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33101por Hsu, Ren-Jun, Yu, Wei-Chieh, Peng, Guan-Ru, Ye, Chih-Hung, Hu, SuiYun, Chong, Patrick Chun Theng, Yap, Kah Yi, Lee, Jamie Yu Chieh, Lin, Wei-Chen, Yu, Shu-Han“…This review focuses on cytokine secretions of innate and adaptive immune responses against COVID-19, including interleukins, interferons, tumor necrosis factor-alpha, and other chemokines. …”
Publicado 2022
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33102por Perez, Ricardo E., Saleiro, Diana, Ilut, Liliana, Schiltz, Gary E., Eckerdt, Frank, Fish, Eleanor N., Platanias, Leonidas C.“…Several studies have proposed that expression of ACE2 and/or dACE2 is induced by interferons (IFNs). Here, we report that drug-targeted inhibition or silencing of Unc51-like kinase 1 (ULK1) results in repression of type I IFN-induced expression of the dACE2 isoform. …”
Publicado 2022
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33103“…Here, using in vitro methods and an in vivo murine model of RSV infection, we showed that baicalin inhibits RSV replication induces translational upregulation of type I interferons (IFNs), IFN-α and IFN-β, and reverses epithelial thickening in lung tissues. …”
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33104por Banday, A. Rouf, Stanifer, Megan L., Florez-Vargas, Oscar, Onabajo, Olusegun O., Papenberg, Brenen W., Zahoor, Muhammad A., Mirabello, Lisa, Ring, Timothy J., Lee, Chia-Han, Albert, Paul S., Andreakos, Evangelos, Arons, Evgeny, Barsh, Greg, Biesecker, Leslie G., Boyle, David L., Brahier, Mark S., Burnett-Hartman, Andrea, Carrington, Mary, Chang, Euijin, Choe, Pyoeng Gyun, Chisholm, Rex L., Colli, Leandro M., Dalgard, Clifton L., Dude, Carolynn M., Edberg, Jeff, Erdmann, Nathan, Feigelson, Heather S., Fonseca, Benedito A., Firestein, Gary S., Gehring, Adam J., Guo, Cuncai, Ho, Michelle, Holland, Steven, Hutchinson, Amy A., Im, Hogune, Irby, Les’Shon, Ison, Michael G., Joseph, Naima T., Kim, Hong Bin, Kreitman, Robert J., Korf, Bruce R., Lipkin, Steven M., Mahgoub, Siham M., Mohammed, Iman, Paschoalini, Guilherme L., Pacheco, Jennifer A., Peluso, Michael J., Rader, Daniel J., Redden, David T., Ritchie, Marylyn D., Rosenblum, Brooke, Ross, M. Elizabeth, Anna, Hanaisa P. Sant, Savage, Sharon A., Sharma, Sudha, Siouti, Eleni, Smith, Alicia K., Triantafyllia, Vasiliki, Vargas, Joselin M., Vargas, Jose D., Verma, Anurag, Vij, Vibha, Wesemann, Duane R., Yeager, Meredith, Yu, Xu, Zhang, Yu, Boulant, Steeve, Chanock, Stephen J., Feld, Jordan J., Prokunina-Olsson, Ludmila“…Our results provide insight into molecular mechanisms through which early treatment with interferons could accelerate SARS-CoV-2 clearance and mitigate against severe COVID-19.…”
Publicado 2022
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33105por Traxinger, Brianna, Vick, Sarah C., Woodward-Davis, Amanda, Voillet, Valentin, Erickson, Jami R., Czartoski, Julie, Teague, Candice, Prlic, Martin, Lund, Jennifer M.“…To determine the mechanisms that drive GzmB expression, we performed ex vivo assays to reveal that a combination of type-I interferons and interleukin-2 is sufficient for GzmB expression. …”
Publicado 2022
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33106“…While neurons have long been considered to not present antigens, recent data indicate that they can be induced to do so, particularly in response to interferons and other forms of stress. Here, we review literature on neuronal antigen presentation and its potential role in PD. …”
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33107por Abbas, Flora, Cenac, Claire, Youness, Ali, Azar, Pascal, Delobel, Pierre, Guéry, Jean-Charles“…Plasmacytoid dendritic cells (pDCs) express TLR7, a ssRNA-sensor encoded on the X chromosome, which escapes X chromosome inactivation (XCI) in females. pDCs are specialized in the production of type 1 interferons (IFN-I) through TLR7 activation which mediates both immune cell activation and also reactivation of latent HIV-1. …”
Publicado 2022
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33108“…Necroptosis is a type of preprogrammed death caused by death receptors, interferons, Toll-like receptors, intracellular RNA and DNA sensors, and other mediators. …”
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33109por Welte, Tobias, Ambrose, Lucy J., Sibbring, Gillian C., Sheikh, Shehla, Müllerová, Hana, Sabir, Ian“…Some reductions in mortality, hospitalisation and need for ventilation were seen with interferons and remdesivir, particularly when administered early, and with the mucolytic drug, bromhexine. …”
