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32401por Moyon, Q., Sterlin, D., Miyara, M., François, A., Lhote, R., Ghillani-Dalbin, P., Cohen Aubart, F., Haroche, J., Pha, M., Boutin, D.L.T.H., Gorochov, G., Amoura, Z., Mathian, A.“…Nous avons également étudié la réponse cellulaire T par des tests Interferon gamma release assay (IGRA) spécifiques du SARS-CoV2. …”
Publicado 2021
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32402por Angel, Alon, Mastboim, Niv Samuel, Shaham, Oded, Ber, Tahel Ilan, Navon, Roy, Simon, Einav, Rosenberg, Michal, Israeli, Yael, Hainrichson, Mary, Avni, Noa, Reiner, Eran, Feigin, Paul, Oved, Kfir, Tadmor, Boaz, Singer, Pierre, Kagan, Ilya, Lev, Shaul, Diker, Dror, Jarjou’i, Amir, Kurd, Ramzi, Ben-Chetrit, Eli, Danziger, Guy, Papan, Cihan, Motov, Sergey, Shapira, Maanit, Stein, Michal, Klein, Adi, Gottlieb, Tanya, Eden, Eran“…Tumor necrosis factor related apoptosis inducing ligand (TRAIL), interferon gamma inducible protein-10 (IP-10) and C-reactive protein (CRP) were measured using an analyzer providing values within 15 minutes (MeMed Key®). …”
Publicado 2021
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32403por Guo, Li, Wang, Geng, Wang, Yeming, Zhang, Qiao, Ren, Lili, Gu, Xiaoying, Huang, Tingxuan, Zhong, Jingchuan, Wang, Ying, Wang, Xinming, Huang, Lixue, Xu, Liuhui, Wang, Conghui, Chen, Lan, Xiao, Xia, Peng, Yanchun, Knight, Julian C, Dong, Tao, Cao, Bin, Wang, Jianwei“…We analysed the magnitude and breadth of the SARS-CoV-2-specific memory T-cell responses using the interferon γ (IFNγ) enzyme-linked immune absorbent spot (ELISpot) assay and intracellular cytokine staining (ICS) assay. …”
Publicado 2022
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32404“…Sputum was negative including for atypical infection. Interferon Gamma Release Assay (IGRA) was positive; sputum and urine culture for tuberculosis (TB) were negative after 6 weeks. …”
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32405por Laher, Fatima, Moodie, Zoe, Cohen, Kristen W., Grunenberg, Nicole, Bekker, Linda-Gail, Allen, Mary, Frahm, Nicole, Yates, Nicole L., Morris, Lynn, Malahleha, Mookho, Mngadi, Kathryn, Daniels, Brodie, Innes, Craig, Saunders, Kevin, Grant, Shannon, Yu, Chenchen, Gilbert, Peter B., Phogat, Sanjay, DiazGranados, Carlos A., Koutsoukos, Marguerite, Van Der Meeren, Olivier, Bentley, Carter, Mkhize, Nonhlanhla N., Pensiero, Michael N., Mehra, Vijay L., Kublin, James G., Corey, Lawrence, Montefiori, David C., Gray, Glenda E., McElrath, M. Juliana, Tomaras, Georgia D.“…Antibody (IgG, IgG3 binding, and neutralizing) and CD4+ T-cell (expressing interferon-gamma, interleukin-2, and CD40 ligand) responses were evaluated at month 6.5 for all participants and at months 12, 12.5, and 18 for a randomly selected subset. …”
Publicado 2020
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32406por Folegatti, Pedro M, Ewer, Katie J, Aley, Parvinder K, Angus, Brian, Becker, Stephan, Belij-Rammerstorfer, Sandra, Bellamy, Duncan, Bibi, Sagida, Bittaye, Mustapha, Clutterbuck, Elizabeth A, Dold, Christina, Faust, Saul N, Finn, Adam, Flaxman, Amy L, Hallis, Bassam, Heath, Paul, Jenkin, Daniel, Lazarus, Rajeka, Makinson, Rebecca, Minassian, Angela M, Pollock, Katrina M, Ramasamy, Maheshi, Robinson, Hannah, Snape, Matthew, Tarrant, Richard, Voysey, Merryn, Green, Catherine, Douglas, Alexander D, Hill, Adrian V S, Lambe, Teresa, Gilbert, Sarah C, Pollard, Andrew J“…Cellular responses were assessed using an ex-vivo interferon-γ enzyme-linked immunospot assay. The co-primary outcomes are to assess efficacy, as measured by cases of symptomatic virologically confirmed COVID-19, and safety, as measured by the occurrence of serious adverse events. …”
