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32241por Sherani, Farha, Moogk, Duane, Bapodra, Anuj, Malecek, Karolina, Moran, Una, Lee, Yesung, Osman, Iman, Krogsgaard, Michelle“…Recent evidence suggests loss of the interferon gamma pathway in tumor cells confers resistance to anti-CTLA4 therapy. …”
Publicado 2018
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32242por Krumeich, Lauren Norell, Akimova, Tatiana, Stadanlick, Jason, Rao, Abhishek, Sullivan, Neil, Concors, Seth, Hernandez, Paul, Aufhauser, David, Eruslanov, Evgeniy, Hancock, Wayne, Levine, Matthew“…From each condition, flow cytometry will be used to assess the mean production of interleukin-2, tumor necrosis factor-α, interferon-γ, granzyme B, and perforin expression as an assessment of T-cell function. …”
Publicado 2019
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32243“…C3G also significantly increased the level of interleukin (IL)-10 and the regulatory T (Treg) cell proportion, and it decreased the interleukin (IL)-6 and interferon (IFN)-γ levels and CD38+ NK cell proportion in rat peripheral blood and synovial fluid. …”
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32244por Booth, Jayaum S., Goldberg, Eric, Barnes, Robin S., Greenwald, Bruce D., Sztein, Marcelo B.“…T-CMI was assessed by the production of 4 cytokines [interferon (IFN)γ, interleukin (IL)-2, IL-17A and tumor necrosis factor (TNF)α] in 36 volunteers (18 vaccinees and 18 controls volunteers). …”
Publicado 2020
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32245por Moreira, Cristiani, Tsuhako, Maria H., Tino de Franco, Milene, Modolell, Manuel, Pereira, Carlos A.“…In contrast to BALB/c mouse macrophages (MΦ), MΦ from the A/J mouse strain, upon activation by exogenous interferon gamma (IFNγ), develop an anti-mouse hepatitis virus 3 (MHV3) state which correlates with resistance to virus infection. …”
Publicado 2004
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32246por Wu, Huan, Zhu, Hongmin, Yuan, Chunhui, Yao, Cong, Luo, Wei, Shen, Xin, Wang, Jun, Shao, Jianbo, Xiang, Yun“…Compared with mild cases, levels of inflammatory cytokines including interleukin 6, tumor necrosis factor α, and interferon γ were unchanged, whereas the level of immune suppressive interleukin 10 was markedly increased in moderate cases compared with mild cases (median [IQR], 3.96 [3.34-5.29] pg/mL vs 3.58 [3.10-4.36] pg/mL; P = .048). …”
Publicado 2020
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32247por Yoon, Se Young, Sa, Soo Jin, Cho, Eun Seok, Ko, Han Seo, Choi, Jung Woo, Kim, Jin Soo“…Dietary supplementation with ZnArg2 decreased the mRNA expressions of interferon-γ in the muscle compared with the Con treatment. …”
Publicado 2020
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32248por Thom, Ruth, Tipton, Thomas, Strecker, Thomas, Hall, Yper, Akoi Bore, Joseph, Maes, Piet, Raymond Koundouno, Fara, Fehling, Sarah Katharina, Krähling, Verena, Steeds, Kimberley, Varghese, Anitha, Bailey, Graham, Matheson, Mary, Kouyate, Saidou, Coné, Moussa, Moussa Keita, Balla, Kouyate, Sekou, Richard Ablam, Amento, Laenen, Lies, Vergote, Valentijn, Guiver, Malcolm, Timothy, Joseph, Atkinson, Barry, Ottowell, Lisa, Richards, Kevin