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32381por Raschi, Elena, Privitera, Daniela, Bodio, Caterina, Lonati, Paola Adele, Borghi, Maria Orietta, Ingegnoli, Francesca, Meroni, Pier Luigi, Chighizola, Cecilia Beatrice“…Human umbilical vein endothelial cells (HUVECs) were incubated with ICs, positive and negative controls. mRNA levels of endothelin-1 (et-1), collagenIα1 (colIα1), interferon (IFN)-α, and IFN-β were investigated by real-time PCR; et-1 and il-6 mRNA levels were assessed after pre-treatment with bafilomycin. …”
Publicado 2020
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32382por Battesti, G., El-Khalifa, J., Mekki, N., Ferre, V., Bouscarat, F., Picard-Dahan, C., Brunet-Possenti, F., Lavaud, J., Tournier, A., Rousselot, M., Le Bozec, P., Lheure, C., Deschamps, L., Descamps, V.“…Plus rarement, elles sont un signe d’interféronopathie, groupe de maladie monogénique caractérisé par une forte production d’interferon de type 1 (INF-1). Les engelures ont constitué la plus fréquente des manifestations cutanées associées à la COVID-19. …”
Publicado 2020
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32383por Liu, Panpan, Huang, Zhijun, Yin, Mingzhu, Liu, Chun, Chen, Xiang, Pan, Pinhua, Kuang, Yehong“…INTERVENTION AND COMPARATOR: In the first stage, three subjects are given ixekizumab (“Taltz”) (80 mg/ml, 160 mg as a single hypodermic injection) and antiviral therapy (α-interferon (administer 5 million U by aerosol inhalation twice daily), lopinavir/ritonavir (administer 100mg by mouth twice daily, for the course of therapy no more than 10 days), chloroquine (administer 500mg by mouth twice daily, for the course of therapy no more than 10 days), ribavirin (administer 500mg by intravenous injection two to three times a day, for the course of therapy no more than 10 days), or arbidol (administer 200mg by mouth three times a day, for the course of therapy no more than 10 days), but not more than 3 types). …”
Publicado 2020
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32384por Zhu, Feng-Cai, Guan, Xu-Hua, Li, Yu-Hua, Huang, Jian-Ying, Jiang, Tao, Hou, Li-Hua, Li, Jing-Xin, Yang, Bei-Fang, Wang, Ling, Wang, Wen-Juan, Wu, Shi-Po, Wang, Zhao, Wu, Xiao-Hong, Xu, Jun-Jie, Zhang, Zhe, Jia, Si-Yue, Wang, Bu-Sen, Hu, Yi, Liu, Jing-Jing, Zhang, Jun, Qian, Xiao-Ai, Li, Qiong, Pan, Hong-Xing, Jiang, Hu-Dachuan, Deng, Peng, Gou, Jin-Bo, Wang, Xue-Wen, Wang, Xing-Huan, Chen, Wei“…Both doses of the vaccine induced significant neutralising antibody responses to live SARS-CoV-2, with GMTs of 19·5 (95% CI 16·8–22·7) and 18·3 (14·4–23·3) in participants receiving 1 × 10(11) and 5 × 10(10) viral particles, respectively. Specific interferon γ enzyme-linked immunospot assay responses post vaccination were observed in 227 (90%, 95% CI 85–93) of 253 and 113 (88%, 81–92) of 129 participants in the 1 × 10(11) and 5 × 10(10) viral particles dose groups, respectively. …”
Publicado 2020
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32385“…Chez l’adulte, il existe une surexpression du CD169 sur les monocytes, qui est un récepteur activé par le système interféron de type 1. Cette surexpression serait corrélée à la charge virale et pourrait constituer un nouveau biomarqueur pour les patients atteints du SARS-CoV-2. …”
