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32121por Zhang, Fan, Mears, Joseph R., Shakib, Lorien, Beynor, Jessica I., Shanaj, Sara, Korsunsky, Ilya, Nathan, Aparna, Donlin, Laura T., Raychaudhuri, Soumya“…These cells exhibited a distinct arrangement of pro-inflammatory and interferon response genes, including elevated levels of CXCL10, CXCL9, CCL2, CCL3, GBP1, STAT1, and IL1B. …”
Publicado 2021
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32122por Aldunate, Fabián, Echeverría, Natalia, Chiodi, Daniela, López, Pablo, Sánchez-Cicerón, Adriana, Soñora, Martín, Cristina, Juan, Moratorio, Gonzalo, Hernández, Nelia, Moreno, Pilar“…He had previously not responded to dual therapy (pegylated interferon-α plus ribavirin) and was going to start a direct-acting agent-based therapy (DAAs). …”
Publicado 2021
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32123por Saadat, Nadia, Zhang, Liying, Padmanabhan, Vasantha, Engeland, Christopher G, Misra, Dawn P, Giurgescu, Carmen“…Plasma cytokine levels (interferon [IFN]-γ, tumor necrosis factor [TNF]-α, IL-6, IL8 and IL10) were measured by multiplex array and CRP was measured by ELISA. …”
Publicado 2021
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32124por Tarhini, Ahmad A, Kang, Ni, Lee, Sandra J, Hodi, F Stephen, Cohen, Gary I, Hamid, Omid, Hutchins, Laura F, Sosman, Jeffrey A, Kluger, Harriet M, Eroglu, Zeynep, Koon, Henry B, Lawrence, Donald P, Kendra, Kari L, Minor, David R, Lee, Carrie B, Albertini, Mark R, Flaherty, Lawrence E, Petrella, Teresa M, Streicher, Howard, Sondak, Vernon K, Kirkwood, John M“…PATIENTS AND METHODS: E1609 enrolled 1673 patients with resected high-risk melanoma and evaluated adjuvant ipilimumab 3 mg/kg (ipi3) and 10 mg/kg (ipi10) versus interferon-α. We investigated the association of irAEs and of use of immunosuppressants with RFS and OS for patients treated with ipilimumab (n=1034). …”
Publicado 2021
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32125“…DS induced IR, similar to the traditionally used pharmacological factors, namely dexamethasone, TNF-α, and palmitate, which can be attributed to the significantly higher pro-inflammatory cytokines levels (TNF-α (2.28 ± 0.03 pg/mL vs. 2.38 ± 0.03 pg/mL, P < 0.01), interleukin 6 (IL)-6 (1.94 ± 0.02 pg/mL vs. 2.17 ± 0.04 pg/mL, P < 0.01), IL-17 (2.16 ± 0.02 pg/mL vs. 2.22 ± 0.002 pg/mL, P < 0.05), and interferon gamma (IFN-γ) (2.07 ± 0.02 pg/mL vs. 2.15 ± 0.04 pg/mL, P < 0.05)) in DS. …”
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32126“…Hypothesized mechanisms include an imbalance in the normal PTH-Ca axis caused by SARS-CoV-2 mediated release of inflammatory cytokines (e.g. interferon, previously reported to lower serum calcium), or development of antibodies against the parathyroid or CaSR. …”
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32127“…BACKGROUND: Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from damaged mitochondria into the cytosol. mtDNA stress may contribute to cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway activation in infectious diseases. …”
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32128por Ehsan, Muhammad, Hu, Rui-Si, Hou, Jun-Ling, Elsheikha, Hany M., Li, Xiao-Dong, Liang, Pan-Hong, Zhu, Xing-Quan“…Co-incubation of rFg-CaBP4 with concanavalin A-stimulated monocytes increased the transcription levels of interleukin (IL)-2, IL-4, interferon gamma and transforming growth factor-β. However, a reduction in the expression of IL-10 and no change in the expression of tumor necrosis factor-α were detected. …”