Publicado 2020
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32407“…Abbreviations: ABCD3: ATP binding cassette subfamily D member 3; AD: Alzheimer disease; ALS: amyotrophic lateral sclerosis; AMBRA1: autophagy and beclin 1 regulator 1; AMPK: AMP-activated protein kinase; ARIH1: ariadne RBR E3 ubiquitin protein ligase 1; ATF: activating transcription factor; ATG: autophagy related; ATM: ATM serine/threonine kinase; BCL2: BCL2 apoptosis regulator; BCL2L11/BIM: BCL2 like 11; BCL2L13: BCL2 like 13; BECN1: beclin 1; BNIP3: BCL2 interacting protein 3; BNIP3L/NIX: BCL2 interacting protein 3 like; CALCOCO2/NDP52: calcium binding and coiled-coil domain 2; CANX: calnexin; CAT: catalase; CCPG1: cell cycle progression 1; CHDH: choline dehydrogenase; COPD: chronic obstructive pulmonary disease; CSE: cigarette smoke exposure; CTSD: cathepsin D; DDIT3/CHOP: DNA-damage inducible transcript 3; DISC1: DISC1 scaffold protein; DNM1L/DRP1: dynamin 1 like; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; EIF2S1/eIF2α: eukaryotic translation initiation factor 2 alpha kinase 3; EMD: emerin; EPAS1/HIF-2α: endothelial PAS domain protein 1; ER: endoplasmic reticulum; ERAD: ER-associated degradation; ERN1/IRE1α: endoplasmic reticulum to nucleus signaling 1; FBXO27: F-box protein 27; FKBP8: FKBP prolyl isomerase 8; FTD: frontotemporal dementia; FUNDC1: FUN14 domain containing 1; G3BP1: G3BP stress granule assembly factor 1; GBA: glucocerebrosidase beta; HIF1A/HIF1: hypoxia inducible factor 1 subunit alpha; IMM: inner mitochondrial membrane; LCLAT1/ALCAT1: lysocardiolipin acyltransferase 1; LGALS3/Gal3: galectin 3; LIR: LC3-interacting region; LMNA: lamin A/C; LMNB1: lamin B1; LPS: lipopolysaccharide; MAPK8/JNK: mitogen-activated protein kinase 8; MAMs: mitochondria-associated membranes; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MFN1: mitofusin 1; MOD: multiple organelles dysfunction; MTPAP: mitochondrial poly(A) polymerase; MUL1: mitochondrial E3 ubiquitin protein ligase 1; NBR1: NBR1 autophagy cargo receptor; NLRP3: NLR family pyrin domain containing 3; NUFIP1: nuclear FMR1 interacting protein 1; OMM: outer mitochondrial membrane; OPTN: optineurin; PD: Parkinson disease; PARL: presenilin associated rhomboid like; PEX3: peroxisomal biogenesis factor 3; PGAM5: PGAM family member 5; PHB2: prohibitin 2; PINK1: PTEN induced putative kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; RB1CC1/FIP200: RB1 inducible coiled-coil 1; RETREG1/FAM134B: reticulophagy regulator 1; RHOT1/MIRO1: ras homolog family member T1; RIPK3/RIP3: receptor interacting serine/threonine kinase 3; ROS: reactive oxygen species; RTN3: reticulon 3; SEC62: SEC62 homolog, preprotein translocation factor; SESN2: sestrin2; SIAH1: siah E3 ubiquitin protein ligase 1; SNCA: synuclein alpha; SNCAIP: synuclein alpha interacting protein; SQSTM1/p62: sequestosome 1; STING1: stimulator of interferon response cGAMP interactor 1; TAX1BP1: Tax1 binding protein 1; TBK1: TANK binding kinase 1; TFEB: transcription factor EB; TICAM1/TRIF: toll-like receptor adaptor molecule 1; TIMM23: translocase of inner mitochondrial membrane 23; TNKS: tankyrase; TOMM: translocase of the outer mitochondrial membrane; TRIM: tripartite motif containing; UCP2: uncoupling protein 2; ULK1: unc-51 like autophagy activating kinase; UPR: unfolded protein response; USP10: ubiquitin specific peptidase 10; VCP/p97: valosin containing protein; VDAC: voltage dependent anion channels; XIAP: X-linked inhibitor of apoptosis; ZNHIT3: zinc finger HIT-type containing 3.…”
