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  1. 32681
    “…It mediates the activities of several cytokines, interferons, and growth factors and transduces extracellular signals into transcriptional programs to regulate cell growth and differentiation. …”
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    Proteomimetics of Natural Regulators of JAK–STAT Pathway: Novel Therapeutic Perspectives
  2. 32682
    “…The activation of IFI16 triggers the production of type I, III interferons, and also pro-inflammatory cytokines via the STING-TBK1 and Pro-caspase-1 signaling axis, thereby promoting cell death (apoptosis and pyroptosis in IAV infected cells). …”
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    Innate immune sensing of influenza A viral RNA through IFI16 promotes pyroptotic cell death
  3. 32683
    “…The innate immune system plays a critical role in eliminating the virus, which induces inflammatory cytokine and chemokine secretion, produces different interferons, and activates the adaptive immune system. …”
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    Hold Breath: Autonomic Neural Regulation of Innate Immunity to Defend Against SARS-CoV-2 Infection
  4. 32684
    “…We found that TME factors such as regulatory T cells and adenosine downregulated type I interferons (IFN1) receptor IFNAR1 on CD8(+) cytotoxic T lymphocytes (CTL). …”
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    Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors
  5. 32685
    por Zheng, Yi, Gao, Chengjiang
    Publicado 2023
    “…SARS-CoV-2 has been a pandemic threat to human health and the worldwide economy, but efficient treatments are still lacking. Type I and III interferons are essential for controlling viral infection, indicating that antiviral innate immune signaling is critical for defense against viral infection. …”
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    Phase Separation: The Robust Modulator of Innate Antiviral Signaling and SARS-CoV-2 Infection
  6. 32686
    “…Elevated NO(x) level was observed in patients who received the first-line disease-modifying therapy (interferons beta-1a and beta-1b) in comparison with the subjects treated with the second-line disease-modifying therapy (natalizumab; fingolimod) and healthy controls without significant differences in C-reactive protein and interleukin-1 beta. …”
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    Assessment of Serum Nitrogen Species and Inflammatory Parameters in Relapsing-Remitting Multiple Sclerosis Patients Treated with Different Therapeutic Approaches
  7. 32687
    por Kotyla, Przemyslaw J.
    Publicado 2018
    “…The Janus Kinases (JAKs) are a family of intracellular tyrosine kinases that provide transmission signals from cytokine, interferons, and many hormones receptors to the nucleus resulting in synthesis of many biologically active compounds and changing cell metabolism and function. …”
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    Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?
  8. 32688
    “…In this review, we explore the role of DPP4 and other host factors in MERS-CoV transmission and pathogenesis—such as sialic acids, host proteases, and interferons. Further characterization of these host determinants may potentially offer novel insights to develop intervention strategies to tackle ongoing outbreaks.…”
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    Host Determinants of MERS-CoV Transmission and Pathogenesis
  9. 32689
    “…Until six years ago, the regimen for treating advanced melanoma mainly comprised cytotoxic agents such as dacarbazine, and type I interferons. Since 2014, anti-programmed cell death 1 (PD1) antibodies have become recognized as anchor drugs for treating advanced melanoma with or without additional combination drugs such as ipilimumab. …”
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    Treatment of Advanced Melanoma: Past, Present and Future
  10. 32690
    por Alomari, Nedaa, Totonchy, Jennifer
    Publicado 2020
    “…The cytokines that appear to be promising candidates as KSHV antiviral therapies include interleukins 6, 10, and 12 as well as interferons and tumor necrosis factor-family cytokines. …”
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    Cytokine-Targeted Therapeutics for KSHV-Associated Disease
  11. 32691
    “…Viral genomes or early products of viral replication are sensed by a number of pattern recognition receptors, leading to the synthesis and production of type I interferons (IFNs) that, in turn, activate a cascade of IFN-stimulated genes (ISGs) with antiviral functions. …”
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    TRIM22. A Multitasking Antiviral Factor
  12. 32692
    “…Type I interferons (IFNs) are consequential cytokines in antibacterial defense. …”
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    A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3
  13. 32693
    “…Type I interferons (IFNs-α/β) are antiviral cytokines that constitute the innate immunity of hosts to fight against viral infections. …”
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    Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses
  14. 32694
    “…When complexed with self-DNA or self-RNA, AMPs act as autoantigens which activate plasmacytoid dendritic cells and myeloid dendritic cells leading to the production of interferons and cytokines. These trigger a series of self-directed inflammatory reactions, leading to the emergence of diverse autoimmune disorders. …”
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    Understanding the Role of Antimicrobial Peptides in Neutrophil Extracellular Traps Promoting Autoimmune Disorders
  15. 32695
    “…Autoimmune diseases are characterized by production of autoantibodies, activation of immune cells, increased expression of pro-inflammatory cytokines, and activation of type I interferons. Despite improvements in treatments and diagnostic tools, the time it takes for the patients to be diagnosed is too long, and the main treatment for these diseases is still non-specific anti-inflammatory drugs. …”
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    Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus
  16. 32696
    “…Gene variant forms commonly implicated in the pathogenesis of psoriasis include those encoding for interleukins, interferons, and other mediators involved in inflammatory pathways, such as JAK/STAT, and NF-κB. …”
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    The Genetic Susceptibility to Psoriasis and the Relationship of Linked Genes to Our Treatment Options
  17. 32697
    “…Activation of multiple inflammatory pathways (interferons and tumor necrosis factor alpha) occurs ontogenically early in primitive hematopoietic cells and particularly in the myeloid lineage in VEXAS, and inflammation is prominent in UBA1-mutated cells. …”
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    Early activation of inflammatory pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS
  18. 32698
    “…The digestive system has the greatest mucosal tissue overall, and the pDC therein is responsible for shaping the adaptive and innate immunity of the gastrointestinal tract, resisting pathogen invasion through generating type I interferons, presenting antigens, and participating in immunological responses. …”
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    Current perspective on biological properties of plasmacytoid dendritic cells and dysfunction in gut
  19. 32699
    “…CHIKV was highly sensitive to the antiviral activity of type I and II interferons. These results provide a general insight into the interaction between CHIKV and its mammalian host.…”
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    Characterization of Reemerging Chikungunya Virus
  20. 32700
    “…The ribonucleic acid (RNA) helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation–associated gene 5 (MDA5) recognize distinct viral and synthetic RNAs, leading to the production of interferons. Although 5′-triphosphate single-stranded RNA is a RIG-I ligand, the role of RIG-I and MDA5 in double-stranded (ds) RNA recognition remains to be characterized. …”
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    Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
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