S, Bosworth, Andrew, Longet, Stephanie, Mellors, Jack, Pannetier, Delphine, Duraffour, Sophie, Muñoz-Fontela, César, Sow, Oumou, Koivogui, Lamine, Newman, Edmund, Becker, Stephan, Sprecher, Armand, Raoul, Herve, Hiscox, Julian, Henao-Restrepo, Ana Maria, Sakoba, Keita, Magassouba, N'Faly, Günther, Stephan, Kader Konde, Mandy, Carroll, Miles W“…The dominant CD8+ polyfunctional T cell phenotype, as measured among 53 Ebola virus disease survivors, was interferon γ+, tumour necrosis factor+, interleukin-2–, and the mean response was 0·046% of total CD8+ T cells (95% CI 0·021–0·071). …”
Publicado 2020
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32249por Cappelli, Katia, Amadori, Massimo, Mecocci, Samanta, Miglio, Arianna, Antognoni, Maria Teresa, Razzuoli, Elisabetta“…Moreover, via RT-qPCR, we investigated the expression of, Interleukin 1β (IL-1β), Interleukin 4 (IL-4) Interleukin 6 (IL-6), Interleukin 2 (IL-2), Interleukin 3 (IL-3), Interleukin 5 (IL-5) Interleukin 8 (IL-8), Trasformig Growth Factor β and α (TGF-β), Tumor necrosis factor α (TNF-α), and Interferon γ (IFN-γ)genes. Main corpuscular volume (MCV) showed a significant (p = 0.008) increase at T90. …”
Publicado 2020
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32250por Shi, Bingbo, Gao, Dengfeng, Zhong, Liang, Zhi, Minglei, Weng, Xiaogang, Xu, Junjun, Li, Junhong, Du, Xuguang, Xin, Yanli, Gao, Jie, Zhu, Qianqian, Cao, Suying, Liu, Zhonghua, Han, Jianyong“…Furthermore, the key transcription factors (TFs) defining the naïve state in piPSCs also remain elusive, even though TFs in the inner cell mass (ICM) are believed to be key molecular determinants of naïve pluripotency. In this study, interferon regulatory factor 1 (IRF-1) was screened to express higher in ICM than trophectoderm (TE). …”
Publicado 2020
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32251por Gudmundsdottir, Valborg, Pedersen, Helle Krogh, Mazzoni, Gianluca, Allin, Kristine H., Artati, Anna, Beulens, Joline W., Banasik, Karina, Brorsson, Caroline, Cederberg, Henna, Chabanova, Elizaveta, De Masi, Federico, Elders, Petra J., Forgie, Ian, Giordano, Giuseppe N., Grallert, Harald, Gupta, Ramneek, Haid, Mark, Hansen, Torben, Hansen, Tue H., Hattersley, Andrew T., Heggie, Alison, Hong, Mun-Gwan, Jones, Angus G., Koivula, Robert, Kokkola, Tarja, Laakso, Markku, Løngreen, Peter, Mahajan, Anubha, Mari, Andrea, McDonald, Timothy J., McEvoy, Donna, Musholt, Petra B., Pavo, Imre, Prehn, Cornelia, Ruetten, Hartmut, Ridderstråle, Martin, Rutters, Femke, Sharma, Sapna, Slieker, Roderick C., Syed, Ali, Tajes, Juan Fernandez, Thomas, Cecilia Engel, Thomsen, Henrik S., Vangipurapu, Jagadish, Vestergaard, Henrik, Viñuela, Ana, Wesolowska-Andersen, Agata, Walker, Mark, Adamski, Jerzy, Schwenk, Jochen M., McCarthy, Mark I., Pearson, Ewan, Dermitzakis, Emmanouil, Franks, Paul W., Pedersen, Oluf, Brunak, Søren“…We furthermore identified an overlap between genetic signals for T2D and co-expression modules involved in type II interferon signaling. CONCLUSIONS: Our results offer a large-scale map of whole blood transcriptomic modules in the context of metabolic disease and point to novel biological candidates for future studies related to T2D.…”
Publicado 2020