Publicado 2021
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33110“…Cytokines such as the Type I and II interferons synergise in their local antiviral effects. …”
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33111por Xiong, Tian-Chen, Wei, Ming-Cong, Li, Fang-Xu, Shi, Miao, Gan, Hu, Tang, Zhen, Dong, Hong-Peng, Liuyu, Tianzi, Gao, Pu, Zhong, Bo, Zhang, Zhi-Dong, Lin, Dandan“…Knockdown or knockout of ARIH1 significantly inhibits herpes simplex virus 1 (HSV-1)- or cytoplasmic DNA-induced expression of type I interferons (IFNs) and proinflammatory cytokines. Consistently, tamoxifen-treated ER-Cre;Arih1(fl/fl) mice and Lyz2-Cre; Arih1(fl/fl) mice are hypersensitive to HSV-1 infection compared with the controls. …”
Publicado 2022
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33112por Miltner, Noémi, Linkner, Tamás Richárd, Ambrus, Viktor, Al-Muffti, Aya S., Ahmad, Hala, Mótyán, János András, Benkő, Szilvia, Tőzsér, József, Mahdi, Mohamed“…Results showed that a wide variety of genes were differentially expressed, products of which are mainly involved in cell adhesion, homeostasis, and most notably, antiviral and immune responses, depicted by significant downregulation of protocadherins and type I alpha interferons (IFNAs). While initially, the levels of IFNAs were higher in the medium of S protein expressing cells, the downregulation observed on the transcriptomic level might have been reflected by no further increase of IFNA cytokines beyond the 5 h time-point, compared to the mock control. …”
Publicado 2022
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33113por Mangan, Matthew S. J., Gorki, Friederike, Krause, Karoline, Heinz, Alexander, Pankow, Anne, Ebert, Thomas, Jahn, Dieter, Hiller, Karsten, Hornung, Veit, Maurer, Marcus, Schmidt, Florian I., Gerhard, Ralf, Latz, Eicke“…The Pyrin inflammasome response was enabled in hMDM by prolonged priming with either LPS or type I or II interferons and required an increase in Pyrin expression. …”
Publicado 2022
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33114por Garmendia, Jenny Valentina, García, Alexis Hipólito, De Sanctis, Claudia Valentina, Hajdúch, Marián, De Sanctis, Juan Bautista“…Antibodies against cytokines (interferons α, γ and ω, IL1β, IL6, IL10, IL-17, IL21), chemokines, complement, nuclear proteins and DNA, anticardiolipin, and several extracellular proteins have been reported. …”
Publicado 2022
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33115por Fujisawa, Sotaro, Murata, Shiro, Isezaki, Masayoshi, Win, Shwe Yee, Sato, Takumi, Oishi, Eiji, Taneno, Akira, Maekawa, Naoya, Okagawa, Tomohiro, Konnai, Satoru, Ohashi, Kazuhiko“…In addition, SME suppressed the expression of interferons and inflammatory cytokines in HD-11 chicken macrophages. …”
Publicado 2023
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33116por Mantovani, Stefania, Oliviero, Barbara, Varchetta, Stefania, Renieri, Alessandra, Mondelli, Mario U.“…Toll-like receptors (TLRs), crucial components in the initiation of innate immune responses to different pathogens, trigger the downstream production of pro-inflammatory cytokines, interferons, and other mediators. It has been demonstrated that they contribute to the dysregulated immune response observed in patients with severe COVID-19. …”
Publicado 2023
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33117“…Type I and type III interferons (IFNs) are antiviral cytokines that play a key role in protecting IECs against viruses with the type III IFN being the most important. …”
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33118“…Interferons (IFN) exert antiviral, immunomodulatory and cytostatic activities. …”
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33119por Le Tortorec, A., Denis, H., Satie, A-P., Patard, J-J., Ruffault, A., Jégou, B., Dejucq-Rainsford, N.“…METHODS: Leydig cell production of mRNA and protein for interferons (IFNs) and of three antiviral proteins—2′5′ oligoadenylate synthetase (2′5′OAS), double-stranded RNA-activated protein kinase (PKR) and MxA—was investigated, in the absence or presence of mumps virus or viral stimuli including poly I:C, a mimetic of RNA viruses replication product. …”
Publicado 2008
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33120por Gonsette, R. E.“…Interestingly, the beneficial effects of currently approved immunomodulators (interferons β and glatiramer acetate) are associated with a restored regulatory T cell homeostasis. …”
Publicado 2012
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