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32681“…It mediates the activities of several cytokines, interferons, and growth factors and transduces extracellular signals into transcriptional programs to regulate cell growth and differentiation. …”
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32682por Mishra, Shalabh, Raj, Athira S., Kumar, Akhilesh, Rajeevan, Ashwathi, Kumari, Puja, Kumar, Himanshu“…The activation of IFI16 triggers the production of type I, III interferons, and also pro-inflammatory cytokines via the STING-TBK1 and Pro-caspase-1 signaling axis, thereby promoting cell death (apoptosis and pyroptosis in IAV infected cells). …”
Publicado 2021
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32683“…The innate immune system plays a critical role in eliminating the virus, which induces inflammatory cytokine and chemokine secretion, produces different interferons, and activates the adaptive immune system. …”
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32684por Zhang, Hongru, Yu, Pengfei, Tomar, Vivek S., Chen, Xiangjie, Atherton, Matthew J., Lu, Zhen, Zhang, Hong-Guang, Li, Shifeng, Ortiz, Angelica, Gui, Jun, Leu, N. Adrian, Yan, Fangxue, Blanco, Andres, Meyer-Ficca, Mirella L., Meyer, Ralph G., Beiting, Daniel P., Li, Jinyang, Nunez-Cruz, Selene, O’Connor, Roddy S., Johnson, Lexus R., Minn, Andy J., George, Subin S., Koumenis, Constantinos, Diehl, J. Alan, Milone, Michael C., Zheng, Hui, Fuchs, Serge Y.“…We found that TME factors such as regulatory T cells and adenosine downregulated type I interferons (IFN1) receptor IFNAR1 on CD8(+) cytotoxic T lymphocytes (CTL). …”
Publicado 2022
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32685“…SARS-CoV-2 has been a pandemic threat to human health and the worldwide economy, but efficient treatments are still lacking. Type I and III interferons are essential for controlling viral infection, indicating that antiviral innate immune signaling is critical for defense against viral infection. …”
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32686por Niedziela, Natalia, Adamczyk-Sowa, Monika, Niedziela, Jacek T., Mazur, Bogdan, Kluczewska, Ewa, Sowa, Paweł, Gąsior, Mariusz“…Elevated NO(x) level was observed in patients who received the first-line disease-modifying therapy (interferons beta-1a and beta-1b) in comparison with the subjects treated with the second-line disease-modifying therapy (natalizumab; fingolimod) and healthy controls without significant differences in C-reactive protein and interleukin-1 beta. …”
Publicado 2016
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32687por Kotyla, Przemyslaw J.“…The Janus Kinases (JAKs) are a family of intracellular tyrosine kinases that provide transmission signals from cytokine, interferons, and many hormones receptors to the nucleus resulting in synthesis of many biologically active compounds and changing cell metabolism and function. …”
Publicado 2018
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32688por Widagdo, W., Sooksawasdi Na Ayudhya, Syriam, Hundie, Gadissa B., Haagmans, Bart L.“…In this review, we explore the role of DPP4 and other host factors in MERS-CoV transmission and pathogenesis—such as sialic acids, host proteases, and interferons. Further characterization of these host determinants may potentially offer novel insights to develop intervention strategies to tackle ongoing outbreaks.…”
Publicado 2019
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32689“…Until six years ago, the regimen for treating advanced melanoma mainly comprised cytotoxic agents such as dacarbazine, and type I interferons. Since 2014, anti-programmed cell death 1 (PD1) antibodies have become recognized as anchor drugs for treating advanced melanoma with or without additional combination drugs such as ipilimumab. …”
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32690“…The cytokines that appear to be promising candidates as KSHV antiviral therapies include interleukins 6, 10, and 12 as well as interferons and tumor necrosis factor-family cytokines. …”
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32691“…Viral genomes or early products of viral replication are sensed by a number of pattern recognition receptors, leading to the synthesis and production of type I interferons (IFNs) that, in turn, activate a cascade of IFN-stimulated genes (ISGs) with antiviral functions. …”