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32252por Good, Steven S, Moussa, Adel, Zhou, Xiao-Jian, Sommadossi, Jean-Pierre, Pietropaolo, Keith“…AG129 (α-, β- and γ-interferon knock-out) mice received an oral dose of AT‐752 (1000 mg/kg) 4 h before s.c. inoculation with Dengue virus type 2 (strain D2Y98P, 1x10(5) virus particles) followed by b.i.d. doses (500 mg/kg) for 7 days starting 1 h post‐inoculation (p.i.). …”
Publicado 2020
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32253por Teodorczyk-Injeyan, Julita A., Triano, John J., Gringmuth, Robert, DeGraauw, Christopher, Chow, Adrian, Injeyan, H. Stephen“…The in vitro production of tumor necrosis factor (TNFα), interleukin-1 β (IL-1β), IL-6, IL-2, interferon ɣ (IFNɣ), IL-1 receptor antagonist (IL-1RA), TNF soluble receptor type 2 (sTNFR2) and IL-10 was determined by specific immunoassays. …”
Publicado 2021
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32254por Farias e Silva, Katia, Nanini, Hayandra F, Cascabulho, Cynthia Machado, Rosas, Siane L B, Santana, Patricia T, Carneiro, Antonio José de V, Anaissie, Elias, Nucci, Marcio, de Souza, Heitor Siffert Pereira“…Positive correlations were detected between BG and IL-17 in the CD (r: 0.737; P = 0.001) and the UC group (r: 0.574; P = 0.005), and between BG and interferon-gamma in the CD group (r: 0.597; P = 0.015). …”
Publicado 2021
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32255por Deng, Dao-Xing, Wen, Juan-Juan, Cheng, Yi-Fei, Zhang, Xiao-Hui, Xu, Lan-Ping, Wang, Yu, Yan, Chen-Hua, Chen, Yu-Hong, Chen, Huan, Han, Wei, Wang, Feng-Rong, Wang, Jing-Zhi, Qin, Ya-Zhen, Liu, Kai-Yan, Huang, Xiao-Jun, Zhao, Xiao-Su, Mo, Xiao-Dong“…Both the CIR (5-year CIR: 8.3% vs. 11.3%; P = 0.513) and DFS (5-year DFS: 91.7% vs. 80.8%; P = 0.208) were comparable between patients achieving minimal residual disease (MRD) negativity after preemptive interferon-α (IFN-α) treatment and those without MRD after allo-HSCT, which were better than those of MRD-positive patients without preemptive therapies. …”
Publicado 2021
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32256por Olwenyi, Omalla A., Asingura, Bannet, Naluyima, Prossy, Anywar, Godwin Upoki, Nalunga, Justine, Nakabuye, Mariam, Semwogerere, Michael, Bagaya, Bernard, Cham, Fatim, Tindikahwa, Allan, Kiweewa, Francis, Lichter, Eliezer Z., Podany, Anthony T., Fletcher, Courtney V., Byrareddy, Siddappa N., Kibuuka, Hannah“…Following BD Facs Canto II event acquisition, variations in %CD38, %CD69, Human Leukocyte Antigen -DR (HLA-DR), Programmed cell death protein 1 (PD-1), T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3), interferon gamma (IFN γ) and interleukin 2 (IL-2) CD4 + T cell expression were evaluated. …”
Publicado 2021
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32257por Kasela, Silva, Ortega, Victor E., Martorella, Molly, Garudadri, Suresh, Nguyen, Jenna, Ampleford, Elizabeth, Pasanen, Anu, Nerella, Srilaxmi, Buschur, Kristina L., Barjaktarevic, Igor Z., Barr, R. Graham, Bleecker, Eugene R., Bowler, Russell P., Comellas, Alejandro P., Cooper, Christopher B., Couper, David J., Criner, Gerard J., Curtis, Jeffrey L., Han, MeiLan K., Hansel, Nadia N., Hoffman, Eric A., Kaner, Robert J., Krishnan, Jerry A., Martinez, Fernando J., McDonald, Merry-Lynn N., Meyers, Deborah A., Paine, Robert, Peters, Stephen P., Castro, Mario, Denlinger, Loren C., Erzurum, Serpil C., Fahy, John V., Israel, Elliot, Jarjour, Nizar N., Levy, Bruce D., Li, Xingnan, Moore, Wendy C., Wenzel, Sally E., Zein, Joe, Langelier, Charles, Woodruff, Prescott G., Lappalainen, Tuuli, Christenson, Stephanie A.“…RESULTS: We found that ACE2 expression was higher in relation to active smoking, obesity, and hypertension that are known risk factors of COVID-19 severity, while an association with interferon-related inflammation was driven by the truncated, non-binding ACE2 isoform. …”
