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32201“…Based on Kyoto Encyclopedia of Genes and Genomes pathway analysis and QIAGEN Ingenuity Pathway Analysis, both IDC and SLE were correlated with the changes of multiple components involved in the Interferon (IFN)-Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway. …”
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32202por Vo, Luan Nguyen Quang, Nguyen, Viet Nhung, Nguyen, Nga Thi Thuy, Dong, Thuy Thi Thu, Codlin, Andrew, Forse, Rachel, Truong, Huyen Thanh, Nguyen, Hoa Binh, Dang, Ha Thi Minh, Truong, Vinh Van, Nguyen, Lan Huu, Mac, Tuan Huy, Le, Phong Thanh, Tran, Khoa Tu, Ndunda, Nduku, Caws, Maxine, Creswell, Jacob“…This study assessed the feasibility of using interferon-γ release assays (IGRAs) at lower healthcare levels and the comparative performance of 3-month and 9-month daily TPT regimens (3HR/9H). …”
Publicado 2023
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32203por Zaheer, Reemal, Amin, Roma, Riddick, LaTasha, Roy, Shuvro, Wolff, Sujin, Nathanson, Amy, Newsome, Scott“…Prescribing patterns of lower efficacy self-injectable therapies (interferon-beta and glatiramer acetate) remained stable. …”
Publicado 2023
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32204Association of Higher Ocrelizumab Exposure With Reduced Disability Progression in Multiple Sclerosispor Hauser, Stephen L., Bar-Or, Amit, Weber, Martin S., Kletzl, Heidemarie, Günther, Andreas, Manfrini, Marianna, Model, Fabian, Mercier, Francois, Petry, Claire, Wing, Qing, Koendgen, Harold, Smith, Terence, Kappos, Ludwig“…A consistent trend of higher ocrelizumab exposure leading to lower rates of CDP was seen (0%–25% [lowest] to 75%–100% [highest] quartile hazard ratios and 95% confidence intervals; relapsing MS: 0.70 [0.41–1.19], 0.85 [0.52–1.39], 0.47 [0.25–0.87], and 0.34 [0.17–0.70] vs interferon β-1a; primary progressive MS: 0.88 [0.59–1.30], 0.86 [0.60–1.25], 0.77 [0.52–1.14], and 0.55 [0.36–0.83] vs placebo). …”
Publicado 2023
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32205por Minagawa, Hikaru, Hashii, Yoshiko, Nakajima, Hiroko, Fujiki, Fumihiro, Morimoto, Soyoko, Nakata, Jun, Shirakawa, Toshiro, Katayama, Takane, Tsuboi, Akihiro, Ozono, Keiichi“…Tumor volume, the frequency and phenotypes of WT1-specific CTLs in CD8(+) T cells in peripheral blood (PB) and tumor-infiltrating lymphocytes (TILs), as well as the proportion of interferon-gamma (INF-γ)-producing CD3(+)CD4(+) T cells pulsed with WT1(35–52) peptide in splenocytes and TILs were determined. …”
Publicado 2023
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32206por Armstrong, Heather, Rahbari, Mandana, Park, Heekuk, Sharon, David, Thiesen, Aducio, Hotte, Naomi, Sun, Ning, Syed, Hussain, Abofayed, Hiatem, Wang, Weiwei, Madsen, Karen, Wine, Eytan, Mason, Andrew“…Evidence of MMTV cellular immune responses to MMTV Gag peptides was observed in the IL-10(−/−) splenocytes with amplified interferon-γ production versus the SvEv wild type. To address the hypothesis that MMTV may contribute to colitis, we used HIV reverse transcriptase inhibitors, tenofovir and emtricitabine, and the HIV protease inhibitor, lopinavir boosted with ritonavir, for 12-week treatment versus placebo. …”
Publicado 2023
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32207por McDew-White, Marina, Lee, Eunhee, Premadasa, Lakmini S., Alvarez, Xavier, Okeoma, Chioma M., Mohan, Mahesh“…Chronic THC potently blocked the upregulation of genes associated with type-I interferon responses (NLRC5, CCL2, CXCL10, IRF1, IRF7, STAT2, BST2), excitotoxicity (SLC7A11), and enhanced protein expression of WFS1 (endoplasmic reticulum stress) and CRYM (oxidative stress) in BG. …”
