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31941por Wang, Ying, Liu, Qing, Dong, Hua, Feng, Yanni, Raguthu, Ciri, Liang, Xue, Liu, Chen, Zhang, Zuncheng, Yao, Xiaomei“…The messenger ribonucleic acid expression of interleukin (IL)-17A, interferon gamma (IFN-γ), and IL-10 in the thyroid gland was measured using quantitative real-time polymerase chain reaction, while the protein expression of thyroid-hormone-receptor α1 (TRα1) and thyroid-hormone-receptor β1 (TRβ1) in the thyroid gland was detected using Western blotting. …”
Publicado 2020
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31942por Wen, Shaodi, Peng, Weiwei, Chen, Yuzhong, Du, Xiaoyue, Xia, Jingwei, Shen, Bo, Zhou, Guoren“…We found that signaling pathways involved in hallmark allograft rejection, hallmark apical junction, hallmark interferon gamma response, the hallmark P53 pathway, and the hallmark TNF-α signaling via NF-ĸB were up-regulated in the high-ESTIMATE-score group. …”
Publicado 2022
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31943por Corbett, Caroline, Kalmambetova, Gulmira, Umetalieva, Nagira, Ahmedov, Sevim, Antonenka, Uladzimir, Myrzaliev, Bakyt, Sahalchyk, Evgeni, Vogel, Monica, Kadyrov, Abdylat, Hoffmann, Harald“…METHODS: HCWs from four TB hospitals in the Northern Kyrgyz Republic were tested with the interferon-gamma release assay (IGRA) Quantiferon-TB Gold plus (QFT) for the detection of an immune response to TB as marker of TB infection. …”
Publicado 2022
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31944por McNeel, Douglas G, Eickhoff, Jens C, Wargowski, Ellen, Johnson, Laura E, Kyriakopoulos, Christos E, Emamekhoo, Hamid, Lang, Joshua M, Brennan, Mary Jane, Liu, Glenn“…Immune-related adverse events (irAEs) >grade 1 were observed in 42% of patients overall. Interferon-γ and/or granzyme B immune response to prostatic acid phosphatase was detected in 2/20 patients in arm 3 and 6/20 patients in arm 4. …”
Publicado 2022
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31945por Roex, Gils, Campillo-Davo, Diana, Flumens, Donovan, Shaw, Philip Anthony Gilbert, Krekelbergh, Laurens, De Reu, Hans, Berneman, Zwi N., Lion, Eva, Anguille, Sébastien“…In terms of CD107a degranulation, and secretion of interferon (IFN)-γ and granzyme B, dual-CAR NK-92 significantly outperformed single-CAR NK-92. …”
Publicado 2022
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31946por Friedrich, Maik, Pfeifer, Gabriele, Binder, Stefanie, Aigner, Achim, Vollmer Barbosa, Philippe, Makert, Gustavo R., Fertey, Jasmin, Ulbert, Sebastian, Bodem, Jochen, König, Eva-Maria, Geiger, Nina, Schambach, Axel, Schilling, Erik, Buschmann, Tilo, Hauschildt, Sunna, Koehl, Ulrike, Sewald, Katherina“…It neither led to toxic effects nor induced type I or III interferon production. Of note, sequence analyses revealed the target sequence of siV1 to be highly conserved in SARS-CoV-2 variants. …”
Publicado 2022
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31947por Bilgin, Huseyin, Marku, Marisa, Yilmaz, Sultan Seval, Karahasan Yagci, Aysegul, Sili, Uluhan, Can, Baris, Can Sarinoglu, Rabia, Mulazimoglu Durmusoglu, Lutfiye, Haklar, Goncagul, Sirikci, Onder, Eksioglu Demiralp, Emel“…Memory B cells (CD19(+)CD27(+)), plasmablast B cells (CD19(+)CD138(+)) and long-lived plasma cells (LLPC; CD138(+)CD19(-)) were measured by flow cytometry in 74 patients. Interferon gamma (IFN-γ) release by natural killer (NK) cells were measured by NKVue Test (NKMAX, Republic of Korea) in 76 patients. …”
Publicado 2022
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31948por Wang, Yi-Song, Liu, Dong, Wang, Xin, Luo, Qiao-Li, Ding, Ling, Fan, Dong-Ying, Cai, Qi-Liang, Tang, Chong-Yang, Yang, Wei, Guan, Yu-Guang, Li, Tian-Fu, Wang, Pei-Gang, Luan, Guo-Ming, An, Jing“…In comparison to TLE, RE brain tissues contained higher level of inflammatory cytokines, but the interferon-β level, which was negatively correlated with cumulative viral score, was relatively lower. …”
Publicado 2022