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32408por Mannick, Joan B, Teo, Grace, Bernardo, Patti, Quinn, Dean, Russell, Kerry, Klickstein, Lloyd, Marshall, William, Shergill, Sarb“…BACKGROUND: The COVID-19 pandemic highlights the need for therapies that improve immune function in older adults, including interferon (IFN)-induced antiviral immunity that declines with age. …”
Publicado 2021
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32409por Felten, R., Gallais, F., Schleiss, C., Chatelus, E., Javier, R.M., Pijnenburg, L., Sordet, C., Sibilia, J., Arnaud, L., Fafi-Kremer, S., Gottenberg, J.E.“…Pour explorer la réponse spécifique des cellules T au SARS-CoV-2, un test immunoenzymatique à l’interféron gamma (IFN-γ) (ELISPOT) a été réalisé. L’évaluation sérologique a été réalisée à l’aide du test commercial SARS-CoV-2 IgG II Quant (Spike) (Abbott Architect). …”
Publicado 2021
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32410por Gavriilaki, Eleni, Papadopoulou, Anastasia, Touloumenidou, Tasoula, Stavridou, Fani, Koravou, Evdoxia, Giannaki, Maria, Papalexandri, Apostolia, Karavalakis, Georgios, Batsis, Ioannis, Kourelis, Andreas, Chatzopoulou, Fani, Chatzidimitriou, Dimitrios, Sotiropoulos, Damianos, Yannaki, Evangelia, Sakellari, Ioanna, Anagnostopoulos, Achilles“…Neutralizing antibodies against SARS-CoV-2 (CoV-2-NAbs) were measured using an FDA approved methodology for diagnostic use (ELISA, cPass™ SARS-CoV-2 NAbs Detection Kit; GenScript, Piscataway, NJ, USA; cut-off value for a positive result set at ≥30%) and SARS-CoV-2 spike-specific T cells (spike-STs) by interferon-γ Elispot after pulsing peripheral blood mononuclear cells with spike pepmixes. …”
Publicado 2021
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32411por Funakoshi, Yohei, Yakushijin, Kimikazu, Ohji, Goh, Sakai, Hironori, Hojo, Wataru, Watanabe, Marika, Saeki, Miki, Hirakawa, Yuri, Sakai, Rina, Matsumoto, Sakuya, Mizutani, Yu, Kitao, Akihito, Miyata, Yoshiharu, Saito, Yasuyuki, Kawamoto, Shinichiro, Katsuya, Yamamoto, Ito, Mitsuhiro, Nishimura, Meiko, Imamura, Yoshinori, Kiyota, Naomi, Matsuoka, Hiroshi, Mori, Yasuko, Minami, Hironobu“…To determine the SARS-CoV-2-specific T-cell reactivity in these three patients, we evaluated interferon (IFN)-γ response to the SARS-CoV-2 spike peptide before and after the second vaccination dose, and detected IFN-γ responses after vaccination in all three patients (Figure B). …”
Publicado 2021
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32412por Lucchini, Giovanna, Cozma, Elena, Jackson, Aimee, Gilmour, Kimberly, Protheroe, Rachel Elizabeth, Tholouli, Eleni, Wynn, Robert F, Wilson, Keith, Peggs, Karl S, Potter, Victoria, Parker, Anne, Craddock, Charles, Paneesha, Shankara, Nicholson, Emma, Marks, David I., Mirci-Danicar, Oana, Parrish, Christopher, Martin, Alexander M, McIlroy, Graham, Bishop, Rebecca, Collings, Rebecca, Williams, Ellie, Amrolia, Persis J“…The 11 prospective patients showed normal levels of interleukin (IL)-2, -4, -10, interferon gamma and tumor necrosis factor alpha at COVID-19 presentation. …”
Publicado 2021
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32413por Barnieh, Wenona, Hannah, Jennifer, Connolly, Aveen, Creamer, Daniel, Gordon, Patrick“…Lesional biopsies have demonstrated occlusive small and medium vessel vasculopathy with a type-1-interferon signature. Anti-NXP-2 has also been linked to GI-tract vasculitis and perforation in a JDM case series. …”
Publicado 2021
