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32281por Poizeau, Florence, Barbarot, Sébastien, Le Corre, Yannick, Samimi, Mahtab, Brenaut, Emilie, Aubert, Hélène, Toubel, Alexis, Chambrelan, Estel, Droitcourt, Catherine, Gissot, Valérie, Heslan, Christopher, Laurent, Claire, Martin, Ludovic, Misery, Laurent, Tattevin, Pierre, Thibault, Vincent, Oger, Emmanuel, Dupuy, Alain“…L’hypothèse d’une réponse interféron-médiée au SARS-CoV-2, permettant une clairance rapide du virus qui ne pourrait alors pas activer l’immunité humorale, a été soulevée et pourrait expliquer la séronégativité. …”
Publicado 2021
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32282por Xu, Xin, Wu, Han, Bian, Yuehong, Cui, Linlin, Man, Yuanyuan, Wang, Zhao, Zhang, Xin, Zhang, Changming, Geng, Ling“…RESULTS: Compared to children born after natural conception, children born after ART had elevated interferon-γ (IFN-γ) levels, regardless of embryo transfer and fertilization strategies. …”
Publicado 2021
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32283por Xu, Zhaohui, Glowinski, Rebecca M, Cohen, Shira H, Mertz, Cameron, Mertz, Sara, Ye, Fang, Sanchez, Pablo J, Mejias, Asuncion, Ramilo, Octavio“…Children with symptomatic COVID-19 had significantly higher SARS-CoV-2 viral loads than children with MIS-C or those identified via universal screening. Concentrations of interferon (IFN) related cytokines (IFNg, CXCL9, CXCL10, CXCL11), interleukins (IL6, IL8, IL10, IL17A, IL18, IL24) and other inflammatory cytokines (TGF, TNF, VEGF, MCP, CD40) were significantly increased in children with acute COVID-19 and MIS-C compared with children identified by universal screening and healthy controls. …”
Publicado 2021
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32284por Halabi, Salim, Shiber, Shachaf, Stein, Michal, Paz, Meital, Gottlieb, Tanya, Barash, Eran, Navon, Roy, Moscoviz, Einat, Ber, Tahel Ilan, Shani, Liran, Petersiel, Neta, Boico, Olga, Grupper, Mordechai, Simon, Einav, Kirshner, Dani, Avni, Noa, Haber, Daniel, Maor, Yasmin, Guetta, Claire S, Lishtzinsky, Ynon, Yanai, Shirly, Drescher, Michael, Oved, Kfir, Eden, Eran, Neuberger, Ami, Paul, Mical“…Studies have shown that a host signature comprising TNF-related apoptosis induced ligand (TRAIL), interferon gamma induced protein-10 (IP-10) and C-reactive protein (CRP) accurately differentiates bacterial from viral infection with negative predictive value >98%. …”
Publicado 2021
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32285por Reindl-Schwaighofer, Roman, Heinzel, Andreas, Mayrdorfer, Manuel, Jabbour, Rhea, Hofbauer, Thomas M., Merrelaar, Anne, Eder, Michael, Regele, Florina, Doberer, Konstantin, Spechtl, Paul, Aschauer, Constantin, Koblischke, Maximilian, Paschen, Christopher, Eskandary, Farsad, Hu, Karin, Öhler, Barbara, Bhandal, Arshdeep, Kleibenböck, Sabine, Jagoditsch, Rahel I., Reiskopf, Bianca, Heger, Florian, Bond, Gregor, Böhmig, Georg A., Strassl, Robert, Weseslindtner, Lukas, Indra, Alexander, Aberle, Judith H., Binder, Michael, Oberbauer, Rainer“…Secondary end points included neutralizing antibodies and T-cell response assessed by interferon-γ release assays (IGRA). In addition, the association of patient characteristics and vaccine response was assessed using logistic regression, and the reactogenicity of the vaccines was compared. …”
Publicado 2021
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32286por Salame, Natasha, Bikorimana, Jean-Pierre, El-Hachem, Nehme, Saad, Wael, Kurdi, Mazen, Zhao, Jing, Eliopoulos, Nicoletta, Shammaa, Riam, Rafei, Moutih“…However, they also hold promise in the field of cellular vaccination as they can behave as conditional antigen presenting cells in response to interferon (IFN)-gamma treatment under a specific treatment regimen. …”
Publicado 2022
