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32961por Fleming, Damarius S., Miller, Laura C., Li, Jiuyi, Van Geelen, Albert, Sang, Yongming“…To address these issues with PRRSV and host antiviral functions a novel modified-live vaccine (MLV) able to stimulate known antiviral interferons was created and examined for its ability to potentiate effective immunity and better protection. …”
Publicado 2022
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32962por Yang, Zizhao, Wei, Fei, Zhang, Bin, Luo, Yun, Xing, Xiaoyan, Wang, Min, Chen, Rongchang, Sun, Guibo, Sun, Xiaobo“…As a vital pivot for the human circulatory system, the brain-gut axis is now being considered as an important channel for many of the small immune molecules’ transductions, including interleukins, interferons, neurotransmitters, peptides, and the chemokines penetrating the mesentery and blood brain barrier (BBB) during the development of an ischemic stroke (IS). …”
Publicado 2022
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32963por Duncan, Christopher J.A., Skouboe, Morten K., Howarth, Sophie, Hollensen, Anne K., Chen, Rui, Børresen, Malene L., Thompson, Benjamin J., Stremenova Spegarova, Jarmila, Hatton, Catherine F., Stæger, Frederik F., Andersen, Mette K., Whittaker, John, Paludan, Søren R., Jørgensen, Sofie E., Thomsen, Martin K., Mikkelsen, Jacob G., Heilmann, Carsten, Buhas, Daniela, Øbro, Nina F., Bay, Jakob T., Marquart, Hanne V., de la Morena, M. Teresa, Klejka, Joseph A., Hirschfeld, Matthew, Borgwardt, Line, Forss, Isabel, Masmas, Tania, Poulsen, Anja, Noya, Francisco, Rouleau, Guy, Hansen, Torben, Zhou, Sirui, Albrechtsen, Anders, Alizadehfar, Reza, Allenspach, Eric J., Hambleton, Sophie, Mogensen, Trine H.“…Type I interferons (IFN-I) play a critical role in human antiviral immunity, as demonstrated by the exceptionally rare deleterious variants of IFNAR1 or IFNAR2. …”
Publicado 2022
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32964por King, Kelly, Larsen, Brendan B., Gryseels, Sophie, Richet, Cécile, Kraberger, Simona, Jackson, Robert, Worobey, Michael, Harrison, Joseph S., Varsani, Arvind, Van Doorslaer, Koenraad“…Upon infection, DNA viruses can be sensed by pattern recognition receptors (PRRs), leading to the activation of type I and III interferons to block infection. Therefore, viruses must inhibit these signaling pathways, avoid being detected, or both. …”
Publicado 2022
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32965por Yones, Sara A., Annett, Alva, Stoll, Patricia, Diamanti, Klev, Holmfeldt, Linda, Barrenäs, Carl Fredrik, Meadows, Jennifer R. S., Komorowski, Jan“…This included roles for genes (i) induced by interferons (IFI35 and OTOF), (ii) key to SLE cell types (KLRB1 encoding CD161), or (iii) with roles in autophagy and NF-κB pathway responses (CKAP4). …”
Publicado 2022
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32966por Deng, Lishuang, Yin, Yue, Xu, Zhiwen, Li, Fengqin, Zhao, Jun, Deng, Huidan, Jian, Zhijie, Lai, Siyuan, Sun, Xiangang, Zhu, Ling“…Interferons (IFNs) play a major role in the host’s antiviral innate immunity. …”
Publicado 2022
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32967por Mason, Jessica, Primavera, Victoria, Martignette, Lauren, Clark, Benjamin, Barrera, Jose, Simmons, Janine, Hurtle, William, Neilan, John G., Puckette, Michael“…These include utilization of LF-BK α(V)β(6) cells for field virus isolation, production of high virus titers, and evaluating serological reactivity and virus susceptibility to porcine type I interferons. These four methodologies utilizing LF-BK α(V)β(6) cells were applicable to research with SVA and results support the current use of SVA as a surrogate for FMDV.…”
Publicado 2022
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32968por Zhang, Haili, Huang, Jingbo, Song, Yumeng, Liu, Xingqi, Qian, Meichen, Huang, Pei, Li, Yuanyuan, Zhao, Ling, Wang, Hualei“…It monitors the invading pathogens by recognizing the pathogen‐associated molecular patterns and danger‐associated molecular patterns through pattern‐recognition receptors, leading to the production of type I interferons (IFNα/β), inflammatory cytokines, and chemokines, or the activation of autophagy or apoptosis to inhibit virus replication. …”
Publicado 2022
