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31961por Lafleur Larivière, Élise, Zhu, Cuilan, Sharma, Ankita, Karrow, Niel A, Huber, Lee-Anne“…The LPS injection increased rectal temperature and reduced jejunal and ileal villus height (versus saline; P < 0.05). Plasma interferon-γ concentration was only increased by LPS for pigs fed PC, NC, and DON+ compared to the saline-injected counterparts (P < 0.05). …”
Publicado 2022
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31962por Ntinginya, Nyanda Elias, te Brake, Lindsey, Sabi, Issa, Chamba, Nyasatu, Kilonzo, Kajiru, Laizer, Sweetness, Andia-Biraro, Irene, Kibirige, Davis, Kyazze, Andrew Peter, Ninsiima, Sandra, Critchley, Julia A., Romeo, Renee, van de Maat, Josephine, Olomi, Willyhelmina, Mrema, Lucy, Magombola, David, Mwayula, Issakwisa Habakkuk, Sharples, Katrina, Hill, Philip C., van Crevel, Reinout“…METHODS: The ‘Prevention of tuberculosis in diabetes mellitus’ (PROTID) consortium will randomise 3000 HIV-negative eligible adults with DM and LTBI, as evidenced by a positive tuberculin skin test or interferon gamma release assay, to 12 weeks of 3HP or placebo. …”
Publicado 2022
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31963por Ding, Rui, Li, Haiyan, Liu, Yaqi, Ou, Weiyang, Zhang, Xifang, Chai, Huihui, Huang, Xiaofei, Yang, Weijie, Wang, Qiujing“…The cyclic GMP-AMP synthase–stimulator of interferon gene (cGAS–STING) axis is a cytoplasmic double-stranded DNA (dsDNA) sensing pathway has recently emerged as a crucial mediator of neuroinflammation in ischemic stroke. …”
Publicado 2022
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31964por Zhong, Yafang, Zhang, Wei, Hong, Xiaoping, Zeng, Zhipeng, Chen, Yumei, Liao, Shengyou, Cai, Wanxia, Xu, Yong, Wang, Gang, Liu, Dongzhou, Tang, Donge, Dai, Yong“…RESULTS: We obtained a total of 284 DEGs and uncovered that they were largely involved in several immune relevant pathways, such as type І interferon signaling pathway, defense response to virus, and inflammatory response. …”
Publicado 2022
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31965por Goda, Vera, Kriván, Gergely, Kulcsár, Andrea, Gönczi, Márton, Tasnády, Szabolcs, Matula, Zsolt, Nagy, Ginette, Bekő, Gabriella, Horváth, Máté, Uher, Ferenc, Szekanecz, Zoltán, Vályi-Nagy, István“…Anti-SARS-CoV-2 immunoglobulin A became less positive in CVID after boosting, but the difference was not significant. The cumulative interferon-γ positive T cell response by ELISpot was over the cut-off value in 53% of the tested individuals and raised to 83% after boosting. …”
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31966por Krajnc, Nik, Hegen, Harald, Traxler, Gerhard, Leutmezer, Fritz, Di Pauli, Franziska, Kornek, Barbara, Rommer, Paulus, Zulehner, Gudrun, Riedl, Katharina, Dürauer, Sophie, Bauer, Angelika, Kratzwald, Sarah, Klotz, Sigrid, Winklehner, Michael, Deisenhammer, Florian, Guger, Michael, Höftberger, Romana, Berger, Thomas, Bsteh, Gabriel“…PwMS were categorized as follows: untreated (N-DMT, n = 32), receiving disease-modifying therapy (DMT) with expected humoral response (er-DMT: interferon-beta preparations, glatiramer acetate, dimethyl fumarate, teriflunomide, natalizumab, cladribine, alemtuzumab; n = 120) or no expected humoral response (nr-DMT: S1PMs, CD20mAb; n = 140). …”
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31967por Huang, Hui, Wang, Xia, Yang, Ling, He, Wenxiang, Meng, Tiantian, Zheng, Ke, Xia, Xin, Zhou, Yingjun, He, Jianhua, Liu, Chunming, Zou, Shengwen, Xiao, Dingfu“…Compared with the bacitracin zinc group, the serum interleukins (IL-1, IL-10) content of 400 mg/kg FSE group were significantly increased (P ≤ 0.05), and the serum interferon-γ (IFN-γ) content of 100 and 200 mg/kg FSE groups was significantly increased (P < 0.05). …”