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31949por Kim, So Young, Gupta, Purva, Johns, Scott C., Zuniga, Elina I., Teijaro, John R., Fuster, Mark M.“…Induction of under-sulfated HS via Ndst1 silencing in a model dendritic cell line (DC2.4) resulted in up-regulated basal expression of the antiviral cytokine interferon β (IFN-β) relative to control. Stimulating cells with the TLR9 ligand CpG resulted in greater nuclear factor-κB (NFκB) phosphorylation in Ndst1 silenced DC2.4 cells. …”
Publicado 2022
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31950por Ferreira, Bárbara Roque, Pio-Abreu, José Luís, Figueiredo, Américo, Misery, Laurent“…For instance, in chronic spontaneous urticaria, the mast cell activation may include autoimmune mechanisms, where autoantibodies against the extracellular α subunit of the high-affinity IgE receptor (FcεRIα) and to IgE are observed, with the involvement of Th1 lymphocytes and the production of interferon-γ (INF-γ). The role of autoimmunity is also suggested in the etiopathogenesis of other psychophysiological dermatoses, namely psoriasis, atopic dermatitis and alopecia areata. …”
Publicado 2021
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31951por He, Chuan-Yu, Zhang, Yu-Zhuo, Liu, Meng-Zhi, Zhao, Hai-Long, Ren, Li-Song, Liu, Bao-Shan, He, Sun, Chen, Ze-Liang“…Subsequently, the immune and protective efficacy of the vaccines were evaluated by measuring splenic bacterial burden, spleen weight, serum IgG, interferon-gamma (IFN-γ), interleukin-4 (IL-4) percentage of CD4 + and CD8 + T cells of mice via bacterial isolation, weighing, ELISA and flow cytometry, respectively. …”
Publicado 2022
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31952por Yan, Jiaxiu, Zhao, Yifei, Du, Juan, Wang, Yu, Wang, Shaohua, Wang, Qing, Zhao, Xu, Xu, Wei, Zhao, Ke“…Although MDA5 is an endogenous RNA sensor able to activate the innate immune system, increased interferon (IFN) expression only contributed in part to MDA5-mediated LINE-1 suppression. …”
Publicado 2022
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31953SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency: Findings from the COV-AD Studypor Shields, Adrian M., Faustini, Sian E., Hill, Harriet J., Al-Taei, Saly, Tanner, Chloe, Ashford, Fiona, Workman, Sarita, Moreira, Fernando, Verma, Nisha, Wagg, Hollie, Heritage, Gail, Campton, Naomi, Stamataki, Zania, Klenerman, Paul, Thaventhiran, James E. D., Goddard, Sarah, Johnston, Sarah, Huissoon, Aarnoud, Bethune, Claire, Elcombe, Suzanne, Lowe, David M., Patel, Smita Y., Savic, Sinisa, Burns, Siobhan O., Richter, Alex G.“…Serological and cellular responses were determined using ELISA, live-virus neutralisation and interferon gamma release assays. SARS-CoV-2 infection and clearance were determined by PCR from serial nasopharyngeal swabs. …”
Publicado 2022
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31954por Bonifacius, Agnes, Tischer-Zimmermann, Sabine, Santamorena, Maria Michela, Mausberg, Philip, Schenk, Josephine, Koch, Stephanie, Barnstorf-Brandes, Johanna, Gödecke, Nina, Martens, Jörg, Goudeva, Lilia, Verboom, Murielle, Wittig, Jana, Maecker-Kolhoff, Britta, Baurmann, Herrad, Clark, Caren, Brauns, Olaf, Simon, Martina, Lang, Peter, Cornely, Oliver A., Hallek, Michael, Blasczyk, Rainer, Seiferling, Dominic, Köhler, Philipp, Eiz-Vesper, Britta“…Methods: Antiviral SARS-CoV-2-specific T cells were detected in blood of convalescent COVID-19 patients following stimulation with PepTivator SARS-CoV-2 Select using Interferon-gamma Enzyme-Linked Immunospot (IFN-γ ELISpot), SARS-CoV-2 T Cell Analysis Kit (Whole Blood) and Cytokine Secretion Assay (CSA) and were characterized with respect to memory phenotype, activation state and cytotoxic potential by multicolor flow cytometry, quantitative real-time PCR and multiplex analyses. …”
Publicado 2022
