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32101por Benedetti, Francesca, Snyder, Greg A., Giovanetti, Marta, Angeletti, Silvia, Gallo, Robert C., Ciccozzi, Massimo, Zella, Davide“…In addition, substitution of the two amino acids (KS) from nsp1 of SARS-CoV was previously reported to revert loss of interferon-alpha expression. The deletion that we describe indicates that SARS-CoV-2 is undergoing profound genomic changes. …”
Publicado 2020
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32102por Stifter, Katja, Krieger, Jana, Ruths, Leonie, Gout, Johann, Mulaw, Medhanie, Lechel, Andre, Kleger, Alexander, Seufferlein, Thomas, Wagner, Martin, Schirmbeck, Reinhold“…Similarly, we explored the antigenicity and PD-L1/PD-1 sensitivity of PDACCs versus interferon-γ (IFN-γ)-treated PDACCs in PD-1/PD-L1-competent/deficient mice. …”
Publicado 2020
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32103por d’Ettorre, Gabriella, Recchia, Gregorio, Ridolfi, Marco, Siccardi, Guido, Pinacchio, Claudia, Innocenti, Giuseppe Pietro, Santinelli, Letizia, Frasca, Federica, Bitossi, Camilla, Ceccarelli, Giancarlo, Borrazzo, Cristian, Antonelli, Guido, Scagnolari, Carolina, Mastroianni, Claudio Maria“…RATIONALE: Complex immune dysregulation in interferon (IFN) and T cell response has been observed in human immunodeficiency virus (HIV-1)-infected patients as well as in coronavirus disease-2019 (COVID-19) patients. …”
Publicado 2020
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32104por Frazao, Alexandra, Rethacker, Louise, Jeudy, Géraldine, Colombo, Marina, Pasmant, Eric, Avril, Marie-Françoise, Toubert, Antoine, Moins-Teisserenc, Helene, Roelens, Marie, Dalac, Sophie, Maubec, Eve, Caignard, Anne“…SK28R and M14R cells induced higher NK degranulation and interferon gamma secretion and were more efficiently lysed by donor and patient NK cells. …”
Publicado 2020
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32105“…Enzyme-linked immunosorbent assay kits were used to measure serum BAFF and interferon-alpha (IFN-α) concentrations. Cytometric bead array analysis was used to measure serum concentrations of cytokines. …”
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32106por Dragon, Anna Christina, Zimmermann, Katharina, Nerreter, Thomas, Sandfort, Deborah, Lahrberg, Julia, Klöß, Stephan, Kloth, Christina, Mangare, Caroline, Bonifacius, Agnes, Tischer-Zimmermann, Sabine, Blasczyk, Rainer, Maecker-Kolhoff, Britta, Uchanska-Ziegler, Barbara, Abken, Hinrich, Schambach, Axel, Hudecek, Michael, Eiz-Vesper, Britta“…RESULTS: After co-cultivation with EBV target cells, TÜ165 CAR-Ts and TRUCKs showed an increased activation marker expression (CD137, CD25) and release of proinflammatory cytokines (interferon-γ and tumor necrosis factor-α). Moreover, TÜ165 CAR-Ts and TRUCKs released apoptosis-inducing mediators (granzyme B and perforin) and were capable to specifically lyse EBV-positive target cells. …”
Publicado 2020
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32107por Chettimada, Sukrutha, Lorenz, David R., Misra, Vikas, Wolinsky, Steven M., Gabuzda, Dana“…Over-representation and pathway enrichment analyses of miRNAs and their target genes predicted functional association with oxidative stress responses, interferon gamma signaling, Toll-like receptor signaling, TGF beta signaling, and Notch signaling. …”
Publicado 2020
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32108por Boi, Shannon K, Orlandella, Rachael M, Gibson, Justin Tyler, Turbitt, William James, Wald, Gal, Thomas, Lewis, Buchta Rosean, Claire, Norris, Katlyn E, Bing, Megan, Bertrand, Laura, Gross, Brett P, Makkouk, Amani, Starenki, Dmytro, Farag, Kristine I, Sorge, Robert E, Brown, James A, Gordetsky, Jennifer, Yasin, Hesham, Garje, Rohan, Nandagopal, Lakshminarayanan, Weiner, George J, Lubaroff, David M, Arend, Rebecca C, Li, Peng, Zakharia, Yousef, Yang, Eddy, Salem, Aliasger K, Nepple, Kenneth, Marquez-Lago, Tatiana T, Norian, Lyse A“…Tumors from lean and obese treatment responders displayed similar immunogenetic profiles, robust infiltration by PD-1(int) interferon (IFN)γ(+)CD8(+) T cells and reduced myeloid-derived suppressor cells (MDSC), yielding favorable CD44(+)CD8(+) T cell to MDSC ratios. …”