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31968por Li, Zhenyu, Li, Qingxian, Tong, Kai, Zhu, Jiayong, Wang, Hui, Chen, Biao, Chen, Liaobin“…RESULTS: Bioinformatics analysis showed that miR-23a-3p was highly expressed in rat BMSC-Exos and could target interferon regulatory factor 1 (IRF1, a crucial regulator in M1 macrophage polarization). …”
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31969por Lekpor, Cecilia Elorm, Botchway, Felix, Kusi, Kwadwo Asamoah, Adjei, Andrew A., Wilson, Michael D., Stiles, Jonathan K., Wilson, Nana O.“…BACKGROUND: Malaria related mortality is associated with significant deregulation of host inflammatory factors such as interferon-inducible protein 10, a member of the CXC or α-subfamily (CXCL10), and host angiogenic factors such as angiopoietin 1 (Ang-1) and angiopoietin 2 (Ang-2). …”
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31970“…Tissue-derived cell lines exhibited increased interferon-gamma signalling and aberrant ferroptosis. …”
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31971por Viurcos-Sanabria, Rebeca, Manjarrez-Reyna, Aarón N., Solleiro-Villavicencio, Helena, Rizo-Téllez, Salma A., Méndez-García, Lucía A., Viurcos-Sanabria, Victoria, González-Sanabria, Jacquelina, Arroyo-Valerio, América, Carrillo-Ruíz, José D., González-Chávez, Antonio, León-Pedroza, Jose I., Flores-Mejía, Raúl, Rodríguez-Cortés, Octavio, Escobedo, Galileo“…In response to polyclonal stimuli, basal production of interleukin-2 (IL-2) and interferon (IFN-) gamma significantly decreased, and the programmed cell death protein 1 (PD-1) increased in CD4+ and CD8+ T cells from participants who posteriorly developed severe COVID-19 compared to mild cases. …”
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31972“…Both compounds also significantly lowered endotoxin-induced levels of peripheral nitrate/nitrite, interleukin (IL)-1β, IL-18, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and High-mobility group box 1 protein (HMGB-1), and levels of nitrate/nitrite, IL-1β, TNF-α, and IFN-γ in spleen and mesenteric lymph nodes (MLNs) (P < 0.05). …”
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31973por Zhu, Wen, Tang, Xiaoyu, Heyman, Rock A., Cai, Tianxi, Suh, Kangho, Seeger, John D., Xia, Zongqi“…We assigned patients to different treatment arms: no DMT (ND), high-efficacy (HE) DMT (alemtuzumab, B cell depletion, cladribine, and natalizumab), and standard-efficacy (SE) DMT (dimethyl fumarate, glatiramer acetate, interferon beta, sphingosine-1-phosphate receptor modulator, and teriflunomide). …”
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31974por Maleknia, Samaneh, Tavassolifar, Mohammad Javad, Mottaghitalab, Faezeh, Zali, Mohammad Reza, Meyfour, Anna“…The gene ontology and enrichment results of the WB dataset represented the enhancement in inflammatory host response, cell cycle, and interferon signature in COVID-19 patients. Furthermore, NP samples of COVID-19 in comparison with HC and non-viral ARIs showed the significant upregulation of genes associated with cytokine production and defense response to the virus. …”
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31975por Inthawong, Manutsanun, Sunyakumthorn, Piyanate, Wongwairot, Sirima, Anantatat, Tippawan, Dunachie, Susanna J., Im-Erbsin, Rawiwan, Jones, James W., Mason, Carl J., Lugo, Luis A., Blacksell, Stuart D., Day, Nicholas P. J., Sonthayanon, Piengchan, Richards, Allen L., Paris, Daniel H.“…C-reactive protein (CRP) plasma levels, interferon gamma (IFN-γ, interleukin-1 receptor antagonist (IL-1ra), IL-15 serum concentrations, CRP/IL10- and IFN-γ/IL-10 ratios correlated positively with bacterial load in blood, implying activation of the innate immune response and preferential development of a T helper-type 1 immune response. …”