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32386por Bailén, Rebeca, Kwon, Mi, Aguado, Beatriz, Duarte, Rafael F., Calbacho, Maria, Chinea, Anabelle, Llamas, Pilar, Riaza Grau, Rosalía, Hernandez-Rivas, Jose Angel, Jimenez Yuste, Victor, Martínez-Chamorro, Carmen, Penalver, F. Javier, González, Ataulfo, del Campo, Juan F, Quiroz, Keina, Oarbeascoa, Gillen, Garcia Suarez, Julio, Díez-Martín, José Luis“…Most patients received anti-viral treatment with either hydroxichloroquine (47 patients, 54%), lopinavir/ritonavir (34 patients, 39%), remdesivir (5, 4%) and/or other treatments including azythromicin or interferon. 23 patients (26%) received anticytokine treatment with tocilizumab (15, 17%) and/or anakinra (8, 9%) and 27 patients (31%) received steroids. …”
Publicado 2020
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32387por Moor, Matthias B, Suter-Riniker, Franziska, Horn, Michael P, Aeberli, Daniel, Amsler, Jennifer, Möller, Burkhard, Njue, Linet M, Medri, Cesare, Angelillo-Scherrer, Anne, Borradori, Luca, Radonjic-Hoesli, Susanne, Seyed Jafari, S Morteza, Chan, Andrew, Hoepner, Robert, Bacher, Vera Ulrike, Mani, Laila-Yasmin, Iype, Joseena Mariam, Hirzel, Cédric, Maurer, Britta, Sidler, Daniel“…Patients with a treatment history of anti-CD20-depleting agents (rituximab or ocrelizumab) and with no previous history of SARS-CoV-2 infection were enrolled between April 26 and June 30, 2021, for analysis of humoral and cell-mediated immune responses (by interferon-γ [IFNγ] release assay) at least 4 weeks after completing vaccination against SARS-CoV-2. …”
Publicado 2021
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32388por Ader, Florence, Bouscambert-Duchamp, Maude, Hites, Maya, Peiffer-Smadja, Nathan, Poissy, Julien, Belhadi, Drifa, Diallo, Alpha, Lê, Minh-Patrick, Peytavin, Gilles, Staub, Thérèse, Greil, Richard, Guedj, Jérémie, Paiva, Jose-Artur, Costagliola, Dominique, Yazdanpanah, Yazdan, Burdet, Charles, Mentré, France“…Participants were randomly assigned (1:1:1:1:1) to receive standard of care alone or in combination with remdesivir, lopinavir–ritonavir, lopinavir–ritonavir and interferon beta-1a, or hydroxychloroquine. Randomisation used computer-generated blocks of various sizes; it was stratified on severity of disease at inclusion and on European administrative region. …”
Publicado 2022
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32389por Angyal, Adrienn, Longet, Stephanie, Moore, Shona C, Payne, Rebecca P, Harding, Adam, Tipton, Tom, Rongkard, Patpong, Ali, Mohammad, Hering, Luisa M, Meardon, Naomi, Austin, James, Brown, Rebecca, Skelly, Donal, Gillson, Natalie, Dobson, Sue L, Cross, Andrew, Sandhar, Gurjinder, Kilby, Jonathan A, Tyerman, Jessica K, Nicols, Alexander R, Spegarova, Jarmila S, Mehta, Hema, Hornsby, Hailey, Whitham, Rachel, Conlon, Christopher P, Jeffery, Katie, Goulder, Philip, Frater, John, Dold, Christina, Pace, Matthew, Ogbe, Ane, Brown, Helen, Ansari, M Azim, Adland, Emily, Brown, Anthony, Chand, Meera, Shields, Adrian, Matthews, Philippa C, Hopkins, Susan, Hall, Victoria, James, William, Rowland-Jones, Sarah L, Klenerman, Paul, Dunachie, Susanna, Richter, Alex, Duncan, Christopher J A, Barnes, Eleanor, Carroll, Miles, Turtle, Lance, de Silva, Thushan I“…We measured spike-specific IgG antibodies and quantified T-cell responses by interferon-γ enzyme-linked immunospot assay in all participants where samples were available at the time of analysis, comparing SARS-CoV-2-naive individuals to those with previous infection. …”