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31955por Molodtsov, Ivan A, Kegeles, Evgenii, Mitin, Alexander N, Mityaeva, Olga, Musatova, Oksana E, Panova, Anna E, Pashenkov, Mikhail V, Peshkova, Iuliia O, Alsalloum, Almaqdad, Asaad, Walaa, Budikhina, Anna S, Deryabin, Alexander S, Dolzhikova, Inna V, Filimonova, Ioanna N, Gracheva, Alexandra N, Ivanova, Oxana I, Kizilova, Anastasia, Komogorova, Viktoria V, Komova, Anastasia, Kompantseva, Natalia I, Kucheryavykh, Ekaterina, Lagutkin, Denis А, Lomakin, Yakov A, Maleeva, Alexandra V, Maryukhnich, Elena V, Mohammad, Afraa, Murugin, Vladimir V, Murugina, Nina E, Navoikova, Anna, Nikonova, Margarita F, Ovchinnikova, Leyla A, Panarina, Yana, Pinegina, Natalia V, Potashnikova, Daria M, Romanova, Elizaveta V, Saidova, Aleena A, Sakr, Nawar, Samoilova, Anastasia G, Serdyuk, Yana, Shakirova, Naina T, Sharova, Nina I, Sheetikov, Saveliy A, Shemetova, Anastasia F, Shevkova, Liudmila V, Shpektor, Alexander V, Trufanova, Anna, Tvorogova, Anna V, Ukrainskaya, Valeria M, Vinokurov, Anatoliy S, Vorobyeva, Daria A, Zornikova, Ksenia V, Efimov, Grigory A, Khaitov, Musa R, Kofiadi, Ilya A, Komissarov, Alexey A, Logunov, Denis Y, Naigovzina, Nelli B, Rubtsov, Yury P, Vasilyeva, Irina A, Volchkov, Pavel, Vasilieva, Elena“…METHODS: In 5340 Moscow residents, we evaluated anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin M (IgM)/immunoglobulin G (IgG) titers and frequencies of the T cells specific to the membrane, nucleocapsid, and spike proteins of SARS-CoV-2, using interferon gamma (IFN-γ) enzyme-linked immunosorbent spot (ELISpot) assay. …”
Publicado 2022
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31956por Zhang, Ling-Xian, Gao, Jian, Long, Xiang, Zhang, Peng-Fei, Yang, Xin, Zhu, Shu-Qiang, Pei, Xu, Qiu, Bai-Quan, Chen, Shi-Wei, Lu, Feng, Lin, Kun, Xu, Jian Jun, Wu, Yong-Bing“…Mechanistically, circHMGB2 relieves the inhibition of downstream CARM1 by sponging miR-181a-5p, thus inactivating the type 1 interferon response in the LUAD and LUSC. Moreover, we found that the upregulation of circHMGB2 expression decreased the efficacy of anti-PD-1 therapy, and we revealed that the combination of the CARM1 inhibitor EZM2302 and an anti-PD-1 antibody exerted promising synergistic effects in a preclinical model. …”
Publicado 2022
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31957por Huang, Kai, Li, Fangyuan, Wang, Xuechen, Yan, Bing, Wang, Ming, Li, Shuling, Yu, Wenling, Liu, Xiaofang, Wang, Chengshuo, Jin, Jianmin, Zhang, Luo“…Sputum samples from Cluster 3 showed significantly higher levels of Interleukin (IL)-5, IL-13, IL-33, and tumor necrosis factor (TNF)-α than the other two clusters; and remarkably elevated IL-4, IL-17 and interferon (IFN)-γ compared with cluster 2. The levels of IL-10 and IL-25 were not significantly different among the three clusters. …”
Publicado 2022
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31958por Larroquette, Mathieu, Guegan, Jean-Philippe, Besse, Benjamin, Cousin, Sophie, Brunet, Maxime, Le Moulec, Sylvestre, Le Loarer, François, Rey, Christophe, Soria, Jean-Charles, Barlesi, Fabrice, Bessede, Alban, Scoazec, Jean-Yves, Soubeyran, Isabelle, Italiano, Antoine“…Moreover, in tumors with high macrophage infiltration, the upregulation of genes associated with the interferon-γ signaling pathway and the M1 phenotype was associated with better responses under immunotherapy. …”
Publicado 2022
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31959por Aiken, Taylor J, Erbe, Amy K, Zebertavage, Lauren, Komjathy, David, Feils, Arika S, Rodriguez, Matthew, Stuckwisch, Ashley, Gillies, Stephen D, Morris, Zachary S, Birstler, Jen, Rakhmilevich, Alexander L, Sondel, Paul M“…Induction of MHC-I expression in 9464D-GD2 cells in response to interferon-γ (IFN-γ) and CAIR was measured in vitro and in vivo, respectively, by flow cytometry and quantitative real-time PCR. …”
Publicado 2022
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31960por Goel, Anshita, Ward, Douglas G., Noyvert, Boris, Yu, Minghao, Gordon, Naheema S., Abbotts, Ben, Colbourne, John K., Kissane, Stephen, James, Nicholas D., Zeegers, Maurice P., Cheng, Kar Keung, Cazier, Jean-Baptiste, Whalley, Celina M., Beggs, Andrew D., Palles, Claire, Arnold, Roland, Bryan, Richard T.“…The expression of individual genes was not prognostic in BCG-treated G3pT1 NMIBCs; however, downregulated interferon-alpha and gamma response pathways were significantly associated with worse PFS (adjusted p-value < 0.005). …”
Publicado 2022
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