Publicado 2023
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32208por Tischer-Zimmermann, Sabine, Bonifacius, Agnes, Santamorena, Maria Michela, Mausberg, Philip, Stoll, Sven, Döring, Marius, Kalinke, Ulrich, Blasczyk, Rainer, Maecker-Kolhoff, Britta, Eiz-Vesper, Britta“…Deep T-cell profiling of the tumor-reactive EBV-specific T cells in terms of activation, exhaustion, target cell killing, and cytokine profile was performed, assessing the expression of T-cell differentiation and activation markers as well as regulatory and cytotoxic molecules by interferon-γ (IFN-γ) EliSpot assay, multicolor flow cytometry, and multiplex analyses. …”
Publicado 2023
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32209por Hwang, In-Chan, Valeriano, Valerie Diane, Song, Ji Hoon, Pereira, Marcela, Oh, Ju Kyoung, Han, Kyudong, Engstrand, Lars, Kang, Dae-Kyung“…When orally administered of recombinant L. plantarum expressing SARS-CoV-2 epitopes in mice, all epitopes most increased the expression of IL-4, along with induced levels of TNF-α, interferon-gamma, and IL-10, specifically in spike protein groups. …”
Publicado 2023
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32210por Leland, Pamela, Kumar, Dhiraj, Nimmagadda, Sridhar, Bauer, Steven R., Puri, Raj K., Joshi, Bharat H.“…In addition, T cell subtype characterization and product attributes of radiolabeled CAR-T cells were studied to assess their overall quality including cell viability, proliferation, phenotype markers of T-cell activation and exhaustion, cytolytic activity and release of interferon-γ upon co-culture with IL-13Rα2 expressing glioma cells. …”
Publicado 2023
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32211por Luo, Haiying, Tan, Guili, Hu, Xiaoxia, Li, Yadi, Lei, Dingjia, Zeng, Yueying, Qin, Bo“…OBJECTIVE: To investigate whether the expression of triple motif protein 19/38 (TRIM19/38) mRNA in peripheral blood mononuclear cells (PBMCs) of HBeAg-negative chronic hepatitis B virus (HBV) carriers is associated with the response to pegylated interferon alpha (peg-IFN-α) treatment and HBsAg clearance. …”
Publicado 2023
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32212por Nadal, Ernest, Saleh, Mansoor, Aix, Santiago Ponce, Ochoa-de-Olza, Maria, Patel, Sandip Pravin, Antonia, Scott, Zhao, Yumin, Gueorguieva, Ivelina, Man, Michael, Estrem, Shawn T., Liu, Jiangang, Avsar, Emin, Lin, Wen Hong, Benhadji, Karim A., Gandhi, Leena, Guba, Susan C., Diaz, Inmaculada Ales“…The median progression-free survival was 5.26 months (95% CI: 1.77, 9.20) and the median overall survival was 11.99 months (95% CI: 8.15, NR). Interferon gamma response genes were induced post-treatment and cell adhesion genes were repressed, although the association of these observations with tumor response and clinical outcomes was not statistically powered due to limited samples available. …”
Publicado 2023
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32213por Schett, Georg, Chen, Warner, Gao, Sheng, Chakravarty, Soumya D., Shawi, May, Lavie, Frederic, Zimmermann, Miriam, Sharaf, Mohamed, Coates, Laura C., Siebert, Stefan“…Levels of serum cytokines, including interferon γ (IFNγ), IL-10, and tumor necrosis factor α (TNFα); T helper 17 (Th17) effector cytokines IL-17A, IL-17F, and IL-22; and acute phase proteins C-reactive protein (CRP), IL-6, and serum amyloid A (SAA), were assessed and compared with demographically matched healthy controls; guselkumab pharmacodynamics through Week 24 were also assessed. …”