Publicado 2022
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32390por Itchaki, Gilad, Rokach, Lior, Benjamini, Ohad, Bairey, Osnat, Sabag, Adi, Vernitsky, Helly, Cohen, Hila, Rotem, Shahar, Elia, Uri, Raanani, Pia, Bar-Haim, Erez, Tadmor, Tamar“…Aim of the study: To investigate T-cell response determined by interferon gamma (IFNγ) secretion in patients with CLL following BNT162b mRNA Covid-19 vaccine, in comparison with serologic response. …”
Publicado 2021
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32391por Chiuppesi, Flavia, Zaia, John A, Frankel, Paul H, Stan, Rodica, Drake, Jennifer, Williams, Brenda, Acosta, Anne Marie, Francis, Karyn, Taplitz, Randy A, Dickter, Janet K, Dadwal, Sanjeet, Puing, Alfredo G, Nanayakkara, Deepa D, Ash, Patricia, Cui, Yujie, Contreras, Heidi, La Rosa, Corinna, Tiemann, Katrin, Park, Yoonsuh, Medina, Joybelle, Iniguez, Angelina, Zhou, Qiao, Karpinski, Veronica, Johnson, Daisy, Faircloth, Katelyn, Kaltcheva, Teadora, Nguyen, Jenny, Kha, Mindy, Nguyen, Vu H, Francisco, Sandra Ortega, Grifoni, Alba, Wong, Angela, Sette, Alessandro, Wussow, Felix, Diamond, Don J“…Post-prime and post-boost four times increase in spike-specific or nucleocapsid-specific T cells secreting interferon-γ was measured in 48 (98%; 95% CI 89–100) of 49 participants who received at least one dose of COH04S1 and provided a sample for immunological analysis. …”
Publicado 2022
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32392por Nguyen, Thuy P., Do, Quyet, Phan, Lan T., Dinh, Duc V., Khong, Hiep, Hoang, Luong V., Nguyen, Thuong V., Pham, Hung N., Chu, Men V., Nguyen, Toan T., Pham, Quang D., Le, Tri M., Trang, Tuyen N.T., Dinh, Thanh T., Vo, Thuong V., Vu, Thao T., Nguyen, Quynh B.P., Phan, Vuong T., Nguyen, Luong V., Nguyen, Giang T., Tran, Phong M., Nghiem, Thuan D., Tran, Tien V., Nguyen, Tien G., Tran, Tuynh Q., Nguyen, Linh T., Do, Anh T., Nguyen, Dung D., Ho, Son A., Nguyen, Viet T., Pham, Dung T., Tran, Hieu B., Vu, Son T., Hoang, Su X., Do, Trung M., Nguyen, Xuan T., Le, Giang Q., Tran, Ton, Cao, Thang M., Dao, Huy M., Nguyen, Thao T.T., Doan, Uyen Y, Le, Vy T.T., Tran, Linh P., Nguyen, Ngoc M., Nguyen, Ngoc T., Pham, Hang T.T., Nguyen, Quan H., Nguyen, Hieu T., Nguyen, Hang L.K., Tran, Vinh T., Tran, Mai T.N., Nguyen, Truc T.T., Ha, Phat T., Huynh, Hieu T., Nguyen, Khanh D., Thuan, Ung T., Doan, Chung C., Do, Si M.“…Secondary outcomes were surrogate virus neutralisation (inhibition percentage), wild-type SARS-CoV-2 neutralisation (dilution fold), and T-cell responses by intracellular staining for interferon gamma (IFNg). Anti-S IgG and neutralising antibody levels were compared with convalescent serum samples from symptomatic Covid-19 patients. …”
Publicado 2022
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32393“…The 10 hub genes in the upregulated network [G Protein Subunit Alpha I2 (GNAI2), G Protein Subunit Alpha I1 (GNAI1), G Protein Subunit Alpha I3 (GNAI3), G Protein Subunit Gamma 2 (GNG2), G Protein Subunit Beta 1 (GNB1), G Protein Subunit Gamma 13 (GNG13), G Protein Subunit Gamma Transducin 1 (GNGT1), G Protein Subunit Gamma 12 (GNG12), AKT Serine/Threonine Kinase 1 (AKT1) and GNAS Complex Locus (GNAS)] and the 10 hub genes in the downregulated