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32321por Patil, V., Hernandez-Franco, J. F., Yadagiri, G., Bugybayeva, D., Dolatyabi, S., Feliciano-Ruiz, N., Schrock, J., Hanson, J., Ngunjiri, J., HogenEsch, H., Renukaradhya, G. J.“…We evaluated the performance of split swine influenza A virus (SwIAV) H1N2 antigens with a plant-derived nanoparticle adjuvant alone (Nano-11) [Nano11-SwIAV] or in combination with the synthetic stimulator of interferon genes (STING) agonist ADU-S100 (NanoS100-SwIAV). …”
Publicado 2022
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32322por Liao, Chengcheng, Talluri, Srikanth, Zhao, Jiangning, Mu, Shidai, Kumar, Subodh, Shi, Jialan, Buon, Leutz, Munshi, Nikhil C., Shammas, Masood A.“…In addition, immune-related pathways such as PD-1 and Interferon Signaling were also induced by DNA breaking agent whereas their induction prevented by RAD51 inhibitor. …”
Publicado 2022
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32323por Xu, Yang Xiu Yue, Zhang, Xin Zhuo, Weng, Min Min, Cheng, Yong Kang, Liu, Ruo Dan, Long, Shao Rong, Wang, Zhong Quan, Cui, Jing“…Oral immunization of mice with rTsgal vaccine induced specific forms of serum immunoglobulin G (IgG), namely IgG1/IgG2a, as well as IgA and gut mucosal secretion IgA (sIgA). The levels of interferon gamma and interleukin-4 secreted by cells of the spleen, mesenteric lymph nodes, Peyer's patches and intestinal lamina propria were significantly elevated at 2–6 weeks after immunization, and continued to rise following challenge. …”
Publicado 2022
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32324por Stenhouse, Claire, Newton, Makenzie G., Halloran, Katherine M., Moses, Robyn M., Sah, Nirvay, Suva, Larry J., Bazer, Fuller W.“…BACKGROUND: Recent evidence suggests important roles for progesterone (P4) and interferon tau in the regulation of calcium, phosphate, and vitamin D signaling in the uteri of pregnant sheep. …”
Publicado 2023
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32325por Cheemarla, Nagarjuna R, Hanron, Amelia, Fauver, Joseph R, Bishai, Jason, Watkins, Timothy A, Brito, Anderson F, Zhao, Dejian, Alpert, Tara, Vogels, Chantal B F, Ko, Albert I, Schulz, Wade L, Landry, Marie L, Grubaugh, Nathan D, van Dijk, David, Foxman, Ellen F“…Transcriptomic signatures showed an interferon response in virus-positive samples and an additional neutrophil-high hyperinflammatory signature in samples with high amounts of bacterial pathobionts. …”
Publicado 2023
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32326por Marquardt, Viktoria, Theruvath, Johanna, Pauck, David, Picard, Daniel, Qin, Nan, Blümel, Lena, Maue, Mara, Bartl, Jasmin, Ahmadov, Ulvi, Langini, Maike, Meyer, Frauke-Dorothee, Cole, Allison, Cruz-Cruz, Joselyn, Graef, Claus M, Wölfl, Matthias, Milde, Till, Witt, Olaf, Erdreich-Epstein, Anat, Leprivier, Gabriel, Kahlert, Ulf, Stefanski, Anja, Stühler, Kai, Keir, Stephen T, Bigner, Darell D, Hauer, Julia, Beez, Thomas, Knobbe-Thomsen, Christiane B, Fischer, Ute, Felsberg, Jörg, Hansen, Finn K, Vibhakar, Rajeev, Venkatraman, Sujatha, Cheshier, Samuel H, Reifenberger, Guido, Borkhardt, Arndt, Kurz, Thomas, Remke, Marc, Mitra, Siddhartha“…Furthermore, RNA sequencing revealed nuclear factor-kB (NF-κB) pathway induction as a response to CI-994 treatment, followed by transglutaminase 2 (TGM2) expression, which enhanced inflammatory cytokine secretion. We further show interferon-γ release and cell surface expression of engulfment (‘eat-me’) signals (such as calreticulin). …”
Publicado 2023
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32327por Ueta, Mayumi, Nishigaki, Hiromi, Komai, Seitaro, Mizushima, Katsura, Tamagawa-Mineoka, Risa, Naito, Yuji, Katoh, Norito, Sotozono, Chie, Kinoshita, Shigeru“…Of the eight miRNAs, hsa-let-7a-5p, hsa-let-7e-5p, has-miR-27b-3p, and hsa-miR-146a-5p mimic-transfected THP-1 cells showed the up-regulation of CXCL10 (IP-10; interferon gamma-induced protein 10), which might be one of the innate immune-related genes. …”