Publicado 2020
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32109por Lev, Shaul, Gottesman, Tamar, Levin, Gal Shachaf, Ber, Tahel Ilan, Angel, Alon, Kellerman, Lior, Barash, Eran, Navon, Roy, Simon, Einav, Avni, Noa, Hainrichson, Mary, Gottlieb, Tanya, Oved, Kfir, Eden, Eran, Tadmor, Boaz“…BACKGROUND: It is estimated that up to 10% of SARS-CoV-2 patients progress from early and pulmonary stages to the most severe stage of illness, which manifests as an extra-pulmonary systemic hyperinflammatory syndrome. Interferon gamma-induced protein 10 (IP-10) is an inflammatory marker that plays a role in the dysregulated host response of COVID-19 infected patients. …”
Publicado 2020
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32110por Yang, Xinting, Zhang, Jing, Liang, Qingtao, Pan, Liping, Duan, Hongfei, Yang, Yang, Li, Hua, Guo, Chao, Sun, Qi, Jia, Hongyan, Du, Boping, Wei, Rongrong, Xing, Aiying, Zhang, Zongde, Chen, Xiaoyou“…This study estimates diagnostic efficacy of the interferon gamma release assay (IGRA: T-SPOT.TB) in TPE patients of different characteristics. …”
Publicado 2021
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32111por Patel, Neha A.“…Various treatment regimens including interferon, antivirals, and hydroxychloroquine therapies have been trialed on the pediatric population but there are currently no studies showing efficacy of one regimen over the other. …”
Publicado 2020
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32112por Huang, Xianwei, Pan, Mandong, Du, Penghui, Chen, Yinrong, Zhang, Caixia, Lu, Wang, Lin, Jiyan“…Mechanistically, MEG3 inhibited the expression of inflammatory factors including interleukin (IL)-1β, tumor necrosis factor (TNF)-α, interferon-gamma (IFN)-γ, inflammatory factors including interleukin (IL)-10, and transforming growth factor beta (TGFb)-1, as well as nuclear factor-kappa B (NF-κB) signaling. …”
Publicado 2021
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32113por Dai, Siyuan, Zeng, Han, Liu, Zhaopei, Jin, Kaifeng, Jiang, Wenbin, Wang, Zewei, Lin, Zhiyuan, Xiong, Ying, Wang, Jiajun, Chang, Yuan, Bai, Qi, Xia, Yu, Liu, Li, Zhu, Yu, Xu, Le, Qu, Yang, Guo, Jianming, Xu, Jiejie“…CXCL13(+)CD8(+)T cells possessed higher level of immune checkpoints like programmed cell-death protein 1 (PD-1), T-cell immunoglobulin mucin 3 (Tim-3), T cell immunoreceptor with Ig and ITIM domains (TIGIT) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), higher Ki-67 expression and lower tumor necrosis factor α (TNF-α), interferon γ (IFN-γ) expression. Total CD8(+)T cells in high-level CXCL13(+)CD8(+)T cells infiltration subgroup exhibited elevated exhausted markers (PD-1, Tim-3, TIGIT) and descended activated markers (TNF-α, IFN-γ) without quantity variance. …”
Publicado 2021
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32114por Qi, Shaohua, Al Mamun, Abdullah, Ngwa, Conelius, Romana, Sharmeen, Ritzel, Rodney, Arnold, Arthur P., McCullough, Louise D., Liu, Fudong“…Chromatin immunoprecipitation (ChIP) assays were conducted to detect DNA levels of inflammatory interferon regulatory factor (IRF) 4/5 precipitated by histone H3K4 and H3K27 antibodies. …”
Publicado 2021