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32287por Khani, Leila, Jazayeri, Mir Hadi, Nedaeinia, Reza, Bozorgmehr, Mahmood, Nabavi, Seyed Masood, Ferns, Gordon A.“…METHODS: CD19(+)CD5(+) B, CD3(−) CD16(+)CD56(+) NK, and CD3(+)CD56(+) NKT cells were quantitated by flow cytometry in 15 individuals with Interferon-Beta (IFN-β) treated relapsing–remitting MS (RRMS), 15 untreated RRMS, and 15 NMOSD patients as well as 30 healthy controls (HC). …”
Publicado 2022
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32288por Ullah, Shahan, Ali, Salamat, Daud, Muhammad, Paudyal, Vibhu, Hayat, Kawsar, Hamid, Syed Muhammad, Ur-rehman, Tofeeq“…Individuals who did not achieve sustained virological response 24 weeks after treatment with interferon-based therapy, compared to treatment naïve individuals, reported lower trust in being successfully treated with newer anti-HCV agents (i.e., direct acting antivirals) (p = 0.029). …”
Publicado 2022
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32289por Hakovirta, Harri, Jalkanen, Juho, Saimanen, Eija, Kukkonen, Tiia, Romsi, Pekka, Suominen, Velipekka, Vikatmaa, Leena, Valtonen, Mika, Karvonen, Matti K., Venermo, Maarit“…The aim of the present study was to assess, if intravenous (IV) Interferon (IFN) beta-1a improve survival after surgery by up-regulating Cluster of differentiation (CD73). …”
Publicado 2022
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32290“…Her urine dipstick was normal. Interferon signature was abnormal with very high levels. …”
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32291por Ciampi, Ethel, Uribe-San-Martin, Reinaldo, Soler, Bernardita, García, Lorena, Guzman, Jorge, Pelayo, Carolina, Jürgensen, Lukas, Guzman, Ignacio, Vera, Francisco, Galleguillos, Lorna, Cárcamo, Claudia“…Positive anti-S1-antibodies were observed in 100% of patients with no DMT (n = 3), 100% with interferon/glatiramer-acetate (n = 11), 100% with teriflunomide/dimethyl-fumarate (n = 16), 100% with natalizumab (n = 10), 100% with alemtuzumab (n = 8), 90% with cladribine (n = 10), and 88% with fingolimod (n = 17), while 43% of patients receiving antiCD20 (n = 99) were positive (38% inactivated vaccine vs. 59% mRNA vaccine, p = 0.05). …”
Publicado 2022
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32292por Spelman, Timothy, Herring, William L., Zhang, Yuanhui, Tempest, Michael, Pearson, Isobel, Freudensprung, Ulrich, Acosta, Carlos, Dort, Thibaut, Hyde, Robert, Havrdova, Eva, Horakova, Dana, Trojano, Maria, De Luca, Giovanna, Lugaresi, Alessandra, Izquierdo, Guillermo, Grammond, Pierre, Duquette, Pierre, Alroughani, Raed, Pucci, Eugenio, Granella, Franco, Lechner-Scott, Jeannette, Sola, Patrizia, Ferraro, Diana, Grand’Maison, Francois, Terzi, Murat, Rozsa, Csilla, Boz, Cavit, Hupperts, Raymond, Van Pesch, Vincent, Oreja-Guevara, Celia, van der Walt, Anneke, Jokubaitis, Vilija G., Kalincik, Tomas, Butzkueven, Helmut“…BACKGROUND: Patients with highly active relapsing-remitting multiple sclerosis inadequately responding to first-line therapies (interferon-based therapies, glatiramer acetate, dimethyl fumarate, and teriflunomide, known collectively as “BRACETD”) often switch to natalizumab or fingolimod. …”
Publicado 2021
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32293por Zhang, Leyi, Lu, Chenglong, Kang, Li, Li, Yingji, Tang, Wenjing, Zhao, Dengfa, Yu, Shengyuan, Liu, Ruozhuo“…Then, we detected the variation with time of cytokines levels in the TNC tissue extraction and serum, including c-c motif chemokine ligand 2 (CCL2), c-c motif chemokine ligand 5 (CCL5), c-c motif chemokine ligand 7 (CCL7), c-c motif chemokine ligand 12 (CCL12), c-x-c motif chemokine ligand 1 (CXCL1), c-x-c motif chemokine ligand 13 (CXCL13), interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), macrophage colony-stimulating factor (M-CSF), interleukin 1beta (IL-1β), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 17A (IL-17A). …”
Publicado 2022