Publicado 2023
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32328por Obase, Bekindaka Ngemani, Francis, Zeukeng, Forgu, Esemu Livo, Honore, Awanakam, Bigoga, Jude Daiga, Nsagha, Dickson S“…The study aims to determine the prevalence of malaria infection, assess the occurrence of Plasmodium falciparum genetic diversity, and evaluate the antibody (immunoglobulin [Ig]G and IgM: apical membrane antigen-1 [AMA1], merozoite surface protein [MSP]1, MSP2, MSP3, and erythrocyte-binding antigen [EBA]175) and cytokine (interleukin [IL]-10, tumor necrosis factor alpha [TNF-α], and interferon gamma [IFNγ]) response to malaria infection among pregnant women with and without HIV in Kumba. …”
Publicado 2023
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32329por Crisafulli, Salvatore, Cutroneo, Paola Maria, Luxi, Nicoletta, Fontana, Andrea, Ferrajolo, Carmen, Marchione, Pasquale, Sottosanti, Laura, Zanoni, Giovanna, Moretti, Ugo, Franzè, Silvia, Minghetti, Paola, Trifirò, Gianluca“…The hypersensitivity reaction reporting rates were higher for PEGylated medicinal products versus non-PEGylated medicinal products, with reporting rate ratios that ranged from 1.4 (95% confidence interval 0.8–2.5) for pegfilgrastim versus filgrastim to 20.0 (95% confidence interval 2.8–143.5) for peginterferon alpha-2a versus interferon alpha-2a. The median time to onset of hypersensitivity reactions was 10 days (interquartile range: 0–61) for PEGylated medicinal products, and 36 days (interquartile range: 3–216) for non-PEGylated comparators. …”
Publicado 2023
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32330por Yang, Zhifen, Pietrobon, Violena, Bobbin, Maggie, Stefanson, Ofir, Yang, Jin, Goswami, Angshumala, Alphson, Bennett, Choi, Hana, Magallanes, Khristina, Cai, Qi, Barrett, David, Wang, Bing, Qi, Lei S., Marincola, Francesco M.“…RESULTS: The inducible CRISPRa system activated endogenous IL-12 expression resulting in enhanced secondary interferon (FN)-γ production, cytotoxicity, and CAR-T proliferation in vitro, prolonged in vivo persistence and greater suppression of HER2(+) FaDu oropharyngeal cancer cell growth compared to the conventional CAR-T cell product. …”
Publicado 2023
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32331por Li, Shuang, Liu, Hui, Ruan, Zhe, Guo, Rongjing, Sun, Chao, Tang, Yonglan, Huang, Xiaoxi, Gao, Ting, Hao, Sijia, Li, Huanhuan, Song, Na, Su, Yue, Ning, Fan, Li, Zhuyi, Chang, Ting“…Among them, RBM15 possessed the strongest correlation with immune characteristics, including CD56dim natural killer cell (r = 0.77, P = 0.0023), T follicular helper cell (r = − 0.86, P = 0.0002), Interferon Receptor (r = 0.78, P = 0.0017), and HLA-DOA (r = 0.64, P = 0.0200). …”
Publicado 2023
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32332por Bühler, Melanie, Li, Dandan, Li, Lin, Runft, Sandra, Waltl, Inken, Pavlou, Andreas, Kalinke, Ulrich, Ciurkiewicz, Malgorzata, Huehn, Jochen, Floess, Stefan, Beineke, Andreas, Baumgärtner, Wolfgang, Gerhauser, Ingo“…Since earlier studies indicated a critical role of type I interferon (IFN-I) signaling in the control of viral replication in the central nervous system (CNS), mouse strain-specific differences in pathways induced by the IFN-I receptor (IFNAR) might determine the outcome of TMEV infection. …”
Publicado 2023
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32333por Lee, Dae Hyun, Chandrasekhar, Sanjay, Jain, Michael D., Mhaskar, Rahul, Reid, Kayla, Lee, Sae Bom, Corallo, Salvatore, Hidalgo-Vargas, Melanie J., Kumar, Abhishek, Chavez, Julio, Shah, Bijal, Lazaryan, Aleksandr, Khimani, Farhad, Nishihori, Taiga, Bachmeier, Christina, Faramand, Rawan, Fradley, Michael G., Jeong, Daniel, Oliveira, Guilherme H., Locke, Frederick L., Davila, Marco L, Alomar, Mohammed“…In a subset of patients (N = 53), serum inflammatory cytokines interleukin (IL)-2, IL-6, IL-15, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), and angiopoietin 1 & 2 were tested serially, including baseline and daily during hospitalization. …”
