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32801por Read, Scott A., O'Connor, Kate S., Suppiah, Vijay, Ahlenstiel, Chantelle L. E., Obeid, Stephanie, Cook, Kristina M., Cunningham, Anthony, Douglas, Mark W., Hogg, Philip J., Booth, David, George, Jacob, Ahlenstiel, Golo“…Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral infection. …”
Publicado 2017
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32802por Yoshizumi, Takuma, Imamura, Hiromi, Taku, Tomohiro, Kuroki, Takahiro, Kawaguchi, Atsushi, Ishikawa, Kaori, Nakada, Kazuto, Koshiba, Takumi“…Cells lacking mitochondrial DNA or mutant cells with respiratory defects exhibited severely impaired virus-induced induction of interferons and proinflammatory cytokines. Recovery of the OXPHOS activity in these mutants, however, re-established RLR-mediated signal transduction. …”
Publicado 2017
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32803por Guo, Xin, Shu, Chang, Li, Honggui, Pei, Ya, Woo, Shih-Lung, Zheng, Juan, Liu, Mengyang, Xu, Hang, Botchlett, Rachel, Guo, Ting, Cai, Yuli, Gao, Xinsheng, Zhou, Jing, Chen, Lu, Li, Qifu, Xiao, Xiaoqiu, Xie, Linglin, Zhang, Ke K., Ji, Jun-Yuan, Huo, Yuqing, Meng, Fanyin, Alpini, Gianfranco, Li, Pingwei, Wu, Chaodong“…Endogenous cyclic GMP-AMP (cGAMP) binds and activates STING to induce type I interferons. However, whether cGAMP plays any roles in regulating metabolic homeostasis remains unknown. …”
Publicado 2017
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32804“…IL‐6, a cytokine activated by type I interferons (IFNs), is encoded by the IL‐6 gene, and secreted by T cells and macrophages. …”
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32805“…Flt3 ligand failed to enhance the production of type I interferons. Instead, Flt3 ligand boosted the numbers of dendritic cells and, particularly lymphocytes in infected organs with an expansion of spleen B cells, and resulted in an increased titer of virus-specific antibody with neutralizing activity in the serum. …”
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32806por Leong, Sze Wei, Faudzi, Siti Munirah Mohd, Abas, Faridah, Aluwi, Mohd Fadhlizil Fasihi Mohd, Rullah, Kamal, Wai, Lam Kok, Bahari, Mohd Nazri Abdul, Ahmad, Syahida, Tham, Chau Ling, Shaari, Khozirah, Lajis, Nordin H.“…A series of ninety-seven diarylpentanoid derivatives were synthesized and evaluated for their anti-inflammatory activity through NO suppression assay using interferone gamma (IFN-γ)/lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. …”
Publicado 2014
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32807por Langer, Simon, Hammer, Christian, Hopfensperger, Kristina, Klein, Lukas, Hotter, Dominik, De Jesus, Paul D, Herbert, Kristina M, Pache, Lars, Smith, Nikaïa, van der Merwe, Johannes A, Chanda, Sumit K, Fellay, Jacques, Kirchhoff, Frank, Sauter, Daniel“…Gene set enrichment analyses and cytokine arrays showed that Vpu suppresses the expression of NF-κB targets including interferons and restriction factors. Mutational analyses demonstrated that this immunosuppressive activity of Vpu is independent of its ability to counteract the restriction factor and innate sensor tetherin. …”
Publicado 2019
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32808por Ye, Liya, Zhang, Qiang, Liuyu, Tianzi, Xu, Zhigao, Zhang, Meng-Xin, Luo, Min-Hua, Zeng, Wen-Bo, Zhu, Qiyun, Lin, Dandan, Zhong, Bo“…Knockdown or knockout of USP49 potentiated HSV-1-, cytoplasmic DNA- or cGAMP-induced production of type I interferons (IFNs) and proinflammatory cytokines and impairs HSV-1 replication. …”
Publicado 2019
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32809“…The aberrant appearance of DNA in the cytoplasm triggers the activation of cGAS-cGAMP-STING signaling and induces the production of type I interferons, which play critical roles in activating both innate and adaptive immune responses. …”
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32810por Liu, Yang, Crowe, William N., Wang, Lulu, Lu, Yong, Petty, W. Jeffrey, Habib, Amyn A., Zhao, Dawen“…NP-cGAMP designed for enhanced cytosolic release of cGAMP stimulates STING signaling and type I interferons production in APCs, resulting in the pro-inflammatory tumor microenvironment in multifocal lung metastases. …”
Publicado 2019
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32811por Maarifi, Ghizlane, Smith, Nikaïa, Maillet, Sarah, Moncorgé, Olivier, Chamontin, Célia, Edouard, Joanne, Sohm, Frédéric, Blanchet, Fabien P., Herbeuval, Jean-Philippe, Lutfalla, Georges, Levraud, Jean-Pierre, Arhel, Nathalie J., Nisole, Sébastien“…Plasmacytoid dendritic cells (pDCs) play a crucial role in antiviral innate immunity through their unique capacity to produce large amounts of type I interferons (IFNs) upon viral detection. Tripartite motif (TRIM) proteins have recently come forth as important modulators of innate signaling, but their involvement in pDCs has not been investigated. …”
Publicado 2019
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32812por Carriere, Jessica, Rao, Youliang, Liu, Qizhi, Lin, Xiaoxi, Zhao, Jun, Feng, Pinghui“…Upon infection, pattern recognition receptors (PRRs) recognize conserved viral features to trigger signaling cascades that culminate in the production of interferons and pro-inflammatory cytokines. To invoke a proper immune response while avoiding collateral tissue damage, signaling proteins involved in these cascades are tightly regulated by post-translational modifications (PTMs). …”
Publicado 2019
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32813por Kirsebom, Freja, Michalaki, Christina, Agueda-Oyarzabal, Marina, Johansson, Cecilia“…Neutrophil depletion did not substantially affect the levels of inflammatory mediators such as type I interferons, IL-6, TNF-α or IL-1β in response to RSV. …”
Publicado 2020
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32814por Swaminathan, Srividya, Hansen, Aida S., Heftdal, Line D., Dhanasekaran, Renumathy, Deutzmann, Anja, Fernandez, Wadie D. M., Liefwalker, Daniel F., Horton, Crista, Mosley, Adriane, Liebersbach, Mariola, Maecker, Holden T., Felsher, Dean W.“…Lymphoma-intrinsic MYC arrests NK maturation by transcriptionally repressing STAT1/2 and secretion of Type I Interferons (IFNs). Treating T-lymphoma-bearing mice with Type I IFN improves survival by rescuing NK cell maturation. …”
Publicado 2020
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32815“…[Image: see text] The metazoan second messenger 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) is a cyclic dinucleotide (CDN) that induces secretion of type I interferons and activates the immune system and has thus attracted significant interest as a vaccine adjuvant or immunotherapeutic. …”
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32816por Devos, Michael, Tanghe, Giel, Gilbert, Barbara, Dierick, Evelien, Verheirstraeten, Maud, Nemegeer, Josephine, de Reuver, Richard, Lefebvre, Sylvie, De Munck, Jolien, Rehwinkel, Jan, Vandenabeele, Peter, Declercq, Wim, Maelfait, Jonathan“…Inducing ZBP1 expression by interferons triggers necroptosis in RIPK1-deficient keratinocytes, and epidermis-specific deletion of MLKL prevents disease, demonstrating that cell-intrinsic events cause inflammation. …”
Publicado 2020
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32817“…Hydroxychloroquine/chloroquine, lopinavir/ritonavir, ribavirin, interferons, umifenovir, remdesivir, and interleukin antagonists, such as tocilizumab, have been recommended as potential treatment options in COVID-19. …”
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32818por Wang, Mei-Rong, Wu, Di-Di, Luo, Fan, Zhong, Chao-Jie, Wang, Xin, Zhu, Ni, Wu, Ying-Jun, Hu, Hai-Tao, Feng, Yong, Wang, Xu, Xiong, Hai-Rong, Hou, Wei“…Mechanistically, methadone treatment of macrophages reduced the expression of interferons (IFN-β and IFN-λ2) and the IFN-stimulated anti-HIV genes (APOBEC3F/G and MxB). …”
Publicado 2020
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32819por Gunjegaonkar, Shivshankar Malkarjun, Shanmugarajan, Thukani Sathanantham, Arunsundar, Mohanasundaram, Arjun, Uppuluri Varuna Naga Venkata, Devi, Kadirrel, Wankhede, Sagar Baliram, Ravichandiran, Velayutham“…This scientific review throws light on the epidemiology of COVID-19, its pathogenesis and the current clinical scenario of immunotherapeutics including convalescent plasma (CP), type-1 interferons (IFN–I) and human monoclonal antibodies (mAbs) to combat COVID-19. …”
Publicado 2021
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32820“…Interleukin (IL-) 28B, a member of λ-interferons, have been shown to play a protective role in OVA-induced asthma, which is antigen-specific and adaptive immune system dominant. …”
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