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32581por Huang, Wei, Luo, Shuhong, Burgess, Rob, Yi, Yu-Hua, Huang, Gordon F., Huang, Ruo-Pan“…Intercellular communication within this niche is driven by soluble proteins synthesized by local tumor and stromal cells and include chemokines, growth factors, interferons, interleukins, and angiogenic factors. The interaction of tumor cells with their microenvironment is essential for tumorigenesis, tumor progression, growth, and metastasis, and resistance to drug therapy. …”
Publicado 2018
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32582por Escors, David, Gato-Cañas, María, Zuazo, Miren, Arasanz, Hugo, García-Granda, María Jesus, Vera, Ruth, Kochan, Grazyna“…Second, PD-L1 function relies on the delivery of intrinsic intracellular signals that enhance cancer cell survival, regulate stress responses and confer resistance toward pro-apoptotic stimuli, such as interferons. Here, we review the current knowledge on intracellular signal transduction pathways regulated by PD-L1, describe its associated signalosome and discuss potential combinations of targeted therapies against the signalosome with PD-L1/PD-1 blockade therapies.…”
Publicado 2018
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32583“…Cytosolic DNA sensors are the most recently described class of pattern recognition receptors (PRRs), which induce the production of type I interferons (IFN-I) and trigger the induction of a rapid and efficient innate immune response. …”
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32584por Refolo, Giulia, Vescovo, Tiziana, Piacentini, Mauro, Fimia, Gian Maria, Ciccosanti, Fabiola“…In the last years, proteomics has represented a valuable approach to elucidate key aspects in the regulation of type I/III interferons (IFNs) and autophagy, two main processes involved in the response to viral infection, to unveil the molecular strategies that viruses have evolved to counteract these processes. …”
Publicado 2020
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32585por Wang, Shuai, Zhou, Lili, Ling, Li, Meng, Xuli, Chu, Feng, Zhang, Suping, Zhou, Fangfang“…Recognition of pathogen-associated molecular patterns (PAMPs) triggers expression of antiviral interferons and proinflammatory cytokines, which functions as the frontier of host defense against microbial pathogen invasion. …”
Publicado 2020
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32586“…Recombinant AcMNPV was shown to induce interferons alpha/beta even in the absence of transgene expression in human SMMC-7721 cells, while it mediated transgene expression in BHK and L929 mammalian cells without an ensuing antiviral activity.…”
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32587“…The immunological hallmarks in PRRSV-infected pigs include the unusually poor production of type I interferons (IFNs-α/β) and the aberrant and delayed adaptive immune responses, indicating that PRRSV has the ability to suppress both innate and adaptive immune responses in the host. …”
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32588“…In addition, NK cells are activated by cytokines (e.g. interleukin 12 and type I interferons), which are products of activated macrophages and dendritic cells. …”
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32589“…The innate immune response to viruses requires their early detection through pathogen recognition receptors and the recruitment of the efficient antiviral response that is centred around the release of type 1 interferons. The airway epithelium provides both a barrier and an early detector for viruses, and interacts closely with cells of the innate immune response, especially macrophages and dendritic cells, to eliminate infection and trigger a specific adaptive immune response.…”
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32590por Blanco-Melo, Daniel, Nilsson-Payant, Benjamin E., Liu, Wen-Chun, Uhl, Skyler, Hoagland, Daisy, Møller, Rasmus, Jordan, Tristan X., Oishi, Kohei, Panis, Maryline, Sachs, David, Wang, Taia T., Schwartz, Robert E., Lim, Jean K., Albrecht, Randy A., tenOever, Benjamin R.“…This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. …”
Publicado 2020
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32591“…Here, we summarize potential biotherapeutics and their mechanisms of action, including convalescent plasma, therapeutic antibodies, peptides, engineered ACE2, interferons, cytokine inhibitors, and RNAi-based therapeutics, and discuss in depth the advancements and precautions for each type of biotherapeutics in the treatment of COVID-19.…”
