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  1. 33021
    “…Type I interferons (IFN) are important for antiviral responses. …”
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    RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication
  2. 33022
    “…Innate recognition of self-DNA and -RNA and the ensuing production of cytokines such as type I interferons (IFNs) contribute to SLE development. Plasmacytoid dendritic cells (pDCs) have been proposed as a source of pathogenic IFN in SLE; however, their net contribution to the disease remains unclear. …”
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    Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus
  3. 33023
    “…CD14 then transfers the LPS to the TLR4/MD-2 complex which dimerizes and triggers MyD88- and TRIF-dependent production of pro-inflammatory cytokines and type I interferons. The TRIF-dependent signaling is linked with endocytosis of the activated TLR4, which is controlled by CD14. …”
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    Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling
  4. 33024
    “…We show that this unusual configuration of MAP kinase signaling contributes substantially to production of type I interferons, a hallmark of pDC activation.…”
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    Structural and Functional Basis for p38-MK2-Activated Rsk Signaling in Toll-Like Receptor-Stimulated Dendritic Cells
  5. 33025
    “…The expression of the interferons was also upregulated to different degrees in the spleen but that of the brain was various. …”
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    Immune responses of ducks infected with duck Tembusu virus
  6. 33026
    “…Human interferons (IFNs) are key cytokines secreted by immune system. …”
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    Development and Validation of a Micellar Capillary Electrophoresis Method for Determination of IFNβ-1b in Lyophilized Formulation of a Biosimilar Product
  7. 33027
    “…One pathway that inhibits host defense responses involves the induction of type I interferons and subsequently IL-10, yet the mechanism by which type I IFN induces IL-10 remains unclear. …”
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    IL-27 suppresses antimicrobial activity in human leprosy
  8. 33028
    “…This study showed that MuV induced innate immune responses in mouse Sertoli and Leydig cells through TLR2 and retinoic acid-inducible gene I (RIG-I) signaling, which result in the production of proinflammatory cytokines and chemokines, including TNF-α, IL-6, MCP-1, CXCL10, and type 1 interferons (IFN-α and IFN-β). By contrast, MuV did not induce the cytokine production in male germ cells. …”
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    Mumps virus-induced innate immune responses in mouse Sertoli and Leydig cells
  9. 33029
    “…Mitochondrial antiviral signalling protein (MAVS) acts as a common adaptor molecule for retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), which can recognize foreign RNA, including viral RNA, leading to the induction of type I interferons (IFNs). Therefore, MAVS is thought to be a crucial molecule in antiviral innate immunity. …”
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    Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS)
  10. 33030
    “…RESULTS: Gt1‐infected biopsies displayed elevated levels of transcripts regulated by type I and type III interferons (IFN), including genes that predict response to IFN‐α therapy. …”
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    Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection
  11. 33031
    “…ISG15 is a member of the ubiquitin-like modifier family and is induced by stimulation with type I interferons. Similar to ubiquitin and ubiquitination, covalent conjugation of ISG15 to target proteins (ISGylation) regulates their biochemical properties. …”
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    Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin
  12. 33032
    “…Our findings reveal that DENV infection modulates expression of several genes and signalling pathways including interferons, detoxification of ROS and viral assembly. …”
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    Transcriptome meta-analysis reveals a dysregulation in extra cellular matrix and cell junction associated gene signatures during Dengue virus infection
  13. 33033
    “…After phosphorylation of Tyr414 by BTK kinase, DDX41 will act as a sensor to recognize the invaders, followed by induction of type I interferons (IFN). After the immune response, DDX41 is degraded by the E3 ligase TRIM21, using Lys9 and Lys115 of DDX41 as the ubiquitination sites. …”
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    The emerging roles of the DDX41 protein in immunity and diseases
  14. 33034
    “…They are known to efficiently evade early innate immune responses, manifesting in almost negligible expression of type-I interferons (IFN-I). This evasion strategy suggests an evolutionary conserved viral function that has evolved to prevent RNA-based sensing of infection in vertebrate hosts. …”
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    Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication
  15. 33035
    “…He had normal hemoglobin, electroencephalogram, and skeletal survey, with negative autoantibodies to alpha and omega interferons and negative genetic testing for Glial Cell Missing 2 (GCM2) and calcium-sensing receptors (CaSRs) excluding known causes of hypoparathyroidism. …”
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    Idiopathic hypoparathyroidism with extensive intracranial calcification in children: First report from Saudi Arabia
  16. 33036
    “…Upon viral infection, retinoic acid–inducible gene I–like receptors (RLRs) recognize viral RNA and trigger a series of signaling events, leading to the induction of type I interferons (IFNs). These processes are delicately regulated to prevent excessive and harmful immune responses. …”
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    GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome
  17. 33037
    “…In contrast to re-induction of HLA class-I by interferons, HDAC inhibitors did not interfere with the expression of immuno-dominant viral proteins. …”
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    Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma
  18. 33038
    “…Lambda interferons (IFNLs) have immunomodulatory functions at epithelial barrier surfaces. …”
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    A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma
  19. 33039
    “…Moreover, IAV induced the production of type 1 interferons (IFN-α4/β) and the levels of IFN-γ were significantly reduced, which can be associated with impairment of the immune response to Cryptococcus during co-infection. …”
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    Influenza A Virus as a Predisposing Factor for Cryptococcosis
  20. 33040
    “…The expression of immune receptors that have received little or no attention from vagal sensory biologists is highlighted including receptors for certain chemokines (CXCLs), interleukins (IL-4) and interferons (IFNα, IFNγ). Stimulation of immune receptors with their cognate ligands led to activation of the C-fibers in isolated functional assays.…”
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    Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive/TRPV1-positive neurons detected by low input RNA sequencing
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