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  1. 32801
    “…Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral infection. …”
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    Zinc is a potent and specific inhibitor of IFN-λ3 signalling
  2. 32802
    “…Cells lacking mitochondrial DNA or mutant cells with respiratory defects exhibited severely impaired virus-induced induction of interferons and proinflammatory cytokines. Recovery of the OXPHOS activity in these mutants, however, re-established RLR-mediated signal transduction. …”
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    RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity
  3. 32803
    “…Endogenous cyclic GMP-AMP (cGAMP) binds and activates STING to induce type I interferons. However, whether cGAMP plays any roles in regulating metabolic homeostasis remains unknown. …”
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    Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation
  4. 32804
    “…IL‐6, a cytokine activated by type I interferons (IFNs), is encoded by the IL‐6 gene, and secreted by T cells and macrophages. …”
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    Molecular cross‐talk of IL‐6 in tumors and new progress in combined therapy
  5. 32805
    “…Flt3 ligand failed to enhance the production of type I interferons. Instead, Flt3 ligand boosted the numbers of dendritic cells and, particularly lymphocytes in infected organs with an expansion of spleen B cells, and resulted in an increased titer of virus-specific antibody with neutralizing activity in the serum. …”
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    Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses
  6. 32806
    “…A series of ninety-seven diarylpentanoid derivatives were synthesized and evaluated for their anti-inflammatory activity through NO suppression assay using interferone gamma (IFN-γ)/lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. …”
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    Synthesis and Sar Study of Diarylpentanoid Analogues as New Anti-Inflammatory Agents
  7. 32807
    “…Gene set enrichment analyses and cytokine arrays showed that Vpu suppresses the expression of NF-κB targets including interferons and restriction factors. Mutational analyses demonstrated that this immunosuppressive activity of Vpu is independent of its ability to counteract the restriction factor and innate sensor tetherin. …”
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    HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses
  8. 32808
    “…Knockdown or knockout of USP49 potentiated HSV-1-, cytoplasmic DNA- or cGAMP-induced production of type I interferons (IFNs) and proinflammatory cytokines and impairs HSV-1 replication. …”
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    USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA
  9. 32809
    “…The aberrant appearance of DNA in the cytoplasm triggers the activation of cGAS-cGAMP-STING signaling and induces the production of type I interferons, which play critical roles in activating both innate and adaptive immune responses. …”
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    STING: a master regulator in the cancer-immunity cycle
  10. 32810
    “…NP-cGAMP designed for enhanced cytosolic release of cGAMP stimulates STING signaling and type I interferons production in APCs, resulting in the pro-inflammatory tumor microenvironment in multifocal lung metastases. …”
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    An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases
  11. 32811
    “…Plasmacytoid dendritic cells (pDCs) play a crucial role in antiviral innate immunity through their unique capacity to produce large amounts of type I interferons (IFNs) upon viral detection. Tripartite motif (TRIM) proteins have recently come forth as important modulators of innate signaling, but their involvement in pDCs has not been investigated. …”
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    TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells
  12. 32812
    “…Upon infection, pattern recognition receptors (PRRs) recognize conserved viral features to trigger signaling cascades that culminate in the production of interferons and pro-inflammatory cytokines. To invoke a proper immune response while avoiding collateral tissue damage, signaling proteins involved in these cascades are tightly regulated by post-translational modifications (PTMs). …”
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    Post-translational Control of Innate Immune Signaling Pathways by Herpesviruses
  13. 32813
    “…Neutrophil depletion did not substantially affect the levels of inflammatory mediators such as type I interferons, IL-6, TNF-α or IL-1β in response to RSV. …”
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    Neutrophils do not impact viral load or the peak of disease severity during RSV infection
  14. 32814
    “…Lymphoma-intrinsic MYC arrests NK maturation by transcriptionally repressing STAT1/2 and secretion of Type I Interferons (IFNs). Treating T-lymphoma-bearing mice with Type I IFN improves survival by rescuing NK cell maturation. …”
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    MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies
  15. 32815
    por Lim, Jongwon, Kim, Hai-Young
    Publicado 2020
    “…[Image: see text] The metazoan second messenger 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) is a cyclic dinucleotide (CDN) that induces secretion of type I interferons and activates the immune system and has thus attracted significant interest as a vaccine adjuvant or immunotherapeutic. …”
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    Novel Applications of Biocatalysis to Stereochemistry Determination of 2′3′-cGAMP Bisphosphorothioate (2′3′-cG(S)A(S)MP)
  16. 32816
    “…Inducing ZBP1 expression by interferons triggers necroptosis in RIPK1-deficient keratinocytes, and epidermis-specific deletion of MLKL prevents disease, demonstrating that cell-intrinsic events cause inflammation. …”
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    Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation
  17. 32817
    “…Hydroxychloroquine/chloroquine, lopinavir/ritonavir, ribavirin, interferons, umifenovir, remdesivir, and interleukin antagonists, such as tocilizumab, have been recommended as potential treatment options in COVID-19. …”
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    Coronavirus Disease 2019 (COVID-19) and Transplantation: Pharmacotherapeutic Management of Immunosuppression Regimen
  18. 32818
    “…Mechanistically, methadone treatment of macrophages reduced the expression of interferons (IFN-β and IFN-λ2) and the IFN-stimulated anti-HIV genes (APOBEC3F/G and MxB). …”
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    Methadone Inhibits Viral Restriction Factors and Facilitates HIV Infection in Macrophages
  19. 32819
    “…This scientific review throws light on the epidemiology of COVID-19, its pathogenesis and the current clinical scenario of immunotherapeutics including convalescent plasma (CP), type-1 interferons (IFN–I) and human monoclonal antibodies (mAbs) to combat COVID-19. …”
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    Harnessing immunotherapy to combat COVID-19: A modern snake oil or silver bullet?
  20. 32820
    “…Interleukin (IL-) 28B, a member of λ-interferons, have been shown to play a protective role in OVA-induced asthma, which is antigen-specific and adaptive immune system dominant. …”
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    Interleukin-28B dampens protease-induced lung inflammation via IL-25 and TSLP inhibition in epithelial cells
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