicado 2021
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31920por Rivas-Santisteban, Rafael, Lillo, Alejandro, Lillo, Jaume, Rebassa, Joan-Biel, Contestí, Joan S., Saura, Carlos A., Franco, Rafael, Navarro, Gemma“…The print was detected in activated primary microglia treated with lipopolysaccharide and interferon-γ. CB(2)R activation blunted NMDA receptor-mediated signaling in primary hippocampal neurons from APP(Sw/Ind) mice. …”
Publicado 2021
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