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32294por Farroni, Chiara, Picchianti-Diamanti, Andrea, Aiello, Alessandra, Nicastri, Emanuele, Laganà, Bruno, Agrati, Chiara, Castilletti, Concetta, Meschi, Silvia, Colavita, Francesca, Cuzzi, Gilda, Casetti, Rita, Grassi, Germana, Petrone, Linda, Vanini, Valentina, Salmi, Andrea, Repele, Federica, Altera, Anna Maria Gerarda, Maffongelli, Gaetano, Corpolongo, Angela, Salemi, Simonetta, Di Rosa, Roberta, Nalli, Gabriele, Sesti, Giorgio, Vaia, Francesco, Puro, Vincenzo, Goletti, Delia“…Serological response was assessed by quantifying anti-receptor-binding domain (RBD)-specific immunoglobulin G (IgG) and SARS-CoV-2 neutralizing antibodies, while cell-mediated response was assessed by a whole-blood test quantifying the interferon (IFN)-γ response to spike peptides. B-cell phenotype and IFN-γ-specific T-cell responses were evaluated by flow cytometry. …”
Publicado 2022
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32295por Sims, Jonathan T., Poorbaugh, Josh, Chang, Ching-Yun, Holzer, Timothy R., Zhang, Lin, Engle, Sarah M., Beasley, Stephanie, Doman, Thompson N., Naughton, Lynn, Higgs, Richard E., Kallewaard, Nicole, Benschop, Robert J.“…RESULTS: Levels of IL-6, CXCL10, CXCL11, IFNγ and MCP-3 were > fourfold higher in the serum of patients with COVID-19 versus healthy controls and linked with observations of inflammatory and viral-induced interferon response genes detected in nasopharyngeal swab samples from the same patients. …”
Publicado 2022
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32296por Della Corte, Carminia Maria, Fasano, Morena, Ciaramella, Vincenza, Cimmino, Flora, Cardnell, Robert, Gay, Carl M., Ramkumar, Kavya, Diao, Lixia, Di Liello, Raimondo, Viscardi, Giuseppe, Famiglietti, Vincenzo, Ciardiello, Davide, Martini, Giulia, Napolitano, Stefania, Tuccillo, Concetta, Troiani, Teresa, Martinelli, Erika, Wang, Jing, Byers, Lauren, Morgillo, Floriana, Ciardiello, Fortunato“…Furthermore, cetuximab plus avelumab treatment induced 10-, 20-, and 20-fold increase, respectively, in the gene expression of CCL5 and CXCL10, two STING downstream effector cytokines, and of interferon β, as compared to untreated control samples. …”
Publicado 2022
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32297por Berrocal-Almanza, Luis C, Harris, Ross J, Collin, Simon M, Muzyamba, Morris C, Conroy, Olivia D, Mirza, Adil, O'Connell, Anne-Marie, Altass, Lynn, Anderson, Sarah R, Thomas, H Lucy, Campbell, Colin, Zenner, Dominik, Phin, Nick, Kon, Onn Min, Smith, E Grace, Lalvani, Ajit“…Individuals who tested interferon-γ release assay (IGRA)-negative were advised about symptoms of tuberculosis, whereas those who tested IGRA-positive were clinically assessed to rule out active tuberculosis and offered preventive therapy. …”
Publicado 2022
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32298por Zhang, Hui, He, Chuan, Jiang, Fanming, Cao, Shuang, Zhao, Bin, Ding, Haibo, Dong, Tao, Han, Xiaoxu, Shang, Hong“…However, the kinetics of B*13-restricted T-cell responses, viral evolution within epitopes, and the impact on disease progression in CRF01_AE subtype HIV-1-infected men who have sex with men (MSM) are not known. RESULTS: Interferon-γ ELISPOT assays and deep sequencing of viral RNAs were done in 14 early HLA-B*13-positive CRF01_AE subtype HIV-1-infected MSM. …”
Publicado 2022
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32299por Lai, Kuo‐Chu, Hong, Zi‐Xuan, Hsieh, Jyh‐Gang, Lee, Hui‐Ju, Yang, Muh‐Hwa, Hsieh, Chia‐Husu, Yang, Cheng‐Han, Chen, Yan‐Ru“…BACKGROUND: Interferon‐induced protein with tetratricopeptide repeat 2 (IFIT2) is a reported metastasis suppressor in oral squamous cell carcinoma (OSCC). …”
Publicado 2022
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32300por Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., Dossus, Laure“…We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-α, interferon-γ and 6 interleukins were associated with breast cancer risk, overall and by menopausal status. …”
Publicado 2022
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