Publicado 2021
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32129por Rodríguez-Sánchez, Diego Noé, Pinto, Giovana Boff Araujo, Cartarozzi, Luciana Politti, de Oliveira, Alexandre Leite Rodrigues, Bovolato, Ana Livia Carvalho, de Carvalho, Marcio, da Silva, Jorge Vicente Lopes, Dernowsek, Janaina de Andréa, Golim, Marjorie, Barraviera, Benedito, Ferreira, Rui Seabra, Deffune, Elenice, Bertanha, Mathues, Amorim, Rogério Martins“…In vitro, the cells were characterized and directly stimulated with interferon-gamma to evaluate their neuroregeneration potential. …”
Publicado 2021
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32130por Gérard, Alexandre, Doyen, Jerome, Cremoni, Marion, Bailly, Laurent, Zorzi, Kevin, Ruetsch-Chelli, Caroline, Brglez, Vesna, Picard-Gauci, Alexandra, Troin, Laura, Esnault, Vincent L.M., Passeron, Thierry, Montaudié, Henri, Seitz-Polski, Barbara“…On in vitro stimulation, metastatic patients had lower Th1 cytokine levels than healthy donors at baseline for tumor necrosis factor-α and interferon-γ (IFN-γ) (1136 pg/mL vs 5558 pg/mL, p<0.0001; and 3894 pg/mL vs 17 129 pg/mL, p=0.02, respectively). …”
Publicado 2021
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32131por Lee, Han Ah, Goh, Hyun Gil, Lee, Young-Sun, Jung, Young Kul, Kim, Ji Hoon, Yim, Hyung Joon, Lee, Min-Goo, An, Hyunggin, Jeen, Yoon Tae, Yeon, Jong Eun, Byun, Kwan Soo, Seo, Yeon Seok“…The mean age was 62.5 years. At baseline, interferon (IFN)-γ producing NK cell proportion was significantly lower in patients with Barcelona clinic liver cancer (BCLC) stage B, C, or D than in those with BCLC stage 0 (42.9% vs. 56.8%, P = 0.045). …”
Publicado 2021
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32132por Patil, Ajit Mahadev, Choi, Jin Young, Park, Seong Ok, Uyangaa, Erdenebelig, Kim, Bumseok, Kim, Koanhoi, Eo, Seong Kug“…BACKGROUND: The crucial role of type I interferon (IFN-I, IFN-α/β) is well known to control central nervous system (CNS) neuroinflammation caused by neurotrophic flaviviruses such as Japanese encephalitis virus (JEV) and West Nile virus. …”
Publicado 2021
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32133por Mahil, Satveer K, Bechman, Katie, Raharja, Antony, Domingo-Vila, Clara, Baudry, David, Brown, Matthew A, Cope, Andrew P, Dasandi, Tejus, Graham, Carl, Lechmere, Thomas, Malim, Michael H, Meynell, Freya, Pollock, Emily, Seow, Jeffery, Sychowska, Kamila, Barker, Jonathan N, Norton, Sam, Galloway, James B, Doores, Katie J, Tree, Timothy I M, Smith, Catherine H“…The primary outcomes were humoral immunity to the SARS-CoV-2 spike glycoprotein, defined as neutralising antibody responses to wild-type SARS-CoV-2, and spike-specific T-cell responses (including interferon-γ, IL-2, and IL-21) 28 days after vaccination. …”
Publicado 2021
