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31921por Chu, Fuhao, Li, Yicong, Meng, Xiangmei, Li, Yuan, Li, Tao, Zhai, Mengyin, Zheng, Haocheng, Xin, Tianxi, Su, Zeqi, Lin, Jie, Zhang, Ping, Ding, Xia“…Results: The results showed that compared to the control group, the gastric mucosa of the model rats had obvious morphological and pathological malignant changes and the serum levels of inflammatory cytokines including interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and macrophage colony-stimulating factor (M-CSF) increased significantly, while the level of chemokine (C-X-C motif) ligand 1 (CXCL1) in serum reduced significantly. …”
Publicado 2021
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31922por Fernández-Ruiz, Mario, Almendro-Vázquez, Patricia, Carretero, Octavio, Ruiz-Merlo, Tamara, Laguna-Goya, Rocío, San Juan, Rafael, López-Medrano, Francisco, García-Ríos, Estéfani, Más, Vicente, Moreno-Batenero, Miguel, Loinaz, Carmelo, Andrés, Amado, Pérez-Romero, Pilar, Paz-Artal, Estela, Aguado, José María“…SARS-CoV-2-CMI was evaluated at baseline, before the second dose, and at 2 wk after completion of vaccination by an ELISpot-based interferon-γ FluoroSpot assay using overlapping peptides covering the S1 domain. …”
Publicado 2021
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31923por Klopp-Schulze, Lena, Shaw, Jamie, Dong, Jennifer, Khandelwal, Akash, Adams, Elizabeth, Yu, Dongzi, Goteti, Kosalaram“…METHODS: The popPK/PD models were based on plasma PK and PD biomarker (ex vivo-stimulated interleukin [IL]6 and interferon α [IFNα] secretion) data from the enpatoran first-in-human Phase I study in healthy participants (Port A, et al. …”
Publicado 2021
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31924por Gharamti, Amal, Samara, Omar, Monzon, Anthony, Barahona, Lilian Vargas, Scherger, Sias, DeSanto, Kristen, Chastain, Daniel B, Sillau, Stefan, Franco-Paredes, Carlos, Henao Martínez, Andrés F, Shapiro, Leland“…Among these studies, 72 disclosed TNFα levels, 25 showed interleukin (IL)-1β levels, and 6 presented interferon (IFN)γ levels. The pooled estimate mean TNFα concentration in sepsis patients was 58.4 pg/ml (95% CI, 39.8-85.8 pg.ml; I(2) = 99.4%). …”
Publicado 2021
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31925por Wu, Jing, Liu, Xingxiang, Shao, Jianguo, Zhang, Yuanyuan, Lu, Renfei, Xue, Hong, Xu, Yunfang, Wang, Lijuan, Zhou, Hui, Yu, Lugang, Yue, Ming, Dong, Chen“…Although previous studies have suggested that type I interferon (IFN-I) could inhibit the virus replication, the expression characteristics of IFN-I signaling-related miRNAs (ISR-miRNAs) during acute severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and its relationship with receptor-binding domain (RBD) IgG antibody response at the recovery phase remain unclear. …”
Publicado 2021
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31926por de Groot, Nienke, Fariñas, Fernando, Fabà, Lluís, Hambrecht, Ellen, Cabrera-Gómez, Carolina G., Pallares, Francisco J., Ramis, Guillermo“…The results showed that in post-weaning piglets, the feed additive stimulates an immunomodulation effect most evident at 15 days post-weaning, with significant lower expression of cytokines Interferon (IFN) γ, Interleukin (IL) 1α, IL-1β, IL-6, IL-8, IL-10 and Transforming Growth Factor (TGF) β in jejunum, accompanied with an increase in peripheral blood mononuclear cells (PBMC) cytokine gene expression of IL-1β, IL-6, IL-8, IL-10, IL-12p35 (IL-12α), IL-12p40 (IL-12β), Tumor Necrosis Factor (TNF) α, IFN-α, and TGF-β. …”
Publicado 2021
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31927por Lasagna, A., Lilleri, D., Agustoni, F., Percivalle, E., Borgetto, S., Alessio, N., Comolli, G., Sarasini, A., Bergami, F., Sammartino, J.C., Ferrari, A., Zavaglio, F., Arena, F., Secondino, S., Falzoni, M., Schiavo, R., Lo Cascio, G., Cavanna, L., Baldanti, F., Pedrazzoli, P., Cassaniti, I.“…The enzyme-linked immunosorbent spot assay was used for quantification of anti-spike interferon-γ (IFN-γ)-producing cells/10(6) peripheral blood mononuclear cells. …”