Publicado 2023
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32334por Guo, Shuangshuang, He, Lai, Zhang, Yuanke, Niu, Junlong, Li, Changwu, Zhang, Zhengfan, Li, Peng, Ding, Binying“…Compared with the Ctrl group, the VitA and NE groups had higher mRNA expression of interferon-γ in the jejunum (p < 0.05). NE challenge up-regulated mRNA expression of interleukin (IL)-13, transforming growth factor-β4, aldehyde dehydrogenase (RALDH)-2 and RALDH-3 in the jejunum, while VitA supplementation increased jejunal IL-13 mRNA expression and hepatic VitA content, but down-regulated splenic IL-13 mRNA expression (p < 0.05). …”
Publicado 2023
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32335por Guo, Xing, Zhang, Zhenyu, Lin, Chaohui, Ren, Huiling, Li, Yijing, Zhang, Yuan, Qu, Yuxing, Li, Hongxin, Ma, Saiwen, Xia, Huijuan, Sun, Rongkuan, Zu, Haoyu, Lin, Yuezhi, Wang, Xiaojun“…Abbreviations: 293T: human embryonic kidney 293 cells; 293T_LRPPRC: stable LRPPRC expression 293T cells; 3-MA: 3-methyladenine; A549 cells: human non-small cell lung cancer cells; AA: amino acid; ACTB: actin beta; BECN1: beclin 1; BECN1 KO: BECN1 knockout 293T cells; Cal: calyculin A; Co-IP: co-immunoprecipitation; CQ: chloroquine; DC: dendritic cell; Eug: eugenol; GFP: green fluorescent protein; HA: hemagglutinin; HIV: human immunodeficiency virus; IAVs: Influenza A viruses; IFN: interferon; JL89: A/equine/Jilin/1/1989 (H3N8); LAMP2: lysosomal associated membrane protein 2; LRPPRC: leucine rich pentatriicopeptide repeat containing; LRPPRC KO: LRPPRC knockout 293T cells; M2: matrix 2; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MDCK: Madin-Darby canine kidney cells; MOI: multiplicity of infection; MS: mass spectrometry; NP: nucleoprotein; NS1: non-structural protein 1; NS1(JL89): non-structural protein 1 of A/equine/Jilin/1/1989 (H3N8); NS1(pdm09): non-structural protein 1 of A/(H1N1) pdm09; NS1(SC09): non-structural protein 1 of A/Sichuan/2009 (H1N1); NS1(WSN): non-structural protein 1 of A/WSN/1933 (H1N1); PB1: polymerase basic protein 1; PB1-F2: alternate reading frame discovered in PB1 gene segment; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PR8: A/PR/8/34 (H1N1); Rapa: rapamycin; RFP: red fluorescent protein; SC09: A/Sichuan/2009 (H1N1); SQSTM1/p62: sequestosome 1; STK4/MST1: serine/threonine kinase 4; TEM: transmission electron microscopy; TOMM20: translocase of outer mitochondrial membrane 20; WHO: World Health Organization; WSN: A/WSN/1933 (H1N1); WSN-NS1(JL89): WSN recombinant strain in which NS1 was replaced with that of JL89; WSN-NS1(SC09): WSN recombinant strain in which NS1 was replaced with that of SC09.…”
Publicado 2022
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32336por Lo Russo, Giuseppe, Prelaj, Arsela, Dolezal, James, Beninato, Teresa, Agnelli, Luca, Triulzi, Tiziana, Fabbri, Alessandra, Lorenzini, Daniele, Ferrara, Roberto, Brambilla, Marta, Occhipinti, Mario, Mazzeo, Laura, Provenzano, Leonardo, Spagnoletti, Andrea, Viscardi, Giuseppe, Sgambelluri, Francesco, Brich, Silvia, Miskovic, Vanja, Pedrocchi, Alessandra Laura Giulia, Trovo', Francesco, Manglaviti, Sara, Giani, Claudia, Ambrosini, Paolo, Leporati, Rita, Franza, Andrea, McCulloch, John, Torelli, Tommaso, Anichini, Andrea, Mortarini, Roberta, Trinchieri, Giorgio, Pruneri, Giancarlo, Torri, Valter, De Braud, Filippo, Proto, Claudia, Ganzinelli, Monica, Garassino, Marina Chiara“…LASSO integration analysis, with an optimal lambda of 0.28, showed that peripheral blood natural killer cells/CD56dimCD16+ (HR 0.56, 0.41–0.76, p=0.006) abundance at baseline and non-classical CD14dimCD16+monocytes (HR 0.52, 0.36–0.75, p=0.004), eosinophils (CD15+CD16−) (HR 0.62, 0.44–0.89, p=0.03) and lymphocytes (HR 0.32, 0.19–0.56, p=0.001) after first radiologic evaluation correlated with favorable PFS as well as high baseline expression levels of CD244 (HR 0.74, 0.62–0.87, p=0.05) protein tyrosine phosphatase receptor type C (HR 0.55, 0.38–0.81, p=0.098) and killer cell lectin like receptor B1 (HR 0.76, 0.66–0.89, p=0.05). Interferon-responsive factor 9 and cartilage oligomeric matrix protein genes correlated with unfavorable PFS (HR 3.03, 1.52–6.02, p 0.08 and HR 1.22, 1.08–1.37, p=0.06, corrected). …”