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32134por Schrezenmeier, Eva, Bergfeld, Leon, Hillus, David, Lippert, Joerg-Detlev, Weber, Ulrike, Tober-Lau, Pinkus, Landgraf, Irmgard, Schwarz, Tatjana, Kappert, Kai, Stefanski, Ana-Luisa, Sattler, Arne, Kotsch, Katja, Dörner, Thomas, Sander, Leif Erik, Budde, Klemens, Halleck, Fabian, Kurth, Florian, Corman, Victor Max, Choi, Mira“…In addition, SARS-CoV-2-specific T-cell responses were assessed at ~3–4 weeks by an interferon-gamma release assay (IGRA). Antibody and T cell outcomes at this timepoint were compared to a group of 44 elderly patients not on dialysis, after immunization with Tozinameran. …”
Publicado 2021
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32135por Uwimaana, Esther, Bagaya, Bernard S., Castelnuovo, Barbara, Kateete, David P., Godwin, Anguzu, Kiwanuka, Noah, Whalen, Christopher C., Joloba, Moses L.“…Latent TB infection (LTBI) is diagnosed using tuberculin skin test (TST) and interferon gamma release assays (T-Spot and QuantiFERON TB gold tests, respectively). …”
Publicado 2021
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32136por Lu, Danfeng, Zhang, Jian-Bo, Wang, Yue-Xin, Geng, Shi-Tao, Zhang, Zunyue, Xu, Yu, Li, Shao-You, Wang, Kun-Hua, Kuang, Yi-Qun“…RESULTS: Compared to INRs with CD4 count > 200 cells/μL, those with CD4 count < 200 cells/μL had a lower CD4/CD8 ratio, lower nutritional status and higher serum levels of tumor necrosis factor (TNF)-α, interferon-γ-inducible protein (IP)-10 and interleukin (IL)-1α. …”
Publicado 2021
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32137por Espi, M., Charmetant, X., Barba, T., Koppe, L., Pelletier, C., Kalbacher, E., Chalencon, E., Fouque, D., Juillard, L., Thaunat, O.“…MÉTHODES: Nous avons mesuré le taux d’IgG dirigé contre le domaine de fixation de la protéine Spike (IgG anti-RBD) ainsi que la réponse interféron-gamma (IFNγ) des lymphocytes T CD4 et CD8 spécifiques 10 à 14 jours après la 2nde injection vaccinale chez 106 patients hémodialysés chroniques (dont 14 avec un antécédent de COVID-19). …”
Publicado 2021
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32138por Espi, M., Charmetant, X., Barba, T., Koppe, L., Pelletier, C., Kalbacher, E., Chalencon, E., Fouque, D., Juillard, L., Thaunat, O.“…Nous avons ensuite mesuré les taux d’IgG anti-RBD et la réponse interféron gamma des lymphocytes T CD4 et CD8 spécifiques 10 à 14 jours après la 3(e) injection vaccinale chez 56 patients hémodialysés ayant un défaut de réponse après 2 doses. …”
Publicado 2021
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32139por Yi, Ming, Niu, Mengke, Zhang, Jing, Li, Shiyu, Zhu, Shuangli, Yan, Yongxiang, Li, Ning, Zhou, Pengfei, Chu, Qian, Wu, Kongming“…Bivalent manganese (Mn(2+)) is identified as a natural stimulator of interferon genes (STING) agonist, which might enhance cancer antigen presentation and improve the therapeutic effect of YM101. …”
Publicado 2021
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32140por Nishida, Mikako, Yamashita, Nahoko, Ogawa, Taisaku, Koseki, Keita, Warabi, Eiji, Ohue, Tomoyuki, Komatsu, Masaaki, Matsushita, Hirokazu, Kakimi, Kazuhiro, Kawakami, Eiryo, Shiroguchi, Katsuyuki, Udono, Heiichiro“…Expressions of glucose transporter (Glut)-1, mitochondrial reactive oxygen species (mtROS), interferon (IFN)-γ, Ki67, autophagy markers, activation markers for NF-E2-related factor 2 (Nrf2), and mammalian target of rapamaycin complex 1 (mTORC1) in CD8(+) tumor-infiltrating T lymphocytes (CD8TILs) were examined by flow cytometry analysis. …”
Publicado 2021
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