Publicado 2021
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31928por Xu, Li-Qing, Yao, Li-Jie, Jiang, Dan, Zhou, Li-Juan, Chen, Min, Liao, Wen-Zhong, Zou, Wei-Hao, Peng, Hong-Juan“…Inoculation of RH-Δompdc in situ into the 4T1 tumor inhibited tumor growth, reduced lung metastasis, promoted the survival of the tumor-bearing mice and increased the secretion of Th1 cytokines, including interleukin-12 (IL-12) and interferon-γ (INF-δ), in both the serum and tumor microenvironment (TME). …”
Publicado 2021
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31929por Shah, Manish A, Cunningham, David, Metges, Jean-Philippe, Van Cutsem, Eric, Wainberg, Zev, Elboudwarej, Emon, Lin, Kai-Wen, Turner, Scott, Zavodovskaya, Marianna, Inzunza, David, Liu, Jinfeng, Patterson, Scott D, Zhou, Jingzhu, He, Jing, Thai, Dung, Bhargava, Pankaj, Brachmann, Carrie Baker, Cantenacci, Daniel V T“…Programmed cell death ligand 1, interferon-γ (IFN), and intratumoral CD8+ cell density were not associated with treatment response or survival. …”
Publicado 2021
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31930por McDew-White, Marina, Lee, Eunhee, Alvarez, Xavier, Sestak, Karol, Ling, Binhua J, Byrareddy, Siddappa N, Okeoma, Chioma M, Mohan, Mahesh“…FINDINGS: VEH- untreated/SIV but not THC/SIV RMs showed significant enrichment of genes linked to anti-viral defense, interferon-β, NFκB, RIG-1, and JAK-STAT signaling. We focused on the anti-microbial DUOX1 and immune activation marker IDO1 that were reciprocally regulated in the gingiva of VEH-untreated/SIV RMs. …”
Publicado 2021
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31931por Maeng, Hoyoung M., Moore, Brittni N., Bagheri, Hadi, Steinberg, Seth M., Inglefield, Jon, Dunham, Kim, Wei, Wei-Zen, Morris, John C., Terabe, Masaki, England, Lee C., Roberson, Brenda, Rosing, Douglas, Sachdev, Vandana, Pack, Svetlana D., Miettinen, Markku M., Barr, Frederic G., Weiner, Louis M., Panch, Sandhya, Stroncek, David F., Wood, Lauren V., Berzofsky, Jay A.“…Lymphocytes from 10 of 11 patients (90.9%) showed induction of anti-HER2 responses measured by the production of at least one of interferon-gamma, granzyme B, or tumor necrosis factor-alpha, and there were multifunctional responses in 8 of 11 patients (72.7%). …”
Publicado 2021
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31932por Prašnikar, Erika, Kunej, Tanja, Gorenjak, Mario, Potočnik, Uroš, Kovačič, Borut, Knez, Jure“…These included pathways were already associated with endometrial biology, such as “Expression of interferon (IFN)-induced genes” and “Response to IFN-alpha”. …”
Publicado 2022
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31933por Kojima, Fumiaki, Sekiya, Hiroki, Hioki, Yuka, Kashiwagi, Hitoshi, Kubo, Makoto, Nakamura, Masaki, Maehana, Shotaro, Imamichi, Yoshitaka, Yuhki, Koh-ichi, Ushikubi, Fumitaka, Kitasato, Hidero, Ichikawa, Takafumi“…The abnormalities consistent with colitis in mPGES-1(−/−) mice were associated with higher expression of colonic T-helper (Th)17 and Th1 cytokines, including interleukin 17A and interferon-γ. Furthermore, lack of mPGES-1 increased the numbers of Th17 and Th1 cells in the lamina propria mononuclear cells within the colon, even though the number of suppressive regulatory T cells also increased. …”
Publicado 2022
