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33021por Nikonov, Andrei, Mölder, Tarmo, Sikut, Rein, Kiiver, Kaja, Männik, Andres, Toots, Urve, Lulla, Aleksei, Lulla, Valeria, Utt, Age, Merits, Andres, Ustav, Mart“…Type I interferons (IFN) are important for antiviral responses. …”
Publicado 2013
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33022por Sisirak, Vanja, Ganguly, Dipyaman, Lewis, Kanako L., Couillault, Coline, Tanaka, Lena, Bolland, Silvia, D’Agati, Vivette, Elkon, Keith B., Reizis, Boris“…Innate recognition of self-DNA and -RNA and the ensuing production of cytokines such as type I interferons (IFNs) contribute to SLE development. Plasmacytoid dendritic cells (pDCs) have been proposed as a source of pathogenic IFN in SLE; however, their net contribution to the disease remains unclear. …”
Publicado 2014
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33023por Płóciennikowska, Agnieszka, Hromada-Judycka, Aneta, Borzęcka, Kinga, Kwiatkowska, Katarzyna“…CD14 then transfers the LPS to the TLR4/MD-2 complex which dimerizes and triggers MyD88- and TRIF-dependent production of pro-inflammatory cytokines and type I interferons. The TRIF-dependent signaling is linked with endocytosis of the activated TLR4, which is controlled by CD14. …”
Publicado 2014
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33024“…We show that this unusual configuration of MAP kinase signaling contributes substantially to production of type I interferons, a hallmark of pDC activation.…”
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33025por Li, Ning, Wang, Yao, Li, Rong, Liu, Jiyuan, Zhang, Jinzhou, Cai, Yumei, Liu, Sidang, Chai, Tongjie, Wei, Liangmeng“…The expression of the interferons was also upregulated to different degrees in the spleen but that of the brain was various. …”
Publicado 2015
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33026por Dadgarnejad, Manuchehr, Rastegar, Hosein, Ilka, Hooshmand, Shekarchi, Maryam, Adib, Nooshin, Alebouyeh, Mahmood, Keypour, Nadia, Shoeibi, Shahram, Kobarfard, Farzad, Fazeli, Mohammad Reza“…Human interferons (IFNs) are key cytokines secreted by immune system. …”
Publicado 2015
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33027por Teles, Rosane M. B., Kelly-Scumpia, Kindra M., Sarno, Euzenir N., Rea, Thomas H., Ochoa, Maria T., Cheng, Genhong, Modlin, Robert L.“…One pathway that inhibits host defense responses involves the induction of type I interferons and subsequently IL-10, yet the mechanism by which type I IFN induces IL-10 remains unclear. …”
Publicado 2015
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33028por Wu, Han, Shi, Lili, Wang, Qing, Cheng, Lijing, Zhao, Xiang, Chen, Qiaoyuan, Jiang, Qian, Feng, Min, Li, Qihan, Han, Daishu“…This study showed that MuV induced innate immune responses in mouse Sertoli and Leydig cells through TLR2 and retinoic acid-inducible gene I (RIG-I) signaling, which result in the production of proinflammatory cytokines and chemokines, including TNF-α, IL-6, MCP-1, CXCL10, and type 1 interferons (IFN-α and IFN-β). By contrast, MuV did not induce the cytokine production in male germ cells. …”
Publicado 2016
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33029por Xing, Fei, Matsumiya, Tomoh, Hayakari, Ryo, Yoshida, Hidemi, Kawaguchi, Shogo, Takahashi, Ippei, Nakaji, Shigeyuki, Imaizumi, Tadaatsu“…Mitochondrial antiviral signalling protein (MAVS) acts as a common adaptor molecule for retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), which can recognize foreign RNA, including viral RNA, leading to the induction of type I interferons (IFNs). Therefore, MAVS is thought to be a crucial molecule in antiviral innate immunity. …”
Publicado 2016
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33030por Robinson, Mark W., Aranday‐Cortes, Elihu, Gatherer, Derek, Swann, Rachael, Liefhebber, Jolanda M. P., Filipe, Ana Da Silva, Sigruener, Alex, Barclay, Stephen T., Mills, Peter R., Patel, Arvind H., McLauchlan, John“…RESULTS: Gt1‐infected biopsies displayed elevated levels of transcripts regulated by type I and type III interferons (IFN), including genes that predict response to IFN‐α therapy. …”
Publicado 2015
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33031“…ISG15 is a member of the ubiquitin-like modifier family and is induced by stimulation with type I interferons. Similar to ubiquitin and ubiquitination, covalent conjugation of ISG15 to target proteins (ISGylation) regulates their biochemical properties. …”
