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  1. 33101
    “…This review focuses on cytokine secretions of innate and adaptive immune responses against COVID-19, including interleukins, interferons, tumor necrosis factor-alpha, and other chemokines. …”
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    The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections
  2. 33102
    “…Several studies have proposed that expression of ACE2 and/or dACE2 is induced by interferons (IFNs). Here, we report that drug-targeted inhibition or silencing of Unc51-like kinase 1 (ULK1) results in repression of type I IFN-induced expression of the dACE2 isoform. …”
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    Regulation of IFNα-induced expression of the short ACE2 isoform by ULK1
  3. 33103
    “…Here, using in vitro methods and an in vivo murine model of RSV infection, we showed that baicalin inhibits RSV replication induces translational upregulation of type I interferons (IFNs), IFN-α and IFN-β, and reverses epithelial thickening in lung tissues. …”
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    Baicalin Induces a Potent Innate Immune Response to Inhibit Respiratory Syncytial Virus Replication via Regulating Viral Non-Structural 1 and Matrix RNA
  4. 33104
    por Banday, A. Rouf, Stanifer, Megan L., Florez-Vargas, Oscar, Onabajo, Olusegun O., Papenberg, Brenen W., Zahoor, Muhammad A., Mirabello, Lisa, Ring, Timothy J., Lee, Chia-Han, Albert, Paul S., Andreakos, Evangelos, Arons, Evgeny, Barsh, Greg, Biesecker, Leslie G., Boyle, David L., Brahier, Mark S., Burnett-Hartman, Andrea, Carrington, Mary, Chang, Euijin, Choe, Pyoeng Gyun, Chisholm, Rex L., Colli, Leandro M., Dalgard, Clifton L., Dude, Carolynn M., Edberg, Jeff, Erdmann, Nathan, Feigelson, Heather S., Fonseca, Benedito A., Firestein, Gary S., Gehring, Adam J., Guo, Cuncai, Ho, Michelle, Holland, Steven, Hutchinson, Amy A., Im, Hogune, Irby, Les’Shon, Ison, Michael G., Joseph, Naima T., Kim, Hong Bin, Kreitman, Robert J., Korf, Bruce R., Lipkin, Steven M., Mahgoub, Siham M., Mohammed, Iman, Paschoalini, Guilherme L., Pacheco, Jennifer A., Peluso, Michael J., Rader, Daniel J., Redden, David T., Ritchie, Marylyn D., Rosenblum, Brooke, Ross, M. Elizabeth, Anna, Hanaisa P. Sant, Savage, Sharon A., Sharma, Sudha, Siouti, Eleni, Smith, Alicia K., Triantafyllia, Vasiliki, Vargas, Joselin M., Vargas, Jose D., Verma, Anurag, Vij, Vibha, Wesemann, Duane R., Yeager, Meredith, Yu, Xu, Zhang, Yu, Boulant, Steeve, Chanock, Stephen J., Feld, Jordan J., Prokunina-Olsson, Ludmila
    Publicado 2022
    “…Our results provide insight into molecular mechanisms through which early treatment with interferons could accelerate SARS-CoV-2 clearance and mitigate against severe COVID-19.…”
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    Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
  5. 33105
    “…To determine the mechanisms that drive GzmB expression, we performed ex vivo assays to reveal that a combination of type-I interferons and interleukin-2 is sufficient for GzmB expression. …”
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    Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues
  6. 33106
    por Hobson, Benjamin D., Sulzer, David
    Publicado 2022
    “…While neurons have long been considered to not present antigens, recent data indicate that they can be induced to do so, particularly in response to interferons and other forms of stress. Here, we review literature on neuronal antigen presentation and its potential role in PD. …”
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    Neuronal Presentation of Antigen and Its Possible Role in Parkinson’s Disease
  7. 33107
    “…Plasmacytoid dendritic cells (pDCs) express TLR7, a ssRNA-sensor encoded on the X chromosome, which escapes X chromosome inactivation (XCI) in females. pDCs are specialized in the production of type 1 interferons (IFN-I) through TLR7 activation which mediates both immune cell activation and also reactivation of latent HIV-1. …”
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    HIV-1 infection enhances innate function and TLR7 expression in female plasmacytoid dendritic cells
  8. 33108
    por Liu, Xu, Lu, Feng, Chen, Xihang
    Publicado 2022
    “…Necroptosis is a type of preprogrammed death caused by death receptors, interferons, Toll-like receptors, intracellular RNA and DNA sensors, and other mediators. …”
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    Examination of the role of necroptotic damage-associated molecular patterns in tissue fibrosis
  9. 33109
