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  1. 33001
    “…The study also examined the roles of viral proteins, mainly 2A and 3C protease, interferons production and their inhibitory effects.…”
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    Activation of Host Cellular Signaling and Mechanism of Enterovirus 71 Viral Proteins Associated with Hand, Foot and Mouth Disease
  2. 33002
    “…After NB-UVB treatment, the activity score of upstream cytokines, such as interferons, interleukin (IL)-6, IL-17, and IL-22 in pathogenesis decreased. …”
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    Elucidating the NB-UVB mechanism by comparing transcriptome alteration on the edge and center of psoriatic plaques
  3. 33003
    “…However, induction of PRRs is critical for the release of type I interferons (IFN-I) and the maturation of dendritic cells (DCs), which prime systemic antitumor immunity in HCC therapy. …”
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    Pattern recognition receptors in the development of nonalcoholic fatty liver disease and progression to hepatocellular carcinoma: An emerging therapeutic strategy
  4. 33004
    “…Various cytokines, interferons, growth factors, and other specific molecules activate JAK-STAT signaling to drive a series of physiological and pathological processes, including proliferation, metabolism, immune response, inflammation, and malignancy. …”
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    Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
  5. 33005
    “…Intestinal microbes can influence enteric viral infection through direct contact, such as binding, or by affecting interferons (IFNs) production and the intestinal barrier. …”
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    Mini-review: microbiota have potential to prevent PEDV infection by improved intestinal barrier
  6. 33006
    “…Both cell types exhibited activation of common interferons, inflammatory cytokines, and chemokine production upon ZIKV infection. …”
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    ZIKV infection differentially affects the transcriptional profiles in HTR8 and U251 cells
  7. 33007
    “…Further study found that overexpression of piMDA5 mediated the activation of interferons (IFNs) and IFN-stimulated genes (ISGs) while inhibiting NDV replication. …”
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    Pigeon MDA5 inhibits viral replication by triggering antiviral innate immunity
  8. 33008
    “…RIG-I (retinoic acid inducible gene-I) can sense subtle differences between endogenous and viral RNA in the cytoplasm, triggering an anti-viral immune response through induction of type I interferons (IFN) and other inflammatory mediators. …”
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    Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism
  9. 33009
    “…TASL, a recently identified innate immune adaptor protein for endolysosomal TLR7/8/9 signaling, is recruited by the lysosomal proton-coupled amino-acid transporter SLC15A4, and then activates IRF5, which in turn triggers the transcription of type I interferons and cytokines. Here, we report three cryo-electron microscopy (cryo-EM) structures of human SLC15A4 in the apo monomeric and dimeric state and as a TASL-bound complex. …”
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    Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling
  10. 33010
    por Shofa, Maya, Saito, Akatsuki
    Publicado 2023
    “…However, we must consider the possibility of contamination by type I interferons (IFNs), such as IFNα and IFNβ, or IFN-inducing substances, such as virus-derived double-stranded RNA or bacterial lipopolysaccharides, in clinical samples, leading to lower rates of viral isolation. …”
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    Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation
  11. 33011
    “…Plasmacytoid dendritic cells (pDCs) contribute to innate antiviral immune responses by producing type I interferons. Although human pDCs can induce T cell responses upon viral infection, it remains unclear if pDCs can present exogenous antigens. …”
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    Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4(+) T cells after FcγRII-mediated uptake
  12. 33012
    “…The CD45RA(hi)CD11c(int) plasmacytoid predendritic cells (p-preDCs) of mouse lymphoid organs, when stimulated in culture with CpG or influenza virus, produce large amounts of type I interferons and transform without division into CD8(+)CD205(−) DCs. …”
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    Mouse Plasmacytoid Cells: Long-lived Cells, Heterogeneous in Surface Phenotype and Function, that Differentiate Into CD8(+) Dendritic Cells Only after Microbial Stimulus
  13. 33013
    “…The resistance to interferons (IFNs) limits their anticancer therapeutic efficacy. …”
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    Development of IFN-γ resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells
  14. 33014
    “…We show that immunization with YF17D leads to an integrated immune response that includes several effector arms of innate immunity, including complement, the inflammasome, and interferons, as well as adaptive immunity as shown by an early T cell response followed by a brisk and variable B cell response. …”
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    Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
  15. 33015
    “…This leads to the activation of MAP kinases and NF-κB which results in the induction of type I interferons and proinflammatory cytokines to combat the viral infection. …”
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    Predicting Novel Features of Toll-Like Receptor 3 Signaling in Macrophages
  16. 33016
    “…RIG-I and MDA5 are cytoplasmic sensors that recognize different species of viral RNAs, leads to activation of the transcription factors IRF3 and NF-κB, which collaborate to induce type I interferons. In this study, we identified REUL, a RING-finger protein, as a specific RIG-I-interacting protein. …”
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    REUL Is a Novel E3 Ubiquitin Ligase and Stimulator of Retinoic-Acid-Inducible Gene-I
  17. 33017
    “…Detection of virus triggers signalling cascades that induce transcription of type I interferons including IFNβ, which are pivotal for the initiation of an anti-viral state. …”
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    Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection
  18. 33018
    “…T(CM)-cell accumulation depended mainly on type I interferons, interleukin (IL)-6, and IL-15, but was independent of CD4(+) T-cell help. …”
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    Cell-to-Cell Interactions and Signals Involved in the Reconstitution of Peripheral CD8(+) T(CM) and T(EM) Cell Pools
  19. 33019
    “…The ability of bats to remain asymptomatic to viral infection may be due to the rapid control of viral replication very early in the immune response through innate antiviral mechanisms. Type I and III interferons (IFNs) represent the first line of defence against viral infection in mammals, with both families of IFNs present in pteropid bats. …”
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    Type III IFN Receptor Expression and Functional Characterisation in the Pteropid Bat, Pteropus alecto
  20. 33020
    “…Swine generate reassortant influenza viruses because they can be simultaneously infected with avian and human influenza; however, the features that restrict influenza reassortment in swine and human hosts are not fully understood. Type I and III interferons (IFNs) act as the first line of defense against influenza virus infection of respiratory epithelium. …”
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    Antiviral Responses by Swine Primary Bronchoepithelial Cells Are Limited Compared to Human Bronchoepithelial Cells Following Influenza Virus Infection
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