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32592por Maleki, Kimia T., Tauriainen, Johanna, García, Marina, Kerkman, Priscilla F., Christ, Wanda, Dias, Joana, Wigren Byström, Julia, Leeansyah, Edwin, Forsell, Mattias N., Ljunggren, Hans-Gustaf, Ahlm, Clas, Björkström, Niklas K., Sandberg, Johan K., Klingström, Jonas“…In vitro activation of MAIT cells by hantavirus-exposed antigen-presenting cells is dependent on type I interferons (IFNs) and independent of interleukin-18 (IL-18). …”
Publicado 2021
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32593“…In this review, we briefly discuss the virology of this pathogen and focus on the available understanding of the pathogenesis and treatments of this pathogen including the uses of nucleoside analogues, protease inhibitors, interferons, and other small-molecule drugs, on the basis previous comprehensions of SARS and MERS. …”
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32594“…Eliminating virus and blocking cytokines are important checkpoints of COVID-19 therapy, and several agents targeting immunopathology, including interferons, thymosin, glucocorticoids and immunoglobulin, have shown therapeutic effects in severe patients with COVID-19. …”
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32595por Andreakos, Evangelos, Abel, Laurent, Vinh, Donald C., Kaja, Elżbieta, Drolet, Beth A., Zhang, Qian, O’Farrelly, Cliona, Novelli, Giuseppe, Rodríguez-Gallego, Carlos, Haerynck, Filomeen, Prando, Carolina, Pujol, Aurora, Su, Helen C., Casanova, Jean-Laurent, Spaan, András N.“…Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. …”
Publicado 2021
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32596por Lévy, Romain, Zhang, Peng, Bastard, Paul, Dorgham, Karim, Melki, Isabelle, Hadchouel, Alice, Hartoularos, George C., Neven, Bénédicte, Castelle, Martin, Roy, Charlotte, Toin, Tom, Berteloot, Laureline, Bizien, Lucy, Abid, Hanène, Burgard, Marianne, Houhou-Fidouh, Nadhira, Rozenberg, Flore, Jouanguy, Emmanuelle, Ye, Chun Jimmie, Gorochov, Guy, Zhang, Qian, Casanova, Jean-Laurent“…We describe an unvaccinated child at risk for life-threatening COVID-19 due to an inherited deficiency of IRF9, which governs ISGF-3–dependent responses to type I and III interferons (IFN). She was admitted, with a high nasal SARS-CoV-2 load on day 1 of upper respiratory tract infection. …”
Publicado 2021
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32597“…These new drugs include biologics that target B cells, T cells and type 1 interferons, and small molecules that inhibit kinases. …”
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32598por Jiang, Yizhou, Rubin, Limor, Zhou, Zhiwei, Zhang, Haibo, Su, Qiaozhu, Hou, Sheng-Tao, Lazarovici, Philip, Zheng, Wenhua“…Casirivimab/Imdevimab monoclonal antibodies and convalescent plasma to prevent virus entry, Remdesivir, Molnupiravir, and Paxlovid nucleotide analogs to prevent viral replication, a variety of repurposed JAK-STAT signaling pathway inhibitors, corticosteroids, and recombinant agonists/antagonists of cytokine and interferons have been found to provide clinical benefits in terms of mortality and hospitalization. …”
Publicado 2022
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32599por Petralia, Maria Cristina, Nicoletti, Ferdinando, Tancheva, Lyubka, Kalfin, Reni, Fagone, Paolo, Mangano, Katia“…We observed a negative enrichment for genes associated with the control of immune responses and putatively regulated by the transcription factors IRF8 and SPI1 and by both type I and II interferons. Our study provides evidence of altered immune responses, which are likely associated with the occurrence of HAND in the absence of HIV encephalitis (HIVE).…”
Publicado 2022
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32600por Meng, Feng-Zhen, Liu, Jin-Biao, Wang, Xu, Wang, Peng, Hu, Wen-Hui, Hou, Wei, Ho, Wen-Zhe“…Further mechanistic studies revealed that while imiquimod had little effect on interferons expression, its treatment of macrophages resulted in the increased production of the CC chemokines, the natural ligands of the HIV entry co-receptor CCR5, and decreased expression of CD4 and CCR5. …”
Publicado 2021
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