Publicado 2021
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32258por Okushin, Kazuya, Suzuki, Rie, Tsutsumi, Takeya, Okamoto, Koh, Ikeuchi, Kazuhiko, Kado, Akira, Minatsuki, Chihiro, Minami-Kobayashi, Yuka, Satoh, Nobuhiko, Ikeda, Mahoko, Harada, Sohei, Enooku, Kenichiro, Fujinaga, Hidetaka, Yotsuyanagi, Hiroshi, Koike, Kazuhiko, Moriya, Kyoji“…This cross-sectional study was performed to investigate the change in the actual HCV RNA positivity rate in source patients before and after the interferon (IFN)-free DAA era. METHODS: This was a cross-sectional study of NSI source patients at a tertiary academic hospital in Japan from 2009 to 2019. …”
Publicado 2021
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32259por Deamicis, Agustina Roldán, Oakley, Robert H, Helguera, Sergio Andonegui, Lenze, Mariela B, Madera, Santiago, Russo, Rosalia I Cordo, Chervo, María F, Schillaci, Roxana, Fresno, Cristóbal, Cidlowski, John A, Elizalde, Patricia V, Proietti, Cecilia J“…Enrichment analyses showed that the DEGs belonged to the immune response and interferon pathways. Kaplan-Meier analysis revealed that the expression of 6 genes was significantly associated with overall survival in TNBC patients from the METABRIC cohort: CXCL10, TAP1, STAT1, NMI, HLA-A and NLRC5. …”
Publicado 2021
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32260por Ader, Florence, Peiffer-Smadja, Nathan, Poissy, Julien, Bouscambert-Duchamp, Maude, Belhadi, Drifa, Diallo, Alpha, Delmas, Christelle, Saillard, Juliette, Dechanet, Aline, Mercier, Noémie, Dupont, Axelle, Alfaiate, Toni, Lescure, François-Xavier, Raffi, François, Goehringer, François, Kimmoun, Antoine, Jaureguiberry, Stéphane, Reignier, Jean, Nseir, Saad, Danion, François, Clere-Jehl, Raphael, Bouiller, Kévin, Navellou, Jean-Christophe, Tolsma, Violaine, Cabié, André, Dubost, Clément, Courjon, Johan, Leroy, Sylvie, Mootien, Joy, Gaci, Rostane, Mourvillier, Bruno, Faure, Emmanuel, Pourcher, Valérie, Gallien, Sébastien, Launay, Odile, Lacombe, Karine, Lanoix, Jean-Philippe, Makinson, Alain, Martin-Blondel, Guillaume, Bouadma, Lila, Botelho-Nevers, Elisabeth, Gagneux-Brunon, Amandine, Epaulard, Olivier, Piroth, Lionel, Wallet, Florent, Richard, Jean-Christophe, Reuter, Jean, Staub, Thérèse, Lina, Bruno, Noret, Marion, Andrejak, Claire, Lê, Minh Patrick, Peytavin, Gilles, Hites, Maya, Costagliola, Dominique, Yazdanpanah, Yazdan, Burdet, Charles, Mentré, France“…OBJECTIVES: We evaluated the clinical, virological and safety outcomes of lopinavir/ritonavir, lopinavir/ritonavir–interferon (IFN)-β-1a, hydroxychloroquine or remdesivir in comparison to standard of care (control) in coronavirus 2019 disease (COVID-19) inpatients requiring oxygen and/or ventilatory support. …”
Publicado 2021
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