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32861“…Toll-like receptors (TLRs) expressed on macrophages can recognize pathogen-associated-molecular patterns (PAMPs) on Mtb and mediate the production of immune-regulatory cytokines such as tumor necrosis factor (TNF) and type I Interferons (IFNs). In addition, Vitamin D receptor (VDR) and Vitamin D-1-hydroxylase are up-regulated in Mtb-infected macrophages, by which Vitamin D participates in innate immune responses. …”
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32862“…Recent research has focused on genes associated with Toll-like receptors (TLRs), type I interferons, immune regulation pathways, and immune-complex clearance. …”
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32863“…Toll-like receptors (TLRs) sense pathogen-associated molecule patterns and activate antiviral mechanisms including the intracellular antiviral pathways and the production of antiviral effectors like interferons (IFNs) and pro-inflammatory cytokines. Activation of the TLR3 pathway and the production of IFN-β represent one of the major mechanisms leading to the suppression of HBV replication in the liver, as shown in different in vitro and in vivo models. …”
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32864por Tsutsui-Takeuchi, Mizuho, Ushio, Hiroko, Fukuda, Minoru, Yamada, Takahiko, Niyonsaba, François, Okumura, Ko, Ogawa, Hideoki, Ikeda, Shigaku“…PCR array analysis revealed that human mast cells up-regulated several anti-viral genes, including melanoma differentiation-associated gene 5, retinoic acid-inducible gene-I, and Toll-like receptor 3, together with type I interferons and chemokines, upon VSV infection. Additionally, we found that 2′-5′ oligoadenylate synthetase, which also works as a virus recognition receptor by activating the latent form of RNase L, leading to viral RNA degradation, was up-regulated in human mast cells upon VSV infection. …”
Publicado 2014
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32865por Blazek, Katrina, Eames, Hayley L., Weiss, Miriam, Byrne, Adam J., Perocheau, Dany, Pease, James E., Doyle, Sean, McCann, Fiona, Williams, Richard O., Udalova, Irina A.“…The most studied biological role of type III interferons (IFNs) has so far been their antiviral activity, but their role in autoimmune and inflammatory diseases remains largely unexplored. …”
Publicado 2015
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32866por Uehara, Takenori, Fujiwara, Tomohiro, Takeda, Ken, Kunisada, Toshiyuki, Ozaki, Toshifumi, Udono, Heiichiro“…Cytokine therapies with interleukin-2 or interferons have limited efficacy because of their cytotoxicities. …”
Publicado 2015
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32867“…Type I and type III interferons (IFNs) are critical in regulation of viral pathogenesis and host antiviral infection; thus, we propose to incorporate IFN-mediated antiviral states into the framework of macrophage polarization. …”
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32868por Das, Undurti N.“…The inflammatory process seen in inflammatory bowel disease (IBD) is due to excess production of pro-inflammatory cytokines interleukin-1 (IL-1), IL-6, tumor necrosis factor-α (TNF-α), interferons (IFNs), macrophage migration inhibitory factor (MIF), HMGB1 (high mobility group B1) and possibly, a reduction in anti-inflammatory cytokines IL-10, IL-4, and transforming growth factor-β (TGF-β). …”
Publicado 2016
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32869por Wang, Gefei, Li, Rui, Jiang, Zhiwu, Gu, Liming, Chen, Yanxia, Dai, Jianping, Li, Kangsheng“…The mRNA levels of inflammatory cytokines, chemokines, and type I interferons were upregulated at 6 h and 24 h p.i. These results indicate that the influenza virus induces inflammatory response in mouse primary cortical neurons with limited viral replication. …”
Publicado 2016
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32870“…Proinflammatory cytokines such as TNF-α and type I interferons (IFN) are pathogenic signatures of systemic lupus erythematosus, and plasmacytoid dendritic cells (pDCs) play a major role by predominantly producing IFN-α. …”
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32871“…The results showed that two immune related gene, Interferons (INFs) ɑβ and Interleukin (IL)-12 p35 induced a high response in RK. …”
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32872“…Presently, BCG immunotherapy remains the most effective treatment and prophylaxis for TCC (Ta, T1, CIS) and reduces tumor recurrence, disease progression, and mortality. Interferons, Keyhole-limpet hemocyanin (KLH), bropirimine and Photofrin-Photodynamic Therapy (PDT) are under investigation in the management of TCC and early results are encouraging. …”
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32873por Türk Börü, Ülkü, Köseoğlu Toksoy, Cansu, Bölük, Cem, Bilgiç, Adnan, Taşdemir, Mustafa“…The cumulative dosages of methylprednisolone, beta interferons (IFNβs), and glatiramer acetate were calculated. …”
Publicado 2018
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32874por Stockenhuber, Krista, Hegazy, Ahmed N., West, Nathaniel R., Ilott, Nicholas E., Stockenhuber, Alexander, Bullers, Samuel J., Thornton, Emily E., Arnold, Isabelle C., Tucci, Andrea, Waldmann, Herman, Ogg, Graham S., Powrie, Fiona“…Psoriasis is a complex inflammatory skin disease affecting ∼3% of the population worldwide. Although type I interferons (IFN-I) are thought to be involved in its pathogenesis, the details of this relationship remain elusive. …”
Publicado 2018
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32875por Sawai, Catherine M., Serpas, Lee, Neto, Antonio Galvao, Jang, Geunhyo, Rashidfarrokhi, Ali, Kolbeck, Roland, Sanjuan, Miguel A., Reizis, Boris, Sisirak, Vanja“…Plasmacytoid dendritic cells (pDCs) are innate immune cells specialized in the production of type I interferons and were recently implicated in the pathogenesis of autoimmune disorders such as lupus and scleroderma. …”
Publicado 2018
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32876por Ning, Fei, Li, Xiaoyu, Yu, Li, Zhang, Bin, Zhao, Yuna, Liu, Yu, Zhao, Baohong, Shang, Yingli, Hu, Xiaoyu“…Induction of type I interferons (IFNs) is critical for eliciting competent immune responses, especially antiviral immunity. …”
Publicado 2019
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32877“…RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection. …”
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32878“…Pattern recognition receptors sense pathogen components and initiate the host antiviral innate immune response, such as inducing interferons (IFNs). Long non-coding RNAs (lncRNAs) are emerging regulators of multiple biological processes. …”
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32879“…In this review, we summarize the calibrated interactions among the microbiota mediated immune modulation through the production of different interferons (IFNs) ILs, and virus-specific IgA and IgG, and their impact on the severity of viral infections in chickens. …”
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32880por Popeda, Marta, Stokowy, Tomasz, Bednarz-Knoll, Natalia, Jurek, Anna, Niemira, Magdalena, Bielska, Agnieszka, Kretowski, Adam, Kalinowski, Leszek, Szade, Jolanta, Markiewicz, Aleksandra, Zaczek, Anna J.“…The upregulated genes were involved in NF-kappa B signaling and in the production of type I interferons. The clinical significance of the differentially expressed genes was evaluated using The Cancer Genome Atlas (TCGA) data of a breast invasive carcinoma (BRCA) cohort. …”
Publicado 2019
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