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32414por Escoda, T., Jordana, S., Chiche, L., Delord, M., Genot, S., Stavris, C., Retornaz, F., Penaranda, G., Rebaudet, S., Halfon, P.“…Leur réponse humorale a été évaluée par sérologie (Elecsys® anti-SARS-CoV-2) avec mesure du titre d’anticorps anti-Spike exprimés en BAU/mL, et leur réponse cellulaire par mesure de la production d’interféron-γ des lymphocytes T en réponse aux antigènes du SARS-CoV-2 (test ELISA QuantiFERON SARS-CoV-2 de Qiagen®). …”
Publicado 2023
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32415“…Plusieurs études ont souligné le rôle crucial de la réponse interféron (IFN) dans la clairance virale. Cette réponse, altérée dans les formes sévères et critiques de COVID-19, est associée à une production excessive de cytokines pro-inflammatoires. …”
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32416por Pagnano, Katia B, Kok, Chung Hoow, Mauro, Michael J., Cortes, Jorge E., Evans, Nicola, Jiang, Qian, Milojkovic, Dragana, Moiraghi, Beatriz, Nicolini, Franck E., Ongondi, Matilda, Zackova, Daniela, Rea, Delphine, Hughes, Timothy P.“…CML treatment at the time of COVID-19 diagnosis: hydroxyurea in 4 pts (6%), 38 (6%) bosutinib, 96 (15%) dasatinib, 275 (43%) imatinib, 92 (14%) nilotinib, 18 (3%) ponatinib, 3 (0.5%) other 4th generation TKIs; one alpha interferon. Ninety-nine (15%) pts were not receiving any treatment: 53 (8%) were in treatment free-remission (TFR) and 46 were without treatment (7%) for other reasons: treatment side effects (7), stem cell transplantation (12), pregnancy (3), lack of efficacy (2), unknown (1) and newly diagnosed CML (21). …”
Publicado 2021
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32417por Mancuso, Katia, Zamagni, Elena, Solli, Vincenza, Gabrielli, Liliana, Pantani, Lucia, Rocchi, Serena, Rizzello, Ilaria, Tacchetti, Paola, Fusco, Alessio, De Cicco, Gabriella, Ursi, Margherita, Talarico, Marco, Favero, Emanuele, Nepoti, Giuliana, Ruffini, Barbara, Terragna, Carolina, Lazzarotto, Tiziana, Zinzani, Pier Luigi, Cavo, Michele“…To this aim, we measured serum levels of neutralizing IgG anti Spike-protein (IgG anti S-RBD) at 1, 3, 6, 9 and 12 months after the 2 (nd) dose of vaccination, using the electrochemiluminescence (ECLIA) platform (Elecsys® Anti-sars-Cov-2 ECLIA assay) and evaluated CMI response in terms of pts with a SARS-CoV-2 specific IFNγ T cell response by IGRA (Interferon-Gamma Release Assays) test at 3 and 12 months after 2 (nd) dose. …”
Publicado 2021
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32418por Shree, Tanaya, Shankar, Vishnu, Czerwinski, Debra K., Rodriguez, Gladys, Beygi, Sara, Schroers-Martin, Joseph G, Advani, Ranjana, Maeda, Lauren S., Gupta, Neel K., Khodadoust, Michael S., Kurtz, David M., Corbelli, Karen S., Gabriel, Etelka, Kanegai, Alyssa M., Alizadeh, Ash A., Levy, Ronald“…T cell assessments include quantitation of spike-specific activation and cytokine production via interferon-gamma ELISPOTs and multiparameter flow cytometry. …”
Publicado 2021
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32419por Janapala, Rajesh naldu, jayaraj, joseph, Rass, bayan, Zarghamravanbakhsh, Paria, Sachmechi, issac“…He was treated with zidovudine and interferon-alpha as first-line therapy, and intrathecal methotrexate, for suspected intrathecal involvement. …”
Publicado 2020
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32420por Moreno-González, G., Mussetti, A., Albasanz-Puig, A., Salvador, I., Sureda, A., Gudiol, C., Salazar, R., Marin, M., Garcia, M., Navarro, V., de la Haba Vaca, I., Coma, E., Sanz-Linares, G., Dura, X., Fontanals, S., Serrano, G., Cruz, C., Mañez, R.“…In the randomized phase, tocilizumab or interferon will not be allowed in the experimental arm. …”
Publicado 2021
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