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32115por Butler, Daniel, Mozsary, Christopher, Meydan, Cem, Foox, Jonathan, Rosiene, Joel, Shaiber, Alon, Danko, David, Afshinnekoo, Ebrahim, MacKay, Matthew, Sedlazeck, Fritz J., Ivanov, Nikolay A., Sierra, Maria, Pohle, Diana, Zietz, Michael, Gisladottir, Undina, Ramlall, Vijendra, Sholle, Evan T., Schenck, Edward J., Westover, Craig D., Hassan, Ciaran, Ryon, Krista, Young, Benjamin, Bhattacharya, Chandrima, Ng, Dianna L., Granados, Andrea C., Santos, Yale A., Servellita, Venice, Federman, Scot, Ruggiero, Phyllis, Fungtammasan, Arkarachai, Chin, Chen-Shan, Pearson, Nathaniel M., Langhorst, Bradley W., Tanner, Nathan A., Kim, Youngmi, Reeves, Jason W., Hether, Tyler D., Warren, Sarah E., Bailey, Michael, Gawrys, Justyna, Meleshko, Dmitry, Xu, Dong, Couto-Rodriguez, Mara, Nagy-Szakal, Dorottya, Barrows, Joseph, Wells, Heather, O’Hara, Niamh B., Rosenfeld, Jeffrey A., Chen, Ying, Steel, Peter A. D., Shemesh, Amos J., Xiang, Jenny, Thierry-Mieg, Jean, Thierry-Mieg, Danielle, Iftner, Angelika, Bezdan, Daniela, Sanchez, Elizabeth, Campion, Thomas R., Sipley, John, Cong, Lin, Craney, Arryn, Velu, Priya, Melnick, Ari M., Shapira, Sagi, Hajirasouliha, Iman, Borczuk, Alain, Iftner, Thomas, Salvatore, Mirella, Loda, Massimo, Westblade, Lars F., Cushing, Melissa, Wu, Shixiu, Levy, Shawn, Chiu, Charles, Schwartz, Robert E., Tatonetti, Nicholas, Rennert, Hanna, Imielinski, Marcin, Mason, Christopher E.“…We find significant enrichment of a NYC-distinctive clade of the virus (20C), as well as host responses in interferon, ACE, hematological, and olfaction pathways. …”
Publicado 2021
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32116por Reder, Anthony T., Centonze, Diego, Naylor, Maria L., Nagpal, Anjali, Rajbhandari, Rajani, Altincatal, Arman, Kim, Michelle, Berdofe, Aaron, Radhakrishnan, Maha, Jung, Eunice, Sandrock, Alfred W., Smirnakis, Karen, Popescu, Catrinel, de Moor, Carl“…In the Biogen Global Safety Database, we identified 1217 patients who were COVID-19 positive treated with intramuscular interferon beta-1a, peginterferon beta-1a, natalizumab, dimethyl fumarate, diroximel fumarate, or fampridine. …”
Publicado 2021
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32117por Cowan, Robert P., Gross, Noah B., Sweeney, Melanie D., Sagare, Abhay P., Montagne, Axel, Arakaki, Xianghong, Fonteh, Alfred N., Zlokovic, Berislav V., Pogoda, Janice M., Harrington, Michael G.“…We did not find any difference in individuals with EM or CM from controls for CSF cell count, total protein, matrix metalloproteinase‐9, soluble platelet‐derived growth factor receptor β, tumor necrosis factor‐alpha, interferon‐gamma, interleukin (IL)‐6, IL‐8, IL‐10, or C‐reactive protein. …”
Publicado 2021
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32118por Liang, Lin, Zhang, Ya-Mei, Shen, Ya-Wen, Song, Ai-Ping, Li, Wen-Li, Ye, Li-Fang, Lu, Xin, Wang, Guo-Chun, Peng, Qing-Lin“…The mRNA levels of Gal-9 were positively correlated with the levels of type-I interferon-inducible genes MX1 (r = 0.659, p = 0.020) and IFIH1 (r = 0.787, p = 0.002) in PBMCs from anti-MDA5-positive DM patients. …”
Publicado 2021
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32119por Amoako, Yaw Ampem, Loglo, Aloysius Dzigbordi, Frimpong, Michael, Agbavor, Bernadette, Abass, Mohammed Kabiru, Amofa, George, Ofori, Elizabeth, Ampadu, Edwin, Asiedu, Kingsley, Stienstra, Ymkje, Wansbrough-Jones, Mark, van der Werf, Tjip, Phillips, Richard Odame“…BU(+)HIV(−) patients mounted a significantly higher interferon-γ response compared to the BU(+)HIV(+) co-infected patients with respective median (range) responses of [1687(81.11–4399) pg/ml] versus [137.5(4.436–1406) pg/ml, p = 0.03]. …”
Publicado 2021
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32120por Jiang, Xueping, Li, Yangyi, Zhang, Nannan, Gao, Yanping, Han, Linzhi, Li, Shuying, Li, Jiali, Liu, Xingyu, Gong, Yan, Xie, Conghua“…RRM2 silencing induced cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway, and the downstream targets were regulated in a STING-dependent manner. …”
Publicado 2021
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