Publicado 2023
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32214por Galán, Rocío Jiménez, Cidoncha, Elena Calvo, Martin, Mónica Ferrit, Rodriguez, Concepción Carrascosa, Almeida, Carmen V., Verdugo, Ramón Morillo“…We selected patients treated with interferon alfa-2a plus ribavirin between January 2005 and December 2010. …”
Publicado 2013
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32215por Abruzzese, Elisabetta, Bocchia, Monica, Trawinska, Malgorzata Monika, Raspadori, Donatella, Bondanini, Francesco, Sicuranza, Anna, Pacelli, Paola, Re, Federica, Cavalleri, Alessia, Farina, Mirko, Malagola, Michele, Russo, Domenico, De Fabritiis, Paolo, Bernardi, Simona“…The twenty-seven patients enrolled received treatment with either imatinib (12), dasatinib (6), nilotinib (7), bosutinib (1), or interferon (1). Twelve patients were in TFR, while the rest exhibited a DMR. …”
Publicado 2023
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32216por Zhu, Xianming, Gebo, Kelly A, Abraham, Alison G, Habtehyimer, Feben, Patel, Eshan U, Laeyendecker, Oliver, Gniadek, Thomas J, Fernandez, Reinaldo E, Baker, Owen R, Ram, Malathi, Cachay, Edward R, Currier, Judith S, Fukuta, Yuriko, Gerber, Jonathan M, Heath, Sonya L, Meisenberg, Barry, Huaman, Moises A, Levine, Adam C, Shenoy, Aarthi, Anjan, Shweta, Blair, Janis E, Cruser, Daniel, Forthal, Donald N, Hammitt, Laura L, Kassaye, Seble, Mosnaim, Giselle S, Patel, Bela, Paxton, James H, Raval, Jay S, Sutcliffe, Catherine G, Abinante, Matthew, Broderick, Patrick, Cluzet, Valerie, Cordisco, Marie Elena, Greenblatt, Benjamin, Petrini, Joann, Rausch, William, Shade, David, Lane, Karen, Gawad, Amy L, Klein, Sabra L, Pekosz, Andrew, Shoham, Shmuel, Casadevall, Arturo, Bloch, Evan M, Hanley, Daniel, Sullivan, David J, Tobian, Aaron A R“…After adjusting for confounders, geometric mean concentrations of interleukin (IL)-2RA, IL-7, IL-8, IL-15, IL-29 (interferon-λ), inducible protein-10, monocyte chemoattractant protein-1, and tumour necrosis factor-α were significantly lower among the fully vaccinated group than in the unvaccinated group at screening. …”
Publicado 2023
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32217por Ma, Chengxing, Meng, Kaifang, Shi, Shenyun, Zhao, Tingting, Chen, Shanshan, Zhou, Xuan, Shu, Ruilu, Ma, Miao, Tian, Mi, Ding, Jingjing“…The serum concentrations of interferon (IFN)-α, IFN-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17A, and IL-1β were measured by Luminex suspension arrays. …”
Publicado 2023
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32218por Chopra, Karishma A.“…HIV screen negative and interferon gamma response to mycobacterium tuberculosis antigens was not detected. …”
Publicado 2023
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32219por Garcia Ortega, Jessica Rachel, Scott, Lauren N, Wang, Sarah, Zhang, Shile, Chen, Ho-Chung, Huang, Nicole, Lechner, Melissa“…Indeed, CD8(+) T cells expressing Granzyme B, interferon gamma (IFNγ), and chemokine receptor CXCR6 ("CD8(+) autoimmune mediators") were expanded in ICI-treated mice. …”
Publicado 2023
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32220“…OBJECTIVE: To compare the effectiveness of seven major interventions [Bulevirtide (BLV), Interferon (IFN), Nucleoside analogs (NAs), BLV + IFN, BLV + NAs, IFN + NAs, and Placebo] to treat chronic hepatitis D. …”
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