network [Nucleotide-Binding Oligomerization Domain Containing Protein 2 (NOD2), Receptor-Interacting Serine/Threonine Kinase 2 (RIPK2), Nucleotide-Binding Oligomerization Domain Containing Protein 1 (NOD1), Mitochondrial Antiviral Signaling Protein (MAVS), Autophagy Related 16-Like 1 (ATG16L1), Interferon Induced With Helicase C Domain 1 (IFIH1), Autophagy Related 5 (ATG5), TANK-Binding Kinase 1 (TBK1), Caspase Recruitment Domain Family Member 9 (CARD9), and von Willebrand factor (VWF)] were screened using cytoHubba. …”
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32394por Matuozzo, Daniela, Talouarn, Estelle, Marchal, Astrid, Zhang, Peng, Manry, Jeremy, Seeleuthner, Yoann, Zhang, Yu, Bolze, Alexandre, Chaldebas, Matthieu, Milisavljevic, Baptiste, Gervais, Adrian, Bastard, Paul, Asano, Takaki, Bizien, Lucy, Barzaghi, Federica, Abolhassani, Hassan, Abou Tayoun, Ahmad, Aiuti, Alessandro, Alavi Darazam, Ilad, Allende, Luis M., Alonso-Arias, Rebeca, Arias, Andrés Augusto, Aytekin, Gokhan, Bergman, Peter, Bondesan, Simone, Bryceson, Yenan T., Bustos, Ingrid G., Cabrera-Marante, Oscar, Carcel, Sheila, Carrera, Paola, Casari, Giorgio, Chaïbi, Khalil, Colobran, Roger, Condino-Neto, Antonio, Covill, Laura E., Delmonte, Ottavia M., El Zein, Loubna, Flores, Carlos, Gregersen, Peter K., Gut, Marta, Haerynck, Filomeen, Halwani, Rabih, Hancerli, Selda, Hammarström, Lennart, Hatipoğlu, Nevin, Karbuz, Adem, Keles, Sevgi, Kyheng, Christèle, Leon-Lopez, Rafael, Franco, Jose Luis, Mansouri, Davood, Martinez-Picado, Javier, Metin Akcan, Ozge, Migeotte, Isabelle, Morange, Pierre-Emmanuel, Morelle, Guillaume, Martin-Nalda, Andrea, Novelli, Giuseppe, Novelli, Antonio, Ozcelik, Tayfun, Palabiyik, Figen, Pan-Hammarström, Qiang, de Diego, Rebeca Pérez, Planas-Serra, Laura, Pleguezuelo, Daniel E., Prando, Carolina, Pujol, Aurora, Reyes, Luis Felipe, Rivière, Jacques G., Rodriguez-Gallego, Carlos, Rojas, Julian, Rovere-Querini, Patrizia, Schlüter, Agatha, Shahrooei, Mohammad, Sobh, Ali, Soler-Palacin, Pere, Tandjaoui-Lambiotte, Yacine, Tipu, Imran, Tresoldi, Cristina, Troya, Jesus, van de Beek, Diederik, Zatz, Mayana, Zawadzki, Pawel, Al-Muhsen, Saleh Zaid, Alosaimi, Mohammed Faraj, Alsohime, Fahad M., Baris-Feldman, Hagit, Butte, Manish J., Constantinescu, Stefan N., Cooper, Megan A., Dalgard, Clifton L., Fellay, Jacques, Heath, James R., Lau, Yu-Lung, Lifton, Richard P., Maniatis, Tom, Mogensen, Trine H., von Bernuth, Horst, Lermine, Alban, Vidaud, Michel, Boland, Anne, Deleuze, Jean-François, Nussbaum, Robert, Kahn-Kirby, Amanda, Mentre, France, Tubiana, Sarah, Gorochov, Guy, Tubach, Florence, Hausfater, Pierre, Meyts, Isabelle, Zhang, Shen-Ying, Puel, Anne, Notarangelo, Luigi D., Boisson-Dupuis, Stephanie, Su, Helen C., Boisson, Bertrand, Jouanguy, Emmanuelle, Casanova, Jean-Laurent, Zhang, Qian, Abel, Laurent, Cobat, Aurélie“…BACKGROUND: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. …”
Publicado 2023
