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32341por Losurdo, Giuseppe, Giorgio, Floriana, Piscitelli, Domenico, Montenegro, Lucia, Covelli, Claudia, Fiore, Maria Grazia, Giangaspero, Antonio, Iannone, Andrea, Principi, Mariabeatrice, Amoruso, Annacinzia, Barone, Michele, Di Leo, Alfredo, Ierardi, Enzo“…AIM: To evaluate mucosal baseline mRNA expression of tissue transglutaminase 2 (tTG2), interferon gamma (IFNγ), toll-like receptor 2 (TLR2) and Myeloid Differentiation factor 88 (MyD88) in patients with microscopic enteritis (ME). …”
Publicado 2016
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32342por Rahmi, Eldiza Puji, Jamal, Jamia Azdina, Kumolosasi, Endang, Jalil, Juriyati, Aladdin, Nor-Ashila“…[Image: see text] Abbreviations used: BSA: Bovine serum albumin, COX-2: Cyclooxygenase-2, CPM: Count per minute, DAMP: Danger-associated molecular pattern, DCM: Dichloromethane, DMSO: Dimethyl sulfoxide, ELISA: Enzyme-linked immunosorbent assay, FBS: Fetal bovine serum, H(2)O: Water, HEPES: 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid, HMC-1: Human mast cell-1, HMGB1: High-mobility group box 1, ICAM: Intercellular adhesion molecule, IFN: Interferon, IgG: Immunoglobulin G, IKK: IkB kinase, IL: Interleukin, iNOS: Inducible nitric oxide synthase, LPS: Lipopolysaccharide, MeOH: Methanol, MPA: Marantodes pumilum var. alata, MPL: Marantodes pumilum var. lanceolata, MPP: Marantodes pumilum var. pumila, MSU: Monosodium urate, MTT: Methylthiazole tetrazolium, NF-κB: Nuclear factor-kappa B, NLR: NOD-like receptor, NLRP3: NLR family pyrin domain containing protein 3, NO: Nitric oxide, NOD: Nucleotide-binding oligomerization domain, NSAID: Nonsteroidal anti-inflammatory drug, PAMP: Pathogen-associated molecular pattern, PBMC: Peripheral blood mononuclear cell, PBS: Phosphate buffered saline, PGE(2): Prostaglandin E(2,) PMACI: Phorbol-12-myristate 13-acetate and calcium ionosphere A23187, PRR: Pathogen recognition receptor, PTFE: Polytetrafluoroethylene, RIA: Radioimmunoassay, RIG: Retinoic acid-inducible gene I, RLR: RIG I-like receptor, RP-HPLC: Reversed-phase high-performance liquid chromatography, RPMI-1640: Roswell Park Memorial Institute-1640, TLR: Toll-like receptor, TNF: Tumor necrosis factor, VCAM: Vascular cell adhesion molecule.…”
Publicado 2017
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32343por Lindsey, Benjamin B, Jagne, Ya Jankey, Armitage, Edwin P, Singanayagam, Anika, Sallah, Hadijatou J, Drammeh, Sainabou, Senghore, Elina, Mohammed, Nuredin I, Jeffries, David, Höschler, Katja, Tregoning, John S, Meijer, Adam, Clarke, Ed, Dong, Tao, Barclay, Wendy, Kampmann, Beate, de Silva, Thushan I“…Cal09 showed impaired pH1N1 nasopharyngeal shedding (16 of 118 children [14%, 95% CI 8·0–21·1] with shedding at day 2 after administration of LAIV) compared with H3N2 (54 of 118 [46%, 36·6–55·2]; p<0·0001) and influenza B (95 of 118 [81%, 72·2–87·2]; p<0·0001), along with suboptimal serum antibody (seroconversion in six of 118 [5%, 1·9–10·7]) and T-cell responses (CD4+ interferon γ-positive and/or CD4+ interleukin 2-positive responses in 45 of 111 [41%, 31·3–50·3]). …”
Publicado 2019
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32344por Zhang, Jing, Guo, Ming, Huang, Zhi-Xiang, Bao, Rong, Yu, Qian, Dai, Ming, Wang, Xin, Rao, Yan“…To investigate the expression of inflammatory cytokines and anti-microbial peptide genes, we determined the transcriptional levels of interferon-γ (IFN-γ), interleukin-4 (IL-4), mouse β-defensin-2 (mBD2), and cathelicidin LL-37 through real-time quantitative polymerase chain reaction. …”