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32692por Ta, Atri, Ricci-Azevedo, Rafael, Vasudevan, Swathy O., Wright, Skylar S., Kumari, Puja, Havira, Morena S., Surendran Nair, Meera, Rathinam, Vijay A., Vanaja, Sivapriya Kailasan“…Type I interferons (IFNs) are consequential cytokines in antibacterial defense. …”
Publicado 2023
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32693Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses“…Type I interferons (IFNs-α/β) are antiviral cytokines that constitute the innate immunity of hosts to fight against viral infections. …”
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32694por Biswas, Soma, Sarojini, Suma, Jayaram, Saranya, Philip, Indhu, Umesh, Mridul, Mascarenhas, Roseanne, Pappuswamy, Manikantan, Balasubramanian, Balamuralikrishnan, Arokiyaraj, Selvaraj“…When complexed with self-DNA or self-RNA, AMPs act as autoantigens which activate plasmacytoid dendritic cells and myeloid dendritic cells leading to the production of interferons and cytokines. These trigger a series of self-directed inflammatory reactions, leading to the emergence of diverse autoimmune disorders. …”
Publicado 2023
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32695“…Autoimmune diseases are characterized by production of autoantibodies, activation of immune cells, increased expression of pro-inflammatory cytokines, and activation of type I interferons. Despite improvements in treatments and diagnostic tools, the time it takes for the patients to be diagnosed is too long, and the main treatment for these diseases is still non-specific anti-inflammatory drugs. …”
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32696por Patel, Heli A., Revankar, Rishab R., Pedroza, Sofia T., Graham, Shaveonte, Feldman, Steven R.“…Gene variant forms commonly implicated in the pathogenesis of psoriasis include those encoding for interleukins, interferons, and other mediators involved in inflammatory pathways, such as JAK/STAT, and NF-κB. …”
Publicado 2023
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32697por Wu, Zhijie, Gao, Shouguo, Gao, Qingyan, Patel, Bhavisha A., Groarke, Emma M., Feng, Xingmin, Manley, Ash Lee, Li, Haoran, Ospina Cardona, Daniela, Kajigaya, Sachiko, Alemu, Lemlem, Quinones Raffo, Diego, Ombrello, Amanda K., Ferrada, Marcela A., Grayson, Peter C., Calvo, Katherine R., Kastner, Daniel L., Beck, David B., Young, Neal S.“…Activation of multiple inflammatory pathways (interferons and tumor necrosis factor alpha) occurs ontogenically early in primitive hematopoietic cells and particularly in the myeloid lineage in VEXAS, and inflammation is prominent in UBA1-mutated cells. …”
Publicado 2023
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32698por Guo, Xueran, He, Chengwei, Xin, Shuzi, Gao, Han, Wang, Boya, Liu, Xiaohui, Zhang, Sitian, Gong, Fengrong, Yu, Xinyi, Pan, Luming, Sun, Fangling, Xu, Jingdong“…The digestive system has the greatest mucosal tissue overall, and the pDC therein is responsible for shaping the adaptive and innate immunity of the gastrointestinal tract, resisting pathogen invasion through generating type I interferons, presenting antigens, and participating in immunological responses. …”
Publicado 2023
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32699por Sourisseau, Marion, Schilte, Clémentine, Casartelli, Nicoletta, Trouillet, Céline, Guivel-Benhassine, Florence, Rudnicka, Dominika, Sol-Foulon, Nathalie, Roux, Karin Le, Prevost, Marie-Christine, Fsihi, Hafida, Frenkiel, Marie-Pascale, Blanchet, Fabien, Afonso, Philippe V, Ceccaldi, Pierre-Emmanuel, Ozden, Simona, Gessain, Antoine, Schuffenecker, Isabelle, Verhasselt, Bruno, Zamborlini, Alessia, Saïb, Ali, Rey, Felix A, Arenzana-Seisdedos, Fernando, Desprès, Philippe, Michault, Alain, Albert, Matthew L, Schwartz, Olivier“…CHIKV was highly sensitive to the antiviral activity of type I and II interferons. These results provide a general insight into the interaction between CHIKV and its mammalian host.…”
Publicado 2007
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32700por Kato, Hiroki, Takeuchi, Osamu, Mikamo-Satoh, Eriko, Hirai, Reiko, Kawai, Tomoji, Matsushita, Kazufumi, Hiiragi, Akane, Dermody, Terence S., Fujita, Takashi, Akira, Shizuo“…The ribonucleic acid (RNA) helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation–associated gene 5 (MDA5) recognize distinct viral and synthetic RNAs, leading to the production of interferons. Although 5′-triphosphate single-stranded RNA is a RIG-I ligand, the role of RIG-I and MDA5 in double-stranded (ds) RNA recognition remains to be characterized. …”
Publicado 2008
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