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31976por Krogvold, Lars, Leete, Pia, Mynarek, Ida M., Russell, Mark A., Gerling, Ivan C., Lenchik, Nataliya I., Mathews, Clayton, Richardson, Sarah J., Morgan, Noel G., Dahl-Jørgensen, Knut“…The present study aimed to compare the gene and protein expression of selected virally induced pathogen recognition receptors and interferon stimulated genes in islets from these newly diagnosed type 1 diabetes (DiViD) subjects vs age-matched non-diabetic (ND) controls. …”
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31977por Chu, Pei-Yi, Huang, Wei-Chieh, Tung, Shiao-Lin, Tsai, Chung-Ying, Chen, Chih Jung, Liu, Yu-Chin, Lee, Chia-Wen, Lin, Yang-Hsiang, Lin, Hung-Yu, Chen, Cheng-Yi, Yeh, Chau-Ting, Lin, Kwang-Huei, Chi, Hsiang-Cheng“…RESULTS: Using isobaric mass tag-based quantitative proteomics approach, we identified IFITM3, an interferon-induced transmembrane protein that was highly expressed in micro-dissected gastric cancer (GC) tumor regions relative to adjacent non-tumor epithelia. …”
Publicado 2022
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31978por Aiello, Alessandra, Grossi, Adriano, Meschi, Silvia, Meledandri, Marcello, Vanini, Valentina, Petrone, Linda, Casetti, Rita, Cuzzi, Gilda, Salmi, Andrea, Altera, Anna Maria, Pierelli, Luca, Gualano, Gina, Ascoli Bartoli, Tommaso, Castilletti, Concetta, Agrati, Chiara, Girardi, Enrico, Palmieri, Fabrizio, Nicastri, Emanuele, Di Rosa, Enrico, Goletti, Delia“…Cell-mediated response was evaluated by measuring interferon (IFN)-γ levels by ELISA in plasma harvested from whole-blood stimulated with SARS−CoV−2 peptide pools, including spike (S), nucleocapsid (N) and membrane (M) proteins. …”
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31979por Sato, Jun, Shimizu, Toshio, Koyama, Takafumi, Iwasa, Satoru, Shimomura, Akihiko, Kondo, Shunsuke, Kitano, Shigehisa, Yonemori, Kan, Fujiwara, Yutaka, Tamura, Kenji, Suzuki, Takuya, Takase, Takao, Nagai, Reiko, Yamaguchi, Kohei, Semba, Taro, Zhao, Zi-Ming, Ren, Min, Yamamoto, Noboru“…Endothelial [TEK receptor tyrosine kinase (TEK), intercellular adhesion molecule 1 (ICAM1), vascular endothelial growth factor receptor 3 (VEGFR3), platelet/endothelial cell adhesion molecule 1 (PECAM1)], vasculature (collagen IV), and immune-related [interferon gamma (IFNγ), C-X-C motif chemokine ligand 11 (CXCL11), C-X-C motif chemokine ligand 10 (CXCL10)] biomarker levels were increased. …”
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31980por Naesens, Leslie, Nemegeer, Josephine, Roelens, Filip, Vallaeys, Lore, Meuwissen, Marije, Janssens, Katrien, Verloo, Patrick, Ogunjimi, Benson, Hemelsoet, Dimitri, Hoste, Levi, Roels, Lisa, De Bruyne, Marieke, De Baere, Elfride, Van Dorpe, Jo, Dendooven, Amélie, Sieben, Anne, Rice, Gillian I., Kerre, Tessa, Beyaert, Rudi, Uggenti, Carolina, Crow, Yanick J., Tavernier, Simon J., Maelfait, Jonathan, Haerynck, Filomeen“…Impairment of U7 snRNP function results in misprocessing of replication-dependent histone (RDH) pre-mRNA and disturbance of histone occupancy of nuclear DNA, ultimately driving cGAS-dependent type I interferon (IFN-I) release. OBJECTIVE: We performed a clinical, genetic, and immunological workup of 3 unrelated patients with uncharacterized AGS. …”
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