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32969por McMillen, Cynthia M., Boyles, Devin A., Kostadinov, Stefan G., Hoehl, Ryan M., Schwarz, Madeline M., Albe, Joseph R., Demers, Matthew J., Hartman, Amy L.“…Teratogenic events were associated with significant increases in placental pro-inflammatory cytokines, type I interferons, and chemokines. RVFV displays a high degree of tropism for all placental tissue layers and the degree of hemorrhage and inflammatory mediator production is highest in placenta from pups with adverse outcomes. …”
Publicado 2022
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32970por Mead, Jan R.“…Therefore, host cell defenses are important in the early response to infection and may be triggered through toll receptors or inflammasomes which induce a number of signal pathways, interferons, cytokines, and other immune mediators. …”
Publicado 2023
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32971“…These studies indicated that, as in murine and human cells, type I interferons (IFN) play an important role in limiting MYXV replication in canine cancer cells. …”
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32972“…Sensing of the dsDNA activates the cGAS/STING pathway, producing Type 1 interferons essential to recruiting antigen-presenting cells (APCs). …”
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32973“…Successful vaccine requires efficient induction of antibody (Ab), type I interferons (IFN), cytokines/chemokines, cytotoxic T lymphocytes (CTL) and/or NK cells. …”
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32974por Khodarev, Nikolai, Ahmad, Rehan, Rajabi, Hasan, Pitroda, Sean, Kufe, Turner, McClary, Cain, Joshi, Maya Datt, MacDermed, Dhara, Weichselbaum, Ralph, Kufe, Donald“…Signal transducer and activator of transcription 1 (STAT1) is activated in the inflammatory response to interferons. The MUC1 oncoprotein is overexpressed in human breast cancers. …”
Publicado 2009
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32975por Jiang, Bing, Harper, Matthew M., Kecova, Helga, Adamus, Grazyna, Kardon, Randy H., Grozdanic, Sinisa D., Kuehn, Markus H.“…In contrast, expression of many other pro-inflammatory genes, such as interferons or interleukins, was not detected at abnormal levels. …”
Publicado 2010
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32976por Charoenthongtrakul, Soratree, Gao, Linlin, Parvatiyar, Kislay, Lee, David, Harhaj, Edward W.“…A key feature of the innate antiviral immune response is a rapid nonspecific response to virus infection largely mediated by the induction and extracellular secretion of type I interferons (IFNs) that restrict virus replication. …”
Publicado 2013
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32977“…PRR activation can trigger DCs to release the pleiotropic cytokine, Type I interferons (IFN), which facilitates various biological functions in different immune cell types. …”
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32978por Melchjorsen, Jesper“…The innate sensing of the invading virus results in intracellular signal transduction and subsequent production of interferons (IFNs) and proinflammatory cytokines. Cytokines, including IFNs and chemokines, are vital molecules of antiviral defense regulating cell activation, differentiation of cells, and, not least, exerting direct antiviral effects. …”
Publicado 2013
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32979“…To date, numerous mediators of inflammation have been implicated in the development and progression of lupus nephritis, and these include cytokines, chemokines, and glycosaminoglycans. Of these, type I interferons (IFNs) can increase both gene and protein expression of cytokines and chemokines associated with lupus susceptibility, and interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and hyaluronan have been shown to elicit both pro- and anti-inflammatory effects on infiltrating and resident renal cells depending on the status of their microenvironment. …”
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32980“…A few agents have been tried and studied extensively such as cimetidine and interferons; others are new on the horizon, such as Echinacea, green tea catechins and quadrivalent HPV vaccine, and their efficacy is yet to be completely established. …”
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