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33032“…Our findings reveal that DENV infection modulates expression of several genes and signalling pathways including interferons, detoxification of ROS and viral assembly. …”
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33033“…After phosphorylation of Tyr414 by BTK kinase, DDX41 will act as a sensor to recognize the invaders, followed by induction of type I interferons (IFN). After the immune response, DDX41 is degraded by the E3 ligase TRIM21, using Lys9 and Lys115 of DDX41 as the ubiquitination sites. …”
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33034por Kindler, Eveline, Gil-Cruz, Cristina, Spanier, Julia, Li, Yize, Wilhelm, Jochen, Rabouw, Huib H., Züst, Roland, Hwang, Mihyun, V’kovski, Philip, Stalder, Hanspeter, Marti, Sabrina, Habjan, Matthias, Cervantes-Barragan, Luisa, Elliot, Ruth, Karl, Nadja, Gaughan, Christina, van Kuppeveld, Frank J. M., Silverman, Robert H., Keller, Markus, Ludewig, Burkhard, Bergmann, Cornelia C., Ziebuhr, John, Weiss, Susan R., Kalinke, Ulrich, Thiel, Volker“…They are known to efficiently evade early innate immune responses, manifesting in almost negligible expression of type-I interferons (IFN-I). This evasion strategy suggests an evolutionary conserved viral function that has evolved to prevent RNA-based sensing of infection in vertebrate hosts. …”
Publicado 2017
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33035por Kamal, Naglaa M., Alghamdi, Hamed A., Halabi, Abdulrahman A., Bakkar, Ayman A., Algarni, Ali, Alharbi, Abdullah, Alharthi, Abdulla A., Alharbi, Rawan A., Sherief, Laila M.“…He had normal hemoglobin, electroencephalogram, and skeletal survey, with negative autoantibodies to alpha and omega interferons and negative genetic testing for Glial Cell Missing 2 (GCM2) and calcium-sensing receptors (CaSRs) excluding known causes of hypoparathyroidism. …”
Publicado 2017
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33036por Nie, Ying, Ran, Yong, Zhang, Hong-Yan, Huang, Zhe-Fu, Pan, Zhao-Yi, Wang, Su-Yun, Wang, Yan-Yi“…Upon viral infection, retinoic acid–inducible gene I–like receptors (RLRs) recognize viral RNA and trigger a series of signaling events, leading to the induction of type I interferons (IFNs). These processes are delicately regulated to prevent excessive and harmful immune responses. …”
Publicado 2017
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33037por Ritter, Cathrin, Fan, Kaiji, Paschen, Annette, Reker Hardrup, Sine, Ferrone, Soldano, Nghiem, Paul, Ugurel, Selma, Schrama, David, Becker, Jürgen C.“…In contrast to re-induction of HLA class-I by interferons, HDAC inhibitors did not interfere with the expression of immuno-dominant viral proteins. …”
Publicado 2017
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33038por Chinnaswamy, Sreedhar, Wardzynska, Aleksandra, Pawelczyk, Malgorzata, Makowska, Joanna, Skaaby, Tea, Mercader, Josep M., Ahluwalia, Tarunveer S., Grarup, Niels, Guindo-Martinez, Marta, Bisgaard, Hans, Torrents, David, Linneberg, Allan, Bønnelykke, Klaus, Kowalski, Marek L.“…Lambda interferons (IFNLs) have immunomodulatory functions at epithelial barrier surfaces. …”
Publicado 2017
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33039por Oliveira, Lorena V. N., Costa, Marliete C., Magalhães, Thaís F. F., Bastos, Rafael W., Santos, Patrícia C., Carneiro, Hellem C. S., Ribeiro, Noelly Q., Ferreira, Gabriella F., Ribeiro, Lucas S., Gonçalves, Ana P. F., Fagundes, Caio T., Pascoal-Xavier, Marcelo A., Djordjevic, Julianne T., Sorrell, Tania C., Souza, Daniele G., Machado, Alexandre M. V., Santos, Daniel A.“…Moreover, IAV induced the production of type 1 interferons (IFN-α4/β) and the levels of IFN-γ were significantly reduced, which can be associated with impairment of the immune response to Cryptococcus during co-infection. …”
Publicado 2017
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33040por Wang, Jingya, Kollarik, Marian, Ru, Fei, Sun, Hui, McNeil, Benjamin, Dong, Xinzhong, Stephens, Geoffrey, Korolevich, Susana, Brohawn, Philip, Kolbeck, Roland, Undem, Bradley“…The expression of immune receptors that have received little or no attention from vagal sensory biologists is highlighted including receptors for certain chemokines (CXCLs), interleukins (IL-4) and interferons (IFNα, IFNγ). Stimulation of immune receptors with their cognate ligands led to activation of the C-fibers in isolated functional assays.…”
Publicado 2017
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