Publicado 2019
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32345“…After the test resulted, the cellular immune function, humoral immune function, monocyte/macrophage function, NK cell activity and cytokine secretion (tumor necrosis factor-α, interferon-gamma and IL-4) were measured in immunosuppressive mice each group. …”
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32346por Folegatti, Pedro M, Bittaye, Mustapha, Flaxman, Amy, Lopez, Fernando Ramos, Bellamy, Duncan, Kupke, Alexandra, Mair, Catherine, Makinson, Rebecca, Sheridan, Jonathan, Rohde, Cornelius, Halwe, Sandro, Jeong, Yuji, Park, Young-Shin, Kim, Jae-Ouk, Song, Manki, Boyd, Amy, Tran, Nguyen, Silman, Daniel, Poulton, Ian, Datoo, Mehreen, Marshall, Julia, Themistocleous, Yrene, Lawrie, Alison, Roberts, Rachel, Berrie, Eleanor, Becker, Stephan, Lambe, Teresa, Hill, Adrian, Ewer, Katie, Gilbert, Sarah“…The secondary objective was to assess the cellular and humoral immunogenicity of ChAdOx1 MERS, measured by interferon-γ-linked enzyme-linked immunospot, ELISA, and virus neutralising assays after vaccination. …”
Publicado 2020
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32347por Ziemssen, Tjalf, Bass, Ann D., Berkovich, Regina, Comi, Giancarlo, Eichau, Sara, Hobart, Jeremy, Hunter, Samuel F, LaGanke, Christopher, Limmroth, Volker, Pelletier, Daniel, Pozzilli, Carlo, Schippling, Sven, Sousa, Livia, Traboulsee, Anthony, Uitdehaag, Bernard M. J., Van Wijmeersch, Bart, Choudhry, Zia, Daizadeh, Nadia, Singer, Barry A.“…BACKGROUND: Alemtuzumab efficacy versus subcutaneous interferon-β-1a (SC IFNB-1a) was demonstrated over 2 years in patients with relapsing-remitting multiple sclerosis, with continued efficacy over 7 additional years. …”
Publicado 2020
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32348por Logunov, Denis Y, Dolzhikova, Inna V, Zubkova, Olga V, Tukhvatulin, Amir I, Shcheblyakov, Dmitry V, Dzharullaeva, Alina S, Grousova, Daria M, Erokhova, Alina S, Kovyrshina, Anna V, Botikov, Andrei G, Izhaeva, Fatima M, Popova, Olga, Ozharovskaya, Tatiana A, Esmagambetov, Ilias B, Favorskaya, Irina A, Zrelkin, Denis I, Voronina, Daria V, Shcherbinin, Dmitry N, Semikhin, Alexander S, Simakova, Yana V, Tokarskaya, Elizaveta A, Lubenets, Nadezhda L, Egorova, Daria A, Shmarov, Maksim M, Nikitenko, Natalia A, Morozova, Lola F, Smolyarchuk, Elena A, Kryukov, Evgeny V, Babira, Vladimir F, Borisevich, Sergei V, Naroditsky, Boris S, Gintsburg, Alexander L“…Secondary outcome measures were antigen-specific cellular immunity (T-cell responses and interferon-γ concentration) and change in neutralising antibodies (detected with a SARS-CoV-2 neutralisation assay). …”
Publicado 2020
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32349por Jin, Ying-Hui, Zhan, Qing-Yuan, Peng, Zhi-Yong, Ren, Xue-Qun, Yin, Xun-Tao, Cai, Lin, Yuan, Yu-Feng, Yue, Ji-Rong, Zhang, Xiao-Chun, Yang, Qi-Wen, Ji, Jianguang, Xia, Jian, Li, Yi-Rong, Zhou, Fu-Xiang, Gao, Ya-Dong, Yu, Zhui, Xu, Feng, Tu, Ming-Li, Tan, Li-Ming, Yang, Min, Chen, Fang, Zhang, Xiao-Ju, Zeng, Mei, Zhu, Yu, Liu, Xin-Can, Yang, Jian, Zhao, Dong-Chi, Ding, Yu-Feng, Hou, Ning, Wang, Fu-Bing, Chen, Hao, Zhang, Yong-Gang, Li, Wei, Chen, Wen, Shi, Yue-Xian, Yang, Xiu-Zhi, Wang, Xue-Jun, Zhong, Yan-Jun, Zhao, Ming-Juan, Li, Bing-Hui, Ma, Lin-Lu, Zi, Hao, Wang, Na, Wang, Yun-Yun, Yu, Shao-Fu, Li, Lu-Yao, Huang, Qiao, Weng, Hong, Ren, Xiang-Ying, Luo, Li-Sha, Fan, Man-Ru, Huang, Di, Xue, Hong-Yang, Yu, Lin-Xin, Gao, Jin-Ping, Deng, Tong, Zeng, Xian-Tao, Li, Hong-Jun, Cheng, Zhen-Shun, Yao, Xiaomei, Wang, Xing-Huan“…They