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33001“…The study also examined the roles of viral proteins, mainly 2A and 3C protease, interferons production and their inhibitory effects.…”
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33002por Boonpethkaew, Suphagan, Meephansan, Jitlada, Charoensuksira, Sasin, Jumlongpim, Onjira, Tangtanatakul, Pattarin, Wongpiyabovorn, Jongkonnee, Komine, Mayumi, Morita, Akimichi“…After NB-UVB treatment, the activity score of upstream cytokines, such as interferons, interleukin (IL)-6, IL-17, and IL-22 in pathogenesis decreased. …”
Publicado 2023
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33003por Huang, Chen, Zhou, Youlian, Cheng, Jiemin, Guo, Xue, Shou, Diwen, Quan, Ying, Chen, Hanqing, Chen, Huiting, Zhou, Yongjian“…However, induction of PRRs is critical for the release of type I interferons (IFN-I) and the maturation of dendritic cells (DCs), which prime systemic antitumor immunity in HCC therapy. …”
Publicado 2023
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33004por Xue, Chen, Yao, Qinfan, Gu, Xinyu, Shi, Qingmiao, Yuan, Xin, Chu, Qingfei, Bao, Zhengyi, Lu, Juan, Li, Lanjuan“…Various cytokines, interferons, growth factors, and other specific molecules activate JAK-STAT signaling to drive a series of physiological and pathological processes, including proliferation, metabolism, immune response, inflammation, and malignancy. …”
Publicado 2023
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33005por Yang, Shanshan, Liu, Guangliang, Savelkoul, Huub F. J., Jansen, Christine A., Li, Bin“…Intestinal microbes can influence enteric viral infection through direct contact, such as binding, or by affecting interferons (IFNs) production and the intestinal barrier. …”
Publicado 2023
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33006por Chen, Qiqi, Li, Nina, Zeng, Shike, Wu, Shu, Luo, Xin, Zhang, Shengze, Zhu, Lin, Wu, Jiani, Xie, Ting, Bai, Shaohui, Zhang, Hao, Jiang, Zhiyuan, Lin, Shaoli, Wu, Nan, Jiang, Ying, Fang, Shisong, Wang, Xin, Shu, Yuelong, Luo, Huanle“…Both cell types exhibited activation of common interferons, inflammatory cytokines, and chemokine production upon ZIKV infection. …”
Publicado 2023
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33007por Shao, Qi, Fu, Feiyu, Zhu, Pei, Yu, Xiangyu, Wang, Jie, Wang, Zhaofei, Ma, Jingjiao, Wang, Hengan, Yan, Yaxian, Cheng, Yuqiang, Sun, Jianhe“…Further study found that overexpression of piMDA5 mediated the activation of interferons (IFNs) and IFN-stimulated genes (ISGs) while inhibiting NDV replication. …”
Publicado 2023
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33008por Sikorska, Justyna, Hou, Yan, Chiurazzi, Paul, Siu, Tony, Baltus, Gretchen A, Sheth, Payal, McLaren, David G, Truong, Quang, Parish, Craig A, Wyss, Daniel F“…RIG-I (retinoic acid inducible gene-I) can sense subtle differences between endogenous and viral RNA in the cytoplasm, triggering an anti-viral immune response through induction of type I interferons (IFN) and other inflammatory mediators. …”
Publicado 2023
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33009por Chen, Xudong, Xie, Min, Zhang, Sensen, Monguió-Tortajada, Marta, Yin, Jian, Liu, Chang, Zhang, Youqi, Delacrétaz, Maeva, Song, Mingyue, Wang, Yixue, Dong, Lin, Ding, Qiang, Zhou, Boda, Tian, Xiaolin, Deng, Haiteng, Xu, Lina, Liu, Xiaohui, Yang, Zi, Chang, Qing, Na, Jie, Zeng, Wenwen, Superti-Furga, Giulio, Rebsamen, Manuele, Yang, Maojun“…TASL, a recently identified innate immune adaptor protein for endolysosomal TLR7/8/9 signaling, is recruited by the lysosomal proton-coupled amino-acid transporter SLC15A4, and then activates IRF5, which in turn triggers the transcription of type I interferons and cytokines. Here, we report three cryo-electron microscopy (cryo-EM) structures of human SLC15A4 in the apo monomeric and dimeric state and as a TASL-bound complex. …”
Publicado 2023
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33010“…However, we must consider the possibility of contamination by type I interferons (IFNs), such as IFNα and IFNβ, or IFN-inducing substances, such as virus-derived double-stranded RNA or bacterial lipopolysaccharides, in clinical samples, leading to lower rates of viral isolation. …”
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33011por Benitez-Ribas, Daniel, Adema, Gosse J., Winkels, Gregor, Klasen, Ina S., Punt, Cornelis J.A., Figdor, Carl G., de Vries, I. Jolanda M.“…Plasmacytoid dendritic cells (pDCs) contribute to innate antiviral immune responses by producing type I interferons. Although human pDCs can induce T cell responses upon viral infection, it remains unclear if pDCs can present exogenous antigens. …”
