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  1. 32581
    “…Intercellular communication within this niche is driven by soluble proteins synthesized by local tumor and stromal cells and include chemokines, growth factors, interferons, interleukins, and angiogenic factors. The interaction of tumor cells with their microenvironment is essential for tumorigenesis, tumor progression, growth, and metastasis, and resistance to drug therapy. …”
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    New Insights into the Tumor Microenvironment Utilizing Protein Array Technology
  2. 32582
    “…Second, PD-L1 function relies on the delivery of intrinsic intracellular signals that enhance cancer cell survival, regulate stress responses and confer resistance toward pro-apoptotic stimuli, such as interferons. Here, we review the current knowledge on intracellular signal transduction pathways regulated by PD-L1, describe its associated signalosome and discuss potential combinations of targeted therapies against the signalosome with PD-L1/PD-1 blockade therapies.…”
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    The intracellular signalosome of PD-L1 in cancer cells
  3. 32583
    por Lin, Yingying, Zheng, Chunfu
    Publicado 2019
    “…Cytosolic DNA sensors are the most recently described class of pattern recognition receptors (PRRs), which induce the production of type I interferons (IFN-I) and trigger the induction of a rapid and efficient innate immune response. …”
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    A Tug of War: DNA-Sensing Antiviral Innate Immunity and Herpes Simplex Virus Type I Infection
  4. 32584
    “…In the last years, proteomics has represented a valuable approach to elucidate key aspects in the regulation of type I/III interferons (IFNs) and autophagy, two main processes involved in the response to viral infection, to unveil the molecular strategies that viruses have evolved to counteract these processes. …”
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    Mitochondrial Interactome: A Focus on Antiviral Signaling Pathways
  5. 32585
    “…Recognition of pathogen-associated molecular patterns (PAMPs) triggers expression of antiviral interferons and proinflammatory cytokines, which functions as the frontier of host defense against microbial pathogen invasion. …”
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    The Crosstalk Between Hippo-YAP Pathway and Innate Immunity
  6. 32586
    “…Recombinant AcMNPV was shown to induce interferons alpha/beta even in the absence of transgene expression in human SMMC-7721 cells, while it mediated transgene expression in BHK and L929 mammalian cells without an ensuing antiviral activity.…”
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    Group I but not Group II NPV induces antiviral effects in mammalian cells
  7. 32587
    por Ke, Hanzhong, Yoo, Dongwan
    Publicado 2017
    “…The immunological hallmarks in PRRSV-infected pigs include the unusually poor production of type I interferons (IFNs-α/β) and the aberrant and delayed adaptive immune responses, indicating that PRRSV has the ability to suppress both innate and adaptive immune responses in the host. …”
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    The viral innate immune antagonism and an alternative vaccine design for PRRS virus
  8. 32588
    por Lodoen, Melissa B, Lanier, Lewis L
    Publicado 2006
    “…In addition, NK cells are activated by cytokines (e.g. interleukin 12 and type I interferons), which are products of activated macrophages and dendritic cells. …”
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    Natural killer cells as an initial defense against pathogens
  9. 32589
    por See, Hayley, Wark, Peter
    Publicado 2008
    “…The innate immune response to viruses requires their early detection through pathogen recognition receptors and the recruitment of the efficient antiviral response that is centred around the release of type 1 interferons. The airway epithelium provides both a barrier and an early detector for viruses, and interacts closely with cells of the innate immune response, especially macrophages and dendritic cells, to eliminate infection and trigger a specific adaptive immune response.…”
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    Innate immune response to viral infection of the lungs
  10. 32590
    “…This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. …”
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    Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
  11. 32591
    “…Here, we summarize potential biotherapeutics and their mechanisms of action, including convalescent plasma, therapeutic antibodies, peptides, engineered ACE2, interferons, cytokine inhibitors, and RNAi-based therapeutics, and discuss in depth the advancements and precautions for each type of biotherapeutics in the treatment of COVID-19.…”
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    Insights into biological therapeutic strategies for COVID-19
  12. 32592
    “…In vitro activation of MAIT cells by hantavirus-exposed antigen-presenting cells is dependent on type I interferons (IFNs) and independent of interleukin-18 (IL-18). …”
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    MAIT cell activation is associated with disease severity markers in acute hantavirus infection
  13. 32593
    “…In this review, we briefly discuss the virology of this pathogen and focus on the available understanding of the pathogenesis and treatments of this pathogen including the uses of nucleoside analogues, protease inhibitors, interferons, and other small-molecule drugs, on the basis previous comprehensions of SARS and MERS. …”
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    Potential Anti-Coronavirus Agents and the Pharmacologic Mechanisms
  14. 32594
    “…Eliminating virus and blocking cytokines are important checkpoints of COVID-19 therapy, and several agents targeting immunopathology, including interferons, thymosin, glucocorticoids and immunoglobulin, have shown therapeutic effects in severe patients with COVID-19. …”
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    Therapeutic Agents Rounding Up the Immunopathology of COVID-19
  15. 32595
    “…Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. …”
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    A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
  16. 32596
    “…We describe an unvaccinated child at risk for life-threatening COVID-19 due to an inherited deficiency of IRF9, which governs ISGF-3–dependent responses to type I and III interferons (IFN). She was admitted, with a high nasal SARS-CoV-2 load on day 1 of upper respiratory tract infection. …”
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    Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child
  17. 32597
    “…These new drugs include biologics that target B cells, T cells and type 1 interferons, and small molecules that inhibit kinases. …”
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    New developments in systemic lupus erythematosus
  18. 32598
    “…Casirivimab/Imdevimab monoclonal antibodies and convalescent plasma to prevent virus entry, Remdesivir, Molnupiravir, and Paxlovid nucleotide analogs to prevent viral replication, a variety of repurposed JAK-STAT signaling pathway inhibitors, corticosteroids, and recombinant agonists/antagonists of cytokine and interferons have been found to provide clinical benefits in terms of mortality and hospitalization. …”
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    Pharmacological therapies and drug development targeting SARS-CoV-2 infection
  19. 32599
    “…We observed a negative enrichment for genes associated with the control of immune responses and putatively regulated by the transcription factors IRF8 and SPI1 and by both type I and II interferons. Our study provides evidence of altered immune responses, which are likely associated with the occurrence of HAND in the absence of HIV encephalitis (HIVE).…”
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    Gene Co-Expression Network Modular Analysis Reveals Altered Immune Mechanisms in HIV-HAND
  20. 32600
    “…Further mechanistic studies revealed that while imiquimod had little effect on interferons expression, its treatment of macrophages resulted in the increased production of the CC chemokines, the natural ligands of the HIV entry co-receptor CCR5, and decreased expression of CD4 and CCR5. …”
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    TLR7 Activation of Macrophages by Imiquimod Inhibits HIV Infection through Modulation of Viral Entry Cellular Factors
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