    “…Some reductions in mortality, hospitalisation and need for ventilation were seen with interferons and remdesivir, particularly when administered early, and with the mucolytic drug, bromhexine. …”
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    Current evidence for COVID-19 therapies: a systematic literature review
  10. 33110
    “…Cytokines such as the Type I and II interferons synergise in their local antiviral effects. …”
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    Cytokines and chemokines: The vital role they play in herpes simplex virus mucosal immunology
  11. 33111
    “…Knockdown or knockout of ARIH1 significantly inhibits herpes simplex virus 1 (HSV-1)- or cytoplasmic DNA-induced expression of type I interferons (IFNs) and proinflammatory cytokines. Consistently, tamoxifen-treated ER-Cre;Arih1(fl/fl) mice and Lyz2-Cre; Arih1(fl/fl) mice are hypersensitive to HSV-1 infection compared with the controls. …”
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    The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS
  12. 33112
    “…Results showed that a wide variety of genes were differentially expressed, products of which are mainly involved in cell adhesion, homeostasis, and most notably, antiviral and immune responses, depicted by significant downregulation of protocadherins and type I alpha interferons (IFNAs). While initially, the levels of IFNAs were higher in the medium of S protein expressing cells, the downregulation observed on the transcriptomic level might have been reflected by no further increase of IFNA cytokines beyond the 5 h time-point, compared to the mock control. …”
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    Early suppression of antiviral host response and protocadherins by SARS-CoV-2 Spike protein in THP-1-derived macrophage-like cells
  13. 33113
    “…The Pyrin inflammasome response was enabled in hMDM by prolonged priming with either LPS or type I or II interferons and required an increase in Pyrin expression. …”
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    Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever
  14. 33114
    “…Antibodies against cytokines (interferons α, γ and ω, IL1β, IL6, IL10, IL-17, IL21), chemokines, complement, nuclear proteins and DNA, anticardiolipin, and several extracellular proteins have been reported. …”
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    Autoimmunity and Immunodeficiency in Severe SARS-CoV-2 Infection and Prolonged COVID-19
  15. 33115
    “…In addition, SME suppressed the expression of interferons and inflammatory cytokines in HD-11 chicken macrophages. …”
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    Suppressive modulation of host immune responses by Dermanyssus gallinae infestation
  16. 33116
    “…Toll-like receptors (TLRs), crucial components in the initiation of innate immune responses to different pathogens, trigger the downstream production of pro-inflammatory cytokines, interferons, and other mediators. It has been demonstrated that they contribute to the dysregulated immune response observed in patients with severe COVID-19. …”
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    TLRs: Innate Immune Sentries against SARS-CoV-2 Infection
  17. 33117
    “…Type I and type III interferons (IFNs) are antiviral cytokines that play a key role in protecting IECs against viruses with the type III IFN being the most important. …”
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    Regionalization of the antiviral response in the gastrointestinal tract to provide spatially controlled host/pathogen interactions
  18. 33118
    “…Interferons (IFN) exert antiviral, immunomodulatory and cytostatic activities. …”
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    IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo
  19. 33119
    “…METHODS: Leydig cell production of mRNA and protein for interferons (IFNs) and of three antiviral proteins—2′5′ oligoadenylate synthetase (2′5′OAS), double-stranded RNA-activated protein kinase (PKR) and MxA—was investigated, in the absence or presence of mumps virus or viral stimuli including poly I:C, a mimetic of RNA viruses replication product. …”
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    Antiviral responses of human Leydig cells to mumps virus infection or poly I:C stimulation
  20. 33120
    por Gonsette, R. E.
    Publicado 2012
    “…Interestingly, the beneficial effects of currently approved immunomodulators (interferons β and glatiramer acetate) are associated with a restored regulatory T cell homeostasis. …”
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    Self-tolerance in multiple sclerosis
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