covered topics of chemoprophylaxis (including agents and Traditional Chinese Medicine (TCM) agents), diagnosis (including clinical manifestations, reverse transcription-polymerase chain reaction (RT-PCR), respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest x-ray, and CT features of asymptomatic infections), treatments (including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, qingfei paidu decoction, lianhua qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation (ECMO)), and discharge management (including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge). …”
Publicado 2020
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32350por Mille, B., Dezoteux, F., Fievet, C., Moreau, A.S., Poissy, J., Mathieu, D., Kipnis, E., Duhamel, A., Drumez, E., Buche, S., Staumont-Salle, D.“…Sur le plan physiopathologique, plusieurs hypothèses sont avancées comme une réponse immune antivirale de type interféron. Des études sont nécessaires afin de mieux comprendre les mécanismes à l’origine de ces manifestations.…”
Publicado 2020
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32351por Hosseini, Fatemeh Sadat, Malektojari, Alireza, Ghazizadeh, Sara, Hassaniazad, Mehdi, Davoodian, Parivash, Dadvand, Habib, Nikpoor, Amin Reza, Nikoofal-Sahlabadi, Sara, Kahoori, Sara, Sepandi, Mojtaba, Hassanipour, Soheil, Fathalipour, Mohammad“…The inpatient group will receive 200/50 mg Lopinavir/Ritonavir (Heterd Company, India) twice a day for the seven days, plus five doses of 44 mcg Interferon beta-1a (CinnaGen, Iran) every other day. …”
Publicado 2021
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32352por Hashemian, Seyed-Mohammad Reza, Aliannejad, Rasoul, Zarrabi, Morteza, Soleimani, Masoud, Vosough, Massoud, Hosseini, Seyedeh-Esmat, Hossieni, Hamed, Keshel, Saeid Heidari, Naderpour, Zeinab, Hajizadeh-Saffar, Ensiyeh, Shajareh, Elham, Jamaati, Hamidreza, Soufi-Zomorrod, Mina, Khavandgar, Naghmeh, Alemi, Hediyeh, Karimi, Aliasghar, Pak, Neda, Rouzbahani, Negin Hossieni, Nouri, Masoumeh, Sorouri, Majid, Kashani, Ladan, Madani, Hoda, Aghdami, Nasser, Vasei, Mohammad, Baharvand, Hossein“…IL-6 levels decreased in five (P = 0.06) patients and interferon gamma (IFN-γ) levels decreased in four (P = 0.14) patients. …”
Publicado 2021
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32353“…The expression levels of splenic Toll-like receptor 2, interleukin 4, tumor necrosis factor α, and interferon gamma were up-regulated (p < 0.01) in most of the early fed chicks (T2, T3, and T4) compared to fasted ones at 14 day of age. …”
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32354por Borobia, Alberto M, Carcas, Antonio J, Pérez-Olmeda, Mayte, Castaño, Luis, Bertran, María Jesús, García-Pérez, Javier, Campins, Magdalena, Portolés, Antonio, González-Pérez, María, García Morales, María Teresa, Arana-Arri, Eunate, Aldea, Marta, Díez-Fuertes, Francisco, Fuentes, Inmaculada, Ascaso, Ana, Lora, David, Imaz-Ayo, Natale, Barón-Mira, Lourdes E, Agustí, Antonia, Pérez-Ingidua, Carla, Gómez de la Cámara, Agustín, Arribas, José Ramón, Ochando, Jordi, Alcamí, José, Belda-Iniesta, Cristóbal, Frías, Jesús“…Antibody functionality was assessed using a pseudovirus neutralisation assay, and cellular immune response using an interferon-γ immunoassay. The safety outcome was 7-day reactogenicity, measured as solicited local and systemic adverse events. …”
Publicado 2021
