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  1. 32341
    “…AIM: To evaluate mucosal baseline mRNA expression of tissue transglutaminase 2 (tTG2), interferon gamma (IFNγ), toll-like receptor 2 (TLR2) and Myeloid Differentiation factor 88 (MyD88) in patients with microscopic enteritis (ME). …”
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    May the assessment of baseline mucosal molecular pattern predict the development of gluten related disorders among microscopic enteritis?
  2. 32342
    “…[Image: see text] Abbreviations used: BSA: Bovine serum albumin, COX-2: Cyclooxygenase-2, CPM: Count per minute, DAMP: Danger-associated molecular pattern, DCM: Dichloromethane, DMSO: Dimethyl sulfoxide, ELISA: Enzyme-linked immunosorbent assay, FBS: Fetal bovine serum, H(2)O: Water, HEPES: 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid, HMC-1: Human mast cell-1, HMGB1: High-mobility group box 1, ICAM: Intercellular adhesion molecule, IFN: Interferon, IgG: Immunoglobulin G, IKK: IkB kinase, IL: Interleukin, iNOS: Inducible nitric oxide synthase, LPS: Lipopolysaccharide, MeOH: Methanol, MPA: Marantodes pumilum var. alata, MPL: Marantodes pumilum var. lanceolata, MPP: Marantodes pumilum var. pumila, MSU: Monosodium urate, MTT: Methylthiazole tetrazolium, NF-κB: Nuclear factor-kappa B, NLR: NOD-like receptor, NLRP3: NLR family pyrin domain containing protein 3, NO: Nitric oxide, NOD: Nucleotide-binding oligomerization domain, NSAID: Nonsteroidal anti-inflammatory drug, PAMP: Pathogen-associated molecular pattern, PBMC: Peripheral blood mononuclear cell, PBS: Phosphate buffered saline, PGE(2): Prostaglandin E(2,) PMACI: Phorbol-12-myristate 13-acetate and calcium ionosphere A23187, PRR: Pathogen recognition receptor, PTFE: Polytetrafluoroethylene, RIA: Radioimmunoassay, RIG: Retinoic acid-inducible gene I, RLR: RIG I-like receptor, RP-HPLC: Reversed-phase high-performance liquid chromatography, RPMI-1640: Roswell Park Memorial Institute-1640, TLR: Toll-like receptor, TNF: Tumor necrosis factor, VCAM: Vascular cell adhesion molecule.…”
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    Marantodes pumilum (Blume) Kuntze Inhibited Secretion of Lipopolysaccharide- and Monosodium Urate Crystal-stimulated Cytokines and Plasma Prostaglandin E(2)
  3. 32343
    “…Cal09 showed impaired pH1N1 nasopharyngeal shedding (16 of 118 children [14%, 95% CI 8·0–21·1] with shedding at day 2 after administration of LAIV) compared with H3N2 (54 of 118 [46%, 36·6–55·2]; p<0·0001) and influenza B (95 of 118 [81%, 72·2–87·2]; p<0·0001), along with suboptimal serum antibody (seroconversion in six of 118 [5%, 1·9–10·7]) and T-cell responses (CD4+ interferon γ-positive and/or CD4+ interleukin 2-positive responses in 45 of 111 [41%, 31·3–50·3]). …”
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    Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study
  4. 32344
    “…To investigate the expression of inflammatory cytokines and anti-microbial peptide genes, we determined the transcriptional levels of interferon-γ (IFN-γ), interleukin-4 (IL-4), mouse β-defensin-2 (mBD2), and cathelicidin LL-37 through real-time quantitative polymerase chain reaction. …”
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    Calcitriol enhances pyrazinamide treatment of murine tuberculosis
  5. 32345
    “…After the test resulted, the cellular immune function, humoral immune function, monocyte/macrophage function, NK cell activity and cytokine secretion (tumor necrosis factor-α, interferon-gamma and IL-4) were measured in immunosuppressive mice each group. …”
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    Impacts of functional oligosaccharide on intestinal immune modulation in immunosuppressive mice
  6. 32346
    “…The secondary objective was to assess the cellular and humoral immunogenicity of ChAdOx1 MERS, measured by interferon-γ-linked enzyme-linked immunospot, ELISA, and virus neutralising assays after vaccination. …”
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    Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial
  7. 32347
    “…BACKGROUND: Alemtuzumab efficacy versus subcutaneous interferon-β-1a (SC IFNB-1a) was demonstrated over 2 years in patients with relapsing-remitting multiple sclerosis, with continued efficacy over 7 additional years. …”
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    Efficacy and Safety of Alemtuzumab Through 9 Years of Follow-up in Patients with Highly Active Disease: Post Hoc Analysis of CARE-MS I and II Patients in the TOPAZ Extension Study
  8. 32348
    “…Secondary outcome measures were antigen-specific cellular immunity (T-cell responses and interferon-γ concentration) and change in neutralising antibodies (detected with a SARS-CoV-2 neutralisation assay). …”
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    Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia
  9. 32349
    por Jin, Ying-Hui, Zhan, Qing-Yuan, Peng, Zhi-Yong, Ren, Xue-Qun, Yin, Xun-Tao, Cai, Lin, Yuan, Yu-Feng, Yue, Ji-Rong, Zhang, Xiao-Chun, Yang, Qi-Wen, Ji, Jianguang, Xia, Jian, Li, Yi-Rong, Zhou, Fu-Xiang, Gao, Ya-Dong, Yu, Zhui, Xu, Feng, Tu, Ming-Li, Tan, Li-Ming, Yang, Min, Chen, Fang, Zhang, Xiao-Ju, Zeng, Mei, Zhu, Yu, Liu, Xin-Can, Yang, Jian, Zhao, Dong-Chi, Ding, Yu-Feng, Hou, Ning, Wang, Fu-Bing, Chen, Hao, Zhang, Yong-Gang, Li, Wei, Chen, Wen, Shi, Yue-Xian, Yang, Xiu-Zhi, Wang, Xue-Jun, Zhong, Yan-Jun, Zhao, Ming-Juan, Li, Bing-Hui, Ma, Lin-Lu, Zi, Hao, Wang, Na, Wang, Yun-Yun, Yu, Shao-Fu, Li, Lu-Yao, Huang, Qiao, Weng, Hong, Ren, Xiang-Ying, Luo, Li-Sha, Fan, Man-Ru, Huang, Di, Xue, Hong-Yang, Yu, Lin-Xin, Gao, Jin-Ping, Deng, Tong, Zeng, Xian-Tao, Li, Hong-Jun, Cheng, Zhen-Shun, Yao, Xiaomei, Wang, Xing-Huan
    Publicado 2020
    “…They covered topics of chemoprophylaxis (including agents and Traditional Chinese Medicine (TCM) agents), diagnosis (including clinical manifestations, reverse transcription-polymerase chain reaction (RT-PCR), respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest x-ray, and CT features of asymptomatic infections), treatments (including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, qingfei paidu decoction, lianhua qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation (ECMO)), and discharge management (including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge). …”
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    Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version)
  10. 32350
    “…Sur le plan physiopathologique, plusieurs hypothèses sont avancées comme une réponse immune antivirale de type interféron. Des études sont nécessaires afin de mieux comprendre les mécanismes à l’origine de ces manifestations.…”
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    Fréquence des acrosyndromes chez les patients avec infection sévère à SARS-CoV-2 en réanimation
  11. 32351
    “…The inpatient group will receive 200/50 mg Lopinavir/Ritonavir (Heterd Company, India) twice a day for the seven days, plus five doses of 44 mcg Interferon beta-1a (CinnaGen, Iran) every other day. …”
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    The efficacy and safety of Ivermectin in patients with mild and moderate COVID-19: A structured summary of a study protocol for a randomized controlled trial
  12. 32352
    “…IL-6 levels decreased in five (P = 0.06) patients and interferon gamma (IFN-γ) levels decreased in four (P = 0.14) patients. …”
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    Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series
  13. 32353
    “…The expression levels of splenic Toll-like receptor 2, interleukin 4, tumor necrosis factor α, and interferon gamma were up-regulated (p < 0.01) in most of the early fed chicks (T2, T3, and T4) compared to fasted ones at 14 day of age. …”
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    Early Nutrition with Different Diets Composition versus Fasting on Immunity-Related Gene Expression and Histomorphology of Digestive and Lymphoid Organs of Layer-Type Chicks
  14. 32354