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32395por Alhumaid, Saad, Al Mutared, Koblan M., Al Alawi, Zainab, Sabr, Zainah, Alkhars, Ola, Alabdulqader, Muneera, Al Dossary, Nourah, ALShakhs, Fatemah M., Majzoub, Rabab Abbas, Alalawi, Yousef Hassan, Al Noaim, Khalid, Alnaim, Abdulrahman A., Al Ghamdi, Mohammed A., Alahmari, Abdulaziz A., Albattat, Sawsan Sami, Almubarak, Yasin S., Al Abdulmohsen, Essam Mohammed, Al Shaikh, Hanan, Alobaidan, Mortadah Essa, Almusallam, Hadi Hassan, Alhassan, Fatimah Mohammed, Alamer, Mohammed Abdulhadi, Al-Hajji, Jawad Ali, Al-Hajji, Duaa Ali, Alkadi, Anwar Ahmed, Al Mutair, Abbas, Rabaan, Ali A.“…Underlying immune defects does seem to be independent risk factors for severe SARS-CoV-2 infection in children with IEIs, a number of children with SCID and CID were reported to have prolonged infections–though the number of patients is small–but especially immune dysregulation diseases (XLP1 and XLP2) and innate immunodeficiencies impairing type I interferon signalling (IFNAR1, IFNAR2 and TBK1). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13223-023-00831-1.…”
Publicado 2023
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32396por Watkins, Clara, Nagra, Deepak, Alveyn, Edward, Adas, Maryam, Baldwin, Chris, Galloway, James“…Currently the only recognised JAK inhibitor for the treatment of sarcoidosis is tofacitinib as it inhibits both interferon by JAK1 and G-CSF through JAK2/3. STAT1 has been isolated during immunohistological analysis of skin lesions in sarcoidosis which is inhibited by tofacitinib and forms the basis of its use in cutaneous sarcoidosis. …”
Publicado 2023
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32397“…Chest X-ray demonstrated diffuse widespread ∼3-4cm opacifications in keeping with lung nodules. Interferon gamma release assay testing was indeterminate. …”
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32398por Koch, Till, Dahlke, Christine, Fathi, Anahita, Kupke, Alexandra, Krähling, Verena, Okba, Nisreen M A, Halwe, Sandro, Rohde, Cornelius, Eickmann, Markus, Volz, Asisa, Hesterkamp, Thomas, Jambrecina, Alen, Borregaard, Saskia, Ly, My L, Zinser, Madeleine E, Bartels, Etienne, Poetsch, Joseph S H, Neumann, Reza, Fux, Robert, Schmiedel, Stefan, Lohse, Ansgar W, Haagmans, Bart L, Sutter, Gerd, Becker, Stephan, Addo, Marylyn M“…T-cell immunity was evaluated by interferon-γ-linked enzyme-linked immune absorbent spot assay. …”
Publicado 2020
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32399por Faqihi, Fahad, Alharthy, Abdulrahman, Alodat, Mohammed, Asad, Daood, Aletreby, Waleed, Kutsogiannis, Demetrios J., Brindley, Peter G., Karakitsos, Dimitrios“…The rationale is that TPE can remove interleukins-3, 6, 8, 10, interferon-gamma and tumor necrosis factor-alpha. Thus, it may reduce the cytokine release syndrome associated with fulminant COVID-19 disease. …”
Publicado 2020
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32400“…In analyses including observational studies, interferon-alpha (OR 0.05, 95% CI 0.01 to 0.39, p = 0.004), itolizumab (OR 0.10, 95% CI 0.01 to 0.92, p = 0.042), sofosbuvir plus daclatasvir (OR 0.26, 95% CI 0.07 to 0.88, p = 0.030), anakinra (OR 0.30, 95% CI 0.11 to 0.82, p = 0.019), tocilizumab (OR 0.43, 95% CI 0.30 to 0.60, p < 0.001), and convalescent plasma (OR 0.48, 95% CI 0.24 to 0.96, p = 0.038) were associated with reduced mortality rate in non-ICU setting, while high-dose intravenous immunoglobulin (IVIG) (OR 0.13, 95% CI 0.03 to 0.49, p = 0.003), ivermectin (OR 0.15, 95% CI 0.04 to 0.57, p = 0.005), and tocilizumab (OR 0.62, 95% CI 0.42 to 0.90, p = 0.012) were associated with reduced mortality rate in critically ill patients. …”
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