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32355por Corroyer-Simovic, B., Lefevre, G., Demaret, J., Labalette, M., Alidjinou, E., Goffard, A., Puisieux, F., Sobaszek, A., Vuotto, F.“…Les objectifs sont : – évaluer l’amplitude de la réponse lymphocytaire T totale anti-S à 3 mois : nombre de cellules sécrétrices d’interféron gamma ; – évaluer l’amplitude de la réponse lymphocytaire T CD4+ et T CD8+ spécifique anti-S à 3 et 9 mois (nombre de lymphocytes T spécifiques anti-S détectés à 3 et 9 mois, après enrichissement en T CD4+ et en T CD8+) ; – évaluer l’amplitude de la réponse humorale spécifique anti-S à 3 et 9 mois (taux d’anticorps totaux anti-S et d’anticorps neutralisants). …”
Publicado 2021
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32356por Tailor, Imran K, Alshehry, Nawal F, Sabir, Kamran, Zaidi, Abdul Rehman Z, Marei, Mohammed, Motabi, Ibraheem, Alfayez, Mansour, Zaidi, Syed Ziauddin A, Altaf, Syed Y“…All patients were on supportive care and treatment included various options including chloroquine, antibiotics, convalescent plasma, interferon, enoxaparin, Tocilizumab depending on treating physician’s discretion. …”
Publicado 2020
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32357por Dhanota, N., Pilones, K.A., Kraynak, J., Demaria, S., Formenti, S.C., Salvatore, M., Marciscano, A.E.“…Relative to PBS-challenge, bulk RNA analysis demonstrated robust interferon expression (Ifnb1, Ifng) and upregulation of myeloid/T-cell chemotaxis (Ccl2, Cxcl10) [P < 0.05 in all IAV groups]. …”
Publicado 2021
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32358por Simpson-Yap, Steve, De Brouwer, Edward, Kalincik, Tomas, Rijke, Nick, Hillert, Jan A., Walton, Clare, Edan, Gilles, Moreau, Yves, Spelman, Tim, Geys, Lotte, Parciak, Tina, Gautrais, Clement, Lazovski, Nikola, Pirmani, Ashkan, Ardeshirdavanai, Amin, Forsberg, Lars, Glaser, Anna, McBurney, Robert, Schmidt, Hollie, Bergmann, Arnfin B., Braune, Stefan, Stahmann, Alexander, Middleton, Rodden, Salter, Amber, Fox, Robert J., van der Walt, Anneke, Butzkueven, Helmut, Alroughani, Raed, Ozakbas, Serkan, Rojas, Juan I., van der Mei, Ingrid, Nag, Nupur, Ivanov, Rumen, Sciascia do Olival, Guilherme, Dias, Alice Estavo, Magyari, Melinda, Brum, Doralina, Mendes, Maria Fernanda, Alonso, Ricardo N., Nicholas, Richard S., Bauer, Johana, Chertcoff, Aníbal Sebastián, Zabalza, Anna, Arrambide, Georgina, Fidao, Alexander, Comi, Giancarlo, Peeters, Liesbet“…Demographic (age, sex), clinical (MS phenotype, disability), and DMT (untreated, alemtuzumab, cladribine, dimethyl fumarate, glatiramer acetate, interferon, natalizumab, ocrelizumab, rituximab, siponimod, other DMTs) covariates were queried, along with COVID-19 severity outcomes, hospitalization, intensive care unit (ICU) admission, need for artificial ventilation, and death. …”
Publicado 2021
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32359por Bernigaud, Charlotte, Bertold, Clémence, Seitz-Polski, Barbara, Cardot-Leccia, Nathalie, Passeron, Thierry, Chosidow, Olivier“…À 4 mois du diagnostic, le taux d’interféron-α (IFN-α) après stimulation in vitro était bas (5,56 pg/mL) alors que les taux d’IL-1ß (1263 pg/mL) et d’IL-6 (> 5304 pg/mL) étaient très augmentés. …”
Publicado 2021
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32360por Bozonnat, Alizée, Assan, Florence, Bourrat, Emmanuelle, LeGoff, Jérome, Bachelez, Hervé“…L’expression de l’ARNm des gènes de signature de l’interféron (ISG) était normale dans les 2 cas. La poussée de PPG s’est amendée à 2 mois de la réintroduction de l’adalimumab, sans rechute. …”
Publicado 2021
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