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  1. 32441
    “…To investigate the production of type I interferons in response to imiquimod-containing Aldara cream, IFNβ-luciferase reporter mice were imaged in vivo and ex vivo. …”
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    Topical imiquimod yields systemic effects due to unintended oral uptake
  2. 32442
    “…Diese verfügen über Proteine, die als Rezeptoren (beispielsweise toll-like-Rezeptoren, Komplementrezeptoren) für bestimmte Erregerstrukturen und für die löslichen Produkte des unspezifischen Immunsystems (Akutphaseproteine, die Faktoren des Komplementsystems, Cytokine, Chemokine und Interferone) dienen. Auf die Wirkung und Funktion der Cytokine, Chemokine und Interferone wird in ▸ Kapitel 8 gesondert eingegangen.…”
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    Immunologie
  3. 32443
    “…Many studies have reported that the combination of interferons and NRTI causes the loss of hepatitis B surface antigen (HBsAg), which is suggestive of seroconversion. …”
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    Chronic Hepatitis B Treatment Strategies Using Polymerase Inhibitor-Based Combination Therapy
  4. 32444
    “…Accelerated prion infections have been seen in interleukin-10 knockout mice, and type 1 interferons have been found to be protective against these diseases. …”
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    THαβ Immunological Pathway as Protective Immune Response against Prion Diseases: An Insight for Prion Infection Therapy
  5. 32445
    “…Amongst the results, we identified five popular targets of use: IL6 and IL1 inhibitors, interferons, mesenchymal stem cells treatment, and anti-spike antibodies. …”
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    Biologics in COVID-19 So Far: Systematic Review
  6. 32446
    “…Moreover, individuals receiving platinum compounds, sulfonamides (plain), interferons, and antivirals for HCV infection therapy should be carefully observed for DIHL for at least several months.…”
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    Analysis of drug-induced hearing loss by using a spontaneous reporting system database
  7. 32447
    “…No relapses of AIH were observed when IS was stopped after interferons, imatinib, diclofenac, and methylprednisolone. …”
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    Setting up criteria for drug‐induced autoimmune‐like hepatitis through a systematic analysis of published reports
  8. 32448
    “…Interferons are the first lines of defense against viral pathogen invasion during the early stages of infection. …”
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    Deciphering the Fine-Tuning of the Retinoic Acid-Inducible Gene-I Pathway in Teleost Fish and Beyond
  9. 32449
    por Fillatreau, Simon
    Publicado 2023
    “…Bradford et al.(1) now provide evidence that autoantibodies can also be protective by neutralizing type I interferons (IFNs) and restraining the activation of pathogenic B cells.…”
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    Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus
  10. 32450
    por Heo, Gwangbeom, Lee, Yunna, Im, Eunok
    Publicado 2021
    “…SIMPLE SUMMARY: The development of colorectal cancer (CRC) can be affected by various inflammatory mediators, such as tumor necrosis factor, nuclear factor kappa B, interleukins, and interferons. Moreover, these inflammatory mediators can be reciprocally affected by gut microbiota. …”
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    Interplay between the Gut Microbiota and Inflammatory Mediators in the Development of Colorectal Cancer
  11. 32451
    “…(https://doi.org/10.1084/jem.20171749) report an unanticipated role for cGAMP in priming and activation of inflammasomes in addition to its well-characterized function as an endogenous second messenger inducing type I interferons in the cytosolic DNA-sensing pathway.…”
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    cGAMP: A tale of two signals
  12. 32452
    “…TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. …”
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    Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection
  13. 32453
    “…RNA virus infections are detected by the RIG-I family of receptors, which induce type-I interferons through the mitochondrial protein MAVS. …”
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    MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
  14. 32454
    por Coroadinha, Ana Sofia
    Publicado 2023
    “…Some of these RFs are ubiquitously expressed in mammalian cells, while others are cell-specific, and others still are expressed only upon induction by danger signals as type I interferons. Cell restriction factors have evolved to protect the organism against infectious diseases and tissue damage. …”
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    Host Cell Restriction Factors Blocking Efficient Vector Transduction: Challenges in Lentiviral and Adeno-Associated Vector Based Gene Therapies
  15. 32455
    “…Additional agents, such as rimantadine and intranasal interferons, and newer approaches, including thе use of combination chemotherapy, offer promise for the improved management of viral respiratory tract infections.…”
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    Antiviral Chemotherapyand Prophylaxis of Viral Respiratory Disease
  16. 32456
    Publicado 2022
    “…Deacetylation of specific lysine residues in the DNA-binding domain of the transcription factors IRF3 and IRF7 by SIRT1 is necessary for liquid–liquid phase separation and transactivation of type I interferons. SIRT1 agonists partially restored the impaired innate immune responses in senescent cells and aged mice, suggestive of a possible strategy for preventing innate immunosenescence.…”
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    IRF3 and IRF7 require SIRT1 for liquid–liquid phase separation and transactivation of IFN-1
  17. 32457
    por Ben-Efraim, S.
    Publicado 1997
    “…Interleukins 2, 4, 6, 7, 12 and the interferons were extensively tested for their therapeutic effectiveness in experimental tumour models and in cancer clinical trials. …”
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    Cancer immunotherapy: potential involvement of mediators
  18. 32458
    “…NETs contribute to the pathogenesis of autoimmunity by exposing cryptic autoepitopes, which may facilitate the generation of autoantibodies, induce the production of interferons, and activate the complement cascade. In SLE, augmented disease activity and renal disease are associated with increased NET formation, so that NETs could serve as a marker for the monitoring of disease activity. …”
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    “The NET Outcome”: Are Neutrophil Extracellular Traps of Any Relevance to the Pathophysiology of Autoimmune Disorders in Childhood?
  19. 32459
    “…Human immunodeficiency virus type 1 (HIV-1) infection triggers rapid induction of multiple innate cytokines including type I interferons, which play important roles in viral control and disease pathogenesis. …”
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    Dynamics of Transforming Growth Factor (TGF)-β Superfamily Cytokine Induction During HIV-1 Infection Are Distinct From Other Innate Cytokines
  20. 32460
    “…Unsurprisingly it has a strong immune defense system, with involvement of innate (e.g., epithelial barrier, muco- ciliary clearance, nasal secretions with interferons, lysozyme, nitric oxide) and acquired (e.g., secreted immunoglobulins, lymphocytes) arms. …”
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    Review: The Nose as a Route for Therapy. Part 2 Immunotherapy
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