    “…Antibody functionality was assessed using a pseudovirus neutralisation assay, and cellular immune response using an interferon-γ immunoassay. The safety outcome was 7-day reactogenicity, measured as solicited local and systemic adverse events. …”
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    Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial
  15. 32355
    “…Les objectifs sont : – évaluer l’amplitude de la réponse lymphocytaire T totale anti-S à 3 mois : nombre de cellules sécrétrices d’interféron gamma ; – évaluer l’amplitude de la réponse lymphocytaire T CD4+ et T CD8+ spécifique anti-S à 3 et 9 mois (nombre de lymphocytes T spécifiques anti-S détectés à 3 et 9 mois, après enrichissement en T CD4+ et en T CD8+) ; – évaluer l’amplitude de la réponse humorale spécifique anti-S à 3 et 9 mois (taux d’anticorps totaux anti-S et d’anticorps neutralisants). …”
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    Résultats préliminaires de l’évaluation de la réponse immunitaire du vaccin anti-SARS-CoV2 BNT162b2 chez le sujet âgé versus l’immunité naturelle post-COVID
  16. 32356
    “…All patients were on supportive care and treatment included various options including chloroquine, antibiotics, convalescent plasma, interferon, enoxaparin, Tocilizumab depending on treating physician’s discretion. …”
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    Outcomes of Patients of Eastern Mediterranean Region with Lymphoma and COVID-19.Does Recent Chemo Immunotherapy Have a Role on Severity?
  17. 32357
    “…Relative to PBS-challenge, bulk RNA analysis demonstrated robust interferon expression (Ifnb1, Ifng) and upregulation of myeloid/T-cell chemotaxis (Ccl2, Cxcl10) [P < 0.05 in all IAV groups]. …”
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    Evaluating the Immunomodulatory Profile and Treatment Efficacy of Whole Lung Low-Dose Radiation Therapy (LDRT) in a Preclinical Model of Severe Viral Pneumonia
  18. 32358
    por Simpson-Yap, Steve, De Brouwer, Edward, Kalincik, Tomas, Rijke, Nick, Hillert, Jan A., Walton, Clare, Edan, Gilles, Moreau, Yves, Spelman, Tim, Geys, Lotte, Parciak, Tina, Gautrais, Clement, Lazovski, Nikola, Pirmani, Ashkan, Ardeshirdavanai, Amin, Forsberg, Lars, Glaser, Anna, McBurney, Robert, Schmidt, Hollie, Bergmann, Arnfin B., Braune, Stefan, Stahmann, Alexander, Middleton, Rodden, Salter, Amber, Fox, Robert J., van der Walt, Anneke, Butzkueven, Helmut, Alroughani, Raed, Ozakbas, Serkan, Rojas, Juan I., van der Mei, Ingrid, Nag, Nupur, Ivanov, Rumen, Sciascia do Olival, Guilherme, Dias, Alice Estavo, Magyari, Melinda, Brum, Doralina, Mendes, Maria Fernanda, Alonso, Ricardo N., Nicholas, Richard S., Bauer, Johana, Chertcoff, Aníbal Sebastián, Zabalza, Anna, Arrambide, Georgina, Fidao, Alexander, Comi, Giancarlo, Peeters, Liesbet
    Publicado 2021
    “…Demographic (age, sex), clinical (MS phenotype, disability), and DMT (untreated, alemtuzumab, cladribine, dimethyl fumarate, glatiramer acetate, interferon, natalizumab, ocrelizumab, rituximab, siponimod, other DMTs) covariates were queried, along with COVID-19 severity outcomes, hospitalization, intensive care unit (ICU) admission, need for artificial ventilation, and death. …”
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    Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis
  19. 32359
    “…À 4 mois du diagnostic, le taux d’interféron-α (IFN-α) après stimulation in vitro était bas (5,56 pg/mL) alors que les taux d’IL-1ß (1263 pg/mL) et d’IL-6 (> 5304 pg/mL) étaient très augmentés. …”
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    Granulomatose faciale 38 ans après des injections de produits de comblement : rôle précipitant de la COVID-19 et intérêt du méthotrexate
  20. 32360
    “…L’expression de l’ARNm des gènes de signature de l’interféron (ISG) était normale dans les 2 cas. La poussée de PPG s’est amendée à 2 mois de la réintroduction de l’adalimumab, sans rechute. …”
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    Poussée sévère de DITRA causée par le SARS-CoV-2
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