Publicado 2006
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33012por O'Keeffe, Meredith, Hochrein, Hubertus, Vremec, David, Caminschi, Irina, Miller, Joanna L., Anders, E. Margot, Wu, Li, Lahoud, Mireille H., Henri, Sandrine, Scott, Bernadette, Hertzog, Paul, Tatarczuch, Lilliana, Shortman, Ken“…The CD45RA(hi)CD11c(int) plasmacytoid predendritic cells (p-preDCs) of mouse lymphoid organs, when stimulated in culture with CpG or influenza virus, produce large amounts of type I interferons and transform without division into CD8(+)CD205(−) DCs. …”
Publicado 2002
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33013por Fojtova, M, Boudny, V, Kovarik, A, Lauerova, L, Adamkova, L, Souckova, K, Jarkovsky, J, Kovarik, J“…The resistance to interferons (IFNs) limits their anticancer therapeutic efficacy. …”
Publicado 2007
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33014por Gaucher, Denis, Therrien, René, Kettaf, Nadia, Angermann, Bastian R., Boucher, Geneviève, Filali-Mouhim, Abdelali, Moser, Janice M., Mehta, Riyaz S., Drake, Donald R., Castro, Erika, Akondy, Rama, Rinfret, Aline, Yassine-Diab, Bader, Said, Elias A., Chouikh, Younes, Cameron, Mark J., Clum, Robert, Kelvin, David, Somogyi, Roland, Greller, Larry D., Balderas, Robert S., Wilkinson, Peter, Pantaleo, Giuseppe, Tartaglia, Jim, Haddad, Elias K., Sékaly, Rafick-Pierre“…We show that immunization with YF17D leads to an integrated immune response that includes several effector arms of innate immunity, including complement, the inflammasome, and interferons, as well as adaptive immunity as shown by an early T cell response followed by a brisk and variable B cell response. …”
Publicado 2008
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33015por Helmy, Mohamed, Gohda, Jin, Inoue, Jun-ichiro, Tomita, Masaru, Tsuchiya, Masa, Selvarajoo, Kumar“…This leads to the activation of MAP kinases and NF-κB which results in the induction of type I interferons and proinflammatory cytokines to combat the viral infection. …”
Publicado 2009
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33016por Gao, Dong, Yang, Yong-Kang, Wang, Rui-Peng, Zhou, Xiang, Diao, Fei-Ci, Li, Min-Dian, Zhai, Zhong-He, Jiang, Zheng-Fan, Chen, Dan-Ying“…RIG-I and MDA5 are cytoplasmic sensors that recognize different species of viral RNAs, leads to activation of the transcription factors IRF3 and NF-κB, which collaborate to induce type I interferons. In this study, we identified REUL, a RING-finger protein, as a specific RIG-I-interacting protein. …”
Publicado 2009
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33017por Mankouri, Jamel, Fragkoudis, Rennos, Richards, Kathryn H., Wetherill, Laura F., Harris, Mark, Kohl, Alain, Elliott, Richard M., Macdonald, Andrew“…Detection of virus triggers signalling cascades that induce transcription of type I interferons including IFNβ, which are pivotal for the initiation of an anti-viral state. …”
Publicado 2010
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33018por Zaragoza, Bruno, Evaristo, César, Kissenpfennig, Adrien, Libri, Valentina, Malissen, Bernard, Rocha, Benedita, Freitas, António A., Almeida, Afonso R. M.“…T(CM)-cell accumulation depended mainly on type I interferons, interleukin (IL)-6, and IL-15, but was independent of CD4(+) T-cell help. …”
Publicado 2011
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33019por Zhou, Peng, Cowled, Chris, Marsh, Glenn A., Shi, Zhengli, Wang, Lin-Fa, Baker, Michelle L.“…The ability of bats to remain asymptomatic to viral infection may be due to the rapid control of viral replication very early in the immune response through innate antiviral mechanisms. Type I and III interferons (IFNs) represent the first line of defence against viral infection in mammals, with both families of IFNs present in pteropid bats. …”
Publicado 2011
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33020por Hauser, Mary J., Dlugolenski, Daniel, Culhane, Marie R., Wentworth, David E., Tompkins, S. Mark, Tripp, Ralph A.“…Swine generate reassortant influenza viruses because they can be simultaneously infected with avian and human influenza; however, the features that restrict influenza reassortment in swine and human hosts are not fully understood. Type I and III interferons (IFNs) act as the first line of defense against influenza virus infection of respiratory epithelium. …”
Publicado 2013
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