-
32021por Joshi, Monika, Tuanquin, Leonard, Zhu, Junjia, Walter, Vonn, Schell, Todd, Kaag, Matthew, Kilari, Deepak, Liao, Jiangang, Holder, Sheldon L, Emamekhoo, Hamid, Sankin, Alexander, Merrill, Suzzane, Zheng, Hong, Warrick, Joshua, Hauke, Ralph, Gartrel, Benjamin, Stein, Mark, Drabick, Joseph, Degraff, David J, Zakharia, Yousef“…Patients with CR/PR or SD had an increase in naïve CD4 T cells, a decrease in PD-1+CD4 T cells at baseline and an increase in cytokine-producing CD8 T cells, including interferon gamma (IFNγ) producing cells, in the peripheral blood. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32022por Estephan, Lila, Liu, Luke Tzu-Chi, Lien, Chia En, Smith, Emily R., Gurwith, Marc, Chen, Robert T.“…Antigen-specific T-cell responses, particularly a Th1-biased immune response characterized by high levels of interferon gamma and IL-2 cytokines, have also been observed. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32023por Bar-Or, Amit, Bhargava, Pavan, Patti, Francesco, Killestein, Joep, Vollmer, Timothy, Kuenzel, Thomas, Lebrun, Christine“…Les anticorps ont été dosés par électrochimioluminescence (Elecsys®) et les cellules T spécifiques contre 4 pools peptidiques de la protéine spike détectées par ELISpot Interferon-gamma (ImmunoSpot). Une infection perthérapeutique est définie comme une infection COVID-19 suspectée ou confirmée en laboratoire, survenant ≥ 14 jours après la primovaccination. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32024por Zhang, Yi-Bing, Bao, Yong-Rui, Wang, Shuai, Li, Tian-Jiao, Tai, He, Leng, Jia-Peng, Yang, Xin-Xin, Wang, Bo-Cai, Meng, Xian-Sheng“…Average body weight gain, spleen and thymus indices were calculated, tumor tissues were stained with hematoxylin and eosin, and Interferon gamma (IFN-γ), Tumor necrosis factor α (TNF-α), Interleukin-2, aspartate aminotransferase, alanine aminotransferase, alpha-fetoprotein (AFP), Fas, and FasL were measured by Enzyme-linked Immunosorbent Assay. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32025por Rajamanickam, Anuradha, Venkataraman, Aishwarya, Kumar, Nathella Pavan, Sasidaran, R., Pandiarajan, Arul Nancy, Selvaraj, Nandhini, Mittal, Ruchi, Gowshika, K., Putlibai, Sulochana, Lakshan Raj, S., Ramanan, Padmasani Venkat, Babu, Subash“…Acute COVID-19 children had significantly elevated levels of cytokines, (Interferon (IFN)) IFNγ, Interleukins (IL)-2, TNFα, IL-1α, IL-1β, IFNα, IFNβ, IL-6, IL-12, IL-17A and Granulocyte-Colony Stimulating Factors (G-CSF) in comparison to convalescent COVID-19 and controls. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32026por Gomes, Shayane Martins Rodrigues, Brito, Andréia Carolinne de Souza, Manfro, Wânia Ferraz Pereira, Ribeiro-Alves, Marcelo, Ribeiro, Roberto Stefan de Almeida, da Cal, Mariana Soares, Lisboa, Vinicius da Cunha, de Abreu, Daniel Paiva Barros, Castilho, Leda dos Reis, Porto, Luís Cristóvão de Moares Sobrino, Mafort, Thiago Thomáz, Lopes, Agnaldo José, da Silva, Silvia Amaral Gonçalves, Dutra, Patrícia Maria Lourenço, Rodrigues, Luciana Silva“…METHODS: In this cross-sectional study, we aimed to evaluate a set of antigen-specific inflammatory cytokines in blood from recovered COVID-19 individuals or who suffered a post-acute phase of SARS-CoV-2 infection compared to healthy individuals with no history of COVID-19 exposition or infection. Interferon-gamma (IFN-γ), IFN-γ-induced protein 10 (IP-10), tumor necrosis factor (TNF), IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, and IL-17A were quantified by multiplex cytometric bead assay and enzyme-linked immunosorbent assay after stimulation of whole blood with recombinant Spike protein from SARS-CoV-2. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32027por Cornwell, MacIntosh G., Bannoudi, Hanane El, Luttrell-Williams, Elliot, Engel, Alexis, Barrett, Tessa J., Myndzar, Khrystyna, Izmirly, Peter, Belmont, H. Michael, Clancy, Robert, Ruggles, Kelly V., Buyon, Jill P., Berger, Jeffrey S.“…RESULTS: There were 2290 differentially expressed genes enriched for pathways involved in interferon signaling, immune activation, and coagulation when comparing SLE samples vs controls. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32028por Chen, Rui, Hui, Kenrie Pui-Yan, Liang, Yingmin, Ng, Ka-Chun, Nicholls, John Malcolm, Ip, Mary Sau-Man, Peiris, Malik, Chan, Michael Chi-Wai, Mak, Judith Choi-Wo“…CSM exposure caused significant upregulation of long form angiotensin converting enzyme (ACE)2, a functional receptor for SARS-CoV-2 viral entry, transmembrane serine protease (TMPRSS)2 and TMPRSS4, which cleave the spike protein of SARS-CoV-2 to allow viral entry, leading to an aggravated immune response via inhibition of type I interferon pathway. In addition, CSM worsened SARS-CoV-2-induced airway epithelial cell damage, resulting in severe motile ciliary disorder, junctional disruption and mucus hypersecretion. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32029por Kanazawa, Nobuo, Ishii, Taeko, Takita, Yasushi, Nishikawa, Atsushi, Nishikomori, Ryuta“…BACKGROUND: This study evaluated the efficacy and safety of baricitinib (Janus kinase-1/2 inhibitor), in adult and pediatric Japanese patients with Nakajo-Nishimura syndrome/chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (NNS/CANDLE), stimulator of interferon genes-associated vasculopathy with onset during infancy (SAVI), or Aicardi-Goutières syndrome (AGS). …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32030por Pan, Zaozao, Huang, Jiaqiang, Hu, Ting, Zhang, Yonghong, Zhang, Lingyu, Zhang, Jiaxi, Cui, Defeng, Li, Lu, Wang, Jing, Wu, Qiong“…Proinflammatory response mediated by the transcription factor nuclear factor-k-gene binding (NF-κB), such as elevated levels of interleukin-1β(IL-1β), interleukin-6 (IL-6), interferon-γ (IFN-γ), interleukin-17 (IL-17), and tumor necrosis factor-α (TNF-α) expression was induced at 6 and 24 h after BPA exposure. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32031por Zorea, Jonathan, Motro, Yair, Mazor, Roei D., Carmi, Yifat Koren, Shulman, Ziv, Mahajna, Jamal, Moran-Gilad, Jacob, Elkabets, Moshe“…Knockout of TRAF3 (TRAF3KO) activated the type-I interferon pathway and increased MHC-I expression. TRAF3KO tumors exhibited a growth delay in WT mice vs. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32032por Ning, Boting, Tilston-Lunel, Andrew M., Simonetti, Justice, Hicks-Berthet, Julia, Matschulat, Adeline, Pfefferkorn, Roxana, Spira, Avrum, Edwards, Matthew, Mazzilli, Sarah, Lenburg, Marc E., Beane, Jennifer E., Varelas, Xaralabos“…Our observations suggest that YAP/TAZ-TEAD-TP63 associate to cooperatively promote basal epithelial cell proliferation and repress signals associated with interferon responses and immune cell communication. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32033por Hu, Shilin, Chen, Bo, Zhou, Jiannan, Liu, Fangqi, Mao, Tianjiao, Pathak, Janak L., Watanabe, Nobumoto, Li, Jiang“…Salivary gland epithelial cells (SGEC) were treated with interferon-gamma (IFN-γ) to mimic SS in vitro and cultured with or without DPSC-Exos. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32034por Uzun, Sarp, Zinner, Carl, Beenen, Amke C., Alborelli, Ilaria, Bartoszek, Ewelina M., Yeung, Jason, Calgua, Byron, Reinscheid, Matthias, Bonsert, Peter, Stalder, Anna K., Haslbauer, Jasmine, Vosbeck, Jürg, Mazzucchelli, Luca, Hoffmann, Tobias, Terracciano, Luigi M., Hutter, Gregor, Manz, Michael, Panne, Isabelle, Böttler, Tobias, Hofmann, Maike, Bengsch, Bertram, Heim, Markus H., Bernsmeier, Christine, Jiang, Sizun, Tzankov, Alexandar, Beretta-Piccoli, Benedetta Terziroli, Matter, Matthias S.“…Gene expression profiling showed that mitochondrial metabolism and oxidative stress-related pathways were more and interferon response pathways less enriched in VILI. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32035por Waugh, Mihyun Lim, Boltin, Nicholas, Wolf, Lauren, Goodwin, Jane, Parker, Patti, Horner, Ronnie, Hermes, Matthew, Wheeler, Thomas, Goodwin, Richard, Moss, Melissa“…RESULTS: PCA revealed that proinflammatory cytokines interferon gamma, interleukin 12p70, and interleukin 2 are the largest contributors to the variance explained in PC 1, while anti-inflammatory cytokines interleukins 10, 4, and 6 are the largest contributors to the variance explained in PC 2. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32036por Zhang, Lifan, Ma, Yanan, Jiang, Nan, Zou, Xiaoqing, Zhang, Yueqiu, Zhang, Fengchun, Zeng, Xiaofeng, Zhao, Yan, Liu, Shengyun, Zuo, Xiaoxia, Wu, Huaxiang, Wu, Lijun, Li, Hongbin, Zhang, Zhiyi, Chen, Sheng, Zhu, Ping, Zhang, Miaojia, Qi, Wencheng, Liu, Yi, Liu, Huaxiang, Shi, Xiaochun, Liu, Xiaoqing“…The frequencies of CFP-10–specific gamma interferon (IFN-γ)-secreting T cells were significantly lower in SLE patients with severe disease activity or high-dose glucocorticoids (P < 0.05). …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32037por Adam, Fathalrhman Eisa Addoma, Zhao, Xueliang, Guan, Zhao, Chang, Zhengwu, Thrusfield, Michael, Lu, Kejia, El Tigani-Asil, El Tigani Ahmed, Terab, Abdelnasir Mohammed Adam, Ismael, Mohamedelfateh, Tong, Lina, Prince-Theodore, Daguia Wenam, Luo, Chen, Xiao, Sa, Wang, Xinglong, Liu, Haijin, Yang, Zengqi“…Moreover, humoral and adaptive immunological conditions were shown to be in harmony after rAdv-ChGM-CSF-HN inoculation and uniformly enhanced the expression of alpha interferon (IFN-α), IFN-β, IFN-γ, interleukin-1β (IL-1β), IL-2, IL-16, IL-18, and IL-22. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32038por Verburgh, Myrthe L., van Pul, Lisa, Grobben, Marloes, Boyd, Anders, Wit, Ferdinand W. N. M., van Nuenen, Ad C., van Dort, Karel A., Tejjani, Khadija, van Rijswijk, Jacqueline, Bakker, Margreet, van der Hoek, Lia, Schim van der Loeff, Maarten F., van der Valk, Marc, van Gils, Marit J., Kootstra, Neeltje A., Reiss, Peter“…T-cell responses were assessed by gamma interferon (IFN-γ) release and activation-induced marker assay. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32039“…Flow cytometric data showed that EPE-treated Cyp-NOD mice had decreased the CD4(+) subsets T cell distribution of CD4(+)IL-17 and CD4(+) interferon gamma (IFN-γ), but increased the CD4(+) subsets T cell distribution of CD4(+)IL-4 and CD4(+)Foxp3. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
32040por Mann, Tiffeney, Gupta, Rishi K, Reeve, Byron WP, Ndlangalavu, Gcobisa, Chandran, Aneesh, Krishna, Amirtha P, Calderwood, Claire J, Tshivhula, Happy, Palmer, Zaida, Naidoo, Selisha, Mbu, Desiree L, Theron, Grant, Noursadeghi, Mahdad“…INTERPRETATION: RNA biomarkers showed better clinical utility to guide confirmatory TB testing for PLHIV prior to ART initiation than symptom-based screening, but their performance did not exceed that of CRP, and fell short of WHO recommended targets. Interferon-independent approaches may be required to improve accuracy of host-response biomarkers to support TB screening pre-ART initiation. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto