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  1. 32961
    “…To address these issues with PRRSV and host antiviral functions a novel modified-live vaccine (MLV) able to stimulate known antiviral interferons was created and examined for its ability to potentiate effective immunity and better protection. …”
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    Transcriptomic Analysis of Liver Indicates Novel Vaccine to Porcine Reproductive and Respiratory Virus Promotes Homeostasis in T-Cell and Inflammatory Immune Responses Compared to a Commercial Vaccine in Pigs
  2. 32962
    “…As a vital pivot for the human circulatory system, the brain-gut axis is now being considered as an important channel for many of the small immune molecules’ transductions, including interleukins, interferons, neurotransmitters, peptides, and the chemokines penetrating the mesentery and blood brain barrier (BBB) during the development of an ischemic stroke (IS). …”
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    Cellular Immune Signal Exchange From Ischemic Stroke to Intestinal Lesions Through Brain-Gut Axis
  3. 32963
    “…Type I interferons (IFN-I) play a critical role in human antiviral immunity, as demonstrated by the exceptionally rare deleterious variants of IFNAR1 or IFNAR2. …”
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    Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic
  4. 32964
    “…Upon infection, DNA viruses can be sensed by pattern recognition receptors (PRRs), leading to the activation of type I and III interferons to block infection. Therefore, viruses must inhibit these signaling pathways, avoid being detected, or both. …”
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    Coevolutionary Analysis Implicates Toll-Like Receptor 9 in Papillomavirus Restriction
  5. 32965
    “…This included roles for genes (i) induced by interferons (IFI35 and OTOF), (ii) key to SLE cell types (KLRB1 encoding CD161), or (iii) with roles in autophagy and NF-κB pathway responses (CKAP4). …”
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    Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data
  6. 32966
    “…Interferons (IFNs) play a major role in the host’s antiviral innate immunity. …”
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    Antiviral Activity of Porcine IFN-λ3 and IFN-α against Porcine Rotavirus In Vitro
  7. 32967
    “…These include utilization of LF-BK α(V)β(6) cells for field virus isolation, production of high virus titers, and evaluating serological reactivity and virus susceptibility to porcine type I interferons. These four methodologies utilizing LF-BK α(V)β(6) cells were applicable to research with SVA and results support the current use of SVA as a surrogate for FMDV.…”
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    Comparative Evaluation of the Foot-and-Mouth Disease Virus Permissive LF-BK α(V)β(6) Cell Line for Senecavirus A Research
  8. 32968
    “…It monitors the invading pathogens by recognizing the pathogen‐associated molecular patterns and danger‐associated molecular patterns through pattern‐recognition receptors, leading to the production of type I interferons (IFNα/β), inflammatory cytokines, and chemokines, or the activation of autophagy or apoptosis to inhibit virus replication. …”
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    Regulation of innate immune responses by rabies virus
  9. 32969
    “…Teratogenic events were associated with significant increases in placental pro-inflammatory cytokines, type I interferons, and chemokines. RVFV displays a high degree of tropism for all placental tissue layers and the degree of hemorrhage and inflammatory mediator production is highest in placenta from pups with adverse outcomes. …”
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    Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta
  10. 32970
    por Mead, Jan R.
    Publicado 2023
    “…Therefore, host cell defenses are important in the early response to infection and may be triggered through toll receptors or inflammasomes which induce a number of signal pathways, interferons, cytokines, and other immune mediators. …”
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    Early immune and host cell responses to Cryptosporidium infection
  11. 32971
    “…These studies indicated that, as in murine and human cells, type I interferons (IFN) play an important role in limiting MYXV replication in canine cancer cells. …”
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    Oclacitinib and Myxoma Virus Therapy in Dogs with High-Grade Soft Tissue Sarcoma
  12. 32972
    “…Sensing of the dsDNA activates the cGAS/STING pathway, producing Type 1 interferons essential to recruiting antigen-presenting cells (APCs). …”
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    Innate immunity: Looking beyond T-cells in radiation and immunotherapy combinations
  13. 32973
    “…Successful vaccine requires efficient induction of antibody (Ab), type I interferons (IFN), cytokines/chemokines, cytotoxic T lymphocytes (CTL) and/or NK cells. …”
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    Role of Toll-like Receptors in Adjuvant-Augmented Immune Therapies
  14. 32974
    “…Signal transducer and activator of transcription 1 (STAT1) is activated in the inflammatory response to interferons. The MUC1 oncoprotein is overexpressed in human breast cancers. …”
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    COOPERATIVITY OF THE MUC1 ONCOPROTEIN AND STAT1 PATHWAY IN POOR PROGNOSIS HUMAN BREAST CANCER
  15. 32975
    “…In contrast, expression of many other pro-inflammatory genes, such as interferons or interleukins, was not detected at abnormal levels. …”
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    Neuroinflammation in advanced canine glaucoma
  16. 32976
    “…A key feature of the innate antiviral immune response is a rapid nonspecific response to virus infection largely mediated by the induction and extracellular secretion of type I interferons (IFNs) that restrict virus replication. …”
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    RING Finger Protein 11 Targets TBK1/IKKi Kinases to Inhibit Antiviral Signaling
  17. 32977
    por Ng, Dennis, Gommerman, Jennifer L.
    Publicado 2013
    “…PRR activation can trigger DCs to release the pleiotropic cytokine, Type I interferons (IFN), which facilitates various biological functions in different immune cell types. …”
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    The Regulation of Immune Responses by DC Derived Type I IFN
  18. 32978
    por Melchjorsen, Jesper
    Publicado 2013
    “…The innate sensing of the invading virus results in intracellular signal transduction and subsequent production of interferons (IFNs) and proinflammatory cytokines. Cytokines, including IFNs and chemokines, are vital molecules of antiviral defense regulating cell activation, differentiation of cells, and, not least, exerting direct antiviral effects. …”
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    Learning from the Messengers: Innate Sensing of Viruses and Cytokine Regulation of Immunity—Clues for Treatments and Vaccines
  19. 32979
    “…To date, numerous mediators of inflammation have been implicated in the development and progression of lupus nephritis, and these include cytokines, chemokines, and glycosaminoglycans. Of these, type I interferons (IFNs) can increase both gene and protein expression of cytokines and chemokines associated with lupus susceptibility, and interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and hyaluronan have been shown to elicit both pro- and anti-inflammatory effects on infiltrating and resident renal cells depending on the status of their microenvironment. …”
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    Mediators of Inflammation and Their Effect on Resident Renal Cells: Implications in Lupus Nephritis
  20. 32980
    “…A few agents have been tried and studied extensively such as cimetidine and interferons; others are new on the horizon, such as Echinacea, green tea catechins and quadrivalent HPV vaccine, and their efficacy is yet to be completely established. …”
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    Immunomodulators in warts: Unexplored or ineffective?
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