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32601por Ke, Po-Yuan“…Upon viral infection, host cells often activate retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling to induce the transcription of type I interferons, thus establishing the first line of the innate antiviral response. …”
Publicado 2023
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32602“…The immune response elicited by these receptors culminates in the release of cytokines, chemokines, and interferons causing an inflammatory response, which can be both beneficial and harmful to neurodevelopment. …”
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32603“…Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisomes to evade innate sensing and restriction. …”
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32604“…A number of drugs such as immune checkpoint inhibitors, penicillamine, tyrosine kinase inhibitors and interferons may induce de novo MG by altering the immune homeostasis mechanisms which prevent emergence of autoimmune diseases such as MG. …”
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32605“…Here, we will discuss how these mechanisms contribute to pathobiology of SLE and how type I interferons work with them to augment sex specific disease pathogenesis in SLE.…”
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32606por Kim, So Ri“…Furthermore, in most cases, asthmatic patients tend to produce lower levels of antiviral cytokines than healthy subjects, such as interferons produced from immune effector cells and airway epithelial cells. …”
Publicado 2022
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32607por Muri, Jonathan, Cecchinato, Valentina, Cavalli, Andrea, Shanbhag, Akanksha A., Matkovic, Milos, Biggiogero, Maira, Maida, Pier Andrea, Moritz, Jacques, Toscano, Chiara, Ghovehoud, Elaheh, Furlan, Raffaello, Barbic, Franca, Voza, Antonio, De Nadai, Guendalina, Cervia, Carlo, Zurbuchen, Yves, Taeschler, Patrick, Murray, Lilly A., Danelon-Sargenti, Gabriela, Moro, Simone, Gong, Tao, Piffaretti, Pietro, Bianchini, Filippo, Crivelli, Virginia, Podešvová, Lucie, Pedotti, Mattia, Jarrossay, David, Sgrignani, Jacopo, Thelen, Sylvia, Uhr, Mario, Bernasconi, Enos, Rauch, Andri, Manzo, Antonio, Ciurea, Adrian, Rocchi, Marco B. L., Varani, Luca, Moser, Bernhard, Bottazzi, Barbara, Thelen, Marcus, Fallon, Brian A., Boyman, Onur, Mantovani, Alberto, Garzoni, Christian, Franzetti-Pellanda, Alessandra, Uguccioni, Mariagrazia, Robbiani, Davide F.“…While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse coronavirus disease 2019 (COVID-19) outcomes. …”
Publicado 2023
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32608“…Furthermore, the production of ATX is associated with type I interferons, a key cytokine in SLE pathogenesis, and ATX may be a potential biomarker and key molecule in SLE.…”
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32609por Gombos, Gréta, Németh, Nikolett, Pös, Ondrej, Styk, Jakub, Buglyó, Gergely, Szemes, Tomas, Danihel, Ludovit, Nagy, Bálint, Balogh, István, Soltész, Beáta“…In this review, we aim to discuss exosomes, TDEs, and the JAK/STAT pathways, along with mediators like interleukins, tripartite motif proteins, and interferons.…”
Publicado 2023
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32610por Lui, Gabrielle, Manches, Olivier, Angel, Juliette, Molens, Jean-Paul, Chaperot, Laurence, Plumas, Joël“…Among the different subsets of dendritic cells (DC), plasmacytoid dendritic cells (PDC) play a unique role in secreting large amounts of type I interferons upon viral stimulation, but their efficiency as antigen-presenting cells has not been completely characterized. …”
Publicado 2009
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32611“…Type-I interferons (IFN-I) are cytokines essential for vertebrate antiviral defense, including against herpesviruses. …”
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32612“…The role of type I interferons (IFNs) in SLE pathogenesis has been a subject of intense investigation in the last decade. …”
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32613por Pantel, Austin, Teixeira, Angela, Haddad, Elias, Wood, Elizabeth G., Steinman, Ralph M., Longhi, M. Paula“…Type I interferons (IFNs) play an important role in direct antiviral defense as well as linking the innate and adaptive immune responses. …”
Publicado 2014
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32614“…We further discuss the role of type I interferons in infection with S. aureus and the implications of these findings for the development of immune based therapies and vaccination.…”
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32615por Sharma, Shraddha, Patnaik, Santosh K., Thomas Taggart, R., Kannisto, Eric D., Enriquez, Sally M., Gollnick, Paul, Baysal, Bora E.“…Here we show that transcripts of hundreds of genes undergo site-specific C>U RNA editing in macrophages during M1 polarization and in monocytes in response to hypoxia and interferons. This editing alters the amino acid sequences for scores of proteins, including many that are involved in pathogenesis of viral diseases. …”
Publicado 2015
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32616por Dreesen, Erwin, Bossuyt, Peter, Mulleman, Denis, Gils, Ann, Pascual-Salcedo, Dora“…Biopharmaceuticals directed against tumor necrosis factor-alpha, integrins, interleukins, interferons and their receptors have become key agents for the management of inflammatory diseases in the fields of gastroenterology, rheumatology, dermatology and neurology. …”
Publicado 2017
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32617por Zhang, Guoliang, deWeerd, Nicole A., Stifter, Sebastian A., Liu, Lei, Zhou, Boping, Wang, Wenfei, Zhou, Yiping, Ying, Binwu, Hu, Xuejiao, Matthews, Antony Y., Ellis, Magda, Triccas, James A., Hertzog, Paul J., Britton, Warwick J., Chen, Xinchun, Feng, Carl G.“…Type I interferons (IFN), best known for their anti-viral functions, have been shown to impair host resistance to intracellular bacteria in mice. …”
Publicado 2018
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32618por Moyo, Daniel, Beattie, Lynette, Andrews, Paul S., Moore, John W. J., Timmis, Jon, Sawtell, Amy, Hoehme, Stefan, Sampson, Adam T., Kaye, Paul M.“…Cellular activation in trans by interferons, cytokines, and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. …”
Publicado 2018
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32619“…Upon infection, nucleic acid sensing TLRs signal within endosomal compartment triggering the induction of essential proinflammatory cytokines and type I interferons to initiate innate immune responses thereby leading to a critical role in the development of adaptive immune responses. …”
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32620“…Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. …”
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