Publicado 2023
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32337por Filippini, Federica, Giacomelli, Mauro, Bazzani, Chiara, Fredi, Micaela, Semeraro, Paolo, Tomasi, Cesare, Franceschini, Franco, Caruso, Arnaldo, Cavazzana, Ilaria, Giagulli, Cinzia“…METHODS: Total antibody titer to SARS-CoV-2 spike protein was assessed by electrochemiluminescence immunoassay, CD4 and CD4-CD8 T cell-mediated immune response was analyzed by interferon-γ (IFN-γ) release assay, the production of IFN-γ-inducible (CXCL9 and CXCL10) and innate-immunity chemokines (MCP-1, CXCL8, and CCL5) by cytometric bead array after stimulation with different spike peptides. …”
Publicado 2023
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32338por Li, Qing, Zhao, Yujing, Guo, Hongyan, Li, Qiao, Yan, Chaoying, Li, Yansong, He, Shuxuan, Wang, Nan, Wang, Qiang“…Abbreviations: ACTB: beta actin; AIF1/IBA1: allograft inflammatory factor 1; ALB: albumin; ARG1: arginase 1; ATG3: autophagy related 3; Baf: bafilomycin A(1); BECN1: beclin 1, autophagy related; BW: body weight; CNS: central nervous system; Co-IP: co-immunoprecipitation; DACI: diabetes-associated cognitive impairment; DAPI: 4’,6-diamidino-2-phenylindole; DGs: dentate gyrus; DLG4/PSD95: discs large MAGUK scaffold protein 4; DMEM: Dulbecco’s modified Eagle’s medium; DSST: digit symbol substitution test; EDTA: ethylenedinitrilotetraacetic acid; ELISA: enzyme linked immunosorbent assay; GFAP: glial fibrillary acidic protein; HFD: high-fat diet; HG: high glucose; IFNG/IFN-γ: interferon gamma; IL1B/IL-1β: interleukin 1 beta; IL4: interleukin 4; IL6: interleukin 6; IL10: interleukin 10; LDs: lipid droplets; LPS: lipopolysaccharide; MAP2: microtubule associated protein 2; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MWM: morris water maze; NFKB/NF-κB: nuclear factor of kappa light polypeptide gene enhancer in B cells; NLRP3: NLR family pyrin domain containing 3; NOS2/iNOS: nitric oxide synthase 2, inducible; NOR: novel object recognition; OA: oleic acid; PA: palmitic acid; PBS: phosphate-buffered saline; PFA: paraformaldehyde; PLIN2: perilipin 2; PLIN3: perilipin 3; PS: penicillin-streptomycin solution; RAPA: rapamycin; RBFOX3/NeuN: RNA binding protein, fox-1 homolog (C. elegans) 3; RELA/p65: RELA proto-oncogene, NF-kB subunit; ROS: reactive oxygen species; RT: room temperature; RT-qPCR: Reverse transcription quantitative real-time polymerase chain reaction; STZ: streptozotocin; SQSTM1/p62: sequestosome 1; SYK: spleen asociated tyrosine kinase; SYP: synaptophysin; T2DM: type 2 diabetes mellitus; TNF/TNF-α: tumor necrosis factor; TREM1: triggering receptor expressed on myeloid cells 1; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling;…”
Publicado 2023
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32339por Shi, Guihong, Liu, Liang, Cao, Yiyao, Ma, Guangshuo, Zhu, Yanlin, Xu, Jianye, Zhang, Xu, Li, Tuo, Mi, Liang, Jia, Haoran, Zhang, Yanfeng, Liu, Xilei, Zhou, Yuan, Li, Shenghui, Yang, Guili, Liu, Xiao, Chen, Fanglian, Wang, Baolong, Deng, Quanjun, Zhang, Shu, Zhang, Jianning“…Cl-amidine, 2′3′-cGAMP (an activator of stimulating Interferon genes (STING)), C-176 (a selective STING inhibitor), and Kira6 [a selectively phosphorylated inositol-requiring enzyme-1 alpha [IRE1α] inhibitor] were administrated to explore the mechanism by which NETs promote neuroinflammation and neuronal apoptosis after TBI. …”
Publicado 2023
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32340Publicado 2023“…METHODS: A549 cells were cultured in vitro with interleukin (IL)-1β (20 ng/mL), IL-6 (20 ng/mL), tumor necrosis factor-alpha (TNF-α) (20 ng/mL), and interferon-gamma (IFN-γ) (20 ng/mL). The expression of YKL-40 transcription was determined by RT-qPCR. …”
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