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  1. 32601
    por Ke, Po-Yuan
    Publicado 2023
    “…Upon viral infection, host cells often activate retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling to induce the transcription of type I interferons, thus establishing the first line of the innate antiviral response. …”
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    Crosstalk between Autophagy and RLR Signaling
  2. 32602
    “…The immune response elicited by these receptors culminates in the release of cytokines, chemokines, and interferons causing an inflammatory response, which can be both beneficial and harmful to neurodevelopment. …”
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    Counting the Toll of Inflammation on Schizophrenia—A Potential Role for Toll-like Receptors
  3. 32603
    “…Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisomes to evade innate sensing and restriction. …”
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    Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes
  4. 32604
    “…A number of drugs such as immune checkpoint inhibitors, penicillamine, tyrosine kinase inhibitors and interferons may induce de novo MG by altering the immune homeostasis mechanisms which prevent emergence of autoimmune diseases such as MG. …”
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    Drugs That Induce or Cause Deterioration of Myasthenia Gravis: An Update
  5. 32605
    por Bose, Moumita, Jefferies, Caroline
    Publicado 2022
    “…Here, we will discuss how these mechanisms contribute to pathobiology of SLE and how type I interferons work with them to augment sex specific disease pathogenesis in SLE.…”
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    Sex bias in systemic lupus erythematosus: a molecular insight
  6. 32606
    por Kim, So Ri
    Publicado 2022
    “…Furthermore, in most cases, asthmatic patients tend to produce lower levels of antiviral cytokines than healthy subjects, such as interferons produced from immune effector cells and airway epithelial cells. …”
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    Viral Infection and Airway Epithelial Immunity in Asthma
  7. 32607
    por Muri, Jonathan, Cecchinato, Valentina, Cavalli, Andrea, Shanbhag, Akanksha A., Matkovic, Milos, Biggiogero, Maira, Maida, Pier Andrea, Moritz, Jacques, Toscano, Chiara, Ghovehoud, Elaheh, Furlan, Raffaello, Barbic, Franca, Voza, Antonio, De Nadai, Guendalina, Cervia, Carlo, Zurbuchen, Yves, Taeschler, Patrick, Murray, Lilly A., Danelon-Sargenti, Gabriela, Moro, Simone, Gong, Tao, Piffaretti, Pietro, Bianchini, Filippo, Crivelli, Virginia, Podešvová, Lucie, Pedotti, Mattia, Jarrossay, David, Sgrignani, Jacopo, Thelen, Sylvia, Uhr, Mario, Bernasconi, Enos, Rauch, Andri, Manzo, Antonio, Ciurea, Adrian, Rocchi, Marco B. L., Varani, Luca, Moser, Bernhard, Bottazzi, Barbara, Thelen, Marcus, Fallon, Brian A., Boyman, Onur, Mantovani, Alberto, Garzoni, Christian, Franzetti-Pellanda, Alessandra, Uguccioni, Mariagrazia, Robbiani, Davide F.
    Publicado 2023
    “…While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse coronavirus disease 2019 (COVID-19) outcomes. …”
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    Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course
  8. 32608
    “…Furthermore, the production of ATX is associated with type I interferons, a key cytokine in SLE pathogenesis, and ATX may be a potential biomarker and key molecule in SLE.…”
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    Role of autotaxin in systemic lupus erythematosus
  9. 32609
    “…In this review, we aim to discuss exosomes, TDEs, and the JAK/STAT pathways, along with mediators like interleukins, tripartite motif proteins, and interferons.…”
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    New Possible Ways to Use Exosomes in Diagnostics and Therapy via JAK/STAT Pathways
  10. 32610
    “…Among the different subsets of dendritic cells (DC), plasmacytoid dendritic cells (PDC) play a unique role in secreting large amounts of type I interferons upon viral stimulation, but their efficiency as antigen-presenting cells has not been completely characterized. …”
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    Plasmacytoid Dendritic Cells Capture and Cross-Present Viral Antigens from Influenza-Virus Exposed Cells
  11. 32611
    “…Type-I interferons (IFN-I) are cytokines essential for vertebrate antiviral defense, including against herpesviruses. …”
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    Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
  12. 32612
    por Liu, Zheng, Davidson, Anne
    Publicado 2013
    “…The role of type I interferons (IFNs) in SLE pathogenesis has been a subject of intense investigation in the last decade. …”
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    IFNα Inducible Models of Murine SLE
  13. 32613
    “…Type I interferons (IFNs) play an important role in direct antiviral defense as well as linking the innate and adaptive immune responses. …”
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    Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation
  14. 32614
    “…We further discuss the role of type I interferons in infection with S. aureus and the implications of these findings for the development of immune based therapies and vaccination.…”
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    Plasmacytoid Dendritic Cells: Neglected Regulators of the Immune Response to Staphylococcus aureus
  15. 32615
    “…Here we show that transcripts of hundreds of genes undergo site-specific C>U RNA editing in macrophages during M1 polarization and in monocytes in response to hypoxia and interferons. This editing alters the amino acid sequences for scores of proteins, including many that are involved in pathogenesis of viral diseases. …”
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    APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages
  16. 32616
    “…Biopharmaceuticals directed against tumor necrosis factor-alpha, integrins, interleukins, interferons and their receptors have become key agents for the management of inflammatory diseases in the fields of gastroenterology, rheumatology, dermatology and neurology. …”
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    Practical recommendations for the use of therapeutic drug monitoring of biopharmaceuticals in inflammatory diseases
  17. 32617
    “…Type I interferons (IFN), best known for their anti-viral functions, have been shown to impair host resistance to intracellular bacteria in mice. …”
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    A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans
  18. 32618
    “…Cellular activation in trans by interferons, cytokines, and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. …”
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    Macrophage Transactivation for Chemokine Production Identified as a Negative Regulator of Granulomatous Inflammation Using Agent-Based Modeling
  19. 32619
    “…Upon infection, nucleic acid sensing TLRs signal within endosomal compartment triggering the induction of essential proinflammatory cytokines and type I interferons to initiate innate immune responses thereby leading to a critical role in the development of adaptive immune responses. …”
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    Therapeutic Applications of Nucleic Acids and Their Analogues in Toll-like Receptor Signaling
  20. 32620
    por Rehwinkel, Jan, Gack, Michaela U.
    Publicado 2020
    “…Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. …”
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    RIG-I-like receptors: their regulation and roles in RNA sensing
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