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32821“…Expression of the type I/III interferons (IFN) was upregulated following infection in wild-type cells, while this upregulation was severely abolished in MDA5(−/−) and MAVS(−/−), but not in RIG-I(−/−) cells. …”
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32822“…Detection of pathogen-derived DNA or RNA species by cellular nucleic acid sensors prompts release of anti-microbial interferons and cytokines. In contrast to their protective anti-microbial functions, inappropriate or excessive activation of nucleic acid sensors can cause inflammatory diseases. …”
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32823por Wu, Zhaozhen, Cui, Pengfei, Tao, Haitao, Zhang, Sujie, Ma, Junxun, Liu, Zhefeng, Wang, Jinliang, Qian, Yuanyu, Chen, Shixue, Huang, Ziwei, Zheng, Xuan, Huang, Di, Hu, Yi“…Further studies suggest that PARP inhibitors (PARPi) can also exhibit efficacy in HR-competent cancers, by amplifying the DNA damage and inducing immunogenic cell death, and PARPi lead to increasing tumor neoantigen, upregulation of interferons and PD-L1, and modulation of the tumor microenvironment, which may facilitate a more profound antitumor immune response. …”
Publicado 2021
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32824“…After invading into the cells, pathogen-associated-molecular-patterns derived from viruses are recognized by pattern recognition receptors to activate the downstream signaling pathways to induce the production of type I interferons (IFN-I) and inflammatory cytokines, which play critical functions in the host antiviral innate immune responses. …”
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32825por Palacio, Nicole, Dangi, Tanushree, Chung, Young Rock, Wang, Yidan, Loredo-Varela, Juan Luis, Zhang, Zhongyao, Penaloza-MacMaster, Pablo“…Type I interferons (IFN-I) are a major antiviral defense and are critical for the activation of the adaptive immune system. …”
Publicado 2020
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32826por Dorrington, Michael G., Bradfield, Clinton J., Lack, Justin B., Lin, Bin, Liang, Jonathan J., Starr, Tregei, Ernst, Orna, Gross, Julia L., Sun, Jing, Miller, Alexandra H., Steele-Mortimer, Olivia, Fraser, Iain D. C.“…The importance of type I interferons (IFNs) in orchestrating innate immune responses to pathogenic microbes has become clear in recent years. …”
Publicado 2021
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32827por Shen, Hai‐feng, Zhang, Wen‐juan, Huang, Ying, He, Yao‐hui, Hu, Guo‐sheng, Wang, Lei, Peng, Bing‐ling, Yi, Jia, Li, Ting‐ting, Rong, Rui, Chen, Xiao‐yan, Liu, Jun‐yi, Li, Wen‐juan, Ohgi, Kenny, Li, Shao‐Wei, Rosenfeld, Michael G., Liu, Wen“…Here, it is reported that KDM5C, a repressive histone demethylase, unexpectedly activates estrogen receptor alpha (ERα)‐target genes, and meanwhile suppresses type I interferons (IFNs) and IFN‐stimulated genes (ISGs) to promote ERα‐positive breast cancer cell growth and tumorigenesis. …”
Publicado 2021
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32828“…Treatment and management of herpes-related eye conditions continue to revolve around antiviral drugs, although corticosteroids, interferons, and other newer therapies may also be appropriate depending on the disease presentation. …”
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32829por Sampaio, Natalia G., Chauveau, Lise, Hertzog, Jonny, Bridgeman, Anne, Fowler, Gerissa, Moonen, Jurgen P., Dupont, Maeva, Russell, Rebecca A., Noerenberg, Marko, Rehwinkel, Jan“…Human cells respond to infection by SARS-CoV-2, the virus that causes COVID-19, by producing cytokines including type I and III interferons (IFNs) and proinflammatory factors such as IL6 and TNF. …”
Publicado 2021
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32830“…Different cell types are part of the innate immunity response and produce soluble factors, cytokines, chemokines, and type I interferons. Improper maturation of innate immune cells or their dysfunction have been linked to numerous age-related diseases. …”
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32831por Thongsri, Piyanoot, Pewkliang, Yongyut, Borwornpinyo, Suparerk, Wongkajornsilp, Adisak, Hongeng, Suradej, Sa-ngiamsuntorn, Khanit“…Current agents (nucleos(t)ide analogs and interferons) could only attenuate HBV infection. A combination of agents targeting different stages of viral life cycle (e.g., entry, replication, and cccDNA stability) was expected to eradicate the infection. …”
Publicado 2021
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32832“…Importantly, NOX2 is involved in regulating many aspects of innate and adaptive immunity, including regulation of type I interferons, the inflammasome, phagocytosis, antigen processing and presentation, and cell signaling. …”
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32833“…Since the beginning of the COVID-19 pandemic in 2019–2020, Cytokine & Growth Factor Reviews has published several Special Issues focused on the biology, pathogenesis and therapeutic options in the treatment of COVID-19 infection, including articles on the involvement of the chemokine system in the cytokine storm in COVID-19, intervention in the early stages of COVID-19 pneumonia, the therapeutic value of corticosteroid treatment, early clinical intervention with type 1 interferons, progress in vaccine development, and organ specific complications of COVID-19. …”
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32834“…Current treatment goals for chronic hepatitis B (CHB) are to prevent or significantly delay liver‐related adverse outcomes and death, and two types of treatments are available: nucleos(t)ide analogues (NAs) and interferons (IFNs). NAs effectively suppress HBV replication, and IFNs improve serological response rates, thereby decreasing the risk of adverse outcomes. …”
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32835por Li, Xin-yu, Hou, Lei, Zhang, Lu-yu, Zhang, Liming, Wang, Deming, Wang, Zhenfeng, Wen, Ming-Zhe, Yang, Xi-tao“…2′,5′-oligoadenylate synthase (OAS) is a class of enzymes induced by interferons and mainly encoded by the OAS1, OAS2, and OAS3 genes, which activate the potential RNA enzymes to degrade viral mRNA, inhibit viral protein synthesis and promote apoptosis in virus-infected cells. …”
Publicado 2022
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32836“…Effector cytokines produced by these immunocytes, such as interferons (IFNs), IL-17, IL-22, IL-21, IL-4, TNF-α, BAFF and APRIL, play critical roles in promoting autoimmune responses and inducing tissue damages. …”
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32837por Gultom, Mitra, Kratzel, Annika, Portmann, Jasmine, Stalder, Hanspeter, Chanfon Bätzner, Astrid, Gantenbein, Hans, Gurtner, Corinne, Ebert, Nadine, Gad, Hans Henrik, Hartmann, Rune, Posthaus, Horst, Zanolari, Patrik, Pfaender, Stephanie, Thiel, Volker, Dijkman, Ronald“…Furthermore, we observed that in the camelid AEC models MERS-CoV replication can be inhibited by both type I and III interferons (IFNs). In conclusion, we successfully established camelid AEC cultures that recapitulate the in vivo airway epithelium and reflect MERS-CoV infection in vivo. …”
Publicado 2022
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32838por Jiang, Riqing, Qiu, Yufeng, Zhang, Xiaomei, Zhou, Ningning, Jia, Xiaoyuan, Chen, Kan, Zhou, Yanrong, Ye, Ting, Li, Gongchu“…Further investigation illustrated that oncoVV-AVL could activate tumor immunity by upregulating the expression of type I interferons and enhance virus replication by inhibiting ISRE mediated viral defense response. …”
Publicado 2022
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32839por Rarani, Fahimeh Zamani, Rashidi, Bahman, Jafari Najaf Abadi, Mohammad Hassan, Hamblin, Michael R., Reza Hashemian, Seyed Mohammad, Mirzaei, Hamed“…This review discusses the cytokines involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, focusing on interferons (IFNs) and ILs, and whether they can be used in COVID-19 treatment. …”
Publicado 2022
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32840por Asif, Muhammad, Amir, Muhammad, Hussain, Abrar, Achakzai, Niaz M., Natesan Pushparaj, Peter, Rasool, Mahmood“…However, several options can be investigated to control SARS-CoV-2 infection, including monoclonal antibodies, interferons, therapeutic vaccines, and molecular-based targeted drugs. …”
Publicado 2022
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