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31934por Tarhini, Ahmad A, Lee, Sandra J, Tan, Aik-Choon, El Naqa, Issam M, Stephen Hodi, F, Butterfield, Lisa H, LaFramboise, William A, Storkus, Walter J, Karunamurthy, Arivarasan D, Conejo-Garcia, Jose R, Hwu, Patrick, Streicher, Howard, Sondak, Vernon K, Kirkwood, John M“…We investigated differences in prognosis and candidate immune biomarkers in patients with unknown compared with those with known primary melanoma enrolled in the E1609 adjuvant trial that tested ipilimumab at 3 and 10 mg/kg vs high-dose interferon-alfa (HDI). PATIENTS AND METHODS: MUP status was defined as initial presentation with cutaneous, nodal or distant metastasis without a known primary. …”
Publicado 2022
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31935por Haydu, J. Erika, Maron, Jenny S., Redd, Robert A., Gallagher, Kathleen M. E., Fischinger, Stephanie, Barnes, Jeffrey A., Hochberg, Ephraim P., Johnson, P. Connor, Takvorian, R. W., Katsis, Katelin, Portman, Daneal, Ruiters, Jade, Sechio, Sidney, Devlin, Mary, Regan, Connor, Blumenthal, Kimberly G., Banerji, Aleena, Judd, Allen D., Scorsune, Krista J., McGree, Brianne M., Sherburne, Maryanne M., Lynch, Julia M., Weitzman, James I., Lei, Matthew, Kotton, Camille N., Dighe, Anand S., Maus, Marcela V., Alter, Galit, Abramson, Jeremy S., Soumerai, Jacob D.“…Among treatment-naïve patients, an absolute lymphocyte count ≤24 000/µL was associated with serologic response (94% vs 14%; P < .001). On interferon-γ release assays, 80% (16/20) of patients had functional spike-specific T-cell responses, including 78% (7/9) with a negative RBD immunoassay, a group enriched for prior B-cell–depleting therapies. …”
Publicado 2022
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31936por Ortega, J., Roy, A., Díaz-Castillo, A., de Juan, L., Romero, B., Sáez-Llorente, J. L., Domínguez, L., Regal, P., Infantes-Lorenzo, J. A., Álvarez, J., Bezos, J.“…All the animals were tested using single and comparative intradermal tuberculin (SIT and CIT, respectively) tests, an interferon-gamma release assay (IGRA) and a P22 ELISA. …”
Publicado 2022
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31937por Lebreton, Fanny, Hanna, Reine, Wassmer, Charles H., Bellofatto, Kevin, Perez, Lisa, Othenin-Girard, Véronique, de Tejada, Begoña Martinez, Cohen, Marie, Berishvili, Ekaterine“…To verify our hypothesis, hAEC monocultures, rat islets (RI), or RI-hAEC co-cultures where exposed to a pro-inflammatory cytokine cocktail (Interferon γ: IFN-γ, Tumor necrosis factor α: TNF-α and Interleukin-1β: IL-1β). …”
Publicado 2021
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31938por Verschoor, Chris P., Haynes, Laura, Pawelec, Graham, Loeb, Mark, Andrew, Melissa K., Kuchel, George A., McElhaney, Janet E.“…We have shown that granzyme B (GrB) activity in influenza A/H3N2 challenged peripheral blood mononuclear cells (PBMC) correlates with protection against influenza following standard dose vaccination (SD-SVV) in older adults. Further, the interferon-γ (IFNγ) to interleukin-10 (IL-10) ratio can be a correlate of protection. …”
Publicado 2021
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31939por Tang, Yixun, Liu, Jitong, Huang, Xiaoling, Ding, Huijuan, Tan, Suhong, Zhu, Yimin“…And monitor the levels of interferon-γ (IFN-γ), interleukin-4 (IL-4), myelin basic protein (MBP), neuron-specific enolase (NSE) and S100β. …”
Publicado 2022
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31940por Ryan, Emer, Kelly, Lynne, Stacey, Catherine, Huggard, Dean, Duff, Eimear, McCollum, Danielle, Leonard, Ann, Boran, Gerard, Doherty, Dermot R., Bolger, Turlough, Molloy, Eleanor J.“…METHODS: Pro- and anti-inflammatory cytokines including Interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, IL-17A, Tumor Necrosis Factor (TNF)-α and Interferon (IFN)-γ were examined at baseline and following in vitro treatment with endotoxin of whole blood, in the following children: severe TBI (sTBI: initial Glasgow coma scale(GCS) ≤ 8), mild TBI (mTBI; GCS 14/15) at 0-4d and at 10-14d post-TBI and compared to